Animal Reproduction JP Advis DVM, Ph.D. Bartlett Hall, Animal Sciences, Cook, (732) 932-9240, advis@aesop.rutgers.edu 14 Course website: rci.rutgers.edu/~advis Material to be covered: About lecture Meetings 01-02: Introduction to Animal Reproduction (2) Meetings 03-04: Reproductive Structures and their Functions (2) Meetings 05-07: The HPG axis and its Liposoluble and Watersoluble Hormones (3) Meetings 08-09: The Neuroendocrine Control of Male and Female Puberty Onset (2) Meetings 10-11: REVIEW AND TEST #1 Meetings 12-17: Female and Male Reproduction and Techniques for their Control (6) Meetings 18-19: REVIEW AND TEST #2 Meetings 20-21: Reproductive Behavior and the Spermatozoa in the Female Tract (2) Meetings 22-23: Embryogenesis, Placentation, Parturition and Lactation (3) Meetings 24-25: Puerperium, Lactation and Reproductive Ageing (2) Meeting 26 Reproductive Pathology and Case Studies (1) Meetings 27-28: REVIEW AND TEST #3 AND TEST #4 slides: There are not intended to be the sole source for studying the course material!!!!!!!!!!!!!!!! Slides are good to review the course material after you have study your course textbook Slides are a good indicator of the relative importance of lecture topics (see slide # per topic) Group slides by titles when using them to review course material. Match lectures and text. Reproductive Cyclicity # lectures for cumulative test # 02 book 12 Reproductive cyclicity: terminology and basic concepts 1-9 13 Reproductive cyclicity: the follicular phase 1-9 14 Reproductive cyclicity: the luteal phase 1-9 1-9 15 Reproductive cyclicity: techniques for controlling female reproductive processes 16 Endocrinology of the male and the spermatogenesis process 1-10 1-10 17 Endocrinology of the male and techniques to control male reproductive processes 18 REVIEW material from lecture # 12 through lecture # 17 1-10 19 EXAM # 02 - material from lecture # 01 through lecture # 18 1-10 Page 1
During the early luteal phase there is further thickening of the endometrium, marked growth of the coiled arteries, and increased complexity of the uterine glands. As the corpus luteum wanes, endometrial thickness is reduced by loss of ground substance. Increased coiling of spiral arteries causes ischemia and finally sloughing of endometrium. The upper portion of the figure shows the corresponding events in the ovary. a view from ovary and uterus The menstrual and estrous cycle can be seen from different viewpoints, but are basically the same cycle. Page 2
consists of three processes: luteinization, formation of a CL, and luteolysis. a view from the blood The menstrual and estrous cycle can be seen from different viewpoints, but are basically the same cycle. Page 3
a view from ovary and uterus The menstrual and estrous cycle can be seen from different viewpoints, but are basically the same cycle. last lecture The menstrual and estrous cycle can be seen from different viewpoints, but are basically the same cycle. Page 4
this lecture consists of three processes: luteinization, formation of a CL, and luteolysis. 4 5 1 2 3 6 7 Why do changes in blood P4 levels occur from 1 7??? Page 5
Formation of the corpus luteum: the preovulatory follicle. Formation of the corpus luteum: the corpus hemorragicum. Page 6
Formation of the corpus luteum: the functional CL. Progesterone (P4) has many physiological effects. Page 7
Mechanism of progesterone synthesis by luteal cells. Page 8
Effect of total and unilateral uterectomy upon the estrous cycle duration in ewes. Page 9
Effect of uterectomy upon estrous cycle duration in ewes. Page 10
Changes in PGF2alpha, OT and OTr, during late diestrus and proestrus. Possible ligands involved in luteolysis Page 11
Proposed steps resulting in the loss of P4 production from steroidogenic cells induced by PGF2alpha How could P4 synthesis be inhibited??? What is apoptosis??? Page 12
Linking OT and PGF2a Endometrial synthesis of PGF2alpha Vasoconstriction of endometrial arterioles Endometrial necrosis and sloughing (menses) Proposed mechanism of luteolysis in primates. Linking OT and PGF2a Page 13
Luteolysis as the initiator of menses (figure 9-15 in your textbook) Page 14
P4 (hours) (days) P4 CIDR insertion removal (hours) Blood P4 profiles after CIDR insertion and removal in cows, or how you can make money out of luteolysis Blood P4 profiles in the women menstrual cycle after following various hormonal contraception strategies Page 15
PGF2a injection day 0 6 no effect normal estrous cycle estrus every 21 days PGF2a injection day 6-17 cows in estrus in 3 days Influence of PGF2alpha upon cycle length in the cow How would you synchronize an estrous or menstrual cycle??? punch line, the closest it mimics the real sequence, the better the technique would be Page 16
Presynch and Ovsynch as methods to synchronize ovulation in cows Q6 Page 17
Comments on your weekly questions Page 18
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