LITERATURE SEARCH NatHER meta-analysis SEARCH Date of search: September 4 th 2014 Search strategy Step MEDLINE Results 1 (her2-positive or her2 positive).mp. 2053 2 (HER2+ or HER2 positive).mp. 10052 3 exp *Receptor, erbb-2/ or erb-2.mp. 8242 4 epidermal growth factor receptor-2.m_titl. 354 5 epidermal growth factor receptor-2.mp. 2285 6 exp *Receptor, Epidermal Growth Factor/ or epidermal growth factor receptor 2.mp. 15875 7 1 or 2 or 3 or 4 or 5 or 6 27207 8 exp Breast Neoplasms/ 144571 9 exp Breast/ or Breast Diseases/ 20726 10 Neoplasms/ or Adenocarcinoma/ or Carcinoma/ 249141 11 (brca or (breast adj4 (adenocarcinoma* or cancer* or carcinoma* or metasta* or neoplasm* or tumo?r))).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, 177540 protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 12 8 or 9 or 10 or 11 414287 13 metasta*.mp 229005 14 metastatic.mp. or exp *Neoplasm Metastasis/ 106778 15 secondary.mp. 317462 16 spread.mp. 69143 17 spreads.mp. 3712 18 advanced.mp. 181282 19 stage 4.mp. 2650 20 stage IV.mp. or exp *Neoplasm Staging/ 14091 21 stage-iv.mp. or exp *Neoplasm Staging/ 14091 22 stage-4.mp. 2650 23 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 757053 24 12 AND 23 98703 25 exp *Survival Analysis/ or exp *Survival/ or exp *Survival Rate/ or survival.mp. 581490 26 progression-free survival.mp. or exp *Disease-Free Survival/ 15334 27 mortality.mp. or exp *Mortality/ 339848 28 death.mp. or exp *Death/ 372549 29 25 or 26 or 27 or 28 1069822 30 randomized controlled trial.pt. 275721 31 controlled clinical trial.pt. 42416 32 randomized controlled trial.sh. 275721 33 random allocation.sh. 45806 34 double blind method.sh. 80467 35 single blind method.sh. 16479 1
36 clinical trial.pt. 284461 37 exp clinical trial/ 557343 38 (clin$ adj25 trial$).ti,ab. 200558 39 ((singl$ OR doubl$ OR trebl$ OR tripl$) adj25 (blind$ OR mask$)).ti,ab. 81589 40 placebos.sh. 14046 41 placebo$.ti,ab. 104277 42 random$.ti,ab. 516488 43 research design.sh. 54633 44 comparative study.sh. 947921 45 exp evaluation studies/ 193393 46 follow up studies.sh. 328634 47 prospective studies.sh. 289519 48 (control$ OR prospectiv$ OR volunteer$).ti,ab. 2001976 49 OR/30-48 3474786 50 Epidemiologic studies/ 5877 51 exp case control studies/ 563750 52 exp cohort studies/ 1021522 53 Case control.tw. 61019 54 (cohort adj (study or studies)).tw. 73829 55 Cohort analy$.tw. 2912 56 (Follow up adj (study or studies)).tw. 21063 57 (observational adj (study or studies)).tw. 38395 58 Longitudinal.tw. 97389 59 Retrospective.tw. 214140 60 Cross sectional.tw. 134408 61 Cross-sectional studies/ 156194 62 OR/50-61 1421926 63 #49 or #62 3906900 64 7 AND 24 5387 65 29 and 63 and 64 1617 66 limit 65 to humans 1605 67 limit 66 to English 1527 68 limit 67 to yr="1986 -Current" 1527 2
EMBASE: (http://www.embase.com/home#/search:quicksearch/) Step EMBASE 1 her2 AND positive 10891 2 'her2 positive' 5079 3 'receptor erbb 2' 59 4 'erb 2' 203 5 'epidermal growth factor receptor 2' 25662 6 'receptor epidermal growth factor' 279 7 #1 or #2 or #3 or #4 or #5 or #6 32127 8 breast AND neoplasms 14619 9 'breast neoplasms' 7763 10 'breast diseases' 2794 11 breast* 530275 12 breast AND (adenocarcinoma* OR cancer* OR carcinoma* OR metasta* OR neoplasm* OR tumo?r) 410476 13 breast AND (adenocarcinoma* OR cancer* OR breast AND tumor* OR breast AND tumour*) 30821 14 #8 or #9 or #10 or #11 or #12 or #13 530275 15 metasta* 549881 16 metastatic 202726 17 'neoplasm metastasis' 2129 18 secondary 589005 19 spread 128447 20 spreads OR advanced 494321 21 'stage 4' OR 'stage-4' OR 'stage iv' OR 'stage-iv' OR 'neoplasm staging' 29327 22 #15 or #16 or #17 or #18 or #19 or #20 or #21 1645805 23 #14 AND #22 127231 24 survival AND analysis 326518 25 'survival analysis' 22831 26 'survival/' OR 'survival rate/' OR 'survival' 1000910 27 'progression-free survival' OR 'progression free survival' 45333 28 'disease-free survival' OR 'disease free survival' 51809 29 'mortality' OR 'mortality/' 905369 30 'death' OR 'death/' 772503 31 #24 or #25 or #26 or #27 or #28 or #29 or #30 2201515 32 clinical AND trial 1219077 33 'clinical trial'/exp 979822 34 'randomized controlled trial'/exp 348332 35 'randomization'/exp 63094 36 'single blind procedure'/exp 18520 37 'double blind procedure'/exp 116804 38 'crossover procedure'/exp 40033 39 'placebo'/exp 258168 40 randomized AND controlled AND trial$ 456257 41 rct.tw OR 'rct' 17273 42 randomised AND controlled AND trial$ 57224 43 random AND allocation 2767 44 randomly AND allocated 24208 45 'allocated randomly' 1961 46 'single blind$' 24906 47 'double blind$' 181331 48 'placebo$' 335161 49 'prospective study'/exp 257914 3
50 #32 or #33 or #34 or #35 or #36 or #37 or #38 or #39 or #40 or #41 or #42 or #43 or #44 or #45 or #46 or #47 or #48 or #49 1640154 51 'clinical study'/exp 6690101 52 'case control study' 111577 53 'family study'/exp 10543 54 'longitudinal study'/exp 68815 55 'retrospective study'/exp 352227 56 'prospective study'/exp 257914 57 'randomized controlled trials'/exp 56873 58 #56 NOT #57 256317 59 'cohort analysis'/exp 176434 60 'cohort study' 108555 61 'cohort studies' 16565 62 'cohort analysis' 177811 63 'case control study' OR 'case control studies' 117737 64 'observational study' OR 'observational studies' 90597 65 'epidemiologic$ study' OR 'epidemiologic$ studies' 25076 66 'cross sectional study' OR 'cross sectional studies' 156150 #51 or #52 or #53 or #54 or #55 or #58 or #59 or #60 or #61 or #62 or 67 #63 or #64 or #65 or #66 6881868 68 #50 or #67 7115739 69 #7 AND #23 11429 70 #31 AND #68 AND #69 4280 71 #70 AND [humans]/lim 4140 72 #71 AND [english]/lim 3970 73 #72 AND [1987-2014]/py 3970 4
CENTRAL: (http://onlinelibrary.wiley.com/cochranelibrary/search/) Step CENTRAL 1 "Her2" or "HER-2" or "HER2-neu" or "her2/neu" or "Her2/neu" or 950 "HER2/neu" or "Her-2-neu" or "HER-2-neu" or "her-2-neu" or "Her- 2/neu" or "HER-2/neu" or "her-2/neu" or "Her-2neu" or "HER-2neu" or "her-2neu" or "Her2neu" or "HER2neu" or "her2neu" 2 "erb2 receptor" or "epidermal growth factor receptor" or "epidermal 1309 growth factor" 3 #1 or #2 1917 4 MeSH descriptor: [Breast Neoplasms] explode all trees 8756 5 'breast neoplasms' 10037 6 'breast diseases' 7039 7 breast* 24650 8 breast and (adenocarcinoma* or cancer* or carcinoma* or metasta* or 18785 neoplasm* or tumo?r) 9 breast and (adenocarcinoma* or cancer* or breast and tumor* or breast 18301 and tumour*) 10 #4 or #5 or #6 or #7 or #8 or #9 24650 11 MeSH descriptor: [Neoplasm Metastasis] explode all trees 3800 12 "metasta*" or "metastatic" or "neoplasm metastasis" or "secondary" or 81989 "spread" or "spreads" or "advanced" 13 "stage 4" or "stage-4" or "stage iv" or "stage-iv" or "neoplasm staging" 6686 14 #11 or #12 or #13 85034 15 #10 and #14 9195 16 MeSH descriptor: [Survival Analysis] explode all trees 15632 17 "survival analysis" or "survival/" or "survival rate/" or "survival" 44699 18 MeSH descriptor: [Disease-Free Survival] explode all trees 4595 19 "disease-free survival" or "disease free survival" 6800 20 "progression-free survival" or "progression free survival" 3479 21 MeSH descriptor: [Mortality] explode all trees 11036 22 MeSH descriptor: [Death] explode all trees 1616 23 #16 or #17 or #18 or #19 or #20 or #21 or #22 50237 24 #3 and #15 643 25 #23 and #24 377 26 Publication Year from 1987 to 2014 377 #hits per database: MEDLINE: 1527 EMBASE: 3970 CENTRAL: 377 Total: 5874 potentially relevant references identified with 1149 duplicate references Post de-duplication: MEDLINE: 1527 EMBASE: 3062 CENTRAL: 136 Total: 4725 potentially relevant references after excluding 1149 duplicate references 5
Author: Bindu Kalesan, PPDI Date: September 05, 2014 Checked by: 6