MSM NPN 80044805 What is MSM? MSM is a natural sulfur compound and nutritional component contained in various foods. It is part of the staple diet of humans and almost all other vertebrates. As the main source of sulfur, MSM is essential for the correct functioning of natural antioxidant mechanisms in our body. To neutralize free radicals, the body uses a variety of antioxidant enzymes that contain sulfur amino acids. In addition, sulfur is necessary in the formation of what is regarded as the most potent antioxidant among all nutrients, glutathione. MSM amplifies the effect of such antioxidants as vitamins C and E, coenzyme Q10, selenium, etc... Dr. Stanley Jacob and his colleague, Robert Herschler, a chemist from the Oregon Health Sciences University in Portland, Oregon, pioneered the study of MSM. How the components of MSM contribute to its therapeutic effects? MSM is a natural analgesic: it blocks the transfer of pain that travels through nerve fibers. It enhances the activity of cortisol; a natural anti-inflammatory hormone produced by the body, improves the permeability of cell membranes resulting in better uptake of nutrients and vitamins and effectively eliminates waste
MSM has a vasodilator effect and thus improves circulation and helps the healing process. MSM is an effective muscle relaxant; it slows down and restores the formation of cross-links in collagen. This is a natural process in the healing phenomena which causes the formation of hard tissue and is often a source of pain. MSM vs. Other similar products The treatment provided by conventional medical drugs, such as NSAIDs and corticosteroids target inflammation which are most often accompanied with undesirable side effects. NSAIDs are mostly synthetic products used primarily in the treatment of joint or bone pain, and as antipyretics, analgesics, or antiplatelet agents. The second group of synthetic products with anti-inflammatory effects are corticosteroids. The mode of action of these drugs is quite complex. Their effects are felt in almost all organs. After entering the cell, corticosteroids will bind directly to DNA. On a cellular level, their actions are very diverse; from there they reduce the production of inflammatory and immune factors. Long term usage of these medications can cause aggressiveness, stomach irritation, thinning of the skin, regression of the immune system which can lead to autoimmune disease and abnormal fat distribution.
How MSM differs from other anti-inflammatory and analgesic products? Experimental and clinical trials have shown that MSM heals without side effects. Studies by Dr. Jacob have shown that by having a minimum concentration of MSM in the body is critical to the normal function and structure of our cells. The adult body needs a concentration of MSM that is greater than that obtained through normal diet. At the University of Oregon Health Sciences, Dr. Jacob has treated over 15,000 patients using MSM. He delivered on average 500-1000 mg to each patient. He also noted that higher doses up to 5000 mg or more per day produce therapeutic effects without side effects. MSM is well tolerated by the body and is also active as a pharmaceutical painkiller. There is no known toxicity or side effects related to using MSM. Why and when to take the MSM? MSM can be used to address the following: arthritis asthme menstruel cramps rheumatic diseases back pain muscles spasm
inflammatory disorders fybromyalgia atherosclerosis headache, migraine bursitis carpal tunnel syndrome Who is suitable for taking MSM? MSM has a wide range of applications ranging from arthralgia (including rheumatism and osteoarthritis), lumbar pain, damage to soft tissues, sports injuries and fibromyalgia. Osteoarthritis (OA) is a universal consequence of aging in vertebrates. Unlike some autoimmune and cancer diseases, OA is a disease of civilization, although some factors of modern lifestyle can influence its pathogenicity. Osteoarthritis is a condition which begins by the softening of cartilage in joints, followed by erosion, and degeneration of joint tissue and tearing of cartilage. Conventional drugs against this painful condition are anti-inflammatory and analgesic, but these drugs produce significant side effects. Studies have shown that MSM is an excellent non-toxic treatment for OA. The properties of MSM that can help patients with OA include the following:
Analgesic effects Anti-inflammatory effects Reduction of muscle spasms around joints Decreased formation of scar tissue Better blood circulation Rheumatoid arthritis 40% of people over 65 suffer from some form of rheumatoid arthritis. According to Dr. Jacob, MSM reacts as an anti-inflammatory and analgesic (anti - pain). Physicians and patients report that painful and stiff joints, bursitis, and inflamed joints respond well to supplementary administration of MSM. By adding an extra dose of vitamin C, the symptoms of pain and swelling are reduced and become less sensitive. There is no precise information regarding the optimal dosage treatment for muscle and joint pain. A course of 2000-5000 mg per day for two to four weeks seems very effective. When the pain decreases, a maintenance dose of 250-750 mg can be maintained. If symptoms recur, dosage should be increased again to soothe the pain. Chronic pain Pain relief may well be one of the main applications of MSM. According to the scientific literature and the experience with DMSO and MSM, we can
affirm that the following active mechanisms are responsible for the alleviation of pain: Inhibition of transmission of pain impulses. A 1993 study showed that DMSO may slow conduction of nervous tissues C. This conduction mechanism of inhibition is still not completely clear, but could be based on a potassium channel blocker. DMSO can change the status of hydration of potassium ions, which can modify the penetration of ion channels. C tissue in the body appears to be a primary route for the conduction of pain impulses. MSM can have both local and systemic effects. Anti-inflammatory action Inflammation is a source of chronic pain for many people suffering from diseases such as rheumatism, post-operative trauma and sports injuries. Various studies have demonstrated the anti-inflammatory effects of MSM. Dilation of blood vessels MSM can improve tissue perfusion. This information plays an important role in the long-term effects. Tissue oxygenation is facilitated as nutrients to the lesion or the scar tissue with inflammation is improved. Reduction of muscle spasms Pain is closely related to muscle spasms. When DMSO is applied topically to the skin, it is possible to collect evidence by electromyography on muscle relaxation after one hour after application. Studies on injured or musculoskeletal disorders show a huge improvement when using MSM. When taken in combination with vitamin C, the results
obtained are even better than taking MSM alone. It has been shown that sports injuries heal faster, 75% after administration of MSM. Antiinflammatory properties of MSM appear to improve circulation, which is important for the repair of damaged or inflamed tissues. Gastric hyperacidity / heartburn Heartburn and hyperacidity are common problems today, which is not surprising given our modern menus with pizzas, hamburgers and soft drinks. The constant use of antacids is very harmful to the body. Most people do not realize that the chronic use of antacids can cause permanent damage and alterations to the natural ph in the body. Acid blockers were originally developed for patients suffering from severe stomach ulcers, but they cause a long list of side effects, including liver damage, hepatitis, insomnia, dizziness, severe headache, mental distraction, pancreatitis, constipation, nausea and diarrhea. Clinical studies have shown that MSM is highly effective and almost immediately relieves excessive acidity. Patients suffering from hyperacidity using acid blockers can easily switch to the MSM and get the same results. No side effects have been found to date, unlike antacids. Dr. Jacob administered 750 mg per day for the treatment of hyperacidity, while delivering a dose of 2000 mg per day for a period of six months for patients with more serious problems.
Allergies Patients with allergies can be treated with MSM to reduce environmental and food allergies. The anti- allergenic properties of MSM are comparable to those of conventional antihistamines. Dr. Herschler discovered that MSM is able to put a film on the entire gastro- intestinal canal, completely preventing the penetration of allergens thus making them less harmful. Respiratory conditions in which MSM provides satisfactory results include bronchiectasis, allergies (hay fever), asthma and emphysema. MSM can also protect against exposure to insecticides because it neutralizes anti-cholinesterase (toxic chemicals in insecticides and cyanogen). It also promotes the excretion of substances through the urine that are produced in the body by carbohydrates. The results reported on environmental allergies are based on assays of quantities between 50 mg and 1000 mg per day. Fibromyalgia MSM can relieve fibromyalgia in cases of oral, topical, intravenous or subcutaneous injection. It is important to point out to patients that the effect of MSM is slow. MSM will not completely cure fibromyalgia, but can be used to ease the pain. Constipation In clinical studies, Dr. Jacob found that patients with chronic constipation have a sudden and sustained improvement with supplementary administration of 100 to 500 mg of MSM per day.
Parasites MSM is effective in treating both skin and internal parasitic infections. MSM taken orally is effective against Giardia, Trichimonas and intestinal worms such as Nématoces, Enterobius and others. The researchers believe that MSM is active against parasites by a competition effect at the receptor locations on the mucosal surface. This prevents the organism from attaching to the intestinal wall and allows their removal from the body. Effective doses of MSM against parasites are 750-1500 mg per day, taken for a period of 90-120 days. Problems of the skin, hair and nails MSM has an inhibitory effect on collagen cross-links, and protein, which reduces the hardening of the skin and connective tissues. This property makes the MSM treatment uncommon to enhance the quality of hair, skin and nails. MSM lotions can be applied directly on the skin to treat problems such as acne, burns, local fungal or dry skin, aging and wrinkles. Snoring Chronic snorers can take drops of MSM (16%) in each nostril 15 minutes before bedtime. After 90 days, the chance of a significant reduction in snoring is 80%. For how long can I take MSM? The MSM could be taken for minimum 6 weeks.
Dosage Due to the non-toxic nature, researchers have shown that even massive doses may be safely taken for therapeutic use. The dose depends on the severity of symptoms. Other factors such as size and weight can also influence the required amount of MSM. 1. MSM must be taken daily for effective therapeutic effect. 2. In treating disease, a daily dose ranging between 250 and 2000 mg per day is generally used. In severe cases, doses up to 5000 mg can be used safely. Significant results are usually seen after one to twenty-one days for less severe symptoms. 3. For more serious problems, researchers report that higher doses (2000-5000 mg / day) may be taken during a period of 120 days. It is preferable to distribute the dose evenly throughout the day (for example: for a dose of 1500 mg, 750 mg taken twice daily or 375 mg four times daily, etc.). Can I take MSM even if I have a sensitive stomach? MSM is effective against stomach aches and inflamed mucous membranes. Studies have shown that persistent or recurrent diarrhea, or even the occasional occurrence of intestinal problems can be significantly improved by a daily administration of MSM. Prescribing a daily dose of 500 to 1500 mg of MSM can effectively reduce severe cases of diarrhea.
Are there any situations where I should avoid taking MSM? No, except in the case of an allergic reaction of one of its components What are MSM's interactions with other products / drugs? There are no known complications with other plant products or supplements. How to maximize the therapeutic effects of MSM? MSM can be taken in combination with Titanium2. Precautionary use: It is recommended that pregnant women should not use MSM.