Joint ICTP/IAEA Advanced School on Dosimetry in Diagnostic Radiology and its Clinical Implementation May 2009

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2033-8 Joint ICTP/IAEA Advanced School on Dosimetry in Diagnostic Radiology and its Clinical Implementation 11-15 May 2009 Dosimetry in Interventional Radiology Renato Padovani EFOMP

Joint ICTP-IAEA Advanced school on Dosimetry in Diagnostic Radiology: And its Clinical Implementation 11-15 May 2009; Miramare, Trieste, Italy Dosimetry in interventional radiology Renato Padovani Medical Physics Department University Hospital, Udine, Italy IAEA International Atomic Energy Agency

Introduction Introduction to interventional radiology Dosimetry in IR Code of Practice Skin dosimetry methods IAEA 2

Interventional era started in 1977 Gruntzig, Zurich Crude catheters Long fluoroscopy Many cine runs Big increase in radiation to staff and patients IAEA 3

Interventional radiology: guided fluoroscopy IAEA 4

Interventional cardiology PTCA Case: bifurcation lesion LAD-D1 D1 AP, 38 CR LAO 50, 38 CR IAEA 5

Case 1 bifurcation lesion B stent and balloon inflation balloon angioplasty (PTCA) technique PTCA & stenting technique A IAEA 6

The frequency of procedures in Europe Number of diagnostic and interventional cardiac procedures (PCI) per million inhabitants in European countries is continuously increasing Practice is not uniform across Europe IAEA 7

The practice: type of procedures 19% 3% 5% Distribution of IR procedures (Germany, 1994) 6% 5% 7% 55% Angioplasty Embolization Biliary tract Urinary tract Drenage Pain therapy Biopsy Most of them are fluoroscopy guided procedures IAEA 8

Frequencies and contribution to the collective effective dose of IR GI examinations 1.2% Friuli Venezia Giulia, Italy Frequency of radiological examinations 820 examination/year.1000 inh year 2006 Friuli Venezia Giulia, Italy Year 2006 1.2 msv/year.per-caput Nuclear medicine 2.1% Radiography 84.5% Interventional radiology 10.4% CT 58.4% CT 10.7% Interventional radiology 1.5% Radiography 16% GI examinations 2.8% Nuclear medicine 12.4% R.Padovani & others, North-east Italy, 2006 IAEA 9

Patient dose range in angiographic procedures (UNSCEAR 2000) Angiographic Procedure Technique Fluoro time (min) KAP (Gy.cm 2 ) Effective dose (msv) Coronary Cine film 3.6 9.8 16.1-98 2 15.8 Digital cine 5.7 47.7 9.4 Cerebral DSA/conven tional 1.2 36 12 120 2.7 23.4 Abdominal Hepatic 2.3 28.6 28 279 4 48 (DSA) Renal DSA 5.5-21 41-186 6-34 Renal angiogr. 0.5 9.3 17 327 2.8 11.5 IAEA 10

Patient dose range in interventional procedures (UNSCEAR 2000) Interventional procedures Localized dose to skin (Gy) Fluoro time (min) KAP (Gy.cm 2 ) Effective dose (msv) PTCA 0.05-5 3-92 20-402 7.5-57 PTA 0.4 5 68 5 338 10 12.5 TIPS 0.4 5 9 115 7-1131 2-181 RF ablation 0.1 8.4 3-195 7 532 17 25 Embolization 0.2 0.5 1 90 7 918 6 43 ICRP recognise as high dose procedures, giving potentially high skin doses: - Embolisation: aneurysm and arteriovenous malformation - Angioplasty (cardiac = PTCA) - Radiofrequency ablation IAEA 11 - Transjugular intrahepatic porto-systemic shunt (TIPS)

ICRP report 85 (2001): Avoidance of Radiation Injuries from Interventional Procedures Photograph of the patient's back 21 months after a coronary angiography and two angioplasty procedures within three days; the assessed cumulative dose was 15-20 Gy (Photograph courtesy of F. Mettler). IAEA 12

Staff: high exposure work area 0.5 2.5 msv/h 1-5 msv/h 2-10 msv/h IAEA 13

Patient dosimetry in IR 1. Dosimetry for quality assurance Air kerma area product (KAP, P KA ) 2. Dosimetry for stochastic risk evaluation dose equivalent to selected organs effective dose 3. Dosimetry to prevent deterministic effects of radiation (maximum skin dose assessment) Maximum skin dose (MSD or D skin,max ) IAEA 14

Code of Practice (8.5 Fluoroscopy) Since no standardized method exists, recommendations on how to measure the maximum entrance surface air kerma in interventional procedures will not be given in this Code of Practice. (Appendix VI) Deterministic effects only occur in diagnostic radiology in special circumstances when the local dose is very high. The most important example is the high skin dose which can arise during interventional procedures using X rays. IAEA 15

Code of Practice (cont.) The assessment of absorbed dose to the most exposed area of the skin is essential in complex interventional procedures Knowledge during the procedure of the skin dose is necessary to avoid deterministic effects or to reduce their severity Knowledge after the procedure of the skin dose is necessary in order to decide which patients require followup The determination of the skin dose to the most exposed area is not easy since exposure parameters and projection angle change during the procedure The most exposed area cannot be predicted in most cases IAEA 16

Code of Practice (Appendix VII) In fluoroscopy guided interventional procedures, the air kerma area product, P KA, offers a convenient quantity for monitoring patient exposure. In order to estimate the peak skin absorbed dose it is necessary to have a detector that registers the skin dose at many points IAEA 17

Code of Practice (Appendix VII) Real time measurements are possible with detectors located on or near the skin but these cannot generally provide complete dose mapping Two alternative approaches to estimate the maximum possible incident air kerma: Measurements at a Interventional Reference Point (IEC-60601-2- 43) as a point on the central ray of the X ray beam which is 150 mm from the isocentre of the radiological equipment in the direction of the X ray tube. The cumulative air kerma at the IRP may overestimate the maximum incident air kerma Measurements of P KA can provide an indication of the maximum possible incident air kerma if the focus to skin distance and field area are recorded IAEA 18

Interventional Radiology Point (IRP) Cumulative ESAK to Interventional Radiology Point (IRP) measured with a flat ion chamber or calculated by the system and displayed in the angio room 15 cm 15 cm IRP IRP Isocenter Isocenter (IEC-60601-2-43) IAEA 19

Patient dosimetry to prevent deterministic effects (skin injuries) Dosimetric quantity: Maximum skin dose (MSD) Real time measurement/evaluation of MSD Point or area detectors Cumulative dose at IRP (interventional radiology point) Calculation from technical data Off line methods Area detectors: TLD array, slow films, radiochromic films From KAP and CD measurement IAEA 20

Method for MSD evaluation: TLD grid (Thomas W. Slowey, K&S) 80 LiF TLD s Attached to polyethylene carrier 8 x 10 chip matrix 4 cm x 4 cm grid spacing IAEA 21

Method for MSD evaluation: TLD grid 22 CVL studies: 18 studies 0.1 0.45 Gy Fluoro Time Range: 1.3-53.7 min. Max Dose Range: 0.07 2.52 Gy Area of Dose > 0.2 Gy: 32-328 sq cm 13 PTCAs: 6 PTCA > 1 Gy Fluoro Time Range: 2-51 min. Max Dose Range: 0.22 4.16 Gy Area of Dose > 1 Gy: 32-160 sq cm Diagnostic PTCA Top Top 4 cm 4 cm 400.0-450.0 8 cm 12 cm 16 cm 20 cm 40.0-45.0 35.0-40.0 30.0-35.0 25.0-30.0 20.0-25.0 15.0-20.0 10.0-15.0 5.0-10.0 0.0-5.0 8 cm 12 cm 16 cm 20 cm 350.0-400.0 300.0-350.0 250.0-300.0 200.0-250.0 150.0-200.0 100.0-150.0 50.0-100.0 0.0-50.0 24 cm 24 cm dose (cgy) 28 cm Pt Left B C D E F G H J Pt Right belt width (cm) dose (cgy) 28 cm Pt Left B C D E F G H J Pt Right belt width (cm) IAEA 22

Method for MESAK evaluation: slow film method IAEA MARTIR training programme (EC pub. no. 199) 23 www.europa.eu.int/comm/environment/radprot/#news

Method for MESAK evaluation: radiochromic large area detector Example: Radiochromic films type Gafchromic XR R 14 x17 usefull dose range: 0.1-15 Gy minimal photon energy dependence (60-120 kev) acquisition with a flatbed scanner:b/w image, 12-16 bit/pixel or, measure of OD measurement with a reflection densitometer IAEA 24

Benefits of radiochromic films The radiochromic film: displays the maximum dose and its location shows how the total dose is distributed provides a quantitative record for patient files provides physician with guidance to enable safe planning of future fluoroscopically guided procedures improves fluoroscopic technique and patient safety Example of an exposed radiochromic film in a cardiac interventional procedure IAEA 25

Evaluation methods of radiochromic 1. Rapid semi-quantitative evaluation with comparison chart 2. Quantitative measurements with: a. Densitometer (point measurements) b. Digital flat bed scanner IAEA 26

1. Rapid semi-quantitative evaluation For each batch number (lot #) of gafchromic film a Comparison Tablet is provided A simple direct comparison of the Comparison Tablet with the exposed film allows to estimate the maximum dose IAEA 27

Rapid semi-quantitative evaluation: example In the reported example we easily can recognise that the darkness area of the film, corresponding to the skin area that has received the maximum local dose, has an Optical Density that correspond at about 4 Gy IAEA 28

2.a - Quantitative measurements with spot densitometer 2.a Spot measurements with reflective densitometer Spot reflective densitometer reading the Optical Density (OD) of the gafchromic film in the red region is an easy, accurate and fast method for skin dosimetry and for the estimation of the maximum local skin dose IAEA 29

Calibration procedure for radiochromic film Each piece of gafchromic is read with the reflection densitometer (typical results are reported in the table) Air kerma vs. OD are interpolated in an Excel sheet The resulting calibration curve (a straight line in this case) is adopted for the patient dose calculation In the example: ESD (mgy) = -8290 + 7771*OD Air kerma (mgy) OD 1.050 0 1.077 103 1.094 310 1.155 517 1.163 724 1.198 949 1.238 1161 1.256 1346 1.279 1601 1.297 1732 1.317 1936 1.323 2140 1.367 2325 1.393 2521 1.409 2749 Gafchromic calibration (Densitometer X-Rite Spectrodensitometer) y = 7761.3x - 8289.7 R 2 = 1 1.444 2942 IAEA 30 Air kerma (mgy) 3500 3000 2500 2000 1500 1000 500 0 1.00 1.10 1.20 1.30 1.40 1.50 Optical Density

2. Quantitative measurements with flat bed scanner 2.b OD measurements with a colour flat bed scanner A colour flat bed scanner can be used to digitise an exposed gafchromic film. The dosimetric system, including the scanner, the acquisition parameters and the image processing methodology, has to be properly tested and calibrated. IAEA 31

2.B Calibration procedure for radiochromic film The red component of the image is selected (in RGB format the image has red, blu and green components) because the maximum light absorption is in the red region of the spectrum. Manually, or with a dedicated software, a ROI is created inside each piece and the mean OD calculated. Finally, a calibration curve is calculated; a cubic curve is usually adopted. In the example: (i) in the table the grey levels (GL) vs air kerma values (AK) (ii) the coefficients of the cubic interpolating curve: AK=6.563*10 3-0.2932*GL+4.209*10-6 *GL 2-1.918*10-11 *GL 3 IAEA 32

Patient skin dose evaluation (I) The patient film is acquired with the scanner in manual mode, with the parameters registered/stored in the calibration procedure. The red component of the image is selected. The image can be smoothed with a 5x5 filter. The red levels (GL) of the extracted image is converted to entrance dose to air applying the calibration curve. IAEA 33

Patient dose evaluation and evaluation accuracy Examples of patient skin dose distributions in PTCA procedures Accuracy of dose evaluations: - comparing MSD evaluated with the different quantitative methodologies described, differences of less than 10% are expected. IAEA 34

Monitoring of skin dose in high dose procedures (IAEA survey) Radiochromic films used to measure patient skin dose in a sample of 392 interventional procedures in a IAEA international study In 52 procedures (7.4%) the PSK > 2 Gy, 15 proc. > 4 Gy maximum PSK 6.6 Gy; 38 PTCA, 6 RF ablation, 1 neuro and 6 hepatic embolisations 39 occurred at two hospitals! IAEA 35

MSD evaluation: computational method 72 0 1321 Patient name: Mayer, Friedrich Patient ID: 1947_08_11 Patient size: 186 cm Patient weight: 91 kg Patient position: Head first, Supine Patient-Table pos.:8 cm from top acc. max. Hot Spot: Fluoro: Acquisition: 1321 mgy 720 mgy 480 mgy plane A: acc. dose area product: 148 Gy/cm² Fluoro: 63 Gy/cm² Acquisition: 85 Gy/cm² plane B: acc. dose area product: 45 Gy/cm² Fluoro: 17 Gy/cm² Acquisition: 28 Gy/cm² plane A: fluoro time: plane B: fluoro time: 1 h 18 min 0 h 32 min CAREGRAPH (Siemens) Dose Distribution 200-300 mgy 300-400 mgy 400-500 mgy 500-600 mgy 600-700 mgy 700-800 mgy 800-900 mgy 900-1000 mgy > 1000 mgy x-ray projection: plane A: plane B: -- -- RAO=60 Caud=15 IAEA 36

P.J.Marsden, Y.Washington, J.Diskin Method for MSD evaluation: MSD/KAP factors Skin doses in IR and IC Measurements of dose rates for different type of procedures, field size, orientation, continous/pulsed fluorosocpy Extended assessment of KAP/ESD factors for different procedures/field size/orientations Possible use of ESD/KAP factor to estimate skin dose, in alternative to more direct methods of skin dose measurements IAEA 37

Method for MSD evaluation: MSD/KAP factors for cardiac procedures Projection MSD/KAP (mgy/gycm 2 ) vs field size 23 cm 15 cm 11 cm PA 4.67 7.63 10.93 RAO 30 0 + 25 0 CAU 4.11 6.64 9.33 RAO 10 0 + 10 0 CAU 4.13 6.37 9.53 Lateral 7.64 12.43 17.39 LAO 45 0 3.56 5.73 7.86 LAO 45 0 + 25 0 CAU 3.55 6.08 8.27 RAO 30 0 3.02 5.00 7.21 IAEA 38

MSD vs. Cumulative air kerma In some procedures, CD is well correlated with maximum (peak) skin dose CD can be a good indicator of doses higher than the thresholds for skin injures A trigger value of 2000 mgy for CD can be adopted to alert interventionalists the threshold for skin erythema could be reached A follow-up protocol can be adopted MSD (mgy) Isoc ente r 4500 4000 3500 3000 2500 2000 1500 1000 500 0 Liver Embolisations CD vs. MSD y = 1.1745x R 2 = 0.9256 0 500 1000 1500 2000 2500 3000 3500 CD (mgy) 15 c m About 20% of patient > 2 Gy at the skin (Udine, 2008) I R P Isoc ente r 15 c m I R P (IEC-60601-2-43) IAEA 39

Recommendations to reduce the probability of skin injuries in IR Periodic monitoring of skin doses on high dose procedures A trigger value in term of KAP or CD to IRP should be adopted to alert interventionalist A follow-up protocol should be introduced for patients could have received high skin doses IAEA 40

Udine Friuli-Venezia Giulia region Thank you! Mandi! IAEA 41