DEPARTMENT OF PSYCHIATRY. Newsletter

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DEPARTMENT OF PSYCHIATRY Office of the Chair - Week of October 29 November 2, 2012 Website: http://www.hsc.usf.edu/psych/ Newsletter Meetings Thursday 11/01/12 8:00 a.m. Call Center Meeting Resident Lectures: 8:00 a.m. CHILD CBT GAD, SocPh and Panic Betty Horng 9:00 a.m. CHILD CBT GAD, SocPh and Panic Betty Horng 10:00 a.m. CHILD CBT GAD, SocPh and Panic Betty Horng 12:00 noon No Grand Rounds 1:00 p.m. PGY-3 Clinical Case Conference Dr. Kailie Shaw/Beth Reese, LCSW GERI Alcohol and Other Substance Abuse in the Elderly Dr. Ryan Estevez 2:00 p.m. PGY-2 Pain and Palliative Dr. Barbara Lubrano PGY-3 & PGY-4 Psychiatry & Reproductive Medicine Kaplan & Saddock s Synopsis of Psychiatry, Chapter 30 Dr. Jamie Fernandez 3:00 p.m. PGY-2 Consultation Liaison Series Dr. Kimberly Hartney PGY-3 Long Term Dynamic Therapy Dr. Robert Fernandez PGY-4 Board Review Series Dr. William Hervey 4:00 p.m. Residents Meeting Friday 11/02/12 No Third Year Medical Student Lectures

In The Know! Happy Birthday Wishes to Juan Deng/October 29 th and Dr. Jennifer White/November 2 nd. On November 14, 2012 from 6:00 8:00 p.m. the USF Health Byrd Alzheimer s Institute will have a Physician Open House. You are invited to join them for an evening of cocktails and hors d oeuvres inside their Center for Memory C.A.R.E. to learn about their comprehensive patient services that support your clinical goals and create solutions to help you improve patient care. To make reservations, call (813)396-0606. You are cordially invited to GTBPS Charity Gala benefiting SCID, Angels for Life (Severe Combined Immune Deficiency). Join colleagues, family and friends, for a Saturday evening of gourmet dining, docent tours, live music and cash bar at the Salvador Dali Museum on December 1, 2012 from 7:00-11:00 p.m. For more details, go to www.gtbps.com. For information regarding the USF Memory Disorders Clinic, please click on the following link: http://health.usf.edu/medicine/psychiatry/p_memory_disorders_clinic.htm Research Happenings! For information regarding current clinical trials, please go to the following website: http://health.usf.edu/medicine/psychiatry/index.htm Current Open Studies Call 813-974-2832 or 813-974-1404 for more information on any study or to refer a patient. Autism, Asperger s Disorder, Pervasive Developmental Disorder The ConnectMe clinical research program includes three studies that are evaluating tolerability, safety, and effectiveness of an investigational drug on social interaction and communication skills in children ages 6-12 with Autism, Asperger s Disorder, and Pervasive Developmental Disorder Not Otherwise Specified. The program s first study is an open-label study that can last up 50 weeks. Patients that are eligible for and participate in this study may have the option to participate in the follow-up studies. Study drug, study visits, and study related laboratory work are provided at no cost. Bipolar I in Teens This study is a 3- week investigational medication trial that will test the effectiveness and safety of asenapine compared to placebo in teens ages 12-17 with Bipolar I disorder experiencing a manic or mixed episode. A 26-week extension study is available. Study medication, study visits, and required laboratory work provided at no cost. Volunteers must be between the ages of 12-17 years old and in generally good health with a diagnosis of Bipolar I disorder and currently experiencing manic or mixed symptoms. Principal Investigator Mike Bengtson, MD.

Now Enrolling Bipolar A 9-month outpatient study of Ramelteon sub-lingual as an adjunctive treatment to prevent relapse of manic/mixed/depressive symptoms in patients 18-75 years who have experienced a manic/mixed/depressed episode within the last 9 months. Patients will continue on current mood stabilizers, antidepressants, or antipsychotic medications throughout the trial. PI Carlos Santana, MD Now Enrolling Bipolar I Disorder with Depressive Symptoms An 8-week outpatient study assessing Ramelteon sub-lingual as an adjunctive treatment for patients 18-75 years who are currently experiencing depressive symptoms associated with Bipolar I Disorder. Patients must be on Lithium and/or Depakote. PI Carlos Santana, MD Now Enrolling Schizophrenia Long-Acting IM Depot Open-label Study An open-label naturalistic study of Aripirazole IM (long-acting depot) in patients with schizophrenia 18-65 years. Patients must have been prescribed antipsychotic medication for at least 7 months prior to enrollment and have had at least 1 Inpatient Hospitalization in the past 24 months. PI Carlos Santana, MD http://health.usf.edu/medicine/psychiatry/research/index.htm Antibiotic Treatment Trial for the PANDAS/PANS Phenotype The purpose of this research study is to know if the antibiotic azithromycin improves symptom severity in children with sudden and severe onset obsessive compulsive symptoms known as PANS, Pediatric Acute Onset Neuropsychiatric Syndrome, and PANDAS, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus. This study seeks to compare the effects of placebo vs. azithromycin on symptom severity as well as to assess immune risk factors in children with PANDAS/PANS. Your child is being asked to take part in this research study because he/she may meet criteria for PANS/PANDAS and has a current episode of Obsessive- Compulsive Disorder (OCD) symptoms of less than or equal to 6 months that has been associated with an infection. Children ages 4-14 years old who are not currently taking prophylactic antibiotics or undergoing cognitive behavioral therapy (CBT) are eligible to participate. Please call (727) 767-8230 for more information. Principal Investigator: Tanya Murphy, MD Quality of Life in Youth with Tic Disorders A one-time study visit evaluating the quality of life in youth with tic disorders, specifically on various aspects of family functioning and the daily challenges faced by children and their families. Children ages 6-17 years old with a diagnosis of a tic disorder (i.e. Chronic tic disorder or Tourette Syndrome) and are experiencing current tics are eligible to participate. This study is a one-time visit that will include questionnaires and assessments. Participants will also have the opportunity to attend a focus group with youth of similar age assessing kinds of help they received and accessibility of services and the difficulties faced by having tics. Please call (727) 767-8230 for more information. Principal Investigator: Tanya Murphy, MD

Child and Adolescent Tourette s Disorder Guanfacine Clinical Trial The purpose of this research study is to learn more about the new extended release formula of the drug, guanfacine. This new formula is called Intuniv. This study will help us understand how safe and how well this new extended release formula of guanfacine works for children with chronic tics. Your child is being asked to take part in this research study because he/she has been diagnosed with Chronic Motor or Vocal Tic Disorder or Tourette s Disorder. Main symptoms are motor tics such as uncontrolled movements and/or vocal tics such as repeated noises. These tics occur many times a day, nearly every day lasting for at least 1 year. Children ages 6-17 years old are eligible to participate. Please call (727) 767-8230 for more information. Principal Investigator: Tanya Murphy, MD Living with Tics The Living with Tics research study hopes to show how well a type of psychotherapy helps children better cope with tics and become more resilient. Children who are interested to participate must attend an initial assessment to determine eligibility. Eligible participants must be between 8 and 18 years of age, have a diagnosis of Tourette Syndrome or Chronic Tic Disorder, experience tic-related impairment, and either be medication-free or on stable medication. If eligible, interested participants will be randomly assigned to receive immediate psychotherapy or a 10 week waitlist control condition followed by subsequent psychotherapy. As part of the study, there is no charge for the psychotherapy treatment. The immediate psychotherapy condition consists of weekly therapy sessions over a 10 week period. This multi-component treatment approach includes habit reversal training, anger management, problem solving skills and other related therapeutic components to help improve the quality of life for children with chronic tic disorders. Please call (727) 767-8230 for more information. Principal Investigator: Eric Storch PhD. Adult OCD Ondansetron Clinical Trial The purpose of this research study is to investigate the effectiveness, safety, and tolerability of 2 dosages Ondansetron as compared to placebo (a substance which looks like an active drug but has no active ingredient) in adult who have OCD and who are currently taking a selective serotonin reuptake inhibitor (SRI) such as Anafranil (clomipramine) Paxil (paroxetine), Prozac (fluoxetine), Luvox (fluvoxamine, or Zoloft (sertraline). Another purpose of this study is to find out how the study drug works in the body when taken along with an SSRI. Please call (727) 767-8230 for more information. Principal Investigator: Tanya Murphy, MD Pediatric OCD D-Cycloserine and Cognitive Behavioral Therapy (CBT) Research Study The purpose of this research study is to examine if d-cycloserine enhances cognitive behavioral therapy for pediatric OCD. Participants will be involved in fifteen clinical visits spanning a nine-month period. Each participant will receive ten sessions of cognitive behavioral therapy and seven doses of the study medication or placebo one hour prior to session. Children ages 7-17 years old are eligible to participate. Please call (727) 767-8230 for more information. Principal Investigator: Eric Storch PhD

Cognitive-Behavioral Therapy (CBT) for Anxiety Disorders in Children with Autism Spectrum Disorder Research Study The purpose of this research study is to examine the efficacy of a manualized cognitive-behavioral therapy to treat anxiety disorders in children with autism spectrum disorders. Therapy sessions last approximately one hour a week for sixteen weeks. In addition, participants will be involved in a number of anxiety and developmental assessments free of charge. Children ages 7-16 years old are eligible to participate. Please call (727) 767-8230 for more information. Principal Investigator: Eric Storch PhD.