Alpha Fetoprotein AFP AFP AFP AFP AFP

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Email:mmirzarahimi@yahoo.com Alpha Fetoprotein AFP AFP SPSSAFP AFP AFP r = AFP

Alpha Fetoprotein(AFP) KDa HSA(HumanSerumAlbumin)L-AlbuminD AFP AFP mg/ml AFP AFP AFP AFP AFP AFP AFP () AFP AFP AFP AFP AFP ( AFP AFP AFP AFP AFP AFP AFP AFP AFP AFP AFP CanAgAFP Enzyme Immune Assay) EIA (Direct Sandwich AFPtechnique) Stat fax (Absorbance) SPSS-13Diazotization ANOVA t P

mg/dl mg/dl AFP l g/ g/l g/l AFP AFP AFP AFP r AFP AFP AFP l g/ AFP AFP Pvalue AB A B O AFP dl mg/ AFP l g/

AFP P Lee AFP AFP AFP P AFP AFP P mg/ dl AFP Ikonen P AFP FP g/l g/l AFP AFP AFP CarlloP Goraya AFP AFP AFP AFP g/l g/l g/l

References: 1. American Academy of Pediatrics, Subcommittee on Neonatal Hyperbilirubinemia. Neonatal jaundice and kernicterus. Pediatrics 2001; 108: 763 765. 2. American Academy of Pediatrics, Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia. Practice parameter: management of hyperbilirubinemia in the healthy term newborn. Pediatrics 1994; 94: 558 565. 3. Shibahara S, Kitamuro T, Takahashi K. Heme degradation and human disease: Diversity is the soul of life. Antioxid Redox Signal 2002; 4(4): 593-602. 4. Bergstrand CG, Czar B. Demonstration of a new protein fraction in serum from the human fetus. ScandJClinLabInvest1956;8(2):174. 5. Ruoslahti E, Sepp-Fetoprotein in normal human serum, Nature 1972; 235: 161-162. 6. Morinaga T, Sakai M, Wegmann G, Tamaoki T. Primary structure of human -fetoprotein and mrna. Proc Natl Acad Sci 1983; 80: 4604-4608. 7. Deutsch HF. Chemistry and biology of fetoprotein. Adv Cancer Res 1991; 56: 253-312. 8. Sepp, Ruoslahti E. Alpha fetoprotein: Physiology and pathology during pregnancy and application to antenatal diagnosis. J Perinat Med 1973; 1(2):104-113. 9. Brock DJ, Scrimgeour JB, Nelson MM. Amniotic fluid alpha fetoprotein measurements in the early prenatal diagnosis of central nervous system disorders. Clin Genet 1975; 7: 163-169. 10.Seppfetoprotein. Ann NY Acad Sci 1975; 22: 259, 59-73. 11.Ruoslahti E, Sepp. Alpha-Fetoprotein in cancer and fetal development. Adv Cancer Res 1979; 29: 275-346. 12.Abelev GI. -Fetoprotein in angiogenesis and its association with malignant tumors. Adv Cancer Res 1971; 14: 295-358. 13.Okuda K, Kotoda K, Obata H, Hayashi N, Hisamitsu T. Clinical observations during a relatively early stage of hepatocellular carcinoma, with special reference to serum alphafetoprotein levels. Gastroenterology 1975; 69(1): 226-234. 14.Yoshiki T, Itoh T, Shirt T, Noro T, Tomino Y, HamaJima TI. Primary intracranial yolk sac tumor immuno- fluorescent demonstration of alphafetoprotein synthesis, Cancer 1976; 37: 2343-2348. 15.DeMeesC,LaesJF,BakkerJ,SmitzJ,HennuyB, Van Vooren P, etal. Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action. Mol Cell Biol 2006; 26(5): 2012-2018. 16. Soloff MS, Swartz SK, Pearlmutter AF, Kithier K. Binding of 17beta-estradiol by variants of alphafetoprotein in rat amniotic fluid. Biochim Biophys Acta 1976; 427(2): 644-651. 17.Uriel J, De Nechaud B, Dupiers M. Estrogenbinding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods. Biochem Biophys Res Commun 1972; 46(3): 1175-1180. 18.NishiS,MatsueH,YoshidaH,YamaotoR,Sakai M. Localization of the estrogen-binding site of alpha-fetoprotein in the chimeric human-rat proteins. Proc Natl Acad Sci USA 1991; 88 (8): 3102-3105. 19. Savu L, Benassayag C, Vallette G, Christeff N, Nunez E. Mouse alpha 1-fetoprotein and albumin. A comparison of their binding properties with estrogen and fatty acid ligands. J Biol Chem 1981; 256(18): 9414-9418. 20.Uriel J, BouillonD,AusselC,DupiersM.Alphafetoprotein: the major high-affinity estrogen binder in rat uterine cytosols. Proc Natl Acad Sci USA 1976; 73(5):1452-1456. 21. Mizejewski GJ. New insights into AFP structure and function: potential biomedical applications, In: Mizejewski GJ and Porter IH (eds), Alpha- Fetoprotein and Congenital Disorders. Orlando, Academic Press, 1985. PP: 5-34. 22.Kohler KD. The pre- and post natal influence of hormones and neurotransmitters on sexual differentiation of the mammalian hypothalamus. IntRevCytol1991;131:1 57. 23. Toran-Allerand CD. On the genesis of sexual differentiation of the general nervous system: morphogenetic consequences of steroidal exposure and possible role of alpha-fetoprotein. Prog Brain Res 1984; 61: 63-98. 24. MccLusky NJ, Naftolin F. Sexual differentiation of the central nervous system. Science 1981; 211: 1294 1302. 25. Gillespie JR, Uversky VN. Structure and function of alpha-fetoprotein: a biophysical overview Biochim.BiophysActa2000;1480:41 56. 26. Aoyagi Y, Ikenaka T, Ichida F. Copper(II)-binding ability of human alpha-fetoprotein, Cancer Res 1978; 38: 3483-3486. 27.Torres JM, Laborda J, Naval J, Darracq N,Calvo M, Mishal Z, etal. Expression of alpha-fetoprotein receptors by human T-lymphocytes during blastic transformation. Mol Immunol 1989; 26(9): 851-857. 28. Belanger L, Waite WI, Daguillard F, Larochelle J, DufourD.TheeffectofAFPontheinvitrolym phocyte response. In: Masseyeff R, (ed.) Alpha- Fetoprotein, Institut National De La Sante LaRechercheMe1974:423 440.

29. Tomasi TB Jr. Structure and function of alphafetoprotein. Annu Rev Med 1977; 28: 453-465. 30.Bellini C, Bonacci W, Paridu E, Serra G. Serum alpha-fetoprotein in newborns. Clin Chem 1998; 44(12): 2548-2450. 31.Goraya SS, Smythe PJ, Walker V. Plasma alpha - feto protein concentration in preterm neonates, Ann Clin Biochem 1985; 22: 650-652. 32.Obiekwe BC, Malek N, Kitau MJ, Chard T. Maternal and fetal alphafetoprotein (AFP) level at term, Acta Obstet Gynecol Scand 1985; 64: 251-253. 33.Dierks Tan JS, Zehfuss I, Taubert HD. The significance of alpha-feto-protein (AFP) and human chorionic gonodotrophi (HCG) during the first half of pregnancy. 1982; 42(1): 29-34. 34.Ikonen RS, Lindgren J, Niemi E, Sorto AE, Sepp -fetoproteinlevelin neonatal hyper bilirubinemia. Acta Paediatr Scand 1980; 69(1): 59-63. 35.Riskin A, David M, Peskin B, Tamir A, Vafsi O, Leibovitz Z, etal. The role of umbilical cord alpha fetoprotein as a screening tool for neonatal hyperbilirubinemia. Am J Perinatol 2004; 21(2): 93-98. 36. National committee for clinical laboratory standards. National Evaluation protocols for interference testing. Evaluation Protocol 1986; 7(6):13. 37. National committee for clinical laboratory standards. Evaluation of precision performance of clinical chemistry devices, approved guideline, 2 nd ed. Wayne 2001; EP5-A. 38.Lee PI, Chang MH, Chen DS, Lee CY. Serum alpha-fetoprotein levels in normal infants: a reappraisal of regression analysis and sex difference. J Pediatr Gastroenterol Nutr 1989; 8(1): 19-25.