STRATEGIC RESEARCH PLAN

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STRATEGIC RESEARCH PLAN

SRP: Terms of Reference Frame strategic research for the next 5 years in the Faculties of Medicine and Dentistry To direct recruitment, space attribution, financial support, targeted fund raising. Foster inter-disciplinary research with KT component at the interface of robust basic and clinical research. Achieve a very high level of research excellence in select areas Build on current areas of excellence and past investments Strategically positioned to stimulate innovation in a fundable environment Training the next generation of health researchers in a highly competitive and inter-disciplinary research environment The SRP recognizes the dynamic nature of research. It is a living document to be regularly reviewed and updated

Structure International Advisory Committee Dean of Medicine Dean of Dentistry SRP Steering Committee SRP Planning Committee Directors of Academic Units, Schools, Research Institutes, Centers

International Advisory Committee Philip E. Sharp (Massachusetts Institute of Technology) John Bell (Regius Professor, University of Oxford) Tom Hudson (Director, Ontario Institute for Cancer Research) Nancy Andrews (Dean of Medicine, Vice-Chancelor, Duke University) Lawrence Tabak (Principal Deputy Director, NIH) Alan Bernstein (President, Canadian Institute for Advanced Research)

Steering Committee David Eidelman (Medicine) Paul Allison (Dentistry) Vasilios Papadopoulos (MUHC) Rod McInnes (Lady Davis RI) Rose Goldstein (Vice-Principal, Research, International Relations) Morag Park (Director, Goodman Cancer Research Centre) Alain Gratton (Director, Douglas Institute Research Centre) John Orlowski (Director, Physiology) Jim Martin (Medicine, Meakins-Christie) Susan Law (St-Mary s Hospital Centre) Guy Rouleau (Director, Montreal Neurological Institute) Sam Benaroya (Vice-Dean, Medicine) Annette Majnemer (Director, Physical & Occupational Therapy) Philippe Gros (Vice-Dean, Medicine) Marc McKee (AD Graduate Studies; Dentistry) Marianna Newkirk (AD Research, Medicine)

Planning Committee Philippe Gros (Biochemistry, Committee Chair) Marianna Newkirk (Medicine, Associate Dean Research) Marc McKee (Dentistry, Associate Dean) Marcel Behr (Medicine) Sam Daniel (Otolaryngology) Jocelyne Feine (Dentistry) Alyson Fournier (MNI Neurology & Neurosurgery) Nada Jabado (Pediatrics, Oncology) Carmen Loiselle (Nursing) Keith Murai (Neurology & Neurosurgery, Medicine) Pierre Pluye (Family Medicine) Dieter Reinhardt (Anatomy & Cell Biology) Brent Richard (Human Genetics, Medicine) Gustavo Turecki (Psychiatry)

General Framework for SRP

Major Disease Areas Neuroscience and Mental Health Cancer Infection and Inflammation Diseases associated with aging, disability and chronic conditions

Strategic Priorities (SP) Patient Experience, Population Health and Health Services Genetic and Environmental Determinants of Health and Disease Systems and Networks Approaches to Health Research Personalized Medicine: Customized Approaches to Patient Care

SP1: Patient Experience, Population Health and Health Services Social and environmental determinants of health Healthcare information technology Patients experience with health and illness, patient/family engagement, and interactions across the continuum of care Optimal health trajectories over the life-course

SP2: Genetic and Environmental Determinants of Health and Disease Gene discovery in rare diseases and in common complex disorders Epigenetic modulation of the genome in disease Extracellular matrix in normal cell signalling and in pathological situations Host-microbe interactions in infection, inflammation, development and cancer

SP3: Systems and Networks Approaches to Health Research Integrated omics approaches to biomedical research Integrating with health data Computational approaches to quantitative biology Imaging of cellular networks

SP4: Personalized Medicine: Customized Approaches to Patient Care Biomarkers- and molecular signature-based strategies for disease diagnosis, monitoring and treatment including clinical trials Personalized health improvement devices and delivery systems Precision engineering of animal-, cell- and protein-based models of human disease Customized health care delivery including for vulnerable groups

Implementation Strategies (IS) Encourage Inter-disciplinary research in strategic areas by supporting new research groupings Develop human capital and train the next generation of health researchers Foster creation and maintenance of enabling technology platforms Develop mechanisms to support research in strategic areas

IS1: Encourage Inter-disciplinary research in strategic areas by supporting new research groupings Create the Institute for Public Health and Population Research Create the Institute for Computational Biology and Medicine Develop a mechanism to solicit, and build new centers, institutes and schools Identify novel interfaces for innovative research

IS2: Develop human capital and train the next generation of health researchers Recruit talented junior investigators in the areas of strategic priority Develop innovative training programs for graduate, post-graduate students and health professionals Stimulate recruitment and training of clinician scientists

IS3: Foster creation and maintenance of enabling technology platforms Prioritize for infrastructure investments the areas of Genomics, Bioinformatics, and Imaging Develop a framework to financially support other enabling technology platforms Assist faculty in identifying needs and opportunity, and for obtaining funding

IS4: Develop mechanisms to support research in strategic areas Establish a strategic research fund to provide financial support Continue to support existing programs in studentships, fellowships and bridge funding Implement the Merck research funding program Deploy centers for administrative excellence

Next Steps Broad Consultation with Community for Input (web-based) Develop Metrics, Objectives, and Milestones Approval by International Advisory Committee Initiate Implementation Set-up Mechanism for Periodic Review (Implementation Committee)

Thank you To all at McGill who have directly contributed (n > 70) To Deans Eidelman and Allison for their trust To Marianna Newkirk, and Marc McKee for reviewing many many drafts To Marianne Provost for support

Units that submitted SRP docs (>90 priorities) Anatomy and Cell Biology Biochemistry Biomedical Engineering Dentistry Anesthesia Oncology Douglas Psychiatry Family Medicine Goodman Cancer Research Centre McGill/GQ Innovation Centre Medicine MUHC Res. Institute Microbiology and Immunology Neurology and Neurosurgery Obstetrics and Gynecology Ophthalmology Otolaryngology Pediatric Surgery Pediatrics Pharmacology and Therapeutics Human Genetics LDI School of Communication Sci. and disorders School of Nursing P and OT St. Mary s research Center Surgery Epidemiology, Biostatistics and Occupational Health

Contributors (Chairs, Directors, Colleagues) Craig.mandato@mcgill.ca David.thomas@mcgill.ca Henrietta.galiana@mcgill.ca Marc.mckee@mcgill.ca Steve.backman@mcgill.ca Eduardo.franco@mcgill.ca Alain.gratton@mcgill.ca Howard.bergman@mcgill.ca Morag.park@mcgill.ca Peter.siegel@mcgill.ca David.rosenblatt@mcgill.ca Mark.lathrop@mcgill.ca Rod.mcinnes@mcgill.ca Jim.martin@mcgill.ca Vassilios.papadopoulos@mcgill.ca Joaquin.madrenas@mcgill.ca Lesley.fellows@mcgill.ca Leonard.levin@mcgill.ca Denis.querleu@mcgill.ca Saul.frenkiel@mcgill.ca Jean-pierre.farmer@mcgill.ca Michael.shevell@mcgill.ca Gerhard.multhaup@mcgill.ca John.orlowski@mcgill.ca Marc.pell@mcgill.ca Susan.law@mcgill.ca Annette.majnemer@mcgill.ca Helene.ezer@mcgill.ca Gerald.fried@mcgill.ca Gilles.paradis@mcgill.ca Marianna.newkirk@mcgill.ca Marc.mckee@mcgill.ca Marcel.behr@mcgill.ca Sam.daniel@mcgill.ca Jocelyne.feine@mcgill.ca Pierre.pluye@mcgill.ca Dieter.reinhardt@mcgill.ca Brent.richards@mcgill.ca Nada.jabado@mcgill.ca Gustavo.turecki@mcgill.ca Carmen.loiselle@mcgill.ca Eduardo.franco@mcgill.ca David.eidelman@mcgill.ca Rose.goldstein@mcgill.ca Vassilios.papadopoulos@mcgill.ca Rod.mcinnes@mcgill.ca Guy.rouleau@mcgill.ca Alain.gratton@mcgill.ca Sam.benaroya@mcgill.ca Susan.law@mcgill.ca John.orlowski@mcgill.ca David.rosenblatt@mcgill.ca Joaquin.madrenas@mcgill.ca David.juncker@mcgill.ca Amit.bar-or@mcgill.ca Michel.tremblay@mcgill.ca Jerry.pelletier@mcgill.ca Robin.tamblyn@mcgill.ca Gilles.paradis@mcgill.ca David.buckeridge@mcgill.ca Mark.lathrop@mcgill.ca Rob.kearby@mcgill.ca Celia.greenwood@mcgill.ca Constantin.polychronakos@mcgill.ca Brent.richards@mcgill.ca Phil.barker@mcgill.ca Alain.gratton@mcgill.ca Howard.bergman@mcgill.ca Morag.park@mcgill.ca Phil.branton@mcgill.ca Susan.law@mcgill.ca Nada.jabado@mcgill.ca Annette.majnemer@mcgill.ca Kaberi.dasgupta@mcgill.ca

Timeline 1. May-July 2012: Planning; Terms of Reference; Design and Recruitment of Committees; Questionnaire for Units. 2. August-November 2012: Receipt of Documents; Working Groups in key areas; Recommendations 3. December-January 2013: Input from Steering Committee; Approval of Final Framework and Priorities 4. February-April 2013: Drafting of Narratives (in progress). 5. May-July 2013: Finalize documents; Input from Units; Approval by Steering Committee and Deans. 6. Fall 2013: Meeting of International Advisory; Final Approval