Clinical experiences in Asian skin with new technology of ablative fractional Er:YAG Laser

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Clinical experiences in Asian skin with new technology of ablative fractional Er:YAG Laser Ming-Li Tseng, MD Dr. Tseng Skin and Beauty Clinic, Taipei, Taiwan 2011.05.20 SLOVENIA

Development of Aesthetic Laser in Taiwan CO2 Dye Ruby Q-Alex Q-Nd:YAG Er:YAG IPL CoolTouch Sciton TC C6 Fraxel CoolLipo Fr.Co2 Fr. Er:YAG 92 97 99 03 05 06 07 Develop Lux1540 C6 StarLux IPL 1064, IR HP StarLux IPL Y+G, cryo6 Fidelis Er:YAG M2 Nd:YAG Lynton Nd:YAG Development of Dr. Tseng s s Clinic

QSRL BLISTER IPL Burn QSRL PIH QSRL HYPO SCAR POST CO2 LASER FOR TATTO QSNd:YAG PIH

Laser & IPL Side Effects IPL Pigment Erythema PIH or HYPO Edema Bulla Crusting Scar Pitting Scar Infecti Hair Removal on Ulcer Vascular Invasive Thermage Fractional

Search for Ideal SR Treatment Non-Ablative Low Efficacy - Short Downtime Ablative High Efficacy - Long Downtime 5

Search for Ideal SR Treatment Fractional Story Wound Healing Mechanism Islands of healthy skin are helping in would healing mechanism Re-epithelization of micro treatment zones (MZT) is quicker due to: - Enough healthy cells (epidermal stem cells and transient amplifying cells) - Short migration paths of keratinocytes (quick arrival to wounded sites) 7

What is fractional? Safe, Effective and Short Downtime

November 10, 2003 FDA-Cleared Indications Dermatological procedures requiring the coagulation of soft tissue June 15, 2004 Treatment of periorbital wrinkles Photocoagulation of pigmented lesions including lentigos (age spots), solar lentigos (sun spots), and dyschromia Resurfacing - the only non-ablative device cleared for resurfacing! (3/10/05) Melasma -the only device cleared for melasma! (7/5/05) Acne scars and surgical scars! (3/20/06) Fraxel SR 1500 (3/29/06) Can be used on all skin types anywhere on the body! R. Rox Anderson, M.D

Transepidermal Elimination Avenue

Photo-Acoustic Effects 11

Microspot Histology Comparison Non ablative Fr. Er Glass Ablative Fr.CO2 Ablative Fr.Er YAG

Lasers in Surgery and Medicine 41:179 184 (2009)

Search for Ideal SR Treatment High Efficacy Ideal Frac. Ablative Fractional ErYAG Ablative CO2 Laser 雷 Low Efficacy Frac.. Non- Ablative Non- Ablative NdYAG Fractional ErGlass Short downtime Long downtime

Ablative Fr. Er-Yag Applications Skin Rejuvenation Indications for Ablative Fractional Treatments Hyperpigmentations (Post-Inflamatory Hyperpigmentation - PIH, Melasma, Dyshromia) Photoaged (photodamaged) skin (freckles, age spots, vascular lesions, skin texture ) Wrinkles (moderate to severe rhytides) Scars (acne scars, surgical scars, traumatic scars, burn scars) Stretch marks Skin tightening.. (some new and exciting applications) 15

Dr. Tseng s s Regime I ALWAYS include the Fr. Er-Yag Laser as part of the regime General Parameters of Treatment: Skin Rejuvenation 5 %, 3-14 mj, MSP, 50HZ Acne Scar 5-10%,14-Turbo 6-120mj, MSP-XLP Remember: Once the pigment has reduced to a satisfactory level, continue with the philosophy of Preventing Pigment Gain

SR, 38y/o, F,2-5%,6mj-turb3, MSP, 50Hz, 3 Sessions before after

SR, 56 y/o, F, 2-5%, 6mj-turb3,MSP, 50Hz, 3 Sessions before after

SR, 44 y/o, F, 2-5%, 7mj-turb2,MSP, 50Hz, 2 Sessions before after

SR, 35 y/o, F, 2-5%, 3mj-turb3,MSP, 50Hz, 3 Sessions before after

SR, 55 y/o, F, 2-5%, 8mj-turb3,MSP, 50Hz, 2 Sessions before after

Acne+SR, 41y/o, F,2%, 3mj-trub3, MSP,50Hz, 3 Sessions before after

Acne Scar 34y/o, M, 10%, 14mj-trub3, SP,40Hz, 2 Sessions before after

Acne Scar 34y/o, M, 10%, 14mj-trub3, SP,40Hz, 2 Sessions before after

Ota Nevus 75y/o, F, 5%, 14mJ-Trubo2, MSP,50Hz, 8 Sessions before after

Evaluation of Improvement After Ablative Fractional ER YAG laser for Skin Rejuvenation Improvement Assessment by the physician (%) Assessment by the patient(%) Excellent ( 75%) 10(4.1) 8(3.1) Good (50-75%) 134(51.9) 130(50.6) Fair (25-50%) 99 (38.9) 103(39.7) Poor ( 25%) 15(5.1) 17(6.6)

Rejuvenation efficacy of Fractional ErYAG Facial Skin Rejuvenation (258 patients) Patients 60% 50% 40% 30% 20% 10% 0% Physicians Patients Poor Fair Good Excellent Improvement Fig.2 Results of fractional Skin rejuvenation. (2 5% of coverage, energy 6 mj with Turbo 4 and MSP pulse duration)

Evaluation of Improvement After Ablative Fractional ER YAG laser for Acne Scar Improvement Assessment by the physician (%) Assessment by the patient(%) Excellent ( 75%) 3(7.1) 1(2.3) Good (50-75%) 25(59.5) 28(66.9) Fair (25-50%) 13(30.9) 12(28.5) Poor ( 25%) 1(2.5) 1(2.3)

Acne Scar efficacy of Fractional ErYAG Acne Scars (42 patients) Patients 80% 70% 60% 50% 40% 30% 20% 10% 0% Physicians Patients Poor Fair Good Excellent Improvement Fig.1 Results of fractional ErYAG treatment of Acne scars. (5 10% of coverage, 14 mj, Turbo 6, MSP LP pulse duration)

Side Effects After Ablative Fr. ER YAG laser for Skin Rejuvenation Side effects n(%) Mean Duration, Days Erythema 258(100) 2.8 Edema 258(100) 0.9 Mild crusting 241(93.7) 4.1 Acneiform eruption 9(3.8) 6.7 Postinflammatoryhyperpigmentation 0(0) 0

Side Effects After Ablative Fractional ER YAG laser for Acne Scar Side effects n(%) Mean Duration, Days Erythema 42(100) 5.6 Edema 42(100) 1.6 Mild crusting 40(95.2) 5.1 Acneiform eruption 2(4.8) 6.7 Postinflammatoryhyperpigmentation 1(2.4) 14

Conclusions Fractional Er-Yag represents an Alternative treatment of several dermatologic conditions without the adverse effects of classic ablative laser devices despite of darker skin patients. Ablative Fractional treatments are less effective than full ablative ones, but are offering shorter down time

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