Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Hartman M, Loy EY, Ku CS, Chia KS. Molecular epidemiology and its current clinical use in cancer management. Lancet Oncol 2010; 11: 385 92.
Table 1: List of cancer GWAS publications No. Cancer Reference Initial Sample Size Replication Sample Size Number of SNP tested 1 Colorectal Nat Genet. 2007;39: 984-988 930 cases, 960 7,334 cases, 5,246 [547,647] 2 Colorectal Nat Genet. 2007;39: 989-994 1,257 cases, 1,336 6,223 cases, 6,443 [99,632] 3 Colorectal Nat Genet. 2007;39: 1315-1317 940 cases, 965 7,473 cases, 5,984 [547,647] 4 Colorectal Nat Genet. 2008;40: 623-630 922 cases, 927 17,872 cases, 17,526 [547,647] 5 Colorectal Nat Genet. 2008;40: 631-637 981 cases, 1,002 16,476 cases, 15,351 [541,628] 6 Colorectal Nat Genet. 2008;40: 1426-1435 1,902 cases, 1,929 4,878 cases, 4,914 [up to 548,586] 7 Breast Nat Genet. 2007;39:865-869 1,599 cases, 11,546 2,934 cases, 5,967 [311,524] 8 Breast Nat Genet. 2007;39:870-874 1,145 cases, 1,142 1,176 cases, 2,072 [528,173] 9 Breast Nature. 2007;447:1087-1093 390 cases, 364 26,646 cases, 24,889 [205,586] 10 Breast BMC Med Genet. 1,345 individuals [70,897] 2007;19:Suppl 1:S6 (Framingham) 11 Breast Proc Natl Acad Sci U S A. 249 cases, 299 1,193 cases, 1,166 [150,080] 2008;105:4340-4345 12 Breast Breast Cancer Res Treat. 30 cases, 30 [200,220] 2009;114:463-477 13 Breast Nat Genet. 2009;41:324-328 1,505 cases, 1,522 1,554 cases, 1,576 [up to 607,728] 14 Breast Nat Genet. 2009;41:579-584 1,145 cases, 1,142 8,625 cases, 9,657 [528,173] 15 Prostate Nat Genet. 2007; 39:645-649 1,172 cases, 1,157 3,124 cases, 3,142 [538,548] 16 Prostate Nat Genet. 2007;39:631-637 1,453 cases, 3,064 1,583 cases, 2,817 [316,515] 17 Prostate Nat Genet. 2007;39:977-983 1,501 cases, 11,290 1,992 cases, 3,058 [310,520] 18 Prostate BMC Med Genet. 2007;8 Suppl 1,345 individuals [70,897]
1:S6 (Framingham) 19 Prostate J Natl Cancer Inst. 1,235 cases, 1,599 1,242 cases, 917 [60,275] 2007;99:1836-1844 20 Prostate Nat Genet. 2008;40:310-315 1,172 cases, 1,157 3,941 cases, 3,964 [527,869] 21 Prostate Nat Genet. 2008;40:281-283 1,854 cases, 21,372 8,239 cases, 7,590 [310,520] 22 Prostate Nat Genet. 2008;40:316-321 1,854 cases, 1,894 3,268 cases, 3,366 [541,129] 23 Prostate Cancer Res. 2009;69:10-15 1,235 aggressive cases, 1,599 3,629 aggressive cases, 4,255 non-aggressive cases, [~2 million] (imputed) 5,738 24 Lung Cancer Lett. 2007;251:311-316 338 cases, 335 265 cases, 356 [~116,204] (pooled) 25 Lung Nature. 2008;452:633-637 1,926 cases, 2,522 2,513 cases, 4,752 [310,023] 26 Lung Nat Genet. 2008;40:616-622 1,154 cases, 1,137 2,724 cases, 3,694 [317,498] 27 Neuroblastoma N Engl J Med. 2008;358:2585-1,032 cases, 2,043 720 cases, 2,128 [464,934] 2593 28 Melanoma Nat Genet. 2008;40:838-840 864 cases, 864 1,230 cases 1,251 [535,150] (pooled) 29 Lung Adenocarcinoma Int J Cancer. 2008;123:2327-2330 482 cases, 522 [~318,000] (pooled) 30 Chronic Lymphocytic Leukemia Nat Genet. 2008;40:1204-1210 505 cases, 1,438 1,024 cases, 1,677 [345,665] 31 Bladder Nat Genet. 2008;40:1307-1312 1,803 cases, 2,165 cases, 3,800 [302,140] 34,336 32 Basal Cell Carcinoma Nat Genet. 2008;40:1313-1318 930 cases, 33,117 1,216 cases, 2,844 [304,083] 33 Lung J Natl Cancer Inst. 194 cases, 219 3,878 cases, 4,831 [up to 722,376] 2008;100:1326-1330 34 Lung Nat Genet. 2008;40:1407-1409 1,952 cases, 1,438 7,579 cases, 8,236 [223,891] 35 Lung Nat Genet. 2008;40:1404-1406 2,971 cases, 3,746 2,899 cases, 5,573 [315,194] 36 Thyroid Nat Genet. 2009;41:460-464 192 cases, 37,196 432 cases, 1,727 [304,083] 37 Neuroblastoma Nat Genet. 2009;41:718-723 397 cases, 2,043 189 cases, 1,178 [462,866]
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