putty Good bones good base! Superior bone formation: Unique bone formula Controlled osteoinduction Safety for doctor and patient Quick and easy application since 1888
Superior bone formation Information on the NanoBone synthetic bone grafting material Extremely fast bone regeneration 1 Direct augmentation after approx. 12 months: NanoBone complete biodegraded = complete autologous bone 12 months after 10 days: Matrix change: Organic material in silica gel out 9 months 3 months from 3 months: Implant insertion following external sinus lift 2 6 months from 6-9 months: Lateral widening/ block augmentation of the alveolar ridge from 4-6 months: Extraction alveole/ socket preservation 1 Kruse A, Jung RE, Nicholls F, Zwahlen RA, Hämmerle CHF, Weber FE. Clin Oral Implants Res. 2011 May; 22 (5):506-11. 2 Meier J, Wolf E, Bienengräber V: Implantologie 2008; 16(3):301-314.
Unique bone formula using nanotechnology Patented combination of nanocrystalline hydroxylapatite and a highly porous silica gel matrix 3 Controlled osteoinduction 4 The biggest internal surface area using physiological nanostructures The large internal surface area is decisive for protein adhesion and biological functionality 5. 250 200 Internal surface area m 2 /g 150 100 50 0 0.4 Bioglass 1.2 Beta TCP 79.4 unsintered HA of bovine origin approx. organic HA 6 206.8 NanoBone putty The internal surface area (m 2 /g) has been measured using mercury porosimetry and BET. Fast capillary vessel growth and growth factors (BMP) Complete remodelling = complete conversion of NanoBone into autologous bone tissue 7 3 Gerber et al.: European Journal of Trauma 32 (2006): 132-140. 4 Gerber Th, Lenz S, Holzhüter G, Götz W, Helms K, Harms C, Mittlmeier Th, Trans Tech Publications Switzerland 2012, 147-152. 5 Kirchhoff M et al.: Journal of Biomedical Materials Research B: Applied Biomaterials, Feb 2011, Vol. 96B, Issue 2. 6 Hench L, An Introduction to Bioceramics, World Scientifi c, 1993. 7 Götz W, Gerber T, Michel B, Lossdörfer S, Henkel KO, Heinemann F: Clin Oral Implants Res. 2008 Oct;19(10):101626.doi: 10.1111/j.1600-0501.2008.01569.x.
Superior bone formation Information on the NanoBone synthetic bone grafting material Safety for doctor and patient Volume stability Long-term study on NanoBone confirms its reliability 8 : The augmented bone height remained constant over a period of at least 3 years. NanoBone is completely converted and rebuilt New autologous bone was formed Extract from the measurement of vertical bone height after 3 years: I-A: Implant abutment line; M: Mesial bone height; D: Distal bone height Bone height during the observation period (average value and 98% confi dence interval) 18 17 16 Total bone height (mm) 15 14 13 12 Mesial Distal 11 0 1 2 3 4 Time (years) 8 Heinemann F., Mundt T., Biffar R., Gedrange T., Götz W. Journal of Physiology and Pharmacology 2009, 60, Suppl 8, 91-97.
Socket preservation using NanoBone putty Dr. Frank Maier, Dental Health at Loretto, Tübingen 1 2 1 Condition after tooth extraction due to a longitudinal fracture of the palatal root; small surface mouth-antrum connection 2 Filling of the alveole with NanoBone l putty; easy application using the ready-to-use applicator 3 4 3 Covering of the augmentation material with collagen fl eece (Resorba) 4 Condition 6 days post-extraction; irritation-free healing 5 6 5 Augmented area 5 months post-op 6 Very stable hard tissue situation on exposure 7 8 7 Primarily stable insertion of an Ankylos implant after performing an endoscopically controlled internal sinus lift; monitoring of the augmentation material using a microendoscope shows no indication of residual particles 8 Advanced buccal fl ap and easy wound closure
Superior bone formation Information on the NanoBone synthetic bone grafting material Safety for doctor and patient Over 300,000 treatment cases in 5 years Comprehensive trial documentation 9 Advantages of synthetic NanoBone No second/parallel operation: fewer side-effects Free from animal and plastic residues: free from infection and allergy risks Made in Germany Free from contamination risks dependent on material Mixing with autologous blood does not apply 9 Bibliography NanoBone : Knochenaufbau in neuer Dimension, ARTOSS GmbH Photo below: fotolia contrastwerkstatt
Quick and easy application Dimensional stability Easy to mould putty Ready to use direct augmentation No more mixing pure time saving 1 From the applicator into the defect No waiting time for IV blood samples and intermediate steps Easy insertion into the defect No crumbling 1 NanoBone l putty is used direct from the applicator 2 No loss of material 2 Quick and easy application Shortens your treatment times Shortens healing times 3 100% biocompatible 3 NanoBone l putty is very adaptable Photos 1 3: PD Dr. F Blake MKG am Kurpark, Bad Oldesloe
DISTRIBUTION Hager & Meisinger GmbH Hansemannstr. 10 41468 Neuss Germany Tel.: +49 (0) 2131 2012-303 Fax: +49 (0) 2131 2012-222 info@meisinger.de www.meisinger.de MANUFACTURER ARTOSS GmbH Friedrich-Barnewitz-Straße 3 18119 Rostock Germany Tel.: +49 (0) 381 54345-701 Fax: +49 (0) 381 54345-702 info@nanobone.de www.nanobone.de putty Recommended indications and volumes* Socket preservation Anterior tooth region 1 x 0.25 ml premolar molar Addition of implants and peri-implantatis 1 x 0.25 ml Periodontal defects Furcation grade 1+2 1 x 0.25 ml Cystectomy 1 x 2.5 ml Root tip resection 1 x 0.25 ml Lateral widening of the alveolar ridge Sinus floor elevation per implant Bilateral sinus floor elevation NanoBone block 5 x 10 x 15 mm 1 x 2.5 ml 1 x 2.5 ml * The quantity of material always depends on the clinical situation, the size of the defect and the anatomical conditions. All items indicated in ml refer to NanoBone putty. Application recommendation The safety catch is released by twisting and subsequently removed. 600043.0 85PNB8SE