BIOMATERIAL COLLECTION

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INDEX GRAFTING PAGE Xenograft Bone Grafting DirectOss 1 Allograft Bone Grafting DirectGen 2-3 Bone Grafting DirectGen Putty 4 Synthetic Bone Grafting DirectGen FLEX 5 Bone Grafting BioResorb Macro Pore 6 Soft Tissue Grafting DirectGen DERM 7 MEMBRANES Resorbable Kontour Adapt 8 Kontour Sustain 9 CytoPlast RTM 10 Non-Resorbable CytoPlast TI250, TXT & GBR 11 SUTURES Resorbable Vilet 12 Non-Resorbable CytoPlast 13 Availability Not all products listed in this catalog are available in all countries. Please contact Implant Direct or your local dealer for more information on product availability.

DirectOss BONE GRAFTING - XENOGRAFT DirectOss slow resorbing support for integrative new bone growth allows you to treat with confidence. This natural hydroxyapatite extracted from bovine cancellous bone boasts greater inner surface area than comparable materials on the market giving it more space for osteoblast adhesion as well as high hydrophilicity for rapid vascularization. ANORGANIC CANCELLOUS GRANULES 100% natural hydroxyapatite extracted from bovine cancellous bone Derived from BSE-free herds in Australia Mimics human bone both structurally and chemically Sintered at a low temperature to reduce crystallinity content Supports new bone in-growth throughout each granule due to its interconnected macro, meso and micro pore structure Packaged in both vials and syringes for easy delivery Gamma irradiated to SAL 10-6 for sterility COMMON APPLICATIONS Socket preservation Maxillary sinus floor elevation Alveolar ridge augmentation Periodontal regeneration Peri-implantitis DirectOss has up to 55% greater inner surface to support new bone in-growth Inner Surface Area (m2/g) 100 80 60 40 20 88.2 79.7 57.0 Granule Size 0.25-1.0mm 0.25-1.0mm 0.25-1.0mm 0.25-1.0mm 0.25-1.0mm 0.25-1.0mm 0.25-1.0mm Weight 0.25g 0.50g 1.0g 2.0g 0.25cc ( 0.125g) 0.5cc ( 0.25g) 1.0cc ( 0.5g) Packaging Vial Vial Vial Vial Syringe Syringe Syringe Reference # DXCA251025 DXCA251005 DXCA251010 DXCA251020 DXCA251025S DXCA251005S DXCA251010S Price $59 $89 $159 $299 $49 $69 $99 0 DirectOss Bio-Oss NuOss 1.0-2.0mm 1.0-2.0mm 0.50g 2.0g Vial Vial DXCA102005 DXCA102020 $89 $299 Ref. NuOss, a Bone Grafting Material for Oral Surgery: A Comparative Study with BioOss by Collagen Matrix Inc. Ref. Biomaterials 2001; 22:1005-1012 1

DirectGen BONE GRAFTING-ALLOGRAFT DirectGen Allograft is a natural, safe and easy to use grafting material. This product comes in a variety of donated tissue types (cortical, cancellous or cortical-cancellous blend) and is suited for a wide range of clinical needs. DirectGen has been processed utilizing a proprietary process. This process allows for microbial inactivation while minimally manipulating the tissue. This process meets or exceeds requirements set forth by the FDA and American Association of Tissue Banks (AATB) and as a result, there have been no confirmed cases of disease transmission from allografts in its extensive history. Cancellous Particulate DirectGen Mineralized cancellous particulate has the interconnecting porosity associated with trabecular bone structure. This allows for increased capillary action of the blood which in turn promotes rapid formation of osteoblasts for new bone growth. Has increased porosity and surface area which promotes revascularization and supports in-growth of new bone Cortical Particulate DirectGen Mineralized cortical particulate offers the structural strength and integrity associated with cortical bone. This results in a slower resorbing graft material that is ideal for space maintenance in grafting procedures. Provides longer lasting scaffold for new bone ingrowth Cortical-Cancellous Blend DirectGen Mineralized Blend is a 50:50 mixture of cortical and cancellous particulate. This pre-mixed, easy to use product is intended to provide the clinician with the features and benefits of both tissue types. Simplifies procedure by eliminating need to mix tissues chairside Single donor per vial Demineralized Cortical Particulate DirectGen Demineralized particulate has been processed to expose the bone morphogenic proteins within the bone matrix. This results in a graft material that has the potential to induce cell differentiation and new bone formation. Each lot is tested via BMP-2 assay POST sterilization DirectGen Mineralized/Demineralized Cortical Combo DirectGen Mineralized/Demineralized Cortical Combo is a 50:50 combination of mineralized cortical tissue and demineralized cortical tissue. This pre-mixed combination results in a material with osteoconductive properties as well as osteoinductive potential. Saves time and effort by eliminating need to mix tissues chairside Mineralized content ideal for space maintenance while demineralized content provides osteoinductive potential 2 www.implantdirect.com

DirectGen Packaging Allograft: DirectGen Mineralized Cortical Item# (250-1000μm) - 0.5cc DCOR251005 $60 (250-1000μm) - 1.0cc DCOR251010 $80 (250-1000μm) - 2.0cc DCOR251020 $140 (1000-2000μm) - 0.5cc DCOR102005 $60 (1000-2000μm) - 1.0cc DCOR102010 $80 (1000-2000μm) - 2.0cc DCOR102020 $140 Allograft: DirectGen Mineralized Cancellous Item# (250-1000μm) - 0.5cc (250-1000μm) - 1.0cc (250-1000μm) - 2.0cc (1000-2000μm) - 0.5cc (1000-2000μm) - 1.0cc (1000-2000μm) - 2.0cc DCAN251005 DCAN251010 DCAN251020 DCAN102005 DCAN102010 DCAN102020 $80 $105 $170 $80 $105 $170 Allograft: DirectGen Mineralized Cortical/Cancellous blend Item# (250-1000μm) - 0.5cc DBLN251005 $80 (250-1000μm) - 1.0cc DBLN251010 $105 (250-1000μm) - 2.0cc DBLN251020 $170 Allograft: DirectGen Demineralized Cortical Item# (125-850μm) - 0.5cc (125-850μm) - 1.0cc (125-850μm) - 2.0cc DDCOR128505 DDC0R128510 DDCOR128520 $60 $80 $140 Allograft: DirectGen Mineralized/ Demineralized Cortical Combo Item# (125-1000μm) - 0.5cc DCMB121005 $80 (125-1000μm) - 1.0cc DCMB121010 $105 (125-1000μm) - 2.0cc DCMB121020 $170 www.implantdirect.com 3

DirectGen PUTTY BONE GRAFTING - PUTTY Innovation often follows the straightest path. In bone grafting, attention to basic fundamentals has always been the key to the best and most predictable clinical outcomes. Historically, bone itself is the best substrate for new bone formation. This is the philosophy behind DirectGen Putty, which is simply comprised of human bone and buffered water. DEMINERALIZED PUTTY Made from 100% human bone nothing added that may get in the way of bone healing Osteoconductive DBM provides an ideal scaffold that directs and supports bone formation Osteoinductive the osteoinductive potential of DBM is well established Excellent handling characteristics will shape and conform to fill unique bony voids, retains shape and resists wash-out, or migration, from graft site Easy to store and use stores at ambient room temperature, long three-year shelf life, and ready for immediate use; no prep time or reconstitution required Sterile gamma irradiated to SAL 10-6 Safe donor recovery and screening performed according to AATB and FDA guidelines Clinically versatile available in a flowable putty or as a flowable putty plus mineralized chips Available in two options and a variety of sizes: DirectGen Putty Size DP070 DP100 DP250 0.7cc 1.0cc 2.5cc $135 $175 $350 DirectGen Putty PLUS Size DPP100 DPP250 1.0cc 2.5cc $220 $435 4 www.implantdirect.com

DirectGen FLEX BONE GRAFTING - ALLOGRAFT DEMINERALIZED CORTICAL ALLOGRAFT SHEET Proprietary processing leaves cortical sheet flexible which allows it to be easily adapted to act as missing wall in 3 wall defect or as an onlay to cover a graft site. Product retains enough rigidity to allow it to be easily tucked into periosteal envelope (as compared to a membrane) and maintains its position during flap closure and suturing. Rehydrates in minutes and can be easily shaped with scissors or scalpel. Can be tacked or sutured. Provides 3 dimensional osteoconductive scaffold that promotes revascularization and in-growth of new bone. Demineralization process exposes BMP-2 content native in the tissue. Each LOT is assayed and tested for its osteoinductive potential post sterilization. COMMON APPLICATIONS Repair of 3 wall defects Repair of access windows Ridge Augmentations DirectGen FLEX inserted subperiostelly to act as temporary wall 10mm x 10mm 10mm x 17mm 15mm x 15mm DFLX1010 (1/box) $100 DFLX1017 (1/box) $195 DFLX1515 (1/box) $215 www.implantdirect.com 5

BioResorb Macro Pore BONE GRAFTING-SYNTHETIC β-tricalcium PHOSPHATE BONE REGENERATION MATERIAL WITH ADVANCED POROSITY βioresorb Macro Pore is an osteoconductive, pure-phase β-tricalcium phosphate bone grafting material developed via a patented process that creates a porous structure most similar to human bone. The interconnecting micro & macro porous structure gives the advantage of allowing vascularization and cell transport into and throughout the particle, leading to new bone deposits within the particles themselves. βioresorb Macro Pore is made from 99% pure-phase Beta Tri-Calcium Phosphate (β-tcp). Each batch of product is tested via X-ray diffraction to ensure its purity. In addition, the calcium/phosphor atom ratio in βioresorb is 1.5 (very similar to the mineral phase of human bone which is 1.6). Histology at 7 months improved bone regeneration with a high activity of osteoblasts, homogenous cortical structures and no signs of inflammation. Odontogenic keratocyst 6 months after cyst removal and placement of βioresorb Macro Pore. Complete BioResborb Macro Pore restitution of bone structure. Item# Single pack (1 vial/1 box) 200-500μm 0.5ml 19002105 $65 500-1000μm 0.5ml 19005105 $65 1.0ml 19005110 $100 1000-2000μm 2.0ml 0.5ml 1.0ml 19005120 19010105 19010110 $160 $65 $100 2.0ml 19010120 $160 1400-3200μm 1.0ml 19014110 $100 BioResborb Macro Pore 5- pack (5 vials/1 box) Item# 200-500μm 0.5ml 19002505 500-1000μm 0.5ml 19005505 1.0ml 19005510 1000-2000μm 2.0ml 0.5ml 1.0ml 19005520 19010505 19010510 $260 $260 $400 $640 $260 $400 6 www.implantdirect.com

DirectGen DERM SOFT TISSUE GRAFTING - ALLOGRAFT DECELLURIZED DERMAL ALLOGRAFT TISSUE Biocompatible Retains collagen and elastin and has elasticity of the native dermis Processing preserves biologic properties that promote revascularization and repair of damaged tissues Eliminates morbidity and pain associated with a donor site Allows multiple sites to be treated in same surgery Proprietary processing allows either side to be placed against defect. No special orientation required Rehydrates in minutes and is easily trimmed with scalpel or scissors Retains enough firmness when hydrated to facilitate easy placement in graft site (especially when used for tunnel technique) Available in multiple thickness and size options: Thin (0.5-1.0mm) Size DD101005 10x10mm $80 DD102005 10x20mm $120 DD104005 10x40mm $190 DD204005 20x40mm $230 Thick (1.0-1.5mm) Size DD101010 10x10mm $80 DD102010 10x20mm $120 DD104010 10x40mm $190 DD204010 20x40mm $230 Pre-op DirectGen DERM trimmed for site Insertion of DirectGen DERM Site sutured 4 week post-op Case courtesy of Avi Schetritt, DMD www.implantdirect.com 7

Kontour Adapt RESORBABLE MEMBRANE TYPE I PORCINE PERITONEUM COLLAGEN RESORBABLE MEMBRANE Resorbable; new host collagen is regenerated as membrane resorbs Easy to use; not side specific and easily conforms to defects and contours Can be used dry or hydrated. Membrane does not stick to instruments or gloves when hydrated and can be easily repositioned once placed Membrane s proprietary process assures the membranes are highly biocompatible resulting in minimal inflammation and foreign body response Membrane has excellent strength to support tacking or suturing Initial slower rate of resorption protects wound during early critical period of healing Protects wound from undesired in growth of soft tissue Provides effective barrier functionality for up to 12-16 weeks COMMON APPLICATIONS Periodontal defects Reference# Description Price Sinus lift osteotomies Repair of access windows Soft tissue augmentation KRMA1520 KRMA2030 KRMA3040 15x20mm membrane (1/box) 20x30mm membrane (1/box) 30x40mm membrane (1/box) $109 $139 $195 Periapical lesions SEM micrograph of the Kontour Adapt (side A) at 50x magnification SEM micrograph of the Kontour Adapt (side B) at 50x magnification SEM micrograph of the Kontour Adapt (cross-section) at 50x magnification 8 www.implantdirect.com

Kontour Sustain RESORBABLE MEMBRANE TYPE I PORCINE COLLAGEN RESORBABLE MEMBRANE Fully Resorbable; no second surgery required Easy to use; either side may be placed against defect Can be used dry or hydrated. Hydrates in minutes. Membrane does not stick to itself when hydrated allowing for easy placement and/or repositioning Membrane retains sufficient memory when hydrated which allows it to be easily positioned under the periosteum uniformly without bunching up. This also allows the membrane to maintain its shape and position during closing, suturing and throughout its use Membrane is also soft and conformable. This allows membrane to adapt well to most varying bone topographies Unique fiber orientation provides membrane with high tensile strength and high suture pullout resistance Provides effective barrier functionality for 16-24 weeks COMMON APPLICATIONS Periodontal defects Sinus lift osteotomies Repair of access windows Soft tissue augmentation Periapical lesions 50X Magnification 15mm x 20mm KRM1520 (1/box) $92.50 20mm x 30mm KRM2030 (1/box) $115 30mm x 40mm KRM3040 (1/box) $165 www.implantdirect.com 9

CytoPlast RTM RESORBABLE MEMBRANE TYPE I BOVINE COLLAGEN RESORBABLE TISSUE MATRIX Resorbable; eliminates second surgery Unique fiber orientation provides unusually high tensile strength Safe; manufactured from highly purified Type I bovine achilles tendon Layered construction allows cellular ingrowth of outer layer, but inner layers help prevent cellular and bacterial downgrowth Longer predictable resorption time of 26 to 38 weeks Guides healing of bone and surrounding tissue High mechanical strength for membrane stabilization using either sutures or resorbable tacks Excellent handling when wet, and either side can be placed against the defect Optimized flexibility and rigidity for better maintenance of space COMMON APPLICATIONS Periodontal defects Sinus lift osteotomies Repair of access windows Soft tissue augmentation Periapical lesions This cross sectional SEM view demonstrates the multi-layer construction allowing tissue integration in outer layer while preventing direct passage of bacteria and epithelial cells. CYTOPLAST RTM COLLAGEN 15mm x 20mm RTM1520 (2/box) $185 20mm x 30mm RTM2030 (2/box) $230 30mm x 40mm RTM3040 (2/box) $330 10 www.implantdirect.com

CytoPlast TI250, TXT & GBR NON-RESORBABLE AND NON-RESORBABLE TITANIUM REINFORCED MEMBRANES THE ORIGINAL, PATENTED, HIGH-DENSITY PTFE MEMBRANE Non-resorbable; won t resorb prematurely leaving graft site exposed Made from d-ptfe; <0.3um pore size is impervious to bacteria Primary closure not required; less surgical time required Soft tissue attaches but does not grow through membrane; allows for non-surgical removal Textured surface; increases membrane stabilization Titanium Insert (on TI250 membranes) provides membrane with shape memory and rigidity for superior space creation and maintenance while grafting CYTOPLAST TXT & GBR Cytoplast TXT2530 Cytoplast TXT1224 25mm x 30mm (4 membranes/box) $280 12mm x 24mm (10 membranes/box) $400 Cytoplast GBR2530 Cytoplast GBR1224 25mm x 30mm (4 membranes/box) $220 12mm x 24mm (10 membranes/box) $320 CYTOPLAST TI250 12mm x 24mm 14mm x 24mm Cytoplast Ti250 Anterior Narrow Cytoplast Ti250 Anterior Single Ti250ANL-1 (1 membrane/box) $110 Ti250ANL-2 (2 membranes/box) $200 Ti250AS-1 (1 membrane/box) $140 Ti250AS-2 (2 membranes/box) $250 Ideal for narrow single-tooth extraction sites, especially where one or more bony walls are missing. Ideal size and shape for single-tooth extraction sites, especially where one or more bony walls are missing. 25mm x 30mm 20mm x 25mm 17mm x 25mm Cytoplast Ti250 Posterior Large Cytoplast Ti250 Posterior Singles Cytoplast Ti250 Buccal Ti250PL-1 (1 membrane/box) $200 Ti250PL-2 (2 membranes/box) $365 Ti250PS-1 (1 membrane/box) $180 Ti250PS-2 (2 membranes/box) $325 Ti250BL-1 (1 membrane/box) $150 Ti250BL-2 (2 membranes/box) $270 Designed for grafting large bony defects, including ridge augmentation. Designed for grafting posterior extraction sites and limited ridge augmentation. Ideal for use in large buccal defects. The pilot holes create more secure membrane stabilization. www.implantdirect.com This SEM view shows the micro-machined textured surface, which increases the area available for cellular attachment by 250% without increasing porosity. 11

Vilet RESORBABLE SUTURES Vilet is a braided coated synthetic absorbable suture made from polyglactin (PGLA) 90-10. CHARACTERISTICS Maintain approximately 75-85% of its original strength at two weeks and 50-65% of its original strength at 3 weeks post implantation 1 Excellent knot security and tie down Superb handling Smooth Tissue Passage Reliable absorption profile Meets or exceeds the USP & EP requirements Resorbs completely in 60-90 days Item # Size (USP) Length Color Needle Type Needle Shape QTY/Box V393 3-0 18 Violet FS-2 V393U 3-0 18 Undyed FS-2 V392 4-0 18 Violet FS-2 V392U 4-0 18 Undyed FS-2 V386U 4-0 18 Undyed C-3 V385U 5-0 18 Undyed C-3 19mm 19mm 19mm 19mm 13mm 13mm 12 $60 12 $60 12 $60 12 $60 12 $90 12 $90 Vilet II Quick RESORBABLE SUTURES Is a fast-absorbing synthetic absorbable suture composed of a coated polyglactin (PGA). ADDITIONAL CHARACTERISTICS Maintain approximately 60-70% of its original strength after 1 week post implantation 1 Completely resorbs in 42 days Item # Size (USP) Length Color Needle Type Needle Shape QTY/Box VGQ386 4-0 18 Undyed C-3 VGQ392 4-0 18 Undyed FS-2 13mm 19mm 12 $100 12 $70 1 Times are based on subcutaneous tissue implantation studies in rats. 12 www.implantdirect.com

CytoPlast NON-RESORBABLE SUTURES BENEFITS Non-resorbable, 100% Medical Grade d-ptfe Monofilament construction eliminates bacterial wicking Biologically inert & chemically non-reactive Not subject to weakening by tissue enzymes Excellent soft tissue response Soft; increased patient comfort Great handling, knot-tying & knot-holding characteristics COMMON APPLICATIONS Bone grafting procedures Guided tissue regeneration Implant surgery Periodontal surgery Ridge augmentation Soft tissue grafts Item # Size (USP) Length Color Needle Type Needle Shape QTY/Box CS-04 2-0 18 Undyed FS-2 19mm 12 $100 CS-05 3-0 18 Undyed FS-2 1 16.3mm 12 $100 CS-051819 3-0 18 Undyed FS-2 19mm 12 $100 CS-06 4-0 18 Undyed FS-2 1 16.3mm 12 $100 CS-06 PREM 4-0 18 Undyed P-3 13mm 12 $120 CS-06 PERIO 4-0 18 Undyed TP 1/2 Circle Taper Point 13mm 12 $100 1 Needle size smaller than typical FS-2 needle. www.implantdirect.com 13

Simply Smarter Implantology Innovative Designs with Inclusive Packaging Call to find out which one best fits your practice! www.implantdirect.com 888-649-6425 Copyright 2016 Implant Direct Sybron International. All Rights Reserved. *6-09-16-0062* 6K-09-16-0062 Rev.05 Printed in the U.S.A. All trademarks are property of their respective companies. All prices shown in USD. Pricing and product availability subject to change without notice. Not all products shown are available in all countries. Please contact Implant Direct or your local dealer for more information on product availability.