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MICHIGAN State Protocols Protocol Number 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 1.10 1.11 1.12 1.13 General Treatment Protocols Table of Contents Protocol Name General Pre-hospital Care Abdominal Pain Nausea and Vomiting Syncope Shock Allergic Reaction Adrenal Crisis Behavioral Emergencies Return of Spontaneous Circulation Adult Anaphylaxis (BEES) Adult Respiratory Distress (BEES) Pediatric Anaphylaxis (BEES) Pediatric Bronchospasm (BEES)

Southeast Michigan Regional Protocol GENERAL TREATMENT GENERAL PRE-HOSPITAL CARE Initial Date: 11/15/2012 Revised Date: 2/18/18 Section 1-1 General Pre-Hospital Care Patient care should be initiated at the patient s side prior to patient movement or transport for most medical conditions. Unless otherwise stated, pediatric protocols will apply to patients less than or equal to 14 years of age or up to 36kg. 1. Assess scene safety and use appropriate personal protective equipment. 2. Complete primary survey. 3. When indicated, implement airway intervention as per the Emergency Airway Procedure. 4. When indicated, administer oxygen and assist ventilations as per the Oxygen Administration Procedure. 5. Assess and treat other life threatening conditions per appropriate protocol. 6. Obtain vital signs including pulse oximetry if available or required, approximately every 15 minutes, or more frequently as necessary to monitor the patient s condition (minimum 2 sets suggested). 7. Perform a secondary survey consistent with patient condition. 8. Follow specific protocol for patient condition. 9. Document patient care according to the Patient Care Record Protocol. 10. Establish vascular access per Vascular Access & IV Fluid Therapy Procedure when fluid or medication administration may be necessary. 11. Apply cardiac monitor and treat rhythm according to appropriate protocol. If applicable, obtain 12-lead ECG. Provide a copy of the rhythm strip or 12-lead ECG to the receiving facility, be sure to place patient identifiers on strip. 12. Consider use of capnography as appropriate and if available, per Waveform Capnography Procedure. NOTE: When possible, provide a list of the patient s medications or bring the medications to the hospital. MCA Board Approval Date: February 2, 2018 MCA Implementation Date: June 1, 2018 Page 1 of 1

Michigan GENERAL TREATMENT ABDOMINAL PAIN (NON-TRAUMATIC) Initial Date: 05/31/2012 Revised Date: 10/25/2017 Section 1-2 Abdominal Pain (Non-traumatic) 1. Follow General Pre-hospital Care Protocol. 2. Conduct physical exam of abdomen including assessment of central and bilateral distal pulses. 3. If symptoms of shock present refer to Shock Protocol. 4. Position patient in a position of comfort if pain is non-traumatic. If trauma related, refer to Adult Trauma Protocol. 5. Do not allow patient to take anything by mouth. 6. If patient is experiencing nausea and vomiting refer to Nausea/Vomiting Protocol. 7. Treat pain per Pain Management Procedure. MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 1 of 2

Michigan GENERAL TREATMENT ABDOMINAL PAIN (NON-TRAUMATIC) Initial Date: 05/31/2012 Revised Date: 10/25/2017 Section 1-2 Follow General Pre-hospital Care Protocol Conduct physical exam of abdomen Assess central and bilateral distal pulses If signs of shock are noted, follow Shock Protocol Position patient in a position of comfort if pain is not traumatic in nature. If trauma related, refer to Adult Trauma Protocol Do NOT allow patient to take anything by mouth. If the patient is experiencing nausea/vomiting, refer to Nausea/Vomiting Protocol Paramedics refer to Pain Management Procedure MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 2 of 2

Southeast Michigan Regional Protocol GENERAL TREATMENT NAUSEA & VOMITING Initial Date: 8/24/2012 Revised Date: 2/18/2018 Section 1-3 Nausea & Vomiting 1. Follow General Pre-hospital Care Protocol. 2. For patients >40 kg that are not actively vomiting, administer Ondansetron (Zofran) 4mg ODT, per MCA selection. a. Contraindications: Patients with Phenylketonuria (PKU) ODT Ondansetron included? YES NO 3. For signs of dehydration, administer NS IV/IO fluid bolus up to 1 liter, wide open. a. Pediatrics receive 20 ml/kg 4. Hypotensive patients should receive additional IV/IO fluid boluses, as indicated by hemodynamic state. Continue IV/IO fluid bolus to a maximum of 2 liters. a. Pediatrics repeat dose of 20 ml/kg 5. Administer Ondansetron (Zofran) a. Adults 4mg IV/IM (if ODT not already administered or if patient vomited post ODT administration). b. Pediatrics 0.1 mg/kg IV/IM, max dose of 4 mg 6. Repeat Ondansetron (Zofran) a. Adults 4mg IV/IM (if ODT not already administered or if patient vomited post ODT administration). b. Pediatrics 0.1 mg/kg IV/IM, max dose of 4 mg MCA Board Approval Date: February 2, 2018 MCA Implementation Date: June 1, 2018 Page 1 of 1

Michigan GENERAL TREATMENT SYNCOPE Initial Date: 8/24/2012 Revised Date: 10/25/2017 Section 1-4 Syncope 1. Assess for mechanism of injury, if trauma sustained, refer to General Trauma Protocol. 2. Follow General Pre-hospital Care Protocol. 3. Position patient A. If third trimester pregnancy, position patient left lateral recumbent. B. Supine for all other patients 4. If patient s mental status remains altered, refer to Altered Mental Status Protocol. 5. For signs of dehydration or hypotension, administer NS IV fluid bolus. A. Adults up to 1 liter B. Pediatrics up to 20 ml/kg C. Titrate to normotensive BP 6. Obtain 12-lead ECG per 12 Lead ECG Procedure (May be a basic skill based on MCA selection). If ECG indicates cardiac event or dysrhythmia, refer to Appropriate Cardiac Protocol. 7. Additional IV fluids as ordered. MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 1 of 2

Michigan GENERAL TREATMENT SYNCOPE Initial Date: 8/24/2012 Revised Date: 10/25/2017 Section 1-4 Follow General Prehospital Care Protocol Any Trauma? Refer to General Trauma Protocol Yes No Position Patient 3 rd Trimester? Left Lateral Recumbent All others - Supine Still Altered? Refer to Altered Mental Status Protocol Yes No For Signs of Hypotension, administer NS IV fluid bolus Adults up to 1 liter Pediatrics up to 20 ml/kg Titrate to Normotensive BP Obtain 12 Lead ECG per 12 Lead ECG Procedure If cardiac event or dysrhythmia, refer to Appropriate Cardiac Protocol Additional IV Fluids as Ordered MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 2 of 2

Michigan GENERAL TREATMENT SHOCK Initial Date: 5/31/2012 Revised Date: 10/25/2017 Section 1-5 Shock Assessment: Consider etiologies of shock 1. Follow General Pre-hospital Care Protocol. 2. Control major bleeding per Soft Tissue and Orthopedic Injuries Protocol. 3. Remove all transdermal patches using gloves. 4. Prompt transport following local MCA protocol. 5. Special consideration A. If 3 rd trimester pregnancy, position patient left lateral recumbent. 6. Obtain vascular access (in a manner that will not delay transport). A. The standard NS IV/IO fluid bolus volume will be up to 1 liter, wide open, repeated as necessary, unless otherwise noted by protocol. IV/IO fluid bolus is contraindicated with pulmonary edema. B. Fluid should be slowed to TKO when SBP greater than 90 mm/hg. C. For pediatrics, fluid bolus should be 20 ml/kg, and based on signs/symptoms of shock. 7. Consider establishing a second large bore IV of Normal Saline en route to 8. Obtain 12-lead ECG, if suspected cardiac etiology. 9. If anaphylactic shock, refer to the Anaphylaxis/Allergic Reaction Protocol. 10. For possible hemorrhagic shock, per MCA selection, refer to Tranexamic Acid Protocol. MCA Adoption of Tranexamic Acid Protocol YES NO 11. Additional IV/IO fluid bolus A. Up to 2L total for adult B. Up to 40mL per kg total for pediatric. 1. 12. If hypotension persists after IV/IO fluid bolus, administer Epinephrine by push dose (dilute boluses). A. Prepare by combining 1 ml of Epinephrine 1 mg/10 ml with 9 ml NS B. Adults 1. Administer 10-20 mcg (1-2 ml Epinephrine 10 mcg/ml) 2. Repeat every 3 to 5 minutes 3. Titrate to SBP greater than 90 mm/hg C. Pediatrics 1. Administer 1 mcg/kg (0.1 ml/kg Epinephrine 10 mcg/ml) 2. Maximum dose 10 mcg (1 ml) 3. Repeat every 3-5 minutes MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 1 of 2

Michigan GENERAL TREATMENT SHOCK Initial Date: 5/31/2012 Revised Date: 10/25/2017 Section 1-5 Follow General Prehospital Care Protocol Control major bleeding per Soft Tissue and Orthopedic Injuries Protocol Remove all transdermal patches using gloves Position patient appropriately (3 rd trimester pregnancy, left lateral recumbent) Transport following MCA Protocol Obtain vascular access (without delaying transport) IV bolus NS, up to 1 liter (may repeat as noted) Pediatrics up to 20 ml/kg Titrate to Normotensive BP and signs/symptoms of shock Obtain 12 Lead, if Cardiac Etiology Suspected If anaphylactic shock, refer to Anaphylaxis/ Allergic Reaction Protocol MCA Adoption of Tranexamic Acid Protocol? Yes No If possible hemorrhagic shock, per MCA selection, refer to Tranexamic Acid Protocol Additional IV/IO fluid bolus Up to 2 L total for adult Up to 40 ml/kg total for pediatric If hypotension persists after fluid bolus, administer Epinephrine by push dose Prepare (10mcg/ml by adding 1 ml of 1mg/10mL Epinephrine in 9mL NS then Adult Administer 1-2 ml every 3 to 5 minutes, titrating to SBP >90 mm/hg Pediatric Administer 0.1 ml/kg (1 mcg/kg), maximum dose 10 mcg (1 ml), repeat every 3-5 minutes titrating to signs/symptoms of shock MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 2 of 2

Southeast Michigan Regional Protocol GENERAL TREATMENT PROTOCOLS ANAPHYLAXIS/ALLERGIC REACTION Initial Date: 5/31/2012 Revised Date: 12/18/2017 Section 1-6 Anaphylaxis/Allergic Reaction 1. Follow General Pre-hospital Care Protocol. 2. Determine substance or source of exposure, remove patient from source if known and able. 3. In cases of severe allergic reaction, wheezing or hypotension, administer epinephrine via autoinjector. 4. Assist the patient in administration of their own epinephrine auto-injector, if available. 5. *MCA Approval for MFR epinephrine auto-injector (Agency Option). MCA Approval of Epinephrine Auto-injector for Select MFR Agencies (Provide participating agency list to BETP) YES NO a. If child appears to weigh less than 10 kg (approx. 20 lbs.), contact medical control prior to epinephrine, if possible. b. If child weighs between 10-30 kg (approx. 60 lbs.); administer pediatric epinephrine auto-injector. c. For adults and children weighing greater than 30 kg; administer epinephrine autoinjector. d. May repeat at 3-5 minute intervals if the patient remains hypotensive, if available. 6. Albuterol may be indicated. Refer to Nebulized Bronchodilators Procedure. 7. Administer a Normal Saline IV/IO fluid bolus. a. The standard NS IV/IO fluid bolus volume will be up to 1 liter, wide open, repeated as necessary, unless otherwise noted by protocol. IV/IO fluid bolus is contraindicated with pulmonary edema. b. Fluid should be slowed to TKO when SBP greater than 90 mm/hg. c. For pediatrics, fluid bolus should be 20 ml/kg, and based on signs/symptoms of shock. 8. In cases of suspected anaphylaxis with hypotension, severe respiratory distress, and/or angioedema, administer Epinephrine. a. Adult (1mg / 1mL), 0.3 mg (0.3 ml) IM. May repeat 1 time in 3-5 minutes if patient is still hypotensive. b. Pediatric i. For children less than 10 kg (approx. 20 lbs.), contact medical control prior to epinephrine if possible. ii. For children weighing less than 30 kg (approx. 60 lbs.); administer Epinephrine (concentration of 1mg/1mL) 0.15 mg (0.15mL) IM OR administer pediatric epinephrine auto-injector, if available. iii. Child weighing 30 kg or greater; administer Epinephrine (concentration of 1mg/1mL) 0.3 mg (0.3 ml) IM OR via epinephrine auto-injector if available. iv. May repeat 1 time in 3-5 minutes if patient is still hypotensive. 9. If patient is symptomatic, administer Diphenhydramine. MCA Board Approval Date: February 2, 2018 MCA Implementation Date: June 1, 2018 Page 1 of 4

Southeast Michigan Regional Protocol GENERAL TREATMENT PROTOCOLS ANAPHYLAXIS/ALLERGIC REACTION Initial Date: 5/31/2012 Revised Date: 12/18/2017 Section 1-6 a. Adult 50 mg IM or IV/IO. b. Pediatric 1 mg/kg IM/IV/IO (maximum dose 50 mg). 10. Per MCA selection, administer bronchodilator per Nebulized Bronchodilators Procedure. 11. Per MCA Selection, administer Prednisone OR methylprednisolone. Medication Options: 12. For MCA with both selected, Prednisone PO is the preferred medication. Methylprednisolone is secondary and reserved for when a PO route is inappropriate. 13. If patient remains hypotensive after treatment, refer to Shock Protocol. 14. If patient is symptomatic after treatment without hypotension. a. Additional epinephrine via auto-injector. b. Additional epinephrine (1mg / 1 ml), 0.3 mg (0.3 ml) IM. *MCA approval required for MFR auto-injector use. Prednisone 50 mg tablet PO (Children > 6 y/o) Methylprednisolone Adult 125 mg IV/IO/IM or Pediatric 2 mg/kg IV/IO/IM (max 125 mg) MCA Board Approval Date: February 2, 2018 MCA Implementation Date: June 1, 2018 Page 2 of 4

Southeast Michigan Regional Protocol GENERAL TREATMENT PROTOCOLS ANAPHYLAXIS/ALLERGIC REACTION Initial Date: 5/31/2012 Revised Date: 12/18/2017 Section 1-6 Follow General Prehospital Care Protocol Determine source of exposure, remove from source, if able Severe reaction, wheezing, or hypotension? Yes No Assist patient with own Epinephrine Autoinjector, if available MCA Approval of Epinephrine Autoinjector for MFR Agencies X Yes No Administer Epinephrine Autoinjector If child appears to weigh less than 10 kg (approx. 20 lbs.), contact medical control prior to epinephrine, if possible. If child weighs between 10 30 kg (approx. 60 lbs.); administer pediatric epinephrine auto injector. For adults and children weighing greater than 30 kg; administer epinephrine auto injector. May repeat at 3 5 minute intervals if the patient remains hypotensive, if available. Albuterol may be indicated, refer to Nebulized Bronchodilators Procedure Administer Normal Saline Fluid Bolus Adults up to 1 liter, repeated as necessary, unless otherwise noted. Pediatrics up to 20 ml/kg Titrate to Normotensive BP Administer Epinephrine (1 mg/ 1 ml) Adult 0.3 mg (0.3 ml) IM Pediatrics Less than 10 kg Contact Medical Control Between 10 30 kg, administer 0.01 mg/ kg IM or pediatric autoinjector, if available 30 kg and great, administer 0.3 mg IM or epinephrine autoinjector, if available May repeat 1 time in 3 5 minutes if patient remains hypotensive MCA Board Approval Date: February 2, 2018 MCA Implementation Date: June 1, 2018 Page 3 of 4

Southeast Michigan Regional Protocol GENERAL TREATMENT PROTOCOLS ANAPHYLAXIS/ALLERGIC REACTION Initial Date: 5/31/2012 Revised Date: 12/18/2017 Section 1-6 Patient Otherwise Symptomatic? Yes No Administer Diphenhydramine Adults 50 mg IM or IV/IO Pediatrics 1 mg/kg IM/IV/IO (max dose 50 mg Administer Albuterol, refer to Nebulized Bronchodilators Procedure Administer Prednisone or Methylprednisolone, per MCA Selection X Prednisone 50 mg tablet PO (Children >6 y/o) X Methylprednisolone Adult 125 mg IV/IO/IM Pediatric 2 mg/kg IV/IO/IM (max 125 mg) *For MCA with both selected, Prednisone PO is the preferred medication. Methylprednisolone is secondary and is reserved for when a PO route is inappropriate. If patient remains hypotensive after treatment, refer to Shock Protocol Symptomatic after treatment? Yes No Additional epinephrine auto injector Additional epinephrine MCA Board Approval Date: February 2, 2018 MCA Implementation Date: June 1, 2018 Page 4 of 4

Michigan GENERAL TREATMENT ADRENAL CRISIS Initial Date: 05/31/2012 Revised Date: 10/25/2017 Section 1-7 Adrenal Crisis Purpose: This protocol is intended for the management of patients with a known history of adrenal insufficiency, experiencing signs of crisis. Indications: 1. Patient has a known history of adrenal insufficiency or Addison s disease. 2. Presents with signs and symptoms of adrenal crisis including: a. Pallor, headache, weakness, dizziness, nausea and vomiting, hypotension, hypoglycemia, heart failure, decreased mental status, or abdominal pain. Treatment: 1. Follow General Pre-hospital Care Protocol. Post-Medical Control 2. Administer fluid bolus NS. 3. Assist with administration of patient s own hydrocortisone sodium succinate (Solu- Cortef) a. Adult: 100 mg IV b. Pediatric: 1-2 mg/kg IV OR 4. Per MCA Selection, administer Prednisone OR Methylprednisolone Medication Options: Prednisone - 50 mg tablet PO (ages 6 and up) Methylprednisolone - Adults 125 mg IV or Pediatrics 2 mg/kg IV 5. For MCA with both selected, Prednisone PO is the preferred medication. Methylprednisolone is secondary and reserved for when a patient can t take a PO medication. 6. Transport 7. Notify Medical Control of patient s medical history. 8. Refer to Altered Mental Status Protocol. MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 1 of 1

Michigan ADULT TREATMENT BEHAVIORAL HEALTH EMERGENCIES Initial Date: 11/15/2012 Revised Date: 10/25/2017 Section 1-8 Behavioral Health Emergencies 1. Assure scene is secure. 2. Follow General Pre-hospital Care Protocol. 3. Respect the dignity of the patient. 4. Treat known conditions such as hypoglycemia, hypoxia, or poisoning. Refer to appropriate protocol. 5. Patients experiencing behavioral health emergencies should be transported for treatment if they have any of the following: A. Can be reasonably expected to intentionally or unintentionally physically injure themselves or others or has engaged in acts or made threats to support the expectation. B. Are unable to attend to basic physical needs. C. Have judgement that is so impaired that he or she is unable to understand the need for treatment and whose behavior will cause significant physical harm. D. Have weakened mental processes because of age, epilepsy, alcohol or drug dependence which impairs their ability to make treatment decisions. 6. Communicate in a calm and nonthreatening manner. Be conscious of personal body language and tone of voice. 7. Keep contacts to a minimum; when prudent, utilize a single rescuer for assessment. 8. Offer your assistance to the patient. 9. Constantly monitor and observe patient to prevent injury or harm. 10. Control environmental factors; attempt to move patient to a private area. Maintain escape route. 11. Attempt de-escalation, utilize an empathetic approach. Avoid confrontation. 12. If patient becomes violent or actions present a threat to patient's safety or that of others, restraint may be necessary. Refer to Patient Restraint Procedure. 13. If the patient is severely agitated, combative/aggressive, and shows signs of sweating, delirium, elevated temperature, and lack of fatiguing, refer to Excited Delirium Protocol. Protective Custody - The temporary custody of an individual by a law enforcement officer with or without the individual's consent for the purpose of protecting that individual's health and safety, or the health and safety of the public and for the purpose of transporting the individual if the individual appears, in the judgment of the law enforcement officer, to be a person requiring treatment. Protective custody is civil in nature and is not to be construed as an arrest. (330.1100c (7), Sec. 100c, Michigan Mental Health Code) MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 1 of 1

Michigan GENERAL TREATMENT PROTOCOLS RETURN OF SPONTANEOUS CIRCULATION (ROSC) Initial Date: 5/31/2012 Revised Date: 10/25/2017 Section 1-9 Return of Spontaneous Circulation (ROSC) This protocol should be followed for all cardiac arrests with ROSC. If an arrest is of a known traumatic origin, refer to the Traumatic Arrest Protocol and MCA Transport Protocol. If it is unknown whether the arrest is traumatic or medical, consider other treatable causes. Initiate ALS response if available. 1. If ventilation assistance is required, ventilate at 10-12 breaths per minute. Do not hyperventilate. 2. Reassess patient, if patient becomes pulseless a. Begin CPR b. Follow Adult or Pediatric Cardiac Arrest General Protocol. 3. Monitor vital signs. 4. Check blood glucose (MFR, if MCA approved). 5. Start an IV/IO NS KVO. 6. Treat hypotension (SBP less than 90 mm/hg) with an IV/IO fluid bolus consistent with Shock Protocol. 7. Perform 12- lead ECG (Per MCA selection, may be BLS skill per 12 Lead ECG Procedure) 8. If ventilation assistance is required, target ETCO2 of 35-40 mm Hg. 9. Consider Transport to a facility capable of Percutaneous Coronary Intervention (PCI) per MCA protocol. 10. If hypotension persists after IV/IO fluid bolus, administer Epinephrine by push dose (dilute boluses). a. Prepare (10 mcg/ml) by adding 1mL of 1mg/10mL Epinephrine in 9mL NS, then b. Adults i. Administer 10-20 mcg (1-2 ml Epinephrine 10 mcg/ml) ii. Repeat every 3 to 5 minutes iii. Titrate to SBP greater than 90 mm/hg c. Pediatrics i. Administer 1 mcg/kg (0.1 ml/kg Epinephrine 10 mcg/ml) ii. Maximum dose 10 mcg (1 ml) iii. Repeat every 3-5 minutes 11. If patient is agitated with advanced airway in place, refer to Patient Sedation Protocol. Notes: 1. If a mechanical ventilator is available or there are spontaneous respirations in the non-intubated patient, titrate inspired oxygen on the basis of monitored oxyhemoglobin saturation to maintain a saturation of 94% but <100%. Titrate ETCO2 between 34-45 mmhg. 2. Consider extubation only if wide awake, following commands, and unable to tolerate endotracheal tube. MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 1 of 2

Michigan GENERAL TREATMENT PROTOCOLS RETURN OF SPONTANEOUS CIRCULATION (ROSC) Initial Date: 5/31/2012 Revised Date: 10/25/2017 Section 1-9 This Protocol Should be Followed for all Cardiac Arrests with ROSC Assist Ventilations, as needed If patient becomes pulseless, begin CPR and refer to Cardiac Arrest General Protocol (Adult or Pediatric) Monitor Vital Signs Establish Vascular Access Treat Hypotension with fluid bolus consistent with Shock Protocol 12 Lead ECG Target ETCO2 of 35-45 mmhg Consider transport to PCI facility, per local protocol If Hypotension Persists, Administer Epinephrine Push Dose Prepare by adding 1 ml of 1 mg/10ml Epinephrine in 9 ml NS Adults administer 1-2 ml every 3 to 5 minutes (titrate to BP) Pediatrics administer 0.1 ml/kg, max dose 1 ml, repeat every 3 to 5 minutes If patient is agitated with airway in place, refe Patient Sedation Protocol MCA Board Approval Date: 02/02/2018 MCA Implementation Date: 06/01/2018 Page 2 of 2

Date: March, 2016 Detroit East Medical Control Authority Special Study Protocol Adult Treatment Protocols Section 1.10 Page 1 of 2 Basic EMT-Epinephrine Study Anaphylaxis/Allergic Reaction Pre-Medical Control MFR/EMT/SPECIALIST/PARAMEDIC 1. Follow General Pre-Hospital Care Protocol. 2. Determine substance or source of exposure, remove patient from source if known and able. 3. Assist patient administration of their epinephrine auto-injector, if available. EMT/SPECIALIST 4. In cases of severe allergic reaction, wheezing or hypotension, administer Epinephrine 1 mg/ml 0.3 mg (0.3 ml) IM OR via adult epinephrine auto-injector. 5. Albuterol may be indicated. Refer to Nebulized Bronchodilators Procedure. SPECIALIST 6. Administer a NS IV/IO fluid bolus up to 1 liter, wide open as indicated. PARAMEDIC 4. In cases of severe allergic reaction, wheezing or hypotension: a. Administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM OR via autoinjector 5. In cases of profound anaphylactic shock (near cardiac arrest): a. Administer Epinephrine 0.1 mg/ml, 0.3 mg (3 ml) slow IV/IO. 6. Administer a NS IV/IO fluid bolus up to 1 liter, wide open as indicated. 7. If patient is symptomatic, administer diphenhydramine 50 mg IM or IV/IO. 8. Per MCA selection, administer Bronchodilator per Nebulized Bronchodilators Procedure. 9. Per MCA selection, administer Prednisone OR Methylprednisolone. MCA: Detroit East Medical Control Authority MCA Approval Date: November 15, 2016 MDCH Approval Date: January, 2017 Implementation Date: June 1, 2017

Date: March, 2016 Detroit East Medical Control Authority Special Study Protocol Adult Treatment Protocols Section 1.10 Page 2 of 2 Post-Medical Control: EMT/SPECIALIST/PARAMEDIC 1. Additional Epinephrine IM: a. Administer additional Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM OR via adult Epinephrine auto-injector. PARAMEDIC 1. Additional Epinephrine IV/IO: a. Epinephrine 0.1 mg/ml 0.3 mg (3 ml) slow IV/IO if critically ill (near cardiac arrest). MCA: Detroit East Medical Control Authority MCA Approval Date: November 15, 2016 MDCH Approval Date: January, 2017 Implementation Date: June 1, 2017

Detroit East Medical Control Authority Special Study Protocol Adult Treatment Protocols RESPIRATORY DISTRESS Date: March, 2016 Section 1.11 Page 1 of 2 Basic EMT-Epinephrine Study Respiratory Distress Pre-Medical Control MFR/EMT/SPECIALIST/PARAMEDIC 1. Follow General Pre-hospital Care Protocol. 2. Allow patient a position of comfort. 3. Determine the type of respiratory problem involved: STRIDOR/UPPER AIRWAY OBSTRUCTION: MFR/EMT/SPECIALIST/PARAMEDIC 1. Complete Obstruction: a. Follow Emergency Airway Procedure. 2. Partial Obstruction: epiglottitis, foreign body, anaphylaxis: A. Follow Emergency Airway Procedure. B. Consider anaphylaxis (see Anaphylaxis/Allergic Reaction Protocol). C. Transport in position of comfort. CLEAR BREATH SOUNDS: PARAMEDIC 1. Possible hyperventilation, metabolic problems, MI, pulmonary embolus a. Obtain 12-lead ECG, if available. CRACKLES (CHF/PULMONARY EDEMA): MFR/EMT/SPECIALIST/PARAMEDIC 1. Refer to the Pulmonary Edema/CHF protocol in the adult cardiac protocols. RHONCHI (SUSPECTED PNEUMONIA): MFR/EMT/SPECIALIST/PARAMEDIC 1. Sit patient upright. EMT/SPECIALIST 2. Consider CPAP per MCA selection. Refer to CPAP/BiPAP Procedure. SPECIALIST 3. Consider NS IV/IO fluid bolus up to 1 liter, wide open if tachycardia, repeat as needed. PARAMEDIC 3. Consider CPAP/BiPAP (if available) per CPAP/BiPAP Procedure. 4. Consider NS IV/IO fluid bolus up to 1 liter, wide open if tachycardia, repeat as needed. MCA Board Name: Detroit East Medical Control Authority MCA Board Approval Date: November 2016 MDCH Approval Date: January

Detroit East Medical Control Authority Special Study Protocol Adult Treatment Protocols RESPIRATORY DISTRESS Date: March, 2016 Page 2 of 2 ASYMETRICAL BREATH SOUNDS: PARAMEDIC 1. If evidence of tension pneumothorax and patient unstable, consider decompression (refer to Pleural Decompression Procedure) WHEEZING, DIMINISHED BREATH SOUNDS (ASTHMA, COPD): MFR/EMT/SPECIALIST 1. Assist the patient in using their own Albuterol Inhaler, if available. EMT/SPECIALIST 2. Administer Albuterol if available. Refer to Nebulized Bronchodilators Procedure. 3. Consider CPAP per MCA selection. Refer to CPAP/BiPAP Procedure. 4. Administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM to patients with impending respiratory failure unable to tolerate nebulizer therapy. PARAMEDIC 5. Administer Bronchodilator per Nebulized Bronchodilators Procedure. 6. Administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM in patients with impending respiratory failure unable to tolerate nebulizer therapy. 7. Per MCA Selection, if a second nebulized treatment is needed, administer Prednisone OR Methylprednisolone. 8. Consider CPAP/BiPAP (if available) per CPAP/BiPAP Procedure. Post -Medical Control ASTHMA: EMT/SPECIALIST/PARAMEDIC 1. Consider Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM in patients with impending respiratory failure unable to tolerate nebulizer therapy. PARAMEDIC 2. Consider Magnesium Sulfate 2 gm slowly IV in refractory Status Asthmaticus. Administration of Magnesium Sulfate is best accomplished by adding Magnesium Sulfate 2 gm to 100 to 250 ml of NS and infusing over approximately 10 minutes. MCA Board Name: Detroit East Medical Control Authority MCA Board Approval Date: November 2016 MDCH Approval Date: January

Detroit East Medical Control Authority Study Protocol Pediatric Treatment Protocols PEDIATRIC ANAPHYLAXIS/ALLERGIC REACTION Date: March, 2016 Section 1.12 Page 1 of 2 Basic EMT-Epinephrine Study Pediatric Anaphylaxis/Allergic Reaction Pre-Medical Control MFR/EMT/SPECIALIST/PARAMEDIC 1. Follow Pediatric Assessment and Treatment Protocol. 2. Determine substance or source of exposure, remove patient from source if known and able. 3. Assist the patient in administration of their own epinephrine auto-injector, if available. EMT/SPECIALIST 4. In cases of severe allergic reaction, wheezing or hypotension: A. If child appears to weigh less than 10 kg (approx. 20 lbs.), contact medical control prior to Epinephrine if possible. B. If child weighs between 10-30 kg (approx. 60 lbs.); administer Epinephrine 1 mg/ml, 0.15 mg (0.15 ml) IM OR via pediatric epinephrine auto-injector. C. Child weighing greater than 30 kg; administer Epinephrine 1 mg/ml 0.3 mg (0.3 ml) IM OR via adult epinephrine auto-injector. D. Each BLS unit will carry a device to measure pediatric body length in order to determine weighted dose. 5. Albuterol may be indicated. Refer to Nebulized Bronchodilators Procedure. PARAMEDIC 4. In cases of severe allergic reaction, wheezing or hypotension: a. If child appears to weigh less than 10 kg (approx. 20 lbs.), contact medical control prior to epinephrine if possible. b. Child weighing less than 30 kg (approx. 60 lbs.); administer Epinephrine 1 mg/ml, 0.15 mg (0.15 ml) IM OR via pediatric epinephrine auto-injector. c. Child weighing greater than 30 kg; administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM OR via adult epinephrine auto-injector. 5. In cases of profound anaphylactic shock (near cardiac arrest): a. Administer Epinephrine 0.1 mg/ml, 0.01 mg/kg (0.1 ml/kg) slow IV/IO to a maximum of 0.3 mg (3 ml). 6. If patient is symptomatic, administer diphenhydramine 1 mg/kg IM/IV/IO (maximum dose 50 mg). 7. Per MCA selection, administer Bronchodilator per Nebulized Bronchodilators Procedure. MCA: Detroit East Medical Control Authority MCA Board Approval Date: November 2016 MDCH Approval Date: January 2017 MCA Implementation Date: June 1, 2017

Detroit East Medical Control Authority Special Study Protocol Pediatric Treatment Protocols PEDIATRIC ANAPHYLAXIS/ALLERGIC REACTION Date: March, 2016 Page 2 of 2 8. Per MCA Selection administer Prednisone OR Methylprednisolone. Post-Medical Control: EMT/SPECIALIST/PARAMEDIC 1. Additional Epinephrine IM: a. If child weighs between 10-30 kg (approx. 60 lbs.); administer Epinephrine 1 mg/ml, 0.15 mg (0.15 ml) IM OR via pediatric epinephrine auto-injector. b. Child weighing greater than 30 kg; administer Epinephrine 1 mg/ml 0.3 mg (0.3 ml) IM OR via adult epinephrine auto-injector. PARAMEDIC 1. Additional Epinephrine IV/IO: a. Administer Epinephrine 0.1 mg/ml, 0.01 mg/kg (0.1 ml/kg) to a maximum of 0.3 mg (3 ml) slow IV/IO, in cases of profound anaphylactic shock (near cardiac arrest). MCA: Detroit East Medical Control Authority MCA Board Approval Date: November 2016 MDCH Approval Date: January 2017 MCA Implementation Date: June 1, 2017

Date: March, 2016 Detroit East Medical Control Authority Special Study Protocol Pediatric Treatment Protocols PEDIATRIC BRONCHOSPASM Section 1.13 Page 1 of 2 Basic EMT-Epinephrine Study Pediatric Bronchospasm Pre-Medical Control: MFR/EMT/SPECIALIST/PARAMEDIC 1. Follow Pediatric Assessment and Treatment Protocol. MFR/EMT/SPECIALIST 2. Assist the patient in using their own Albuterol Inhaler, if available EMT/SPECIALIST 3. Albuterol may be indicated. Refer to Nebulized Bronchodilators Procedure. 4. Consider CPAP, if available, per CPAP/BiPAP Procedure. 5. In cases of severe respiratory distress/failure: A. If child appears to weigh less than 10 kg (approx. 20 lbs.), contact medical control prior to Epinephrine if possible. B. If child weighs between 10-30 kg (approx. 60 lbs.); administer Epinephrine 1 mg/ml, 0.15 mg (0.15 ml) IM. C. Child weighing greater than 30 kg; administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM. D. Each BLS unit will carry a device to measure pediatric body length in order to determine weighted does. PARAMEDIC 3. Per MCA selection, administer Bronchodilator per Nebulized Bronchodilators Procedure. 4. Per MCA selection, if a second nebulized treatment is needed also administer Prednisone OR Methylprednisolone. 5. If patient is in severe respiratory distress/failure: A. If child appears to weigh less than 10 kg (approx. 20 lbs.), contact medical control prior to epinephrine if possible. B. If child weighs between 10-30 kg (approx. 60 lbs.); administer Epinephrine 1 mg/ml, 0.15 mg (0.15 ml) IM OR via pediatric Epinephrine auto-injector. C. Child weighing greater than 30 kg; administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM OR via Epinephrine auto-injector. MCA Board Name: Detroit East Medical Control Authority MCA Board Approval Date: November 2016 MDCH Approval Date: January 2017 MCA Implementation Date: June 1, 2017

Date: March, 2016 Detroit East Medical Control Authority Special Study Protocol Pediatric Treatment Protocols PEDIATRIC BRONCHOSPASM Section 1.13 Page 1 of 2 6. Consider CPAP/BiPAP (if available) per CPAP/BiPAP Procedure. Post-Medical Control: EMT/SPECIALIST/PARAMEDIC 1. Additional Epinephrine IM: A. If child weighs between 10-30 kg (approx. 60 lbs.); administer Epinephrine 1 mg/ml, 0.15 mg (0.15 ml) IM. B. Child weighing greater than 30 kg; administer Epinephrine 1 mg/ml, 0.3 mg (0.3 ml) IM. MCA Board Name: Detroit East Medical Control Authority MCA Board Approval Date: November 2016 MDCH Approval Date: January 2017 MCA Implementation Date: June 1, 2017