European Journal of Cardio-Thoracic Surgery

European Journal of Cardio-Thoracic Surgery ejcts.oxfordjournals.org 2013 Media Kit Advertising & Sales Contacts Naomi Reeves Advertising Sales Manager t: +44 (0)1865 355396 e: naomi.reeves@oup.com Caroline Bracken Supplements Development Manager t:+44 (0)1865 353794 e: caroline.bracken@oup.com For reprints, eprints or tailored products: e: corporate.services@oup.com The European Journal of Cardio-Thoracic Surgery is the ideal place to reach cardio-thoracic surgeons in Europe and beyond. It is an international journal that accepts submissions from all regions. The journal is supported by a number of leading European societies. A subscription to the journal is a member benefit to the European Society of Thoracic Surgeons and the European Association for Cardio-Thoracic Surgery. Useful Information Print Circulation: 4,800 Geographic Breakdown: UK 4% - Europe 33% - North America 19% - Japan 25% - Rest of World 19% Average Monthly Page Views: 136,066 Average Monthly Unique IPs: 50,000 Average Available Ad Impressions: 270,278* *Combined monthly leaderboard and skyscraper positions Impact Factor: 2.55 Target Audience: Cardio-Thoracic Surgeons Frequency: 12 Peer Reviewed: Yes Editor-In-Chief: Friedhelm Beyersdorf Society Affiliation: European Association for Cardio-Thoracic Surgery European Society of Thoracic Surgeons

2013 Schedule Volume Issue Cover Month Ad artwork due Mailout Date Bonus Conference Distribution 43/1 January 22 November 2012 20 December 2012 43/2 February 19 December 2012 25 January 2013 43/3 March 22 January 2013 25 February 2013 43/4 April 25 February 2013 25 March 2013 AATS 2013 4-8 May Minneapolis 43/5 May 22 March 2013 25 April 2013 43/6 June 25 April 2013 28 May 2013 44/1 July 24 May 2013 24 June 2013 44/2 August 21 June 2013 24 July 2013 44/3 September 24 July 2013 27 August 2013 EACTS 2013 5-9 October Vienna 44/14 October 27 August 2013 25 September 2013 44/5 November 23 September 2013 24 October 2013 44/6 December 24 October 2013 25 November 2013 STS 2014 27-29 January Orlando Print Advertising Options & Rates Colour 1 insertion 3 6 12 Special Position Premiums Full Page 2432 2372 2311 2189 3156 3098 3013 2840 $ 4086 3984 3882 3678 ½ Page 1463 1426 1390 1317 1737 1705 1657 1563 $ 2458 2396 2335 2212 ¼ Page 890 868 846 801 1155 1134 1103 1039 $ 1496 1458 1421 1346 Outside Back Cover 50% extra Inside Front Cover 25% extra Inside Back Cover 25% extra Facing Leading Article 10% extra Facing Contents 20% extra

European Journal of Cardio-Thoracic Surgery 42 (2012) 420 429 doi:10.1093/ejcts/ezs081 Advance Access publication 5 April 2012 Susan C. van t Westeinde a,b, *, Nanda Horeweg b, Paul De Leyn c, Harry J.M. Groen d, Jan-Willem J. Lammers e, Carla Weenink f, Kristiaan Nackaerts c and Rob J. van Klaveren a a Department of Pulmonology, Erasmus MC Rotterdam, Rotterdam, Netherlands b Department of Public Health, Erasmus MC Rotterdam, Rotterdam, Netherlands c Department of Thoracic Surgery, UZ Gasthuisberg, Leuven, Belgium d Department of Pulmonology, UMC Groningen, Groningen, Netherlands e Department of Pulmonology, UMC Utrecht, Utrecht, Netherlands f Department of Pulmonology, Kennemer Gasthuis Haarlem, Haarlem, Netherlands * Corresponding author. Department of Pulmonology, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, Netherlands. Tel: +31-10-4634870; fax: +31-10-4634871; e-mail: s.vantwesteinde@erasmusmc.nl (S.C. van t Westeinde). Received 15 October 2011; received in revised form 8 January 2012; accepted 10 January 2012 Abstract OBJECTIVES: To assess the complication rate in participants of the screen arm of the NELSON lung cancer screening trial who underwent surgical resection and to investigate, based on a literature review, whether the complication rate, length of hospital stay, rethoracotomy and mortality rates after a surgical procedure were different from those of the non-screening series, taking co-morbidity into account. METHODS: Between April 2004 and December 2008, 198 subjects underwent thoracic surgery. Co-morbid conditions were retrieved from the medical records. Postoperative complications were classified as minor and major. RESULTS: In total, 182 thoracotomies, 5 thoracotomies after video-assisted thoracoscopic surgery (VATS) and 11 VATS procedures were performed. In these patients, 36% had chronic obstructive lung disease, 16% coronary artery disease, 14% diabetes mellitus and 11% peripheral vascular disease. Following thoracotomy, 47% (88/187) had 1 minor (7 57% in literature) and 10% (18/187) 1 major complication (2 26% in literature); following VATS, 38% (6/16) had 1 minor complication, but no major complications. Seventeen per cent (3/18) of major complications and 21% (20/96) of minor complications were seen in subjects operated for benign disease. The rethoracotomy rate was 3% and there was no 30-day mortality after thoracotomy or VATS (0 8.3% in literature). The mortality rate of 0% after surgical procedures is low when compared with the non-screening series (0 8.3%); the rate of complications (53%) is within range when compared with the non-screening series (8.5 58%). CONCLUSIONS: In conclusion, mortality rates after surgical procedures are lower in the NELSON lung cancer screening trial than those in the non-screening series. The rate of complications is within the same range as in the non-screening series. Trial registration number: ISR CTN 63545820. Keywords: Postoperative complications Thoracotomy Thoracic surgery Video-assisted Early detection of cancer Lung neoplasms INTRODUCTION It has been shown that lung cancer screening by low-dose multidetector computer tomography (CT) can detect lung cancer in a high proportion at an early stage [1]. Before considering implementation of CT screening, a reduction in lung cancer mortality has to be demonstrated by randomized clinical trials and the balance between the benefits and harms of screening has to be evaluated thoroughly. Important aspects to be taken into account are the effect of CT screening on health-related quality of life, and the occurrence of complications associated with the work-up and treatment of participants with a positive test result. Patient-related factors, such as a poor general health status, age and co-morbidity, contribute to the risk of postoperative pulmonary complications [2]. Screening populations usually consist of heavy current and former smokers at an advanced age and at high risk for co-morbid disease. In several studies, it has been shown that co-morbidity can predict morbidity and mortality of surgical procedures [3]. To be able to make a fair comparison with the mortality and complication data reported in non-lung cancer screening series, the co-morbidity of the screen population has to be assessed. Our objective was to assess the complication rate in participants in the screen arm of the Dutch-Belgian lung cancer screening trial (NELSON) who underwent a surgical resection and to investigate, based on a literature review, whether the complication rate, length of stay and The Author 2012. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. ORIGINAL ARTICLE Black & White 1 insertion 3 6 12 Full Page 1319 1286 1253 1188 1737 1705 1657 1563 $ 2217 2161 2106 1995 ½ Page 824 803 783 741 948 929 904 852 $ 1384 1349 1315 1246 ¼ Page 570 556 542 513 717 703 684 645 $ 958 934 910 862 Incentives Publisher s Discount 10% Agency Commission 10% Double Page Spread = 2 x Full page rate More options and solutions in partnership with European Journal of Cardio-Thoracic Surgery Loose and Bound Inserts available Complications following lung surgery in the Dutch Belgian randomized lung cancer screening trial Belly Band Sponsored supplements published and distributed with the journal Article reprints and eprints useful as conference handouts

Online Advertising Options & Rates Advertise on ejcts.oxfordjournals.org Your ad here Online rates Leaderboard Skyscraper Your ad here Type Size (pixels) CPM* Geo-targeted CPM* Leaderboard 728 x 90 42/ 63/$84 50/ 75/$100 Skyscraper 160 x 600 50/ 75/$100 60/ 90/$120 *Minimum order 10,000 impressions Advertise on table of contents alerts Reach a highly engaged opted in audience etoc Rates & Sizes 325/ 488/$650 per 1000 registrants (min. charge 325/ 488/$650) Banner: 468 x 60 pixels Skyscraper: 160x600 pixels TARGET YOUR AD By country, region, and or therapy area MAXIMUM IMPACT Integrate digital advertising with an ad in the print copy of the journal TRACK RESPONSE In-depth online reports available

Print Specifications Size (depth x width) Bleed Trim Type area Full Page 285mm x 222mm 279mm x 216mm 255mm x 178mm Half Page Landscape 120mm x 178mm Half Page Vertical 255mm x 85mm Quarter Page 120mm x 85mm Double Page Spread - Please supply as two separate full page files PDF specifications: PDF files should be created using Adobe Acrobat Distiller 4.0 or higher. Files should be composite PDFs, not separated. All fonts and images should be embedded and subset below 100%. All mono and colour ads should have an effective resolution of 300 dpi (minimum). Colour ads should be supplied as CMYK only (eg no RGB, Lab colour, ICC colour based or Pantone Colour). Monochrome bitmap images (line-art) should have an effective resolution of 1200 dpi. Half-tone dot range should be in the range of 3% to 95%. Ads set to the type area should be surrounded by a box, and have no registration marks or catchlines. Bleed ads should have crop marks set to the trim size dimensions, and will be trimmed accordingly. Please allow 3mm bleed on all four sides. Any vector-based objects with transparency effect must be rasterized to 600 dpi in the source file itself, before creating the PDF. For more information on technical specifications, please contact us. All advertisements are subject to the approval of the Publisher and/or Editor who reserves the right to reject or cancel any advertisement at any time.