FRAMINGHAM HEART STUDY CODING MANUAL Metabolomics (Hilic - installment 1) COHORT: Offspring TIME INTERVAL: Exam 5 DATASET NAME: l_mtbli1_ex05_1_0610s # OBSERVATIONS: 1075 High throughput metabolite profiling was performed on plasma specimens collected from individuals in the Framingham Offspring cohort attending Examination 5. This dataset includes measurements made on blood specimens (pre-ogtt) that were collected from a subset of the Offspring Cohort participants who attended Examination 5 (and were selected for inclusion in nested case-control studies of incident diabetes and cardiovascular disease). The concentration of plasma metabolites was assessed using a liquid chromatography / mass spectrometry (LC/MS) platform and HILIC method. In the dataset, each value represents the plasma concentration of an analyte (in this case, metabolite) that was assayed. These assays were run in installments. In order to get the complete dataset, this set needs to be combined with l_mtbli2_ex05_1_0660. The value ranges, number of observations and cohorts stated in this manual are based on the original dataset. In some cases, observations may be deleted due to participant consent form restrictions or cohort participation. If observations have been deleted from this dataset, the value ranges, number of observations or cohorts may differ from those stated in this manual. Page 1 of 8
IDTYPE Framingham Heart Study cohort identifier 1 = Offspring Cohort ID Framingham Heart Study participant ID number NOTE for ID: ID deleted - use SHAREID SHAREID Framingham Heart Study participant SHARe ID DM_PAIR Pair ID# assigned for diabetes case-control study, where cases were matched to controls based on propensity score (to within <0.10 score) 1-189. = Not paired DM_CASE Diabetes case status (cases developed CVD within 12 years of follow up) 0 = control 1 = case. = neither case, nor matched control CVD_PAIR Pair ID# assigned for CVD case-control study, where cases were matched to controls based on Framingham Risk Score (to within 1 point) 1-181. = Not paired CVD_CASE CVD case status (cases developed CVD within 12 years of follow up) 0 = control 1 = case. = neither case, nor matched control Page 2 of 8
RANDOM Randomly selected as additional control for the incident diabetes study 0 = No 1 = Yes CKD_CASE Chronic kidney disease case status (cases developed CKD within 8 years of follow up, as part of case-cohort study) 0 = No 1 = Yes CREATINE Creatine 0.2643-5.1098 CREATININE Creatinine 0.3492-3.5417 XANTHOSINE Xanthosine 0.3511-20.0740 KYNURENIC_ACID Kynurenic Acid 0.1837-10.0949 OH_ANTHRANILIC_ACID 3-OH-anthranilic Acid 0.0125-2.4049 ANTHRANILIC_ACID Anthranilic Acid 0.4915-34.8945 ALLANTOIN Allantoin 0.4940-15.7800 Page 3 of 8
AMINOISOBUTYRIC_ACID Aminoisobutyric Acid 0.3021-7.4017 BETAINE Betaine 0.3701-1.7353 CHOLINE Choline 0.5556-3.1181 DIMETHYLGLYCINE Dimethylglycine 0.4334-6.6763 TRIMETHYLAMINE_N_OXIDE Trimethylamine-n-oxide 0.1857-21.1001 CITRULLINE Citrulline 0.4700-3.2271 ORNITHINE Ornithine 0.6544-5.2213 CARNITINE Carnitine 0.5693-1.6607 CIS_TRANS_HYDROZYPROLINE cis/trans-hydroxyproline 0.3945-5.3578 GABA GABA 0.1154-17.9095 Page 4 of 8
NMMA NMMA 0.2528-2.8009 ALPHA_GLYCEROPHOSPHOCHOL Alpha-glycerophosphocholine 1.8057-203.3781 GLYCEROL Glycerol 0.2756-6.5875 N_CARBAMOYL_B_ALANINE n-carbamoyl_b_alanine 0.5282-12.0540 NIACINAMIDE Niacinamide 0.3930-15.9207 TAURINE Taurine 0.4934-2.6523 THIAMINE Thiamine 0.0276-17.1911 THYROXINE Thyroxine 0.2455-3.2208 TRIIODOTHYRONINE Triiodothyronine 0.3286-4.2992 Page 5 of 8
SEROTONIN Serotonin 0.0405-8.3236 HIAA 5-HIAA 0.0479-5.9793 ADENOSYLHOMOCYSTEINE 5'-adenosylhomocysteine 0.4678-24.1832 ADMA ADMA 0.3710-2.9506 SDMA SDMA 0.4717-2.7449 ARGININOSUCCINATE Argininosuccinate 0.3917-8.8206 CARNOSINE Carnosine 0.3671-4419.0000 COTININE Cotinine 0.0964-349.2983 Page 6 of 8
ADENOSINE Adenosine 0.0723-37.9049 ALANINE Alanine 0.6151-2.3465 ASPARTATE Aspartate 0.6671-15.6283 GLUTAMIC_ACID Glutamic Acid 1.1055-31.1417 PHENYLALANINE Phenylalanine 0.4818-2.3084 GLYCINE Glycine 0.1803-2.4822 HISTIDINE Histidine 0.5276-2.2451 ISOLEUCINE Isoleucine 0.5716-2.6314 LYSINE Lysine 0.6057-4.5691 LEUCINE Leucine 0.6356-2.2947 Page 7 of 8
METHIONINE Methionine 0.5194-2.4136 ASPARAGINE Asparagine 0.0404-1.4830 PROLINE Proline 0.5133-2.1273 GLUTAMINE Glutamine 0.0057-1.7888 ARGININE Arginine 0.3831-7.5528 SERINE Serine 0.5066-3.2322 THREONINE Threonine 0.2962-2.5688 VALINE Valine 0.5893-2.1716 TRYPTOPHAN Tryptophan 0.2891-2.0055 TYROSINE Tyrosine 0.6057-3.2416 Page 8 of 8