CANCER FACT SHEETS: ALL CANCERS EXCLUDING NON-MELANOMA SKIN CANCER

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CANCER FACT SHEETS: ALL CANCERS EXCLUDING NON-MELANOMA SKIN CANCER Estimated age-standardised rates (World) in the world (per 100 000) At a glance United States of America European Union (EU-28) More developed regions WHO European Region WHO Region of the Americas IARC Member State (24 countries) WHO Western Pacific Region China World Less developed regions Males Females Incidence Mortality In 2012, worldwide, there were 14.1 million new cancer cases, 8.2 million cancer deaths, and 32.6 million people living with cancer within 5 years of diagnosis; 57% (8 million) of those new cancer cases, 65% (5.3 million) of the cancer deaths, and 48% (15.6 million) of the 5-year prevalent cancer cases occurred in the less developed regions. The overall age-standardized cancer incidence rate is almost 25% higher in men than in women, with rates of 205 and 165 cases per 100 000 personyears, respectively. Cancer incidence rates among males vary by a factor of almost 5 across the various regions of the world, with annual rates ranging from 79 cases per 100 000 males in western Africa to 365 cases per 100 000 males in Australia/New Zealand (with high rates of prostate cancer constituting a significant contribution to the latter). There is less variation among females, with annual cancer incidence rates varying by a factor of about 3, ranging from 103 cases per 100 000 females in southcentral Asia to 295 cases per 100 000 females in North America. WHO Eastern Mediterranean Region WHO African Region WHO South-East Asia Region India 400 200 0 200 400 There is less regional variability in mortality than in incidence; the mortality rates in more developed regions are 15% higher in men and 8% higher in women than the corresponding rates in less developed regions. In men, the rate (per 100 000) is highest in central and eastern Europe (173 deaths per year) and lowest in western Africa (69 deaths per year). In contrast, the highest rates in women are seen in Melanesia (119 deaths per year) and eastern Africa (111 deaths per year), and the lowest rates are in Central America (72 deaths per year) and south-central Asia (65 deaths per year).

Estimated incidence, mortality and prevalence (5 years) worlwide in 2012 Estimated numbers Males Females Both sexes Cases Deaths 5-year-prev Cases Deaths 5-year-prev Cases Deaths 5-year-prev World 7 410 376 4 653 385 15 296 119 6 657 518 3 548 190 17 159 060 14 067 894 8 201 575 32 455 179 More developed regions 3 226 739 1 591 501 8 549 600 2 826 882 1 286 961 8 273 689 6 053 621 2 878 462 16 823 289 Less developed regions 4 183 637 3 061 884 6 746 519 3 830 636 2 261 229 8 885 371 8 014 273 5 323 113 15 631 890 WHO African Region 264 569 205 378 467 820 380 502 250 317 895 005 645 071 455 695 1 362 825 WHO Region of the Americas 1 453 678 676 645 3 843 203 1 428 747 618 221 4 114 742 2 882 425 1 294 866 7 957 945 WHO Eastern Mediterranean Region 262 641 191 302 461 190 292 677 176 139 732 587 555 318 367 441 1 193 777 WHO European Region 1 970 418 1 080 574 4 791 316 1 744 289 852 186 4 909 685 3 714 707 1 932 760 9 701 001 WHO South-East Asia Region 816 013 616 212 1 237 475 908 319 555 070 2 040 925 1 724 332 1 171 282 3 278 400 WHO Western Pacific Region 2 641 596 1 882 428 4 492 687 1 901 763 1 095 656 4 463 736 4 543 359 2 978 084 8 956 423 IARC Member State (24 countries) 3 689 369 1 900 220 9 192 817 3 348 716 1 569 966 9 401 981 7 038 085 3 470 186 18 594 796 United States of America 824 698 323 876 2 402 172 778 888 293 353 2 373 019 1 603 586 617 229 4 775 191 China 1 822 769 1 429 461 2 495 611 1 242 669 776 485 2 549 427 3 065 438 2 205 946 5 045 038 India 477 482 356 730 664 538 537 452 326 100 1 125 960 1 014 934 682 830 1 790 498 European Union (EU-28) 1 429 715 715 509 3 692 805 1 205 507 560 780 3 463 915 2 635 222 1 276 289 7 156 720

Estimated age-standardized rates (World) of incidence cases, males, all cancers excluding non-melanoma skin cancer, worldwide in 2012 373.9 184.1 283.3 136.2 184.1 90.4 136.2 < 56.7 No data Not applicable All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization / International Agency for Research on Cancer concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate borderlines for which there may not yet be full agreement. Data source: GLOBOCAN 2012 Graph production: IARC (http://gco.iarc.fr/today) World Health Organization International Agency for Research on Cancer 2016

Estimated age-standardized rates (World) of incidence cases, males, all cancers excluding non-melanoma skin cancer, worldwide in 2012 NORDCAN (www.ancr.nu) ECO (eco.iarc.fr) England: www.ons.gov.uk CI5.iarc.fr CI5.iarc.fr Australia : www.aih.gov.au New Zealand : wwww.health.govt.nz USA: seer.cancer.gov

Estimated age-standardized rates (World) of deaths, males, all cancers excluding non-melanoma skin cancer, worldwide in 2012 209.6 117.8 143.1 96.5 117.8 76.5 96.5 < 46.4 No data Not applicable All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization / International Agency for Research on Cancer concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate borderlines for which there may not yet be full agreement. Data source: GLOBOCAN 2012 Graph production: IARC (http://gco.iarc.fr/today) World Health Organization International Agency for Research on Cancer 2016

Estimated age-standardized rates (World) of deaths, males, all cancers excluding non-melanoma skin cancer, worldwide in 2012 WHO (www.who.int/healthinfo/en/) WHO (www.who.int/healthinfo/en/) WHO (www.who.int/healthinfo/en/)

Estimated age-standardized rates (World) of incidence cases, females, all cancers excluding non-melanoma skin cancer, worldwide in 2012 328.8 169.0 219.9 140.7 169.0 112.0 140.7 < 69.6 No data Not applicable All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization / International Agency for Research on Cancer concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate borderlines for which there may not yet be full agreement. Data source: GLOBOCAN 2012 Graph production: IARC (http://gco.iarc.fr/today) World Health Organization International Agency for Research on Cancer 2016

Estimated age-standardized rates (World) of incidence cases, females, all cancers excluding non-melanoma skin cancer, worldwide in 2012 NORDCAN (www.ancr.nu) ECO (eco.iarc.fr) England: www.ons.gov.uk CI5.iarc.fr CI5.iarc.fr Australia : www.aih.gov.au New Zealand : wwww.health.govt.nz USA: seer.cancer.gov

Estimated age-standardized rates (World) of deaths, females, all cancers excluding non-melanoma skin cancer, worldwide in 2012 146.5 88.4 96.6 78.3 88.4 69.2 78.3 < 42.3 No data Not applicable All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization / International Agency for Research on Cancer concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate borderlines for which there may not yet be full agreement. Data source: GLOBOCAN 2012 Graph production: IARC (http://gco.iarc.fr/today) World Health Organization International Agency for Research on Cancer 2016

Estimated age-standardized rates (World) of deaths, females, all cancers excluding non-melanoma skin cancer, worldwide in 2012 WHO (www.who.int/healthinfo/en/) WHO (www.who.int/healthinfo/en/) WHO (www.who.int/healthinfo/en/)