Valve Disease. Valve Surgery. Total Volume. In 2016, Cleveland Clinic surgeons performed 3039 valve surgeries.

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Valve Surgery Total Volume 1 1 Volume 35 3 5 15 1 5 1 13 1 N = 773 5 79 15 93 1 339 In 1, surgeons performed 339 valve surgeries. surgeons have implanted more than 1, bioprosthetic aortic valves since the 199s, with excellent short- and long-term outcomes. 3 Outcomes 1

Primary Operation and Reoperation Volume (N = 339) 1 Volume 5 15 1 5 Primary Operation Reoperation N = 791 In 1, surgeons performed primary valve procedures and 791 valve reoperations. Primary Operation and Reoperation In-Hospital Mortality (N = 339) 1 Expected Primary Reoperation Operation N = 791 Patients who have valve surgery reoperations have a somewhat higher risk of death compared with patients who have a primary operation, due to the overall decrease in health over time. Despite this, the in-hospital mortality rates were lower than expected for both reoperations and primary procedures. Source: Data from the Vizient Clinical Data Base/Resource Manager TM used by permission of Vizient. All rights reserved. Sydell and Arnold Miller Family Heart & Vascular Institute 33

In-Hospital Mortality by Procedure Type (N = 11) 1 1 1 Surgical Isolated AVR Transcatheter AVR AVR + CABG Isolated MVR MVR + CABG Isolated MV Repair N = 9 37 9 3 31 3 STS expected AVR = aortic valve replacement, CABG = coronary artery bypass graft, MV = mitral valve, MVR = mitral valve replacement surgeons performed a total of 339 valve surgeries in 1. However, the procedures included in this graph represent only those that are recognized by the Society of Thoracic Surgeons (STS). The mortality rates for valve surgery were lower than the STS-expected rates. Source: Society of Thoracic Surgeons (STS) National Adult Cardiac Surgery Database 1 Aortic Valve Surgery 1 1 Volume 5 15 In 1, 11 aortic valve procedures were performed at. 1 5 N = 1 193 13 1 175 17 15 193 1 11 3 Outcomes 1 3

STS Rating for Aortic Valve Replacement July 13 June 1 ranked among the top % of US hospitals for aortic valve replacement (AVR) surgery, earning the Society of Thoracic Surgeons (STS) 3-star rating for this category. This denotes the highest category of quality. Participant Score (95% Confidence Interval) STS Mean Participant Score Participant Rating 97.5% 95.3% (9.9, 9.) STS Min. 1th 9.9 5th 9.7 9th 97.3 Max 9. = STS mean participant score Source: Society of Thoracic Surgeons (STS) National Adult Cardiac Surgery Database 1 Isolated Aortic Valve Replacement Complications (N = 379) 1 1 STS expected Deep Sternal Wound Infection Postop Stroke Postop Renal Failure Postop Reoperation (Any) N = 5 1 13 had lower-than-expected rates of complications for isolated aortic valve replacement surgery. Source: Society of Thoracic Surgeons (STS) National Adult Cardiac Surgery Database 1 Sydell and Arnold Miller Family Heart & Vascular Institute 35

STS Rating for Coronary Artery Bypass Graft and Aortic Valve Replacement July 13 June 1 is ranked among top US hospitals for coronary artery bypass graft (CABG) surgery plus aortic valve replacement (AVR), earning the Society of Thoracic Surgeons (STS) 3-star rating for this category (based on data from July 13 through June 1). This denotes the highest category of quality. Participant Score (95% Confidence Interval) STS Mean Participant Score Participant Rating 95.1% 9.% (9., 9.) STS Min 7. 1th. 5th 9. 9th 95. Max 97. = STS mean participant score Source: Society of Thoracic Surgeons (STS) National Adult Cardiac Surgery Database 1 Combined AVR and CABG Surgery In-Hospital Mortality (N = 9) 1 1 N = Primary Operation Reoperation 7 STS expected Aortic valve replacement, in combination with CABG surgery, is a complex operation. Despite this complexity and the associated increase in risks, inhospital mortality rates for both primary operations and reoperations were low. Source: Society of Thoracic Surgeons (STS) National Adult Cardiac Surgery Database 1 3 Outcomes 1

Mitral Valve Surgery (N = 139) Volume, Repair vs Replacement 1 1 1 13 1 15 1 Repair Replacement performs mitral valve repair procedures rather than replacement whenever possible. Mitral valve repair is possible for more than 95% of patients who have mitral valve prolapse. The procedure is associated with better survival, improved lifestyle, better preservation of heart function, and a lower risk of stroke and infection (endocarditis) compared with mitral valve replacement. Repair procedures also do not require postprocedure anticoagulation therapy. Isolated Mitral Valve Surgery In-Hospital Mortality (N = 39) 1 STS expected The 1 in-hospital mortality rates for patients who had isolated mitral valve surgery were lower than expected for both repair and replacement procedures. Replacement Repair N = 3 3 Source: Society of Thoracic Surgeons (STS) National Adult Cardiac Surgery Database 1 Sydell and Arnold Miller Family Heart & Vascular Institute 37

Surgical Treatment of Active Infective Endocarditis Primary Operation, In-Hospital Mortality 13 1 15 1 Observed Expected The in-hospital mortality rates for patients who had primary operations for infective endocarditis were lower than expected in 1. 5 N = 13 1 15 59 59 1 77 Source: Data from the Vizient Clinical Data Base/Resource Manager TM used by permission of Vizient. All rights reserved. Reoperation, In-Hospital Mortality 13 1 15 1 Observed Expected The in-hospital mortality rates for patients who had reoperations for infective endocarditis were lower than expected in 1. 5 N = 13 1 1 15 9 9 1 75 Source: Data from the Vizient Clinical Data Base/Resource Manager TM used by permission of Vizient. All rights reserved. 3 Outcomes 1

Transcatheter Aortic Valve Replacement is a national leader in the use of percutaneous treatment options for patients with valve disease. Volume and In-Hospital Mortality 1 1 Volume 3 Mortality (%) 1 1 Observed Expected 1 1 13 N = 15 17 1 33 15 33 1 37 1 13 1 15 N = 15 17 33 33 1 37 A total of 37 patients had transcatheter aortic valve replacement procedures at in 1. The in-hospital mortality rate was % compared with an expected rate of.9%. The 3-day mortality rate was.3% (N = 1). Source: Data from the Vizient Clinical Data Base/Resource Manager TM used by permission of Vizient. All rights reserved. Since the inception of the transcatheter aortic valve replacement (TAVR) program in, has become a world leader in the use of this specialized treatment in patients carefully selected based on stringent clinical criteria. A total of 139 patients have had this procedure done from 1 to 1. Source: STS/ACC TVT Registry Sydell and Arnold Miller Family Heart & Vascular Institute 39

Volume by Approach (N = 155) 1 1 Of the 155 TAVR procedures performed from 1 through 1, 77% have been done using a transfemoral approach. 1% 77% transfemoral (N = 97) 13% transapical (N = 13) % transaortic (N = 75) % other (transaxillary, transcarotid) (N = 3) % subclavian (N = ) Outcomes 1