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brought to you by www.thebacteriophages.org and www.phage.org REFERENCES 1. Butcher, S. J., T. Dokland, P. M. Ojala, D. H. Bamford, and S. D. Fuller. 1997. Intermediates in the assembly pathway of the double-stranded RNA virus φ6. EMBO J. 16:4477-4487. 2. Butcher, S. J., J. M. Grimes, E. V. Makeyev, D. H. Bamford, and D. I. Stuart. 2001. A mechanism for initiating RNA-dependent RNA polymerization. Nature 410:235-240. 3. Butcher, S. J., E. V. Makeyev, J. M. Grimes, D. I. Stuart, and D. H. Bamford. 2000. Crystallization and priliminary X-ray crystallographic studies on the bacteriophage Φ6 RNA-dependent RNA polymerase. Acta. Cryst. 56:1473-1475. 4. Casini, G., X. Qiao, and L. Mindich. 1994. Reconstitution of active replicase in procapsids of the segmented dsrna bacteriophge Φ6. Virology 204:251-253. 5. Chao, L., T. T. Tran, and T. T. Tran. 1997. The advantage of sex in the RNA virus Φ6. Genetics 147:953-959. 6. Day, L. A., and L. Mindich. 1980. The molecular weight of bacteriophage Φ6 and its nucleocapsid. Virology 103:376-385. 7. de Haas, F., A. O. Paatero, L. Mindich, D. H. Bamford, and S. D. Fuller. 1999. A symmetry mismatch at the site of RNA packaging in the polymerase complex of dsrna bacteriophage φ6. J. Mol. Biol. 294:357-372. 8. Dijk, A. A. V., M. Frilander, and D. H. Bamford. 1995. Differentiation between minus- and plus-strand synthesis: polymerase activity of dsrna bacteriophage Φ6 in an in vitro packaging and replication system. Virology 211:320-323. 1

9. Frilander, M., and D. H. Bamford. 1995. In vitro packaging of the singlestranded RNA genomic precursors of the segmented double-stranded RNA bacteriophage Φ6: The three segments modulate each other's packaging efficiency. J. Mol. Biol. 246:418-428. 10. Frilander, M., P. Gottlieb, J. Strassman, D. H. Bamford, and L. Mindich. 1992. Dependence of minus strand synthesis upon complete genomic packaging in the dsrna bacteriophage Φ6. J. Virol. 66:5013-5017. 11. Gottlieb, P., C. Potgieter, H. Wei, and I. Toporovsky. 2002. Characterization of Φ12, a bacteriophage related to Φ6: nucleotide sequence of the large doublestranded RNA (dsrna). Virology 295:266-271. 12. Gottlieb, P., X. Qiao, J. Strassman, M. Frilander, and L. Mindich. 1994. Identification of the packaging regions within the genomic RNA segments of bacteriophage Φ6. Virology 200:42-47. 13. Gottlieb, P., J. Strassman, and L. Mindich. 1992. Protein P4 of the bacteriophage Φ6 procapsid has a nucleoside triphosphate-binding site with associated nucleoside triphosphate phosphohydrolase activity. J. Virol. 66:6220-6222. 14. Gottlieb, P., J. Strassman, X. Qiao, A. Frucht, and L. Mindich. 1990. In vitro replication, packaging and transcription of the segmented dsrna genome of bacteriophage Φ6 : studies with procapsids assembled from plasmid encoded proteins. J. Bacteriol. 172:5774-5782. 2

15. Gottlieb, P., H. Wei, C. Potgieter, and I. Toporovsky. 2002. Characterization of Φ12, a bacteriophage related to Φ6: nucleotide sequence of the small and middle double-stranded RNA. Virology 293:118-124. 16. Grimes, J. M., J. N. Burroughs, P. Gouet, J. M. Diprose, R. Malby, S. Zientara, P. P. C. Mertens, and D. I. Stuart. 1998. The atomic structure of the bluetongue virus core. Nature 395:470-478. 17. Hoogstraten, D., X. Qioa, Y. Sun, A. Hu, S. Onodera, and L. Mindich. 2000. Characterization of Φ8, a bacteriophage containing three double-stranded RNA genomic segments and distantly related to Φ6. Virology 272:218-224. 18. Johnson, M. D., III, and L. Mindich. 1994. Plasmid directed assembly of the lipid-containing membrane of bacteriophage φ6. J. Bacteriol. 176:4124-4132. 19. Juuti, J. T., and D. H. Bamford. 1997. Protein P7 of phage Φ6 RNA polymerase complex, acquiring of RNA packaging activity by in vitro assembly of the purified protein onto deficient particles. J. Mol. Biol. 266:891-900. 20. Juuti, J. T., D. H. Bamford, R. Tuma, and G. J. T. Jr. 1998. Structure and NTPase activity of the RNA-translocating protein (P4) of bacteriophage φ6. J. Mol. Biol. 279:347-359. 21. Kainov, D. E., S. J. Butcher, D. H. Bamford, and R. Tuma. 2003. Conserved intermediates on the assembly pathway of double-stranded RNA bacteriophages. J Mol Biol 328:791-804. 22. Kainov, D. E., M. Pirttimaa, R. Tuma, S. J. Butcher, G. J. Thomas, D. H. Bamford, and E. V. Makeyev. 2003. RNA packaging device of dsrna 3

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31. Mindich, L., X. Qiao, J. Qiao, S. Onodera, M. Romantschuk, and D. Hoogstraten. 1999. Isolation of additional bacteriophages with genomes of segmented double-stranded RNA. J. Bacteriol. 181:4505-4508. 32. Olkkonen, V. M., P. Gottlieb, J. Strassman, X. Qiao, D. H. Bamford, and L. Mindich. 1990. In vitro assembly of infectious nucleocapsids of bacteriophage Φ6: Formation of a recombinant double-stranded RNA virus. Proc. Natl. Acad. Sci. USA 87:9173-9177. 33. Olkkonen, V. M., P. Ojala, and D. H. Bamford. 1991. Generation of infectious nucleocapsids by in vitro assembly of the shell protein onto the polymerase complex of the dsrna bacteriophage Φ6. J. Mol. Biol. 218:569-581. 34. Onodera, S., V. M. Olkkonen, P. Gottlieb, J. Strassman, X. Qiao, D. H. Bamford, and L. Mindich. 1992. Construction of a transducing virus from dsrna bacteriophage Φ6 : establishment of carrier states in host cells. J. Virol. 66:190-196. 35. Onodera, S., X. Qiao, P. Gottlieb, J. Strassman, M. Frilander, and L. Mindich. 1993. RNA structure and heterologous recombination in the dsrna bacteriophage Φ6. J. Virol. 67:4914-4922. 36. Onodera, S., X. Qiao, J. Qiao, and L. Mindich. 1998. Directed changes in the number of dsrna genomic segments in bacteriophage Φ6. Proc. Nat. Acad. Sci. USA 95:3920-3924. 37. Onodera, S., X. Qiao, J. Qiao, and L. Mindich. 1998. Isolation of a mutant that changes genomic packaging specificity in Φ6. Virology 252:438-442. 5

38. Onodera, S., Y. Sun, and L. Mindich. 2001. Reverse genetics and recombination in Φ8, a dsrna bacteriophage. Virology 286:113-118. 39. Pirttimaa, M. J., and D. H. Bamford. 2000. RNA secondary structures of the bacteriophage phi6 packaging regions. RNA 6:880-889. 40. Poranen, M. M., A. O. Paatero, R. Tuma, and D. H. Bamford. 2001. Selfassembly of a viral molecular machine from purified protein and RNA constituents. Mol. Cell 7:845-854. 41. Qiao, X., G. Casini, J. Qiao, and L. Mindich. 1995. In vitro packaging of individual genomic segments of bacteriophage Φ6 RNA: serial dependence relationships. J. Virol. 69:2926-2931. 42. Qiao, X., J. Qiao, and L. Mindich. 2003. Analysis of the specific binding involved in genomic packaging of the dsrna bacteriophage Φ6. J. Bacteriol. 185:6409-6414. 43. Qiao, X., J. Qiao, and L. Mindich. 1997. An in vitro system for the investigation of heterologous RNA recombination. Virology 227:103-110. 44. Qiao, X., J. Qiao, and L. Mindich. 1995. Interference of bacteriophage Φ6 genomic RNA packaging by hairpin structures. J. Virol. 69:5502-5505. 45. Qiao, X., J. Qiao, and L. Mindich. 1997. Stoichiometric packaging of the three genomic segments of dsrna bacteriophage Φ6. Proc. Natl. Acad. Sci. USA 94:4074-4079. 46. Qiao, X., J. Qiao, S. Onodera, and L. Mindich. 2000. Characterization of Φ13, a bacteriophage related to Φ6 and containing three dsrna genomic segments. Virology 275:218-224. 6

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