Guidelines and Best Practices for High Velocity Nasal Insufflation (Hi-VNI Technology) Emergency Medicine Pocket Guide

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Guidelines and Best Practices for High Velocity Nasal Insufflation (Hi-VNI Technology) Emergency Medicine Pocket Guide

Patient Selection Diagnoses When considering Vapotherm Hi-VNI Technology, the patient should: Be spontaneously breathing Be alert and oriented Have a protected airway Patient presents with one or more of the following symptoms: General Dyspnea NIPPV Intolerant Hypercapnia These symptoms are indicative of but not solely attributed to: Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Mild or Moderate Congestive Heart Failure (CHF) Asthma Pneumonia Bronchitis Bronchiolitis (includes RSV) Infuenza Hypoxemia Increased Work of Breathing Disclaimer: Vapotherm Hi-VNI Technology is a tool to treat the signs and symptoms of respiratory distress. Vapotherm does not practice medicine or provide medical services. These guidelines are based on Vapotherm s assessment of peer-reviewed published literature, physician interviews, and physiological modeling. Providers should refer to the full indications for use, operating instructions, and/or prescribing information of any products referenced before exercising their independent 1 Vapotherm Emergency Medicine Pocket Guide

Vapotherm Cannula & Flow Selection Fitting the Cannula: Make sure not to occlude greater than 50% of the internal diameter of each of the nares. Cannula prongs should be wide enough not to pinch the nasal septum (erosion risk). Cannula Sizes Cannula Flow Range Tip OD Pediatric Small 1-20 L/min 1.9 mm Pediatric/Adult Small 5-40 L/min 2.7 mm Adult 5-40 L/min 4.8 mm Cannula Application: Vapotherm cannulae must be used with the Vapotherm Precision Flow Select the appropriate cannula based on the above sizing chart Place the cannula on the patient before attaching the delivery tube Allow the system to reach the set point (temperature display will stop flashing) before connecting delivery tube to the cannula The Precision Flow s operational flow range is locked depending on the disposable patient circuit (DPC) selected: High Flow DPC (Blue packaging): 5-40 L/min Low Flow DPC (Red packaging): 1-8 L/min Vapotherm Emergency Medicine Pocket Guide 2

Clinical Use Guidelines Assess these parameters to determine therapy initiation: PaO 2 < 80 mmhg SaO 2 < 90% PaCO 2 > 45 mmhg Tachycardia Tachypnea Start with high fow rates (35-40 L/min) and titrate down to effect *For pediatric flow rates, refer to the Vapotherm Pediatric Pocket Guide Hypoxia Start Titrate to Effect Flow 40 L/min Comfort/ventilatory effect O 2 100% Desired SpO 2 Temperature 37 C Comfort/secretion mobilization Hypercapnia Start Titrate to Effect Flow 40 L/min Comfort/ventilatory effect O 2 35% Desired SpO 2 Temperature 37 C Comfort/secretion mobilization 3 Vapotherm Emergency Medicine Pocket Guide

Vapotherm Transfer Unit (VTU) Transferring Patients The Vapotherm Transfer Unit fits seamlessly into the Emergency Department workflow. Patients can be transferred to procedures and out of the Emergency Department without compromising respiratory support. Workfow Integration 3-Step Hot Swap Disposable Once patient is stabilized and ready for transfer: 1. Put stationary Precision Flow unit in Standby, and remove Disposable Patient Circuit (DPC) and water bag from stationary unit. Keep the DPC in an upright confguration until it is placed in the VTU. 2. Place DPC into the VTU Precision Flow docking station. 3. Enter desired settings on the VTU Precision Flow and press the Run/Standby button to initiate therapy. Patient is now ready to be transferred. Patient transferred to temporary location (i.e. procedures): Simply plug power and gas cables/hoses into wall outlets (close e-cylinders). When patient is ready to be transferred again: Unplug the VTU Open e-cylinders Disconnect wall hoses Patient transferred to ICU/Step Down Unit/General Care Floor: Use above 3-Step Hot Swap instructions to transfer patient to new, stationary Precision Flow unit. Close the VTU e-cylinders and return the VTU to its designated storage location. WARNING: Do not attempt to transfer a patient with <= 250 PSI in either tank. VTU should remain plugged in when not in use, and whenever possible during transfer. The VTU takes two hours to fully charge, and has up to a one hour run time (depending on O 2 or air) Vapotherm Emergency Medicine Pocket Guide 4

Vapotherm Transfer Unit Runtime Chart Duration of use blending from E-size oxygen and E-size air cylinders; times shown in minutes. Above chart applicable for High Flow Disposable only. For complete runtimes, set up and operation of the VTU, please refer to the VTU Quick Reference Guide. 5 Vapotherm Emergency Medicine Pocket Guide

Accessories Use with Aerogen An adapter is available for the Precision Flow to enable nebulizer treatments. The Vapotherm inline adapter (AAA-1) is designed to be used specifically with the Aerogen Aeroneb solo. The adapter is not for continuous use and should be removed after each treatment. It is important to maintain proper upright orientation of the inline adapter during the drug administration process. Vapotherm recommends the AAA-1 be at an upright 45 angle to minimize condensation. Use with Nitric Oxide Vapotherm technology is verified for use with INOmax DS and DSIR (PF- NODPC-LOW 1-8 L/min, PF-NODPC-HIGH 5-40 L/min). Use with Precision Flow Heliox Vapotherm offers an ideal solution for convenient delivery of conditioned helium-oxygen gas mixtures (Heliox). Heliox has a significantly lower density than typical air/oxygen mixtures. The lower gas density reduces the work of breathing by reducing the force needed to move gas through the airways. Heliox is commonly used on patients with diseases of increased airway resistance, such as bronchiolitis, asthma, post-extubation stridor, intra and extrathoracic airway obstruction. Vapotherm Emergency Medicine Pocket Guide 6

Vapotherm, Inc. 100 Domain Drive Exeter, NH 03833 603.658.0011 www.vapotherm.com MKT-0046 Rev. E Last Modified 1/2018