Imaging Strategies for Endovascular Cardiovascular Procedures and Percutaneous Aortic Valves. Roy K Greenberg, MD

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Imaging Strategies for Endovascular Cardiovascular Procedures and Percutaneous Aortic Valves Roy K Greenberg, MD

Disclosure Research support Cook Inc, Boston Scientific, W.L.Gore, Cordis, Vascutek, Terarecon Consulting, Intellectual Property, Travel Expenses Cook Inc

Patient Presentation 83 female Severe aortic stenosis and coronary artery disease PCI of circumflex, and aortic valvuloplasty (2006 ) Complaining of: SOB with minimal exertion, PND, on home oxygen Denies angina and syncope Case 9

Echocardiogram Aortic valve Severe calcific AS AVA 0.7 cm 2 by continuity equation Peak gradient 95 mm Hg Mean gradient 59 mm Hg Severe calcification of the aortic cusps Mitral valve Anterior and posterior annular calcification MR 1-2+ Tricuspid valve TR 1+ RVSP 41 mm Hg LVEF 55% with moderate LVH, normal size and function Case 8

Root Measurements LVOT CT Measurements Geometry 20 mm (min) Circular 20 mm (max) Echo 18 mm Annulus 23 mm (min) 23 mm (max) Circular 31 mm AVA 0.5 cm 2 0.7 cm 2

PVT Implantation

Transition to Bypass

Coronary Artery Wire Access

Salvage With Coronary Stents

Post Procedure Imaging

Purpose of Imaging Avoiding Complications Patient selection Access vessels Femoral, external iliac, common iliac, aorta Valve access Valve sizing Valve characteristics Optimizing technique Predicting complications Preop Echo CT Scanning Intraop Echo Intraop Angiography

CT Root Measurements Tops et al. Noninvasive Evaluation of the Aortic Root with Multislice Computed Tomography. JACC Imaging 2008;1:321-330

Objective for Valve Analysis ECHO Degree of stenosis B-plane Continuity equation Functional analysis of the heart LV function RV function All valves CT Degree of stenosis Characteristics of the valve, root and annulus Diameter or area measurements Annulus STJ LVOT

Interrogating Valve Patients CT Mode = spiral, gated Minimal slice thickness = 0.75 mm Temporal Resolution: Dual Scanner 83msec 64 Row Scanner 165 msec Mode = spiral, non-gated Slice thickness = 3 mm

Access Vessels Concerns: Diameter Tortuosity Calcification Imaging Modality CT

Ilio-femoral Access Questions Where to make an incision Femoral or distal external iliac Potential need for conduit Predilation, hydrophyllic dialators Conduit construct End-to-end, end-to-side, aortic versus iliac Clamp location Understand anatomy Bailout procedures may be necessary

Valve Characteristics Stenosis Mechanism

Valve Analysis Tissue Characterization

Geometry The Root, Valve, and Ascending Aorta STJ annulus STJ annulus Tubular aorta Aortic Root LV outflow

Longitudinal Root Remodeling Control AS 1 = AN to STJ 2 = AN to COR 3 = AN to CUSP Akhtar et al. Submitted JTCVS 2008

Valve Area and Volume Systolic Measurement

Transfemoral C-arm Orientation RAO 20, caudal 57 LAO 34, cranial 21

Trans-apical Orientation

Post-procedure Analysis

Dimensions: LVOT LVOT Measurements (CT versus Echo) 45 40 p value <0.05 LVOT (mm) 35 30 25 20 15 10 5 CT Echo 0 1 2 3 4 5 6 Patient

Dimensions: Annulus Annulus Measurements (CT versus Echo) 45 40 35 p value <0.05 Annulus (mm) 30 25 20 15 10 5 CT Echo 0 1 2 3 4 5 6 7 8 9 Patient

Dimensions: Sino-tubular Junction Sino-tubular Junction Measurements (CT versus Echo) 60 50 p value >0.05 NS STJ (mm) 40 30 20 CT Echo 10 0 1 2 3 4 5 Patient

Aortic Valve Area ECHO versus CT planimetry AVA: Continuity Equation versus CT planimetry 2.5 2 p value >0.05 NS AVA (cm^2) 1.5 1 0.5 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Patient ECHO CT

Radiation Exposure Scan 4D with narrow z-coverage Additional entire aorta Standard invasive coronary angiography Standard coronary acquisition Standard thoracic aorta Standard thoracoabdominal aorta Exposure 10 msv 14 msv 2-3 msv 11 msv 10 msv 21 msv

Intraoperative Imaging What Procedures Will Be Performed In The Operating Room? Open operations Percutaneous procedures Hybrid procedures

Fundamental Considerations Available space Available budget Services Surgical Interventional Anesthesia Nursing Image quality Endovascular equipment Surgical instruments Anesthetic equipment Other Cardiopulmonary bypass TEE IVUS

Imaging Equipment Portable Units Flexibility Image Quality Procedural Duration Integration

Imaging Equipment Fixed Systems Floor Mounted Footprint Floor versus ceiling Weight restrictions Competition with other equipment OR lights Anesthesia Cardiopulmonary bypass Sterility Radiation exposure Ceiling Mounted

Imaging Equipment Advances Flat Panel Detectors Cine/Digital Subtration Variable Field of View Fusion Imaging OR Floating Point Tables

Disposable Materials and Storage Procedural Variety Vascular intervention Coronary intervention Hybrid procedures -Endografts, Valves Regional Storage Restricted Access Surgical Instruments

OR Layout Injector Lights Shields Imaging Equipment Monitor Bank A OR Bed Supplies Monitor Bank Supplies Surgeons

OR Layout Imaging Equipment Cardiopulmonary Bypass Monitor Bank TEE OR Bed Supplies A Gas Supplies Monitor Bank

Safety

Equipment Boom

Control Room Visibility Communication Storage Record Keeping Training Education

OR Data visualization

OR Data visualization

Updating OR Data Acquisition

Imaging Advances Updating OR Data visualization

Fusion Imaging

3D Data Exportation To Surgical Imaging Courtesy Dr. Indibir Gill

Using 3D Datasets to Assist with 2D Imaging

CTA Guided Angio Interventions Rotational angio used to acquire 3D vascular imaging data Remote CTA Rotational Angio CT Reference 3D dataset to 2D landmarks Calcium Spine Manually Link 3D dataset to C-arm rotation Appropriate project overlay on 2D image

Fusing Datasets

Merging 3D Projection To 2D Image

Four Dimensional Fusion

Fusion With Mathematical Modelling

Data Processing 3D Dataset Assume 600 images Segmentation/selection Exportation 2D dataset 10-12 bit depth 1024x1024 C-arm position Patient position ECG Respiration

Everything is a Process.