Pharma Services Full Service Testing Menu Anatomic Pathology Genomics MultiOmyx Flow Cytometry CDx & IVD Cytogenetics FISH Data Comprehensive testing from one responsive laboratory
Covering the continuum with standardof-care, innovative, customized, and clinical research options NeoGenomics has served the oncology and pathology communities for over 13 years. In December 2015, NeoGenomics Laboratories acquired Clarient Diagnostics. With the combined medical and technical expertise of both companies, NeoGenomics has a unique depth of service in hematologic and solid tumor cancer diagnostics. We remain vigilant of patient care and customer service as we continually strive to build a better lab, not just a bigger one. What makes NeoGenomics Pharma Services different from other laboratories? Our service promises, including: We start when you re ready We guarantee you a one-business-day response on project inquiries We will deliver your project data at the highest level Menu Overview NeoGenomics provides one of the largest clinical menus in the world. We add dozens of new tests and testing enhancements each year. If you don t see a test you need, we can develop it. Highlights are: 320+ IHC antibodies 160+ molecular tests 17 liquid biopsy tests 93 FISH probe sets + 252 individual probes 3000+ single genes NeoGenomics also runs a wide variety of clinically validated FDA-approved and FDA-cleared assays that include: Molecular FDA Oncomine Dx Target Test (Tafinlar +Mekinist / dabrafenib+trametinib, Xalkori /crizotinib, Iressa / gefitinib) cobas 4800 BRAF V600 (Zelboraf /vemurafenib) cobas EGFR Mutation Test v2 (Tagrisso /osumertinib, Tarceva /erlotinib) therascreen EGFR RGQ PCR (Gilotrif /afatinib, Iressa /gefitinib) offered as LDT therascreen KRAS RGQ PCR (Erbitux /cetuximab, Vectibix /panitumumab) THxID BRAF (Tafinlar /dabrafenib, Mekinist / trametinib) FISH FDA PathVysion HER-2 (Herceptin /trastuzumab) UroVysion Bladder Cancer Kit Vysis CLL (Venclexta /venetoclax) Vysis ALK (Xalkori /crizotinib) 2 NeoGenomics Laboratories IHC FDA ALK, D5F3 (Xalkori /crizotinib) ER PharmDx Her2/neu Pathway (4B5) PD-L1 SP263 (Imfinzi / durvalumab) HercepTest (Herceptin /trastuzumab) INFORM HER2 Dual ISH (Herceptin /trastuzumab) PD-L1 22C3 PharmDx (Keytruda /pembrolizumab) PD-L1 28-8 PharmDX (Opdivo /nivolumab) PD-L1 SP142 (Tecentriq /atezolizumab) PD-L1 SP263 (Imfinzi /durvalumab) CDx and IVD Development If you don t see a test for your project on our menu, we can help develop an IVD or CDx for your clinical trial. The CDx process works best when development of the test begins before the drug enters clinical trials. Early collaborations between pharmaceutical companies, test manufacturers, and laboratory services can result in faster access to promising new treatments.
FISH HemeFISH Acute Lymphocytic Leukemia (ALL) Adult ALL Panel Pediatric ALL Panel Acute Myeloid Leukemia (AML) AML Standard Panel AML Favorable-Risk Panel AML Non-Favorable Risk Panel BCR/ABL1/ASS1 CLL Panel Eosinophilia Panel Lymphoma High-Grade/Large B-Cell Lymphoma Panel Low-Grade/Small B-Cell Lymphoma Panel NHL Panel TCL1 Myelodysplastic Syndrome (MDS) MDS Extended Panel MDS Standard Panel Multiple Myeloma MM/MGUS Panel MM IgH Complex Reflex Panel Plasma Cell Myeloma Prognostic Profile Plasma Cell Myeloma Risk Stratification Profile MPN Panel PML/RARA and RARA Break-Apart X/Y for Engraftment Comprehensive Menu of Individual Hematologic FISH Probes FISH for Solid Tumors 1p/19q Deletion (Glioma) Bladder Cancer FISH BRAF Translocation (Brain & Others) EGFR Amplification (Solid Tumors) HER2 HER2 Breast HER2 Breast Equivocal HER2 Non-Breast Lung Cancer - NSCLC ALK RET ROS1 MET (Solid Tumors) MYCN Amplification (Solid Tumors) NeoSITE B.E. (Barrett s Esophagus) NeoSITE Cervical NeoSITE Melanoma PDGFRA Amplification (Brain) PTEN (Prostate & Others) RET (Solid Tumors) Sarcoma DDIT3 (CHOP) EWSR1 MDM2 SS18 (SYT) TOP2A (Breast) X/Y for Molar Pregnancy *All probes available individually Flow Cytometry Comprehensive Leukemia/Lymphoma Analysis CD4/CD8 Ratio for BAL DNA Ploidy/Cell Cycle Analysis Follow-Up and Add-On Panels Plasma Cell Panel PNH High Sensitivity Evaluation T&B Tissue Panel T-Cell Therapy Panel V-Beta T-Cell Clonality ZAP-70 Lymphoid Panel NeoGenomics Laboratories 3
Histology Digital Image Analysis In Situ Hybridization (ISH) CMV EBER HER2 Dual ISH HPV RNA ISH Kappa/Lambda Special Stains AcP AFB Alcian Blue Calcium Stain Chloroacetate Esterase Colloidal Iron Congo Red Copper Stain Elastic Stain Fite Stain Fontana Masson Giemsa GMS Gram Stain Hall Bile Stain Iron MPO Cytochemical Stain Mucicarmine Naphthol Acetate Esterase ± sodium fluoride inhibition Naphthol Butyrate Esterase PAS PAS for Fungus PAS with Digestion Reticulin TRAP Cytochemical Trichrome Warthin Starry Wright Giemsa Immunohistochemistry (IHC) Antibodies AACT AAT ACTH Adenovirus AFP ALK (D5F3) ALK-1 (heme) Amyloid A Amyloid P Annexin A1 AR Ariginase 1 ATRX B72.3 BCA-225 BCL1/Cyclin D1 BCL2 BCL6 BerEP4 Beta Catenin BG8 BOB1 BRAF V600E BRCA1 Breast Triple Stain (CK5 + p63 + CK 8/18) CA125 CA19.9 Calcitonin Caldesmon Calponin Calretinin CAM 5.2 (CK LMW) Carbonic Anhydrase IX (CA IX) Cat Scratch Cathepsin D CD1a CD2 CD3 CD4 CD5 CD7 CD8 CD10 CD11c CD14 CD15 CD19 CD20 CD21 CD22 CD23 CD25 CD30 CD31 CD33 CD34 CD35 CD38 CD42b CD43 CD44 CD45 (LCA) CD45RB CD45RO CD56 CD57 CD61 CD68 CD71 CD79a CD99 CD117 ckit CD123 CD138 CD163 CDK4 CDX2 CDX2/CK7 Double Stain CEA (Mono) CEA (Poly) Chromogranin A CK 5/6 CK 7 CK 10/13 CK 14 CK 17 CK 18 CK 19 CK 20 CK AE1/AE3 CK HMW (CK903/34BE12) CK HMW +p63 CK HMW/LMW Double Stain CK OSCAR cmet CMV cmyc 4 NeoGenomics Laboratories
Collagen IV COX2 crel CXCR4 D240 DBA.44 Desmin DOG1 DPC4 EBV (LMP1) E-Cadherin Eg5 EGFR EGFR (E746-A750del specific) EGFR (L858R mutant specific) elf4e EMA ER ERCC1 ERG Factor VIII RA Factor XIIIa Fascin Fli-1 FOXP1 FOXP3 FSH Galectin 3 Gastrin GATA3 GCDFP15 GCET1 GFAP GH Glucagon GLUT1 Glycophorin A Glypican-3 Granzyme B GST Pi H. Pylori HBME1 HCG Beta Hemoglobin A Hepatitis B Core Antigen Hepatitis B Surface Antigen HepPar1 HER2 Breast HER2 Non-Breast HGAL HHV8 HLA-DR HMB45 HPL HPV HSV I HSV I/II HSV II IDH1 IgA IgD IgG IgG4 IgM Inhibin inos Insulin Kappa Ki67 Ki67/Caspase 3 (Double Stain) Lambda Laminin Langerin LEF1 LH LMO2 Lysozyme MAL Mammaglobin MDM2 Melan A (Mart1) Mesothelin MGMT MITF MLH1 MOC31 MPO MSA MSH2 MSH6 MUC1 MUC2 MUC4 MUC5 MUC6 MUM1 MyoD1 Myogenin Myoglobin Napsin A NeuN NF (Neurofilament) NKX2.2 NKX3.1 NSE OCT2 OCT4 Olig2 p16 p21 p27 p40 NeoGenomics Laboratories 5
IHC Antibodies (Continued) p53 p57 p63 p120 Catenin P501S P504S pakt Pan Melanoma (S100 + Melan A + Tyrosinase) Pancreatic Polypeptide (PP) Pan-Cytokeratin Plus (AE1/AE3 + CK8/18) Pan-Keratin (AE1/AE3/PCK26) Pan-Melanoma/Ki67 Parafibromin Parvovirus PAX2 PAX5 PAX8 PD1 PD-L1 28-8 FDA (OPDIVO ) PD-L1 SP142 FDA (TECENTRIQ ) PD-L1 SP263 (IMFINZI ) PD-L1, 22C3 FDA (KEYTRUDA ) Perforin perk PgR phistone H3 (PHH3) PLAP PMS2 Pneumocystis Carinii (Jiroveci) Prealbumin (TTR) Prolactin Prostate Triple Stain PSA PSAP/HPAP PSMA PTEN PTH PU.1 RCC1 Retinoblastoma Protein (RB) ROS1 RRM1 S100 S100p SALL4 SATB2 Serotonin SF1 SMA SMMHC Smoothelin Somatostatin Somatostatin Receptor, Type 2 SOX2 SOX10 SOX11 Spirochete STAT6 Surfactant Survivin SV40 Synaptophysin Tau TCL1 TCR BetaF1 TdT TFE3 TGF Alpha Thrombomodulin (TM) Thyroglobulin (TGB) TIA1 TLE1 TOPO1 Toxoplasma TRAcP Tryptase TS TSH TTF1 Tuberculosis Tyrosinase Uroplakin II Uroplakin III Varicella Zoster Virus (VZV) VEGF Villin Vimentin WT1 ZAP70 6 NeoGenomics Laboratories
Molecular Testing Hematologic Cancer Panels & Profiles NeoTYPE Cancer Profiles Myeloid Disorders (54 genes) Disease-Specific (7 options) BTK Inhibitor Acquired Resistance Panel BTK Inhibitor Primary Susceptibility Panel Chimerism/DNA Fingerprinting MPN Extended Reflex Panel MPN Standard Reflex Panel NeoARRAY SNP/Cytogenetic Profile Immuno-Oncology Microsatellite Instability (MSI) Mismatch Repair IHC (MMR) PD-L1 IHC Tumor Mutation Burden Specialty Tests HPV DNA Tissue Testing NanoString Pan Cancer Immune Profiling Panel (770 genes) Universal Fusion/Expression Profile (1385 genes) Solid Tumor Cancer Panels & Profiles NeoTYPE Cancer Profiles Discovery (315 genes) Precision (48 genes) Tumor-Specific (18 options) NeoLAB Liquid Biopsies Hematologic Cancers AML Profile BTK Inhibitor Acquired Resistance Panel MDS/CMML Profile *Custom assays available Myeloid Disorders Profile ALK/RET/ROS1 Fusion Profile FLT3 ALK/NTRK/RET/ROS1 Fusion Profile Microsatellite Instability IDH1/IDH2 inv(16), CBFB-MYH11 Translocation NeoARRAY SNP/Cytogenetic Profile KIT (c-kit) NGS Comprehensive Sarcoma Fusion Profile KRAS NGS Ewing Sarcoma Fusion Profile NPM1 NRAS NGS Non-Ewing Sarcoma Fusion Profile NGS Rhabdomyosarcoma Fusion Profile NGS Pediatric Sarcoma Fusion Profile NGS Pediatric Sarcoma Fusion Profile NGS Thyroid Fusion Profile RAS/RAF Panel PML-RARA Translocation, t(15;17) RUNX1-RUNX1T1 (AML1-ETO) Translocation, t(8;21) NeoLAB Liquid Biopsies Solid Tumor EGFR T790M Prostate Solid Tumor Monitor (48 genes) Hereditary Cancer Predisposition BRCA1/2 Cancer Susceptibility for Peds Comprehensive Panel (73 genes) DNA Repair Panel EGFR T790M Germline Mutation HOXB13 Genotyping (Prostate) Inherited Bone Marrow Failure Panel (58 genes) Lynch Syndrome (5 genes) NeoGenomics Laboratories 7
Our Differentiators Expertise, Flexibility, Scalability Rapid Project Start-Up Dedicated Project Scientists Extensive Menu Custom Assay Design Platform Agnostic New tests are added frequently. See our website for the most current and complete listing. NeoGenomics Laboratories is a specialized oncology reference laboratory providing the latest technologies, testing partnership opportunities, and interactive education to the oncology and pathology communities. We offer the complete spectrum of diagnostic services in molecular testing, FISH, cytogenetics, flow cytometry, and immunohistochemistry through our nation-wide network of CAP-accredited, CLIA-certified laboratories. Committed to research as the means to improve patient care, we provide Pharma Services for pharmaceutical companies, in vitro diagnostic manufacturers, and academic scientist-clinicians. We promote joint publications with our client physicians. NeoGenomics welcomes your inquiries for collaborations. Please contact us for more information. neogenomics.com 2017 NeoGenomics Laboratories, Inc. All Rights Reserved. All other trademarks are the property of their respective owners. Rev. 112217 12701 Commonwealth Dr., Suite 9 Fort Myers, FL 33913 United States Phone: 866.776.5907 Fax: 239.690.4237 31 Columbia Aliso Viejo, CA 92656 United States Phone: 800.720.4363 Fax: 949.425.5865 2575 West Bellfort St., Suite 2001 Houston, TX 77054 United States Phone: 800.720.4363/ 713.528.4363 Fax: 713.668.3565 A-One Business Center Bâtiment A5, 2nd Floor Z.A. La Pièce/Route de l Etraz 1 1180 Rolle, Switzerland Phone: +41 (0)21 721 06 00 Fax: +41 (0)21 826 00 73