NEURO-AUDIO. Auditory EP (ABR, VEMP, ASSR, ECochG) and OAE tes ng in one unit. Complete solu on: screening, diagnos cs, research

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NEURO-AUDIO Clinical ABR & OAE Analyzer, Screening Audiometer Auditory EP (ABR, VEMP, ASSR, ECochG) and OAE tes ng in one unit Complete solu on: screening, diagnos cs, research High quality of recording Both manual and automa c test control HEARING DIAGNOSTICS AUDIOMETRY OAE, ABR

NEURO-AUDIO NEW STANDARD IN AEP Neuro-Audio is the most comprehensive AEP diagnos c device on the market. It is also a diagnos c OAE device and a screening audiometer. It is designed to meet the most stringent requirements of today and is ready for the future. It can be easily adapted for daily clinical rou ne (including newborn hearing screening and follow-up diagnos cs) or for advanced cu ng-edge research. 15 YEARS IN AUDIOLOGY

WIDE RANGE OF FEATURES IN A COMPACT UNIT Neuro-Audio has a high-quality two-channel amplifier and a built-in auditory s mulator with a wide range of intensi es and many supported transducers. It is a portable device that has excep onally high quality of recording. It can record non-sedated ABR easily and does not require a shielded room or audiometric booth! USB INTERFACE TRIG IN/OUT IMPEDANCE INDICATORS ELECTRODE CONNECTORS HEADPHONES OAE PROBE BONE VIBRATOR UPDATED SOFTWARE The modern and user-friendly so ware with mul ple analysis op ons is easily customizable to ensure the simple workflow and allow you to focus on a pa ent. Our so ware is constantly updated (based on feedback from our users) to stay on the cu ng edge of the technology.

CLINICAL APPLICATION OAE DPOAE, TEOAE, SOAE AEP ASSR сvemp, ovemp AABR, ABR, eabr MLR, LLR (CAEP), ECochG Cognitive ERP (P300, MMN) PTA Working with the Neuro-Audio system is working with a very user-friendly system. The system is robust and open, which creates many opportuni es in order to obtain reliable responses. The service and willingness of the people from Neuroso to improve their system is certainly an asset. Robby Vanspauwen, PhD, Clinical Scien st (Ves bular Research), Dept. for Otorhinolaryngology, Sint-Augus nus Hospital, European Ins tute for ORL, Antwerp, Belgium

POWER OF INTEGRATION OPTIMIZED FOR YOUR EFFICIENCY The common database and user interface, built-in protocols for all tests, integrated reference values and automa c algorithms all of these are ul mately intended to increase your efficiency and op mize test me usage. FLEXIBLE SETTINGS You can adjust almost any so ware se ng and device parameter the way you want it and save it as a new protocol for repeated use. CUSTOMIZED REPORTS You can customize design and content of your reports using a powerful report template editor. Also you can use a built-in word processor for advanced edi ng of your reports. DATA EXPORT You can easily export the data and PDF reports to another computer or integrate them with your hospital informa on system (GDT, HL7 protocols are supported). RELIABLE STORAGE OF PATIENT RECORDS AND TEST DATA All your pa ent records and test data are stored safely and securely in a single database used by all other Neuroso devices. Autosave and backup features protect against data loss. OUR SOFTWARE SPEAKS YOUR LANGUAGE The whole graphical user interface and printed reports are translated to many of the world's languages. This makes our so ware significantly easier to use no ma er which country you are from. SUPPORTED TRANSDUCERS: INSERT EARPHONES (ER-3C, ETC.) AUDIOMETRIC HEADPHONES (TDH-39, ETC.) BONE VIBRATOR (B-71) LOUDSPEAKERS

ABR CLINICAL APPLICATION Objec ve audiometry (hearing threshold search using wave V as the indicator). Neurology (iden fica on of pathologies in the VIII cranial nerve and auditory pathways of the brainstem). Fi ng of a cochlear implant (electrically evoked ABR). CALCULATION OF RESIDUAL NOISE AND FMP (KNOWING WHEN TO STOP) During recording it's recommended to rely on objec ve parameters of the response. The residual noise (RN) value helps you determine when to stop averaging. Fmp value indicates presence or absence of a response. Our so ware calculates these values automa cally and shows their reference values. It provides confidence in your results. WEIGHTED AVERAGING FOR HIGH-QUALITY RECORDING The weighted averaging maintains the steadily high record quality even in the condi on of a noisy pa ent (for example, a lot of movements and muscle ac vity). As a result the waveform morphology is improved and the residual noise is decreased. It allows saving your me and recording non-sedated ABR from young children. WIDE RANGE OF POSSIBILITIES FOR WAVEFORM ANALYSIS Superimpose ABR waveforms for visual assessment of reproducibility. Just place markers to see the latencies, intervals and amplitudes in analysis tables. Compare results with reference values on the latency/intensity chart. This will improve your efficiency. OPTIMIZED STIMULUS (CHIRP) The Chirp and Chirp-LS s muli are designed with a cochlea model in mind (frequency rises with me) to maximize the evoked response. That's why they are op mal for hearing screening and hearing threshold search (wave V is up to twice the size of a click response). Chirp-LS is op mized to be efficient at any s mulus intensity, so it saves your me. MINIMIZATION OF MAINS INTERFERENCE The unique adap ve notch filter (and high harmonic filter) together with the minimize interference feature (s mula on rate ji er ) allow recording clear waveforms even with low-quality mains and absence of a shielded room. It saves you me and money. AUTOMATIC HEARING THRESHOLD SEARCH Our so ware has automa c hearing threshold search protocol. Also you can manually select the list of intensi es used during the test which can be modified on the fly. It increases ease of use. ABR latency/intensity chart Comparison of Click and Chirp ABR waveforms Dual displays with unlimited waveforms

CLINICAL APPLICATION Es ma on of behavioral audiograms with ASSR. The results of ASSR tes ng can be used to es mate the behavioral pure-tone audiogram in cases when tradi onal audiometric tes ng can't be performed (for example, in infants and young children). ASSR ACCURATE AND OBJECTIVE RESPONSE DETECTION F-test response detec on method accurately and objec vely predicts behavioral audiometric thresholds (based on the analysis of the EEG spectrum). The principal component analysis (PCA) method reduces the impact of muscle-induced noises. The frui ul combina on of 2-channel recording, Chirp s mulus and weighted averaging allows achieving the most accurate results. FULL CONTROL You can independently control any of the 8 frequencies in mul -ASSR test. Depending on pa ent's state (awake/asleep) you can change the modula on frequency during tes ng. Also you can change the maximum test dura on. Signal (EEG) monitoring is always visible on the screen. All of these allow you to have full control of the test. AUTOMATIC HEARING THRESHOLD SEARCH The hearing threshold search is done automa cally with a specified step (in db) and within selected s mulus intensity range. This makes the test significantly easier to perform and saves your me. RESIDUAL NOISE CALCULATION The monitoring of residual noise (RN) and response amplitude (A) for each frequency helps answering the ques on whether to stop the recording or con nue it. It gives you confidence in the obtained results and shortens the test me. MASKING NOISE Masking (white noise) allows obtaining accurate audiometric thresholds even in pa ents suffering from unilateral or conduc ve hearing loss. CHIRP STIMULUS ASSR estimated audiogram ASSR response probability charts Table of ASSR trials

VEMP CLINICAL APPLICATION Diagnos cs of saccular/utricular and inferior/superior ves bular nerve func on in pa ents suffering from dizziness. EMG SCALING OF WAVEFORMS To facilitate comparison of the results obtained from le and right sides, Neuro-Audio so ware has the feature of scaling the recorded waveforms by averaged EMG. This ensures confidence in results. PEDIATRIC VEMP (EMG HISTOGRAM) It is very difficult for children to sit s ll during the whole test. That's why the unique func on was designed especially for them recalcula on of the recorded VEMP responses with the specified EMG range (that can be modified a er recording at any me). All sweeps that don't fall in the required EMG range are automa cally rejected. It saves your me considerably. AUTOMATIC VEMP RATIO CALCULATION The VEMP ra o (asymmetry between ears) is calculated by the Neuro-Audio so ware automa cally, and the value is displayed on the screen and in the report to be printed. Just place two markers on the waveform. FULL SET OF VEMP PROTOCOLS By default Neuro-Audio so ware includes the comprehensive list of VEMP protocols, including cervical and ocular VEMP tests (cvemp and ovemp) and bone conduc on VEMP test with bone vibrator amplifier (purchased separately). This streamlines your workflow. HIGH STIMULATION LEVEL VEMP is generated in response to loud s mulus. That is why the maximum s mulus intensity is of great importance for this test. Neuro-Audio can s mulate up to 100 db nhl with clicks and up to 110 db nhl with tone bursts (for insert earphones). For bone conduc on tes ng the unique bone vibrator amplifier (purchased separately) can be used to s mulate up to 80 db nhl. Normal cvemp response VEMP analysis panel

VISUAL BIOFEEDBACK VEMP amplitude depends on sternocleidomastoid muscle tension. That's why it's important to maintain the same tension level during the test. Neuro-Audio has the biofeedback feature: the muscle tension level indicator which is displayed in the main recording window and also on the second monitor for the pa ent (op onal). It helps you to perform the test correctly. VEMP EMG biofeedback dial

AEP AABR, MLR, LLR/CAEP, ERP, ECochG CLINICAL APPLICATION Newborn hearing screening (AABR). Diagnos cs of Ménière's disease/endolympha c hydrops (ECochG). Objec ve test of sound/speech recogni on in the auditory pathway from the ear to the cortex before/a er hearing aid fi ng (CAEP, cogni ve ERP). FULL SPECTRUM OF AEP: FROM SCREENING TO RESEARCH Neuro-Audio can be used to record auditory evoked poten als for newborn hearing screening (AABR) as well as other diagnos c and research purposes. The so ware includes predefined protocols for all AEP types in order to increase your performance. If you perform AEP research studies, you can fully customize all the hardware and so ware se ngs. You are free to experiment! ECOCHG: CALCULATION OF SP/AP AREA RATIO Besides SP/AP amplitude ra o calcula on, Neuro- Audio so ware calculates SP/AP area ra o. Just place three markers on the response waveform. The area ra o calcula on makes ECochG significantly more sensi ve to diagnose Ménière's disease (according to John Ferraro). AABR: FAST & OBJECTIVE HEARING SCREENING Just place the electrodes on a pa ent and start the AABR test. It only takes a few minutes to get simple Pass / Refer result. The test can be performed for pa ents of all ages and even when a pa ent is asleep. FOR DIAGNOSTICS AND RESEARCH Normal ECochG response

CLINICAL APPLICATION Behavioral pure tone audiometry allows obtaining frequency-specific hearing thresholds (audiograms) for air and bone conduc on and also in a sound field. It is used for adults and older children (star ng from 5 years of age) who can reliably demonstrate a change in behavior when a test sound is heard. PTA Complies with IEC 60645-1:2012 (Type 4: screening/monitoring) requirements. Air and bone conduc on tes ng, tes ng in a sound field. Automa c mode (Hughson & Westlake), manual mode (with mouse and keyboard) Contralateral masking noise (white noise) Silence mode (audiometric booth is not required) High-frequency audiometry (up to 16 khz) with special headphones CLINICAL APPLICATION Objec ve analysis of cochlear func on for pa ents of all ages. Newborn hearing screening. OAE Complies with IEC 60645-6:2009 (Type 1: diagnos c/clinical) requirements. Full spectrum of OAE tests: from screening to advanced diagnos cs. DPOAE up to 12 khz (early objec ve detec on of ototoxic and noise-induced hearing loss). Completely automa c test (including probe fi ng and in-ear calibra on of s mulus). TEOAE analysis DPOAE analysis

NEUROSOFT AUDIOLOGY PRODUCT LINE Neuro-Audio Audio-SMART ascreen APPLICATION Clinical ABR&OAE analyzer Diagnos c/screening ABR&OAE and middle ear analyzer OAE screening TESTS ABR, MLR, LLR, ECochG, VEMP, ASSR, P300, MMN, PTA, TEOAE, DPOAE, SOAE Tympanometry, AR, AR decay, ETF, TEOAE, DPOAE, ABR TEOAE, DPOAE HARDWARE PC-based P ortable standalone Portable smartphone-based www.neuroso.com, info@neuroso.com Phones: +7 4932 24-04-34, +7 4932 95-99-99 Fax: +7 4932 24-04-35 5, Voronin str., Ivanovo, 153032, Russia 2018 January