E-Cigarettes and Health Care:

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E-Cigarettes and Health Care: What They Mean for Hospitals and Clinicians The increasing popularity of electronic cigarettes or e-cigarettes is forcing hospitals and clinicians to determine what to recommend to patients who are looking to quit traditional tobacco. Due to the lack of evidence regarding the safety and efficacy of e-cigarettes, the Oklahoma Hospital Association urges health care providers to use caution. What are electronic cigarettes? Electronic cigarettes (e-cigarettes) are battery powered, rechargeable devices that deliver nicotine (or other substances) in the form of a vapor. They are also referred to as personal vaporizers (or vaping ). These devices heat and vaporize a solution containing nicotine, and many are designed to look outwardly like traditional tobacco cigarettes. Thus, as a cigarette-like device that mimics both hand-tomouth and oral-sensory experiences of a traditional cigarette, e-cigarettes have the potential to attract significant numbers of customers who might otherwise smoke cigarettes. 1 Are they safe? Multiple sources site concerns with the safety of e-cigarettes. There s a need for clinical trials on safety and efficacy if we re going to use these to help people stop smoking and right now we don t have any evidence at all that they help people stop smoking, states Dr. Richard Hurt, founder and director of Mayo Clinic s Nicotine Dependence Center. 2 Additional concerns involve quality testing and effectiveness. Without regulations to control what chemicals are included in the liquid nicotine, various products might look entirely different. In limited study samples, the FDA found significant quality issues that indicate that quality control processes used to manufacture these products are substandard or non-existent. 3 Questions have also been raised to the safety of inhaling substances that have not been regulated or tested in that context. While a product is safe to eat, it may have negative effects when heated and inhaled. 2,4 Other concerns are based on potential cell changes and risks. Studies have shown that e-cigarettes can cause short-term lung changes that are much like those caused by regular cigarettes. But long-term health effects are still unclear. This is an active area of research, but the safety of these products is currently unknown. 4 For patients with a serious lung ailment, it is reasonable to be cautious about recommending the use of any treatment that involves inhaling foreign material into the airways. 1

This may also be an issue for those facing wound healing issues, whether through surgery or personal injury. Nicotine Replacement Therapy in hospitals, using FDA approved and regulated nicotine medications under medical supervision, is not shown to have effects on postoperative outcomes, based on nicotine absorption levels; however that may not be the case for e-cigarettes. Seasoned vapers have been shown to attain a blood nicotine level nearly equal to that of traditional smokers. Therefore, surgical risks for e-cigarette users may be similar to smokers. This could be a particular issue for those patients with compromised circulation. 5 Can they help people stop smoking? E-cigarettes have not been approved as a cessation aid, and currently, none of the e-cigarette manufacturers have submitted applications for them to be used as such. Recent studies are showing mixed reviews regarding their effectiveness. One study states: Smokers who got help through quitlines who reported using e-cigs (to quit or for other reasons) were less likely to succeed during their current quit attempt that those who did not. 6 Part of the concern is driven by the lack of safety and testing, and the lack of understanding of potential future problems caused by e-cigarettes. Currently, many e-cigarette products are advertised for when you can t smoke, or as a cheaper and safer alternative to traditional cigarettes. When used for when you can t smoke the person becomes a dual user. 6 Current scientific evidence shows that those who use two or more tobacco products (dual users) have more difficulty quitting than those who use a single tobacco product. 6 In these terms, we may be creating a bigger problem than we actually fix. Other studies have compared the nicotine e-cigarette, non-nicotine e-cigarette, and the traditional nicotine patch. Neither of the e-cigarette options outperformed the nicotine patch. These studies did not determine if people were using e-cigarettes as a cessation aid, so the efficacy of the e-cigarette cannot be determined. In these studies smokers who used e-cigarettes were less likely to quit smoking than smokers who did not use e-cigarettes. 7 What should I tell my patients? It is important that all tobacco using patients be strongly advised to quit immediately. Explain how their tobacco use is specifically causing or exacerbating their current health situation, and potential future health problems. Let them know that there are effective options available to them, as they overcome their nicotine dependence, including the most effective: medications plus coaching support through a quitline. In Oklahoma that is 1-800 QUIT NOW.

It is also important to counsel your patients on the safety and effectiveness of FDA approved cessation medications, versus e-cigarettes. The safety and effectiveness of e-cigarettes are not fully understood, nor is there any evidence to suggest that e-cigarettes are safer or more effective than existing medications. 1 Once a patient expresses a readiness to quit, offer them support. It is important for them to understand their motivating factors and past attempts, and that past attempts and relapses are normal and necessary steps to learning how to quit permanently. Encourage the use of non-contraindicated, FDA approved cessation medications and counsel the patient on appropriate use. (This may include the need to double patch or consider a combination therapy, based on the patient s nicotine addiction level.) If a patient is already using an e-cigarette in an attempt to quit smoking, it is important to support their decision to improve their health, while talking to them about the need to quit all forms of tobacco. Becoming a dual user can make the transition to tobacco-free much more difficult. Additionally, from a safety and liability standpoint, it is unknown what the long term effects of e-cigarettes will be. Patients should be encouraged to set a quit date for their e-cigarette use as well. Ultimately, patients deserve tobacco treatment assistance from their health care provider. Seventy percent (70%) of smokers want to quit they don t know how and they don t have the most effective tools to quit. Focus on the effectiveness of FDA approved cessation medications (when used correctly), as well as behavior change support (such as the Oklahoma Tobacco Helpline). The following table offers some clinical scenarios to assist providers as they work with patients to establish nicotine dependence treatment plans.

What Does this Mean for Hospitals? OHA Tobacco Treatment staff are seeing several trends: Patients who use tobacco are sometimes using e-cigarettes while they are in the hospital. Because of the newness of this product, there are few policies against their use. Hospital personnel are often not familiar with what e-cigarettes are or the potential health dangers they pose. Most hospitals that have already passed tobacco free campus policies do not include e- cigarettes in their policies. Until more information or evidence is available about the safety of these products, it is recommended that hospitals do the following: Amend tobacco free campus policies to include e-cigarettes as potentially harmful and that they are prohibited from being used on their property. Inform patients at admission that e-cigarettes are prohibited from use, along with all tobacco products, and that other options are available to assist them in with their nicotine withdrawal while they are hospitalized, including medications and the Oklahoma Tobacco Helpline. Educate hospital employees about what e-cigarettes are and the potential risks they pose. Provide them with the tools they need to discuss this with patients. Advise employees who use tobacco that, along with other tobacco products, they are not permitted to use e-cigarettes on campus and that other options are available to assist them in quitting tobacco use. Provide employees, addicted to nicotine, with health benefits that include paid medications and referral to the Oklahoma Tobacco Helpline. Consult with your legal counsel on allowing patients to use e-cigarettes while in the hospital. Allowing the use of a non-fda approved addictive substance that is not regulated and could possibly cause harm, may place your hospital in a libelous situation based on alleged health problems caused by the vapors and fumes. These issues could range from irritation to more serious problems such as respiratory issues and even cancer. 8 Health Care Providers Should Support Effective Tobacco Use Treatment Leading health and tobacco treatment specialists, nationwide, support evidence-based treatment for nicotine addiction based upon the clinical practice guideline, Treating Tobacco Use and Dependence. It should be a routine protocol in patient care. The most effective means for stopping tobacco use include all of the following: Talk to your patients about quitting tobacco use and options available to quit Discuss the FDA approved cessation medications to assist in managing cravings and withdrawal symptoms, such as nicotine replacement therapy (NRT), Chantix or Zyban. Refer patients to the Oklahoma Tobacco Helpline and to talk to a trained Quit Coach who will assist in many ways.

These three things combined are the most effective tools we now have for quitting tobacco use! These three actions combined = 35% chance of success. Quitting with no assistance = 5% chance of success. For more information contact: Jennifer W. Roysdon, OHA Tobacco Treatment Systems Coordinator, jennifer@okoha.com Eric Finley, OHA Outpatient Tobacco Treatment Coordinator, efinley@okoha.com 405 427-9537 Hospitals Helping Patients Quit: Advancing Tobacco Treatment References 1. Cummings KM, Dresler CM, Field JK, Fox J, Gritz ER, Hanna NH, Ikeda N, Jassem J, Mulshine JL, Peters MJ, Yamaguchi NH, Warren G, Zhou C. E-Cigarettes and Cancer Patients. Journal of Thoracic Oncology 2014; V9 4; 438-441. 2. Comments on E-Cigarettes by Richard Hurt, M.D.; Interview 3. FDA, E-Cigarettes: Questions and Answers 4. What about electronic cigarettes? Aren t they safe? American Cancer Society 5. Kempton SJ, Burish NM, Rao VK. Electronic Cigarettes: Have You Asked Your Patients about Vaping? Viewpoints V133 6; 907e. 6. Vickerman KA, Carpenter KM, Altman T, Nash CM, Zbikowski SM. Use of Electronic Cigarettes Among State Tobacco Cessation Quitline Callers. Nicotine and Tobacco Research 2013 7. Grana RA, Ling PM, Benowitz N, Glantz S. Electronic Cigarettes. Circulation 2014; 129; e490- e492. 8. Dillsaver, A. Electronic Cigarettes: It s Time to Include Them in Your Tobacco Use Policy. Oklahoma Bar Journal V82, No 26, Oct. 2011; p. 2275. Oklahoma Hospital Association October 2014