A wide variety of membrane options

A wide variety of membrane options

BOVINE Bovine collagen membrane Neomem is a resorbable collagen membrane derived from highly purified type I collagen fibres from bovine Achilles tendon. The macromolecular pore size allows vital nutrient transfer while the cell occlusive membrane retards epithelium down growth. Longer in vivo stability. Optimized flexibility and rigidity for better space maintenance which allows for desired tissue in-growth. Features & Benefits Gamma irradiated to sterilize / Nonpyrogenic Suture pull out strength between 290g and 350g Cell occlusive - retards epithelium down growth Macromolecular pore size allows nutrient transfer Can be fixated with sutures or tacks COMMON Applications (Resorption: 26 to 38 weeks) Guided Tissue Regeneration Guided Bone Regeneration NeoMem is sterilized by irradiation and packaged in double pouches.

Exceptional clinical performance Suture pull out strength between 290g and 350g Cell occlusive - retards epithelium down growth Macromolecular pore size allows nutrient transfer Why make neomem your membrane of choice? Highly purified type I collagen fibres derived from bovine Achilles tendon Nonpyrogenic Excellent safety profile Easy in situ placement 15 x 20 mm 20 x 30 mm 30 x 40 mm N1520 N2030 N3040

PORCINE Porcine collagen membrane NeoGuarde is a resorbable porcine collagen dental membrane for Guided Bone Regeneration (GBR) and Guided Tissue Regeneration (GTR). This type I and type III collagen is manufactured using unique cross linkage technology that provides the membrane with its ability to maintain barrier functionality for 4-6 months. Features & Benefits Conservation of the fibrous structure (mechanical strength) Easy to place with no need to tack or suture the material Exceptional tissue adherence during application Flexible and adaptable to varying bone topographies Biocompatible /Cells occlusive / Tear resistant COMMON Applications (Resorption: 16 to 24 weeks) Guided Tissue Regeneration Guided Bone Regeneration Excellent handling characteristics Biocompatible and safe Cells occlusive Easy to use NeoGuarde is sterilized by irradiation and packaged in double pouches.

Incredibly tear resistant Mechanical strength tested for tensile strength and suturability Membrane elastic resistance > 1N and at the suture line > 0.5N during in vitro testing Purified collagen Purified collagen from skin Collagen type I and III Conservation of the fibrous structure (mechanical strength) Conforms perfectly Easily cut to size, shaped and applied Easy to place with no need to tack or suture the material Exceptional tissue adherence during application Flexible and adaptable to varying bone topographies 15 x 25 mm 20 x 30 mm 30 x 40 mm NG1525 NG2030 NG3040

ALLOGRAFT Placental allograft membrane BioXclude is a 2nd generation processed, dehydrated and sterilized graft composed of allograft amnion and chorion tissue (300 μm thick) that undergoes Purion, a proprietary tissue processing technology. BioXclude is sourced from the amniotic sac, the part of the placenta that encloses and protects the developing fetus through term. Amniotic tissue consists of an inner amnion layer and an outer chorion layer. Amnion contains collagen types III, IV and V and chorion contains collagen types I, III, IV, V, VI. Features & Benefits Composed of immunoprivileged tissue Reduces inflammation at the wound site Contains cell adhesion factors and cytokines Thin membrane which tightly adapts over grafted area Does not need to be secured into place with sutures or tacks Resorbable / Sterile / Room temperature storage COMMON Applications (Resorption: 8 to 13 weeks) Site preservation Bony defects around teeth and implants Ridge augmentations Over block grafts and ridge splits Covering the lateral window in sinus elevations Mild gingival recession The Science of Placental Allografts Placental allografts are composed of immunoprivileged tissues that possess anti-bacterial properties, reduce wound site inflammation, and provide a protein enriched matrix to facilitate cell migration1. BioXclude is sourced from the amniotic sac, the part of the placenta that encloses and protects the developing fetus through term. Amniotic tissue consists of an inner amnion layer and an outer chorion layer. Amnion contains collagen Types III, IV, and V2. Chorion, the outer layer of the amniotic sac, contains collagen Types I, III, IV, V, and VI3. BioXclude is terminally sterilized by electron beam.

Safety information All placental tissue used in BioXclude is donated under full informed consent from mothers undergoing elective cesarean section delivery. The tissue is procured and processed according to regulations established by the United States Food & Drug Administration and the standards of the American Association of Tissue Banks. A safe and biocompatible material, amnion tissue was used as early as the 1900 s, for skin transplantation to treat burn victims and those with ulcerated skin conditions. Amnion and amnion chorion tissue-based products have been used in ophthalmic surgery for the last decade and more recently in spine and orthopedic surgery and the treatment of chronic wounds. During this time there have been no reported incidents of any type of adverse event associated with their use. Site Preservation: Courtesy of Dan Holtzclaw, DDS, MS, Austin, TX5 BioXclude over grafted #19, site closure 2 weeks postoperative 5 months postoperative 10 x 13 mm 10 x 25 mm 15 x 20 mm 20 x 30 mm GB1130 GB1255 GB1125 GB1235

PTFE TXT-200 & TXT-200 Singles (Non-resorbable - High-Density PTFE Membrane) Designed to withstand exposure Non-surgical removal when left exposed Impervious to bacteria (data on file) Regentex surface increases stability of barrier membrane TXT-200 Singles are the ideal size for single-tooth extraction Cytoplast TXT-200 Micro-textured, high-density PTFE membrane (Regentex TM surface) Increased membrane stability The patented Regentex surface helps stabilize the membrane and the soft tissue flap. GBR-200 & GBR-200 Singles (Non-resorbable - High-Density PTFE Membrane) The original Cytoplast high-density PTFE membrane Designed to withstand exposure Impervious to bacteria (data on file) Non-surgical removal when left exposed CytoPlast GBR-200 The original high-density PTFE membrane CytoPlast TxT-200 GBR-200 12 x 24 mm TXT1224 GBR1224 25 x 30 mm TXT2530 GBR2 530 12 x 24 mm (boxes of 10) 25 x 30 mm (boxes of 4)

Cytoplast Ti-150, Ti-250 Titanium-Reinforced, high-density PTFE membrane Ultra thin layer of e-ptfe to increase surface area for tissue integration. Laser cut, commercially pure titanium strut for increased rigidity in central portion of membrane has little or no memory. Regentex, textured, high density PTFE backing prevents migration of bacteria into wound if exposed. Edges remain soft and supple to prevent flap complications. Membrane can be molded and shaped for tenting and space maintenance Regentex surface increases stability of membrane Impervious to bacteria (data on file at Osteogenics) Membranes can be trimmed to desired shape Titanium frame has little memory for easy placement Common Applications (Non resorbable membrane) On-lay grafting in ridge augmentation procedures Guided Bone Regeneration (GBR) Structural support when grafting 3 or 4-walled extraction sites Cytoplast Ti-150 Ti-150 membranes are 40% thinner than Ti-250 membranes, providing clinicians another handling option in Cytoplast Titanium-Reinforced Membranes. 150 µm thick 250 µm thick 30 x 40 mm 25 x 30 mm 20 x 25 mm 17x 25 mm 14 x 24 mm 12 x 14 mm Ti150XL-2 Ti150PL-2 Ti150PS-2 Ti150BL-2 Ti150AS-2 Ti150ANL-2 Ti250XL-2 Ti250PL-2 Ti250PS-2 Ti250BL-2 Ti250AS-2 Ti250ANL-2

SIS Regenerative tissue matrix DynaMatrix is an extracellular matrix (ECM) derived from porcine small intestinal submucosa (4 layers SIS). ECM contains two of the three essential biological components required for healing: matrix scaffold & signals, which include growth factors and ECM cell receptor-mediated binding sites. It retains both the 3-dimensional structure and the signaling proteins found within the material that communicates with the body to help stimulate the natural healing process. The biologic material guides the patient s soft tissue to form organized tissue, not scar tissue. Common Applications (Remodels: 8 to 12 weeks - Epithelialization) Guided Bone and Tissue Regeneration Gingival Recession Miller s Class I if bone loss, use with Accell Connexus Increasing Zone of Attached Keratinized Tissue Superior handling and ease of use Combines exceptional strength and flexible handling. Can be cut, rolled or folded to accommodate defect site requirements. Pliable enough to facilitate handling, yet strong enough to be sutured or tacked. Significant remodeling and healing properties Supports safe and effective repair by not dissolving in the site or causing chronic inflammation. The biological material guides the patient s soft tissue to form organized tissue, not scar tissue. This tissue becomes functional, without a foreign substance left behind. Not synthetically nor chemically cross-linked. 4 LAYERS SIS 15 x 20 mm 20 x 30 mm 30 x 40 mm 10-401-1520 10-401-2030 10-401-3040 DynaMatrix is sterilized by ethylene oxide to eliminate cell-borne pathogens and provided in sealed packages.

SIS Regenerative tissue matrix DynaMatrix Plus is specifically designed for soft tissue grafting procedures. It is an extracellular matrix (ECM) derived from porcine small intestinal submucosa (8 layers SIS - twice the thickness of standard DynaMatrix). ECM contains two of the three essential biological components required for healing: matrix scaffold & signals, which include growth factors and ECM cell receptor-mediated binding sites. The biologic material guides the patient s soft tissue to form organized tissue. It is a high-performing clinical alternative to connective tissue grafts, and eliminates the need to harvest tissue from the patient s oral cavity. Common Applications (Remodels: 8 to 12 weeks - Epithelialization) Soft tissue augmentation / Bulking Gingival recession Miller s Class II-III (if bone loss, use with Accell Connexus) 8 LAYERS SIS DynaMatrix Plus is specifically designed for soft tissue grafting procedures At twice the thickness of standard DynaMatrix, DynaMatrix Plus has been engineered to generate tissue of increased depth for root coverage and tissue bulking procedures. DynaMatrix Plus is a high-performing clinical alternative to connective tissue grafts, and eliminates the need to harvest tissue from the patient s oral cavity. Bioactive Design Unlike acellular dermal matrices, DynaMatrix Plus communicates with the body, signaling surrounding tissue to grow across the scaffold and generating thick, vascularized tissue. Active proteins support the healing process by attracting cells and nutrients to the wounded area. These proteins include: Growth Factors Initiate wound healing, stimulate blood vessel formation, and maintain tissue homeostasis. Glycoproteins Contribute to cell proliferation, migration and cell and blood vessel attachment. Glycosaminoglycans (GAGs) Regulate the function of growth factors and reduce scar formation. 10 x 20 mm 10 x 30 mm 20 x 40 mm 10-501-1020 10-501-1030 10-501-2040 DynaMatrix Plus is sterilized by ethylene oxide to eliminate cell-borne pathogens and provided in sealed packages.

allograft Bovine porcine dbm dbm SIS dbm SIS allograft synthetic PTFE synthetic Description Neomem Resorbable collagen membrane derived from highly purified type I collagen fibres from bovine Achilles tendon. NeoGuarde Resorbable collagen membrane derived from purified type I and type III collagen from porcine skin. DynaMatrix Extracellular matrix (ECM) derived from porcine small intestinal submucosa (SIS). (4 layers) DynaMatrix Plus Extracellular matrix (ECM) derived from porcine small intestinal submucosa (SIS). (8 layers) BioXclude Allograft amnion and chorion tissue (300 μm thick). Cytoplast Ti-250, Ti-150 Titanium-reinforced highdensity PTFE membrane. Characteristics Cell occlusive Allows nutrient transfer Optimized flexibility and rigidity Either side can be placed towards the soft tissue or bone Easily trimmed and placed, wet or dry Gamma irradiated to sterilize. Fixated with sutures or tacks. Nonpyrogenic Suture pull out strength between 290g and 350g. Flexible and adaptable to varying bone topographies. Exceptional tissue adherence. Conservation of the fibrous structure (mechanical strength). Cell occlusive. Easy to cut to size, shape and apply. No need to tack or suture the material. Incredibly tear resistant. ECM contains two of the three essential biological components required for healing. ECM makes remodeling happen. Combines remarkable strength and flexible handling. Maintains a threedimensional structure. Can be cut, rolled or folded. Guides the patient s soft tissue to form organized tissue. Twice as thick as DynaMatrix. ECM contains two of the three essential biological components required for healing. Guides the patient s soft tissue to form organized tissue. Engineered to generate tissue of increased depth for root coverage and tissue bulking. Not synthetically nor chemically cross-linked Composed of immunoprivileged tissue. Reduces inflammation at the wound site. Contains laminin and laminin-54. Resorbable. Minimal trimming needed. Tightly adapts over placed bone graft. No need to tack or suture the material. Sterile. Titanium frame to maintain space. Engineered to withstand exposure. Textured surface increases the stability of the membrane. Impervious to bacteria. Can be molded and shaped for space maintenance. Can be trimmed to desired shape. Titanium frame has little memory for easy placement. Applications GTR GBR GTR GBR Soft tissue remodeling. Soft tissue grafting. Soft tissue augmentation/ bulking. Gingival recession Miller s Class II-III GTR GBR On-lay grafting in ridge augmentation procedures. GBR Structural support when grafting 3 or 4-walled extraction sites. Resorption 26 to 38 weeks. 4 to 6 months. Epithelialization occurs in 8 to 12 weeks. Epithelialization occurs in 8 to 12 weeks. 8 to 13 weeks. Non resorbable membrane. Citagenix Inc., 1111 Autoroute Chomedey, Laval, QC H7W 5J8 T 1 877-243-6724 Citagenix.com info@citagenix.com