Paul Murray University of Birmingham
College of Medical and Dental Sciences The people of the Midlands have every reason to be supremely proud of this great centre of healing, of teaching and of research. The University of Birmingham: its history and significance Vincent & Hinton. 1947
The University Hospitals NHS Trust 5th largest Trust in UK Major tertiary referral centre The new hospital
College of Medical and Dental Sciences Research Institutes: Applied Health Research Cancer Sciences and Genomic Medicine Cardiovascular Sciences Immunology and Immunotherapy Inflammation and Ageing. Metabolism and Systems Research
College of Medical and Dental Sciences Research Institutes: Applied Health Research Cancer Sciences and Genomic Medicine Cardiovascular Sciences Immunology and Immunotherapy Inflammation and Ageing. Metabolism and Systems Research
College of Medical and Dental Sciences Applied Health Research From research into mental health, obesity and smoking to the development and evaluation of scientific methodologies for health, our research addresses and analyses the global challenges faced by society Major themes: 1) Healthcare Evaluation Methodology 2) Primary Care and Population Health Research- OBESITY
College of Medical and Dental Sciences Applied Health Research Tackling childhood obesity in China Pint sized solution to weight loss Impact Case Study: Atrial fibrillation Educating China's elderly to help fight obesity in the young Can drinking water before meals help you to lose weight? Developing management and therapy through primary care
College of Medical and Dental Sciences Research Institutes: Applied Health Research Cancer Sciences and Genomic Medicine Cardiovascular Sciences Immunology and Immunotherapy Inflammation and Ageing. Metabolism and Systems Research
College of Medical and Dental Sciences Cardiovascular Sciences: Research groups Birmingham Cardio-Renal Group Academic Clinical Cardiovascular Medicine at City Hospital Translational Research on Heart Failure and Arrhythmias Cardiovascular Translational Group: Myocardial Infarction and Heart Failure Haemostasis, Thrombosis and Vascular Biology Unit (HTVBU) Carotid Body and Chemoreceptor Research Group Membrane Protein Structure and Function Physiological Assessment of Animal Models of Health and Disease Patient Reported Outcomes (PROs) Research Group
College of Medical and Dental Sciences Cardiovascular Sciences: Research groups Angiogenesis Group Birmingham Platelet Group Leukocyte Trafficking Microcirculation Research Group Vascular and Reproductive Biology Vascular Tetraspanin Group Membrane Protein Structure and Function
College of Medical and Dental Sciences Research Institutes: Applied Health Research Cancer Sciences and Genomic Medicine Cardiovascular Sciences Immunology and Immunotherapy Inflammation and Ageing. Metabolism and Systems Research
College of Medical and Dental Sciences. Centre for Obesity Research Mechanisms of Disease Exercise and Nutrition Childhood Obesity Motivating Health Lifestyle Obesity in the Community
College of Medical and Dental Sciences. Centre for Endocrinology, Diabetes and Metabolism Research groups Integrative Metabolic Physiology and Obesity Sleep, Metabolism, Obesity and Diabetic Complications Research Group Type-1 Diabetes Research Group
College of Medical and Dental Sciences Research Institutes: Applied Health Research Cancer Sciences and Genomic Medicine Cardiovascular Sciences Immunology and Immunotherapy Inflammation and Ageing. Metabolism and Systems Research
The Institute of Cancer and Genomic Medicine
The Institute of Cancer and Genomic Medicine We focus on both basic and translational research in human cancer.and translate this expert knowledge into new treatments for patients in our Clinical Trials Unit. Major themes Cancer cell biology and epigenetics Cancer genetics and DNA damage Genome biology Epigenetics DNA replication, damage and repair Stem cell biology Viral oncology
The Institute of Cancer and Genomic Medicine We focus on both basic and translational research in human cancer.and translate this expert knowledge into new treatments for patients in our Clinical Trials Unit. Major themes Cancer cell biology and epigenetics Cancer genetics and DNA damage Genome biology Epigenetics DNA replication, damage and repair Stem cell biology Viral oncology
Translational Research: Virus associated cancers Hepatocelullar carcinoma Cervical, head and neck cancer Kaposi s sarcoma Merkel cell carcinoma HCV, HBV HPV KSHV Merkel Cell Polyomavirus
Translational Research: Epstein-Barr virus associated cancers Nasopharyngeal carcinoma B cell lymphomas Gastric cancer
Translational Research: Epstein-Barr virus associated cancers Nasopharyngeal carcinoma B cell lymphomas Gastric cancer
Geographical distribution of nasopharyngeal carcinoma
NPC is a major health problem South East Asia China, Hong Kong Malaysia: Chinese Singapore: Chinese USA, California: Chinese Singapore: Malay Malaysia: Malay China, Shanghai Malaysia: Indian USA, California: White Males F emales 0 5 10 15 20 25 30 35 Age-standardized incidence
Translational Research: Epstein-Barr virus associated cancers Nasopharyngeal carcinoma Major themes: B cell lymphomas Gastric cancer 1) Unravelling virus-driven oncogenic signalling (e.g. Yap L-F, et al., J Pathol 2015; Vockerodt M, et al., J Pathol 2013 2) EBV genome biology and expression (e.g. Ford et al., Current Biol 2015; Qiu J, et al., PLoS Pathogens 2011; Leonard S, et al., J Virol 2011) 3) Tumour microenvironment (e.g. Cader FZ, et al., Blood 2013; hite RE, et al., J Clin Invest 2012) 4) Impact on cellular différentiation (e.g. Vrzalikova K, et al.,. Blood 2011)
Contribution of EBV to tumour microenvironment Hodgkin lymphoma Nasopharyngeal carcinoma
Translational Research: Epstein-Barr virus associated cancers Nasopharyngeal carcinoma Major themes: B cell lymphomas Gastric cancer 1) Unravelling virus-driven oncogenic signalling (e.g. Yap L-F, et al., J Pathol 2015; Vockerodt M, et al., J Pathol 2013 2) EBV genome biology and expression (e.g. Ford et al., Current Biol 2015; Qiu J, et al., PLoS Pathogens 2011; Leonard S, et al., J Virol 2011) 3) Tumour microenvironment (e.g. Cader FZ, et al., Blood 2013; hite RE, et al., J Clin Invest 2012) 4) Impact on cellular différentiation (e.g. Vrzalikova K, et al.,. Blood 2011) CLINICAL TRIALS PRIMARY TISSUE IN VITRO MODELS ANIMAL MODELS Genomics on dissected cells Multiplex quantitative imaging Primary GC B cell models In vitro EBV transformation Xenograft, syngeneic models PDX models, humanised mice
Paul Murray University of Birmingham