With the Presidency of Her Majesty the Queen Sofia

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ay, 21 st 10:00-15:00 Welcome and registration. Posters set-up With the Presidency of Her Majesty the Queen Sofia 12:00-12:15 OFFICIAL OPENING 12:15-13:15 KEYNOTE LECTURE Introduced by: Jesús Ávila. Bengt Winblad, Karolinska Institute, Stockholm, Sweden. Alzheimer s Diseases - Present and future Treatment Strategies. 13:15-15:00 Lunch and poster SESSION 15:00-16:30 PLENARY SESSION I 15:00-15:45 Introduced by: José Ángel Obeso. Anthony Schapira, UCL, London, UK. The Glucocerebrosidase pathway: a paradigm for pathogenesis and treatment in Parkinson disease. 15:45-16:30 Introduced by: Miguel Medina. Eckhard Mandelkow, DZNE, Bonn-Germany.

Wednesday, 16:30-17:00 Coffee break 17:00-18:15 Scientific Session I Chairperson: Guadalupe Mengod 17:00-17:20 José Ramón Naranjo, CIBERNED, National Center of Biotechnology, CSIC, Madrid. DREAM regulates ATF6 processing and HD progression. 17:20-17:40 Eva Carro, CIBERNED, 12 de Octubre University Hospital, Madrid. Metabolic Disorders and inflammation as risk factors for alzheimer s disease. 17:40-18:00 Carlos Vicario, CIBERNED, Cajal Institute, CSIC, Madrid. Using pluripotent stem cell technology to study neurodegeneration in Parkinson s and Alzheimer s diseases. 18:00-18:15 2015 Young Investigator Award Name, affiliation

y, 22 nd 08:00 Transfer Bus from Hotel Meliá Alicante to venue. 08:30-09:30 Meetings of cooperative projects.(closed Session) 09:00 Transfer Bus from Hotel Meliá Alicante to venue. 09:30-10:50 Scientific Session II Chairperson: Adolfo López de Munaín 09:30-09:50 Alberto Lleó, CIBERNED, Santa Creu i Sant Pau Hospital, Barcelona. Synaptic abnormalities in Alzheimer s disease and other dementias. 09:50-10:10 Jordi Pérez-Tur, CIBERNED, Institute of Biomedicine of Valencia-CSIC. 10:10-10:30 Eduardo Tolosa, CIBERNED, Hospital Clinic of Barcelona. Biomarkers of prodromal Parkinson disease. 10:30-10:50 José López-Barneo, CIBERNED, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio, University Hospital, University of Sevilla. Strategies for a GDNF-based therapy in Parkinson disease. 11:00-11:30 Awarding of Fundación Reina Sofía-MAPFRE Grant. 11:30 11:45 Coffee break

Thursday, 11:45-13:10 PLENARY SESSION II 11:45-12:30 Introduced by: Miguel Medina. Luc Buèe, University of Lille, France. 12:30-12:50 Juan Carlos López, Head of Academic Relations and Collaborations, Roche, New York, USA. Challenges and opportunities in transfer of knowledge from academy to industry. 12:50-13:10 Steven Suchting, MRC Technologies Dementia Consortium. 13:15-15:00 Lunch and poster session 13:15-15:00 CIBERNED Steering Committee (Closed Session)

y, 22 nd 15:00-16:15 Scientific Session III Chairperson: Juan Carlos López 15:00-15:15 Antonio Gómez, Janssen. New Models to Fulfill the Potential of Basic Research. 15:15-15:30 Carlos Buesa, Oryzon Genomics. 15:30-15:45 Javier Burgos, NeuronBio. AlzTEST, a novel tool in blood for the diagnosis of Alzheimer s disease. 15:45-16:00 Ainhoa Alzualde, Biobide. Zebrafish as a tool for Drug Discovery and Target Validation in neurodegenerative diseases. 16:00-16:15 Raúl Insa, SOM Biotech. 16:15-17:00 Round table. 17:00-17:30 Coffee break

Thursday, 17:30-18:30 Claustro CIBERNED.(Closed Session) 17:30-17:50 Scientific Director Report. Jesús Ávila. 17:50-18:10 Manager Report. M. Ángeles Pérez. 18:10-18:30 Deputy Scientific Director Report. Miguel Medina.

23 rd 09:30-11:00 Scientific Session IV: Late-breaking news/ poster highlights Chairperson: Javier Sáez. 11:00-11:30 Coffee break and posters 11:30-13:10 Scientific Session V Chairperson: María Asunción Pastor 11:30-11:50 José Luis Labandeira, CIBERNED, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS),University of Santiago de Compostela. Brain Renin-angiotensin system and dopaminergic degeneration 11:50-12:10 Manuel Rodríguez, CIBERNED, University of La Laguna, Santa Cruz de Tenerife. 12:10-12:30 Ana María Pérez, CIBERNED, Institute Biomedical Research, CSIC-UAM, Madrid. Phosphodiesterase-7 as a therapeutic target in Parkinson s disease.

Friday, 12:30-12:50 Valentín Ceña, CIBERNED, University of Castilla- La Mancha, Albacete. 12:50-13:10 Javier Sáez, CIBERNED, Miguel Hernández University (Elche), CSIC, Neurosciences Institute, Alicante. Amyloid-related proteins as potential CSF biomarkers for Alzheimer s disease. 13:15 Concluding remarks 13:30 End of meeting

General SECRETARIAT: FUNDACIÓN CIEN Y CIBERNED: Almudena Flores Soledad Valero C/ Valderrebollo, 5 28031 Madrid. gerencia@fundacioncien.es / gerencia@ciberned.es Phone: (+34) 91 385 22 00 Fax: (+34) 91 385 21 18 www.fundacioncien.es / www.ciberned.es CONGRESS SECRETARIAT: OASIS EVENTS & TRAVEL SOLUTIONS C/ Sor Ángela de la Cruz, 8-1º A - 28020 Madrid. Phone: (+34) 91 555 11 19 Fax: (+34) 91 555 35 81 www.viajesoasis.com / jsanchez@viajesoasis.com VENUE: EUIPO Avenida de Europa, 4, E-03008 Alicante, España. Centro de información: +34 965 139 100 IN GRATITUDE TO:

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