1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 Protocol for Concomitant Temporomandibular Joint Custom-fitted Total Joint Reconstruction and Orthognathic Surgery Using Computer-assisted Surgical Simulation Q2Q3 Reza Movahed, DMD a, *, Larry Wolford, DMD b,c Q4 Q6 Q7 Q8Q9 INTRODUCTION Q5 KEYWORDS Temporomandibular joint Total joint reconstruction Orthognathic surgery Computer-assisted surgical simulation KEY POINTS Combined orthognathic and total joint reconstruction cases can be predictably performed in 1 stage. Use of virtual surgical planning can eliminate a significant time requirement in preparation of concomitant orthognathic and temporomandibular joint (TMJ) prostheses cases. The concomitant TMJ and orthognathic surgery computer-assisted surgical simulation technique increases the accuracy of combined cases. In order to have flexibility in positioning of the total joint prosthesis, recontouring of the lateral aspect of the rami is advantageous. Clinicians who address temporomandibular joint (TMJ) disorders and dentofacial deformities surgically can perform the surgery in 1 stage or 2 separate stages. The 2-stage approach requires the patient to undergo 2 separate operations and anesthesia, significantly prolonging the overall treatment. However, performing concomitant TMJ and orthognathic surgery (CTOS) in these cases requires careful treatment planning and surgical proficiency in the two surgical areas. This article presents a new treatment protocol for the application of computer-assisted surgical simulation (CASS) in CTOS cases requiring reconstruction with patient-fitted total joint prostheses. The traditional and new CTOS protocols are described and compared. The new CTOS protocol helps decrease the preoperative work-up time and increase the accuracy of model surgery. a Orthodontics, Saint Louis University, 40 North Kingshighway Boulevard, Apartment 16A, Saint Louis, MO 63108, USA; b Department of Oral and Maxillofacial Surgery, Baylor College of Dentistry, Texas A&M University Health Science Center, 3409 Worth Street, Suite 400, Dallas, TX 75246, USA; c Department of Orthodontics, Baylor College of Dentistry, Texas A&M University Health Science Center, 3409 Worth Street, Suite 400, Dallas, TX 75246, USA * Corresponding author. E-mail address: movaheddmd@gmail.com Oral Maxillofacial Surg Clin N Am - (2014) - - http://dx.doi.org/10.1016/j.coms.2014.09.004 1042-3699/14/$ see front matter Ó 2014 Published by Elsevier Inc. oralmaxsurgery.theclinics.com 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88
2 Movahed & Wolford 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 Q10 Q11 Q16 INDICATIONS TMJ disorders and dentofacial deformities commonly coexist. The TMJ disorders may be the causative factor of the jaw deformity, or develop as a result of the jaw deformity, or the two entities may develop independently of each other. The most common TMJ disorders that can adversely affect jaw position, occlusion, and orthognathic surgical outcomes include (1) articular disc dislocation, (2) adolescent internal condylar resorption, (3) reactive arthritis, (4) condylar hyperplasia, (5) ankylosis, (6) congenital deformation or absence of the TMJ, (7) connective tissue and autoimmune diseases, (8) trauma, and (9) other end-stage TMJ disorders. 1 These TMJ conditions are often associated with dentofacial deformities, malocclusion, TMJ pain, headaches, myofascial pain, TMJ and jaw functional impairment, ear symptoms, and sleep apnea. Patients with these conditions may benefit from corrective surgical intervention, including TMJ and orthognathic surgery. Some of the aforementioned TMJ disorders may have the best outcome prognosis using custom-fitted total joint prostheses for TMJ reconstruction. Many clinicians choose to ignore the TMJ disorders and perform only orthognathic surgery for these types of cases. Clinicians who address the TMJ disorders and dentofacial deformities surgically can perform the surgery in 1 stage or 2 separate stages. The 2-stage approach requires the patient to undergo 2 separate operations and anesthesia, significantly prolonging the overall treatment. However, performing CTOS in these cases requires careful treatment planning and surgical proficiency in the two surgical areas. Using traditional model surgery and treatment planning techniques exposes the outcome to its own subset of error margin. As a result, CTOS requires experience and expertise. Over the past decade, CASS technology has been integrated into many maxillofacial surgical applications, 2,3 including dentofacial deformities, congenital deformities, defects after tumor ablation, posttraumatic defects, reconstruction of cranial defects, 4 and reconstruction of the TMJ. 5 CASS technology can improve surgical accuracy, provide intermediate and final surgical splints, and decrease surgeons time input for presurgical preparation compared with traditional methods of case preparation. 6 PROTOCOL FOR TRADITIONAL CONCOMITANT TEMPOROMANDIBULAR JOINT AND ORTHOGNATHIC SURGERY Treatment planning for CTOS cases is based on prediction tracing, clinical evaluation, and dental models, which provide the template for movements of the upper and lower jaws to establish optimal treatment outcome in relation to function, facial harmony, occlusion, and oropharyngeal airway dimensions. For patients who require total joint prostheses, a computed tomography (CT) scan is acquired of the maxillofacial region that includes the TMJs, maxilla, and mandible with 1-mm overlapping cuts. Using these CT scan data, a stereolithic model is fabricated, with the mandible as a separate piece. Using the original cephalometric tracing and prediction tracing (Fig. 1A), the mandible on the stereolithic model is placed into its future predetermined position using the planned measurements for correction of mandibular anteroposterior and vertical positions, pitch, yaw, and roll (see Fig. 1). The mandible is stabilized to the maxilla with quick-cure acrylic. Many patients Fig. 1. (A) Measurement of the cephalometric prediction tracing for the amount of open bite produced at the second molar after counterclockwise rotation of the mandible into its final position. (B) Duplication of the measurement obtained from the prediction tracing to the final mandibular position on the stereolithic model and fixating the mandible to the maxilla with methylmethacrylate. (From Movahed R, Teschke M, Wolford LM. Protocol for concomitant temporomandibular joint custom-fitted total joint reconstruction and orthognathic surgery utilizing computer-assisted surgical simulation. J Oral Maxillofac Surg 2013;71(12):2123 9; with permission.) 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202
Q1 Computer-assisted Surgical Simulation 3 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 with temporomandibular disorders requiring concomitant orthognathic surgery benefit from counterclockwise rotation of the maxillomandibular complex, which requires the development of posterior open bites on the model (see Fig. 1B). Because the mandibular position on the stereolithic models is established using hands-on measurements, the operator s manual dexterity and three-dimensional perspective play critical roles in setting the mandible in its proper and final position. This step can predispose the planning process to a certain margin of error. The next step requires the preparation of the lateral aspect of the rami and fossae (Fig 2A, B) for fabrication of the patient-fitted total joint prostheses. The goal of this step is to recontour the lateral ramus to a flat surface in the area where the mandibular component will be placed. The fossa requires recontouring only if heterotopic bone or unusual anatomy is present. The recontouring areas are marked in red for duplication of bone removal at surgery. Because most patients with TMJ problems requiring CTOS can benefit from counterclockwise rotation of the maxillomandibular complex, the stereolithic model is likely to be set with posterior open bites, because the maxilla is maintained in its original position. Once the stereolithic model is finalized, the model is sent to TMJ Concepts (Ventura, CA) to perform the design, blueprint, and wax-up of the custom-fitted total joint prostheses (see Fig. 2C), with the design and wax-up sent to the surgeon for approval before manufacture of the prostheses. The period from CT acquisition to the manufacturer s completion of the custom-fitted prostheses is approximately 8 weeks. The surgical procedures are then performed on articulator-mounted dental models. The mandible is repositioned on the articulator, duplicating the movements performed on the stereolithic model, and the intermediate splint is constructed. The maxillary model is repositioned, segmented if indicated, and placed into the maximal occlusal fit. Then, the palatal splint is constructed. PROTOCOL FOR TRADITIONAL CONCOMITANT TEMPOROMANDIBULAR JOINT AND ORTHOGNATHIC SURGERY 1. CT scan including the entire mandible, maxilla, and TMJs 2. Fabrication of stereolithic model with the mandible separated 3. Surgeon positions the mandible in its final position and fixates it 4. Removal of condyles and recontouring the lateral aspect of the rami and fossae if indicated 5. Model sent to TMJ Concepts for prostheses design, blueprint, and wax-up Fig. 2. (A) Marking the condylectomy osteotomy and the irregularities of the fossa. (B) The stereolithic model after condylectomy and recontouring of the fossae and rami (marked in red). (C) Stereolithic model with prostheses wax-up for approval by the surgeon. (From Movahed R, Teschke M, Wolford LM. Protocol for concomitant temporomandibular joint custom-fitted total joint reconstruction and orthognathic surgery utilizing computerassisted surgical simulation. J Oral Maxillofac Surg 2013;71(12):2123 9; with permission.) 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316
4 Movahed & Wolford 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 Q12 Q13 6. Approval of total joint prostheses blueprint and wax-up by the surgeon 7. Manufacture of custom-fitted total joint prostheses 8. Prostheses sent to hospital for surgical implantation STEPS IN TRADITION ORTHOGNATHIC SURGERY, AND INTERMEDIATE AND PALATAL SPLINT FABRICATION FOR CONCOMITANT TEMPOROMANDIBULAR JOINT AND ORTHOGNATHIC SURGERY 1. Acquisition of dental models 2. Mounting maxillary and mandibular dental models on an articulator 3. Repositioning the mandibular dental model, duplicating the positional changes acquired on the stereolithic model 4. Fabrication of intermediate splint 5. Repositioning maxillary dental models with segmentation if indicated 6. Construction of palatal splint 7. Ready for surgery PROTOCOL FOR CONCOMITANT TEMPOROMANDIBULAR JOINT AND ORTHOGNATHIC SURGERY USING COMPUTER-ASSISTED SURGICAL SIMULATION For CTOS cases, the orthognathic surgery is planned using Medical Modeling (Golden, CO) CASS technology and moving the maxilla and mandible into their final position in a computersimulated environment (Fig. 3A, B). Using the computer simulation, the anteroposterior and vertical positions, pitch, yaw, and roll are accurately finalized for the maxilla and mandible based on clinical evaluation, dental models, prediction tracing, and computer-simulation analysis. Using Digital Imaging and Communications in Medicine (DICOM) data, the stereolithic model is produced with the maxilla and mandible in the final position and provided to the surgeon for removal of the condyle and recontouring of the lateral rami and fossae if indicated (Fig. 4A). The stereolithic model is sent to TMJ Concepts for the design, blueprint, and wax-up of the prostheses. Using the Internet, the design is sent to the surgeon for approval. The custom-fitted total joint prostheses are then manufactured (see Fig. 4B). It takes approximately 8 weeks to manufacture the total joint custom-fitted prostheses. Approximately 2 weeks before surgery, the final dental models are produced, including 2 maxillary models if the maxilla is to be segmented or dental equilibration is required. One of the maxillary models is segmented if indicated, dental equilibration is performed, and the segments are placed in the best occlusion fit with the mandibular dentition and maxillary segments fixed to each other. The dental models do not require mounting on an articulator. The 3 or 4 models (2 maxillary and 1 mandibular, or 2 mandibular models if equilibrations are done) are sent to Medical Modeling for scanning and simulation into the computer model. Because the authors routinely perform the TMJ reconstruction and mandibular advancement with the TMJ Concepts total joint prosthesis first, the unsegmented maxillary model is simulated into the original maxillary position and the mandible is maintained in the final position. The intermediate splint is constructed (see Fig. 3B), and then the segmented maxillary model is simulated into the computer model in its final position, with the maxilla and mandible placed into the best occlusal fit, and the palatal splint is fabricated. The dental models, splints, and images of the computer-simulated surgery are sent to the surgeon for implementation during surgery. PROTOCOL OF CONCOMITANT TEMPOROMANDIBULAR JOINT AND ORTHOGNATHIC SURGERY USING COMPUTER-ASSISTED SURGICAL SIMULATION 1. CT scan of entire mandible, maxilla, and TMJs (1-mm overlapping cuts) 2. Processing of DICOM data to create a computer model in the CASS environment 3. Correction of dentofacial deformity, including final positioning of the maxilla and mandible, with computer-simulated surgery 4. Stereolithic model constructed with jaws in final position and sent to surgeon for condylectomy and rami and fossae recontouring if indicated 5. Model sent to TMJ Concepts for prostheses design, blueprint, and wax-up 6. Surgeon evaluation and approval using the Internet 7. TMJ prostheses manufactured and sent to hospital for surgical implantation 8. Two weeks before surgery, acquisition of final dental models (2 maxillary, 1 or 2 mandibular models if dental equilibrations are required); 1 maxillary model is segmented and models equilibrated if indicated to maximize the occlusal fit; models sent to Medical Modeling 9. Models incorporated into computer-simulated surgery for construction of intermediate and final palatal splints 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430
Computer-assisted Surgical Simulation 5 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 Fig. 3. Staged computer-aided surgical simulation surgical report. (A) Simulated preoperative position of the maxilla and mandible. (B) The maxilla and mandible in the simulated intermediate position, with the maxilla in its original position, but the mandible in its final position with the mandibular surgery performed first for fabrication of the intermediate splint. (C) The final position of maxilla and mandible, after advancement of mandible and segmental osteotomy of the maxilla, for the production of a palatal splint. (From Movahed R, Teschke M, Wolford LM. Protocol for concomitant temporomandibular joint custom-fitted total joint reconstruction and orthognathic surgery utilizing computer-assisted surgical simulation. J Oral Maxillofac Surg 2013;71(12):2123 9; with permission.) 10. Models, splints, and printouts of computersimulated surgery sent to surgeon Using CASS technology for CTOS cases eliminates the traditional steps requiring the surgeon to manually set the mandible into its new final position on the stereolithic model, thus saving time and improving surgical accuracy. Although dental model surgery is necessary only if the maxilla requires segmentation, the models do not require 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544
6 Movahed & Wolford 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 Fig. 4. (A) Stereolithic model fabricated after simulated maxillary and mandibular advancement to the final position. Condylectomy and recontouring of the lateral rami and fossae were performed (red) and sent to TMJ Concepts for construction of the prostheses. (B) Constructed patient-fitted TMJ prosthesis using the computer-aided surgical simulation fabricated stereolithic model. (From Movahed R, Teschke M, Wolford LM. Protocol for concomitant temporomandibular joint custom-fitted total joint reconstruction and orthognathic surgery utilizing computer-assisted surgical simulation. J Oral Maxillofac Surg 2013;71(12):2123 9; with permission.) mounting on an articulator, which saves considerable time by eliminating the time required to mount the models, prepare the model bases for model surgery, reposition the mandible, construct the intermediate occlusal splint, and make the final palatal splint. With CASS technology, the splints are manufactured by Medical Modeling. DISCUSSION Using CASS technology for CTOS cases, the surgeon superimposes the orthognathic computersimulated surgery into the production of the stereolithic model, hence decreasing the margin of error that can occur with hands-on positioning of the mandible on the stereolithic model. Furthermore, this technique decreases the time taken by the surgeon in the laboratory, by TMJ Concepts for the fabrication of prostheses, and for setting the stereolithic model with increased accuracy in the process. The remaining areas in which improvement can be made in CASS technology include performing recontouring of the rami and fossae in the simulated environment in an accurate fashion, eliminating the requirement for the acquisition of dental models by using laser scanning technology, and performing accurate maxillary segmentation and equilibration using CASS technology. Further research is necessary to achieve this goal and to move the workflow directly from the CASS environment to the fabrication of customfitted TMJ Concepts prostheses, without requiring the surgeon to have hands-on involvement in the process. Pearls 1. Combined orthognathic and total joint reconstruction cases can be predictably performed in 1 stage. 2. Use of virtual surgical planning can eliminate a significant time requirement in preparation of concomitant orthognathic and TMJ prostheses cases. 3. The CTOS-CASS technique increases the accuracy of combined cases. 4. In order to have flexibility in positioning of the total joint prosthesis, recontouring of the lateral aspect of the rami is advantageous. CASE A 32-year-old woman was diagnosed with juvenile idiopathic arthritis in grade school, had orthodontics from 15 to 17 years of age with maxillary first bicuspids extractions, and developed an open bite at age 28 years (Figs. 5 9). Over the years she was treated conservatively with occlusal splints and arthroscopic surgeries. Her myofascial pain persisted over the years and worsened before her initial consultation. The maximal incisal opening measured with pain was 36 mm and without pain was 14 mm. Excursion movements to the right were 9 mm and to the left were 10 mm. Her surgery was planned using CTOS- CASS technology: Q14 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658
Computer-assisted Surgical Simulation 7 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 Q17 Fig. 5. Frontal view, before surgery (A) and 1 year after surgery (B). 1. Bilateral TMJ reconstruction and counterclockwise rotation of the mandible with TMJ Concepts patient-fitted total joint prostheses Fig. 6. Frontal view, smiling, before surgery (A) and 1 year after surgery (B). 2. Bilateral TMJ fat grafts packed around the articulating area of the prostheses, harvested from the abdomen 3. Bilateral coronoidectomies 716 717 718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736 737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 764 765 766 767 768 769 770 771 772
8 Movahed & Wolford 773 774 775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 790 791 792 793 794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 828 829 web 4C=FPO Fig. 7. Profile view, before surgery (A) and 1 year after surgery(b). 4. Multiple maxillary osteotomies for counterclockwise rotation and advancement 5. Bilateral partial inferior turbinectomies One-year after surgery she reported no myofascial, TMJ, or headache pain and her Fig. 8. Prediction analysis before surgery (A) and after surgery (B). incisal opening improved to 50 mm. Excursion movements were 4 mm to the right and 2 mm to the left. A class I occlusion was obtained and better facial harmony was achieved. 830 831 832 833 834 835 836 837 838 839 840 841 842 843 844 845 846 847 848 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 867 868 869 870 871 872 873 874 875 876 877 878 879 880 881 882 883 884 885 886
Computer-assisted Surgical Simulation 9 887 888 889 890 891 892 893 894 895 896 897 898 899 900 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 Q15 Fig. 9. Presurgery occlusion (A C) and postsurgery occlusion 1 year after surgery (D F). REFERENCES 1. Wolford LM, Cassano DS, Goncalves JR. Common TMJ disorders: orthodontic and surgical management. In: McNamara JA, Kapila SD, editors. Temporomandibular disorders and orofacial pain: separating controversy from consensus. Craniofacial Growth Series, vol. 6. Ann Arbor (MI): University of Michigan; 2009. p. 159 98. 2. Papadopoulos MA, Christou PK, Athanasiou AE, et al. Three-dimensional craniofacial reconstruction imaging. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:382 93. 3. Xia J, Ip HH, Samman N, et al. Computer-assisted three-dimensional surgical planning and simulation: 3D virtual osteotomy. Int J Oral Maxillofac Surg 2000;29:11 7. 4. Rotaru H, Stan H, Florian I, et al. Cranioplasty with custom-made implants: analyzing the cases of 10 patients. J Oral Maxillofac Surg 2012;70:e169. 5. Gateno J, Xia J, Teichgraeber J, et al. Clinical feasibility of computer-aided surgical simulation (CASS) in the treatment of complex cranio-maxillofacial deformities. J Oral Maxillofac Surg 2007;65:728. 6. Movahed R, Teschke M, Wolford LM. Protocol for concomitant temporomandibular joint custom-fitted total joint reconstruction and orthognathic surgery utilizing computer-assisted surgical simulation. J Oral Maxillofac Surg 2013;71(12):2123 9. 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983 984
Our reference: OMC 697 P-authorquery-v9 AUTHOR QUERY FORM Journal: OMC Article Number: 697 Dear Author, Please check your proof carefully and mark all corrections at the appropriate place in the proof (e.g., by using on-screen annotation in the PDF file) or compile them in a separate list. Note: if you opt to annotate the file with software other than Adobe Reader then please also highlight the appropriate place in the PDF file. To ensure fast publication of your paper please return your corrections within 48 hours. For correction or revision of any artwork, please consult http://www.elsevier.com/artworkinstructions. Any queries or remarks that have arisen during the processing of your manuscript are listed below and highlighted by flags in the proof. Location in article Q1 Q2 Q3 Q4 Q5 Q6 Q7 Q8 Query / Remark: Click on the Q link to find the query s location in text Please insert your reply or correction at the corresponding line in the proof Please approve the short title to be used in the running head at the top of each right-hand page. This is how your name will appear on the contributor's list. Please add your academic title and any other necessary titles and professional affiliations, verify the information, and OK REZA MOVAHED, DMD, Clinical Assistant Professor, Orthodontics, Saint Louis University, Saint Louis, Missouri LARRY WOLFORD, DMD, Clinical Professor, Departments of Oral and Maxillofacial Surgery and Orthodontics, Baylor College of Dentistry, Texas A&M University Health Science Center, Dallas, Texas The following synopsis was created from the Key Points of your article, because a separate abstract was not provided. Please confirm OK, or submit a replacement (also less than 100 words). Please note that the synopsis will appear in PubMed: Combined orthognathic and total joint reconstruction cases can be predictably performed in 1 stage. Use of virtual surgical planning can eliminate a significant time requirement in preparation of concomitant orthognathic and temporomandibular joint (TMJ) prostheses cases. The concomitant TMJ and orthognathic surgeryecomputer-assisted surgical simulation technique increases the accuracy of combined cases. In order to have flexibility in positioning of the total joint prosthesis, recontouring of the lateral aspect of the rami is advantageous. Are the author names and order of authors OK as set? Please verify the affiliation addresses. Please verify that the keywords that have been added are acceptable. If they are not, please provide 3e8 keywords. As per the editorial remarks, Please verify that the Key points are correct, because they were included without a heading at the end of the manuscript. If there are any drug dosages in your article, please verify them and indicate that you have done so by initialing this query. (continued on next page)
Q9 Q10 Q11 Q12 Q13 Q14 Please verify that the headings and subheadings read as intended. Please verify that the sentence TMJ disorders and dentofacial deformities commonly coexist reads as intended. The paragraph beginning Many clinicians choose to ignore the TMJ disorders contains text repeated from earlier in the article. Please verify. Please verify that the section heading beginning Steps in tradition orthognathic surgery reads as intended. Please cite part Fig. 3C citation in the text. As per style, citations are not allowed in the section heading, hence Figs. 5e9 have been placed at the end of the first sentence of the subsequent paragraph. Please verify. Q15 Please verify the series edited book title in Ref. 1. Q16 In all credit lines that require permission, please provide the exact page numbers from which the information was taken. Q17 Please verify that the part labels A and B have been correctly assigned in Figs. 5e8. Please check this box or indicate, your approval if you have no corrections to make to the PDF file Thank you for your assistance.