Clinical Neuroscience BMS 6706C Charles, Ph.D., Course Director charles.ouimet@med.fsu.edu (850) 644-2271 2004 2005 Course Calendar Click here to return to the syllabus Meeting Hours for entire semester: Monday Friday 1-2:30 PM August 30 August 31 Course The 3D brain: introduction, Neurocytology: role of intracellular the threedimensional organelles; role of organelles specific to structure of the neurons; structure brain the function of relationships neurons glial between major cells, blood brain brain components barrier Paull August September September 1 September 2 September 3 Gross anatomy lab: spinal cord 1: spinal cord 2: threedimensional structure of the brain relationships between major brain components in brains sectioned in various planes Paull,, structure of intrinsic connections within the spinal cord; spinal cord nuclei; dorsal root ganglia; dorsal ventral roots; reflex arcs; ANS long tracts in the spinal cord with emphasis on the corticospinal tract, the anterolateral system, the dorsal columns September 6 September 7 September 8 September 9 September 10 spinal cord problem resting potential : action potential : excitability, membrane
Holiday solving imaging: properties: Brown Sequard syndrome, loss of proprioception, loss of pain temperature sensation, syringomyelia, demyelination, localization of lesions selective permeability, Nernst equation,sodium pump, Goldman equation, pacemaker potentials shape of the action potential, control of ionic conductances, voltage clamp, voltage gated channels, thresholds, trigger zones, excitability, passive membrane properties,, Trombley Trombley Trombley September 13 September 14 September 15 September 16 September 17 propagation of synaptic Medulla: synaptic transmission Pons: action potential: transmission receptors I: receptors II : myelin, electrophysiology of nerve bundles, conduction velocity, impulse conduction, conduction block synaptic transmission, synaptic potentials, acetylcholine the neuromuscular junction, inhibition, myasthenia gravis structure of medulla, cranial nerves number 9, 10, 11 12; nuclei of the medulla, long tracts through the medulla second messenger systems, indirectly gated channels, presynaptic mechanisms, quantal release, integration, transmitter criteria structure of the pons, cranial nerves number 5, 6, 7 8; nuclei of the pons, long tracts through the pons Trombley Olcese Olcese September 20 September 21 September 22 September 23 September 24 synaptic transmission receptors III: Midbrain: brainstem lab: The cerebellum: Review problem solving : survey of neurotransmitters (e.g. glutamate, GABA, acetylcholine, DA, NE, E, substance P.,NPY,) their receptors structure of the midbrain, cranial nerves number 3 4; nuclei of the midbrain, long tracts through the midbrain the cranial nerves, the structure of the brainstem, the brainstem radiologic images Olcese Paull // / Cerebellar structure function, deep cerebellar nuclei, red nucleus, cerebellar peduncles Team
September 27 Exam 1 September 28 small group 1 Team September 29 September 30 Nerve muscle: neuromuscular junction, motorneuron units, nerve muscle interactions, reflexes Meredith basal ganglia: caudate, putamen, globus pallidus, substantia nigra, nucleus subthalamicus,parkinson s, Huntington s, hemiballismus October October 1 Basal ganglia Cerebellum lab localization of cerebellar peduncles, identification of cerebellar structures Paull // / October 4 October 5 October 6 October 7 October 8 somatosensory Pain: auditory vestibular visual system: system: system: system: sensory systems in skin, muscles, tendons pathways involved in sensing pain their modulation the physiology of hearing; structure function of the ear the physiology of vestibular function; the inner ear; balance the physiology of vision; structure function of the eye; central visual pathways Meredith Berkeley Meredith Meredith Meredith October 11 October 12 October 13 October 14 October 15 olfactory system: reticular formation: limbic system: Hypothalamus limbic system lab the physiology of olfaction; structure function of the olfactory apparatus; central olfactory pathways nuclei of the reticular formation in the midbrain pons, medulla; functions connections the emotional brain including amygdala, hippocampus, septum, n. accumbens, Papez circuit hypothalamus anatomical organization of the hypothalamus ANS
Meredith Paull // / October 18 October 19 October 20 October 21 October 22 Hypothalamus Homeostasis: regulation of feeding, drinking, body temp, hormone release etc. Houpt small group 2 Team Stress the HPA: the function of the hypothalamicpituitary-adrenal axis; biology of chronic acute stress Depression: biogenic amines their pharmacology at the synapse; uptake blockers, MAOI s etc. review problem solving Houpt Houpt Team October 25 October 26 October 27 October 28 October 29 Thalamus: Cortex I: Cortex 2: Exam 2 Small group 3 structure of the thalamus fundamentals of cortical structure structure function of function of the major nuclei; connection of the major nuclei with cortical subcortical targets relationship to thalamus; prefrontal motor parietal cortex structure function temporal occipital cortex 1 Thalamus, cerebral cortex vasculature lab 2 3 4 5 Plasticity, repair regeneration: Small group 4 ability of the brain to change in response to insult Vasculature Meninges: blood supply to the brain spinal cord; thinking in terms of vascular fields; epidural, subdural subarachnoid bleeds case history review lab Paull // Houpt Paull // 8 10 11 12
Aging; brain death; normal aging, neurodegenerative disorders such as Alzheimer s disease; biological ethical considerations of brain death. 15 Development Critical periods: Major themes in development; gene regulation; induction; timelimited periods Altmann 22 Exam 3 29 Drugs of abuse: biological basis of drug abuse; cocaine, amphetamine, nicotine, alcohol etc. Kabbaj 9 Small group 5 16 Schizophrenia; dopamine theory of schizophrenia; relationship to limbic system; Tomkowiak/ veteran s day Sleep: structure of sleep meaning of brain waves during sleep; disorders of sleep such as apnea narcolepsy Olcese 17 18 19 Learning memory: Small group 6 biological basis of synaptic modification Epilepsy: etiology clinical manifestations of epilepsy review problem solving Houpt 24 25 26 23 primer on Small group neuropharmacology: Thanksgiving Thanksgiving 7 drug action at synapses axons 30 small group 8 Patrick December December 1 December 2 December 3
Levels of disconnection coma review problem solving December 6 December 7 Shelf exam Final exam