AALL1131 MAINTENANCE, ARM B, HR-ALL Properties Laboratory and Take-Home Medications 9/26/2012, Planned Laboratory and Take-Home Medications Planned for 9/26/2012 Release Take-Home Medications prednisone (DELTASONE) tablet 23 mg 20 mg/m2 1.16 m2 (Treatment plan actual BSA) = 23 mg, Oral, 2 Times Daily, Starting S As Scheduled, For 8 doses mercaptopurine (PURINETHOL) 50 mg tablet Take 2 tablets by mouth daily. Give at least 1 hour after evening meal. To be taken without milk or citrus products. Normal, R-0 Release Release Release 75 mg/m2 (87 mg = 1.74 tablet) cannot be prescribed using the selected product. The nearest available dose is 100 mg (86.2 mg/m2). mercaptopurine (PURINETHOL) 50 mg tablet Take by mouth daily. Normal, R-0 Release methotrexate 5 MG tablet Take 5 tablets by mouth once a week. Take by mouth weekly on clinic day. Omit on week of spinal tap. Normal, R-1 Release Cycle 1 9/27/2012 through 12/19/2012 (84 days), Planned Day 1, Cycle 1 Planned for 9/27/2012 Comprehensive metabolic panel Bilirubin, direct (GH L Q YH) CSF cell count with differential (L YH) 9/27/2012 3:25:35 PM Page 1 of 8
open., Starting 4 HOURS PRN, Nausea or vomiting, Starting midazolam (VERSED) injection 1.79 mg 0.05 mg/kg 35.8 kg (Treatment plan actual weight) = 1.79 mg, Intravenous, PRN, for sedation for procedure., Starting, For 3 doses fentanyl PF (SUBLIMAZE) injection 36 mcg 1 mcg/kg 35.8 kg (Treatment plan actual weight) = 36 mcg, IV Push, PRN, for sedation for procedure., Starting, For 3 doses naloxone (NARCAN) injection 0.36 mg 10 mcg/kg 35.8 kg (Treatment plan actual weight) = 0.36 mg, IV Push, PRN, Opioid Reversal, Starting, For 10 doses May repeat every 2-3 minutes. flumazenil (ROMAZICON) injection 0.358 mg 0.01 mg/kg 35.8 kg (Treatment plan actual weight) = 0.358 mg, Intravenous, PRN, for benzodiazepine reversal., Starting, For 5 doses Ordered dose of 0.01 mg/kg PRN exceeds the recommended single dose limit of 0.2 mg. lidocaine (LMX) 4 % cream Topical, PRN, for procedure sites., Starting methotrexate, hydrocortisone sodium succinate (Solu-CORTEF), cytarabine (CYTOSAR) in sodium chloride 0.9 % PF INTRATHECAL chemo injection Intrathecal, ONCE, Starting at treatment start time, For 1 dose Prepared in preservative-free 0.9% sodium chloride. Administration is by MD or other licensed oncology provider. Minutes, ONCE, Starting, For 1 dose draw/administration., Starting Day 29, Cycle 1 Planned for 10/25/2012 9/27/2012 3:25:35 PM Page 2 of 8
CSF cell count with differential (L YH) open., Starting 4 HOURS PRN, Nausea or vomiting, Starting midazolam (VERSED) injection 1.79 mg 0.05 mg/kg 35.8 kg (Treatment plan actual weight) = 1.79 mg, Intravenous, PRN, for sedation for procedure., Starting, For 3 doses fentanyl PF (SUBLIMAZE) injection 36 mcg 1 mcg/kg 35.8 kg (Treatment plan actual weight) = 36 mcg, IV Push, PRN, for sedation for procedure., Starting, For 3 doses naloxone (NARCAN) injection 0.36 mg 10 mcg/kg 35.8 kg (Treatment plan actual weight) = 0.36 mg, IV Push, PRN, Opioid Reversal, Starting, For 10 doses May repeat every 2-3 minutes. flumazenil (ROMAZICON) injection 0.358 mg 0.01 mg/kg 35.8 kg (Treatment plan actual weight) = 0.358 mg, Intravenous, PRN, for benzodiazepine reversal., Starting, For 5 doses Ordered dose of 0.01 mg/kg PRN exceeds the recommended single dose limit of 0.2 mg. lidocaine (LMX) 4 % cream Topical, PRN, for procedure sites., Starting methotrexate in sodium chloride 0.9 % 5 ml PF INTRATHECAL chemo injection Intrathecal ONCE, Starting, For 1 dose Prepared in preservative-free 0.9% sodium chloride. Administration is by MD or other licensed oncology provider. Minutes, ONCE, Starting, For 1 dose 9/27/2012 3:25:35 PM Page 3 of 8
draw/administration., Starting Day 57, Cycle 1 Planned for 11/22/2012 open., Starting 4 HOURS PRN, Nausea or vomiting, Starting Minutes, ONCE, Starting, For 1 dose draw/administration., Starting 9/27/2012 3:25:35 PM Page 4 of 8
Cycle 2 12/20/2012 through 3/13/2013 (84 days), Planned Cycle 3 3/14/2013 through 6/5/2013 (84 days), Planned Cycle 4 6/6/2013 through 8/28/2013 (84 days), Planned Cycle 5 8/29/2013 through 11/20/2013 (84 days), Planned Day 1, Cycle 5 Planned for 8/29/2013 Comprehensive metabolic panel Bilirubin, direct (GH L Q YH) CSF cell count with differential (L YH) open., Starting 4 HOURS PRN, Nausea or vomiting, Starting midazolam (VERSED) injection 1.79 mg 0.05 mg/kg 35.8 kg (Treatment plan actual weight) = 1.79 mg, Intravenous, PRN, for sedation for procedure., Starting, For 3 doses fentanyl PF (SUBLIMAZE) injection 36 mcg 1 mcg/kg 35.8 kg (Treatment plan actual weight) = 36 mcg, IV Push, PRN, for sedation for procedure., Starting, For 3 doses naloxone (NARCAN) injection 0.36 mg 10 mcg/kg 35.8 kg (Treatment plan actual weight) = 0.36 mg, IV Push, PRN, Opioid Reversal, Starting, For 10 doses May repeat every 2-3 minutes. 9/27/2012 3:25:35 PM Page 5 of 8
flumazenil (ROMAZICON) injection 0.358 mg 0.01 mg/kg 35.8 kg (Treatment plan actual weight) = 0.358 mg, Intravenous, PRN, for benzodiazepine reversal., Starting, For 5 doses Ordered dose of 0.01 mg/kg PRN exceeds the recommended single dose limit of 0.2 mg. lidocaine (LMX) 4 % cream Topical, PRN, for procedure sites., Starting methotrexate, hydrocortisone sodium succinate (Solu-CORTEF), cytarabine (CYTOSAR) in sodium chloride 0.9 % PF INTRATHECAL chemo injection Intrathecal, ONCE, Starting at treatment start time, For 1 dose Prepared in preservative-free 0.9% sodium chloride. Administration is by MD or other licensed oncology provider. Minutes, ONCE, Starting, For 1 dose draw/administration., Starting Day 29, Cycle 5 Planned for 9/26/2013 CSF cell count with differential (L YH) 9/27/2012 3:25:35 PM Page 6 of 8
open., Starting 4 HOURS PRN, Nausea or vomiting, Starting Minutes, ONCE, Starting, For 1 dose draw/administration., Starting Day 57, Cycle 5 Planned for 10/24/2013 open., Starting 4 HOURS PRN, Nausea or vomiting, Starting Minutes, ONCE, Starting, For 1 dose 9/27/2012 3:25:35 PM Page 7 of 8
draw/administration., Starting Cycle 6 11/21/2013 through 2/12/2014 (84 days), Planned Cycle 7 2/13/2014 through 5/7/2014 (84 days), Planned Cycle 8 5/8/2014 through 7/30/2014 (84 days), Planned Cycle 9 7/31/2014 through 10/22/2014 (84 days), Planned Cycle 10 10/23/2014 through 1/14/2015 (84 days), Planned Cycle 11 1/15/2015 through 4/8/2015 (84 days), Planned Cycle 12 4/9/2015 through 7/1/2015 (84 days), Planned 9/27/2012 3:25:35 PM Page 8 of 8