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- 21-211 Influenza Season Week 9 ending March 5, 211 All data are preliminary and may change as more reports are received. Synopsis: During week 9 (February 27-March 5, 211), influenza activity in the United States decreased. o Of the 7,556 specimens tested by U.S. World Health Organization (WHO) and National Respiratory and Enteric Virus Surveillance System (NREVSS) collaborating laboratories and reported to CDC/Influenza Division, 1,869 (24.7%) were positive for influenza. o The proportion of deaths attributed to pneumonia and influenza (P&I) was above the epidemic threshold for the sixth consecutive week. o Five influenza-associated pediatric deaths were reported bringing the season total to 6. Three of these deaths were associated with an influenza B virus and two were associated with an influenza A virus for which the subtype was not determined. o The proportion of outpatient visits for influenza-like illness (ILI) was 3.1%, which is above the national baseline of 2.5%. Eight of the 1 regions (Regions 1, 2, 3, 4, 5, 7, 8 and 1) reported ILI at or above region-specific baseline levels. Ten states experienced high ILI activity; 12 states experienced moderate ILI activity; nine states experienced low ILI activity; 19 states and New York City experienced minimal ILI activity, and the District of Columbia had insufficient data. o The geographic spread of influenza in 39 states was reported as widespread; nine states reported regional influenza activity; the District of Columbia and two states reported local influenza activity; Guam and the U.S. Virgin Islands reported sporadic influenza activity, and Puerto Rico did not report. National and Regional Summary of Select Surveillance Components HHS Surveillance Regions* Outpatient ILI Data for current week Data cumulative since October 3, 21 (Week 4) % positive for flu Number of jurisdictions reporting regional or widespread activity A (H3) 29 A (H1N1) A (Subtyping not performed) B Pediatric Deaths Nation Elevated 24.7% 48 of 54 13,25 7,885 9,557 1,581 6 Region 1 Elevated 47.8% 6 of 6 1,353 637 51 221 Region 2 Elevated 28.4% 2 of 4 549 251 894 228 7 Region 3 Elevated 41.% 5 of 6 2,265 2,214 78 566 9 Region 4 Elevated 21.8% 8 of 8 1,85 1,51 2,838 3,526 12 Region 5 Elevated 42.2% 6 of 6 1,385 1,126 332 843 12 Region 6 Normal 31.8% 5 of 5 2,21 439 2,92 2,33 1 Region 7 Elevated 31.8% 4 of 4 572 476 266 514 Region 8 Elevated 27.% 5 of 6 1,586 499 1,677 1,267 4 Region 9 Normal 3.% 4 of 5 1,678 778 69 1,4 6 Region 1 Elevated 26.% 3 of 4 711 414 9 82 *HHS regions (Region 1 CT, ME, MA, NH, RI, VT; Region 2: NJ, NY, Puerto Rico, U.S. Virgin Islands; Region 3: DE, DC, MD, PA, VA, WV; Region 4: AL, FL, GA, KY, MS, NC, SC, TN; Region 5: IL, IN, MI, MN, OH, WI; Region 6: AR, LA, NM, OK, TX; Region 7: IA, KS, MO, NE; Region 8: CO, MT, ND, SD, UT, WY; Region 9: AZ, CA, Guam, HI, NV; and Region 1: AK, ID, OR, WA). Elevated means the % of visits for ILI is at or above the national or region-specific baseline. National data are for current week; regional data are for the most recent three weeks. Includes all 5 states, the District of Columbia, Guam, Puerto Rico, and the U.S. Virgin Islands.

Number of Positive Specimens Percent Positive U.S. Virologic Surveillance: WHO and NREVSS collaborating laboratories located in all 5 states and Washington D.C. report to CDC the number of respiratory specimens tested for influenza and the number positive by influenza type and subtype. The results of tests performed during the current week are summarized in the table below. Week 9 No. of specimens tested 7,556 No. of positive specimens (%) 1,869 (24.7%) Positive specimens by type/subtype Influenza A 1,43 (75.1%) A (29 H1N1) 396 (28.2%) A (subtyping not performed) 51 (36.4%) A (H3) 497 (35.4%) Influenza B 466 (24.9%) All influenza types and subtypes have been identified at high levels this season and continue to circulate widely. The predominant virus has varied by week, region, and even between states within the same region. Influenza Positive Tests Reported to CDC by U.S. WHO/NREVSS Collaborating Laboratories, National Summary, 21-11 Season 55 5 45 4 35 3 A (29 H1N1) A (Unable to Subtype) A (H3) A (H1) A (Subtyping not Performed) B Percent Positive 5 4 3 25 2 2 15 1 1 5 4 42 44 46 48 5 52 2 4 6 8 1 12 14 16 18 2 Week 21-11 Influenza Season Week 9, ending March 5, 211 2

Number of Deaths Number of Hospitalizations Aggregate Hospitalization and Death Reporting Activity (AHDRA): This system tracks weekly counts of laboratory-confirmed influenza-associated hospitalizations and deaths and was implemented on August 3, 29, during the 29 pandemic, and ended on April 4, 21. AHDRA surveillance during the 21-11 season is being continued on a voluntary basis and 14 jurisdictions reported during week 9. From October 3, 21 March 5, 211, 11,79 laboratory-confirmed influenza associated hospitalizations and 183 laboratory-confirmed influenza associated deaths were reported to CDC. Weekly Laboratory-Confirmed Influenza-Associated Hospitalizations and Deaths, National Summary, 21-11 Season 2 16 12 8 4 3 25 2 15 1 5 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 Week Antigenic Characterization: CDC has antigenically characterized 1,52 influenza viruses [18 29 influenza A (H1N1) viruses, 488 influenza A (H3N2) viruses, and 384 influenza B viruses] collected by U.S. laboratories since October 1, 21. 29 Influenza A (H1N1) [18] One hundred seventy-nine (99.4%) of the 18 tested were characterized as A/California/7/29-like, the influenza A (H1N1) component of the 21-11 influenza vaccine for the Northern Hemisphere. One virus (.6%) of the 18 tested showed reduced titers with antiserum produced against A/California/7/29. Influenza A (H3N2) [488] Four hundred eighty-three (99.%) of the 488 tested were characterized as A/Perth/16/29-like, the influenza A (H3N2) component of the 21-11 influenza 21-11 Influenza Season Week 9, ending March 5, 211 3

vaccine for the Northern Hemisphere. Five viruses (1.%) of the 488 tested showed reduced titers with antiserum produced against A/Perth/16/29. Influenza B (B/Victoria/2/87 and B/Yamagata/16/88 lineages) [384] Victoria Lineage [364] Three hundred sixty-four (94.8%) of the 384 influenza B viruses tested belong to the B/Victoria lineage of viruses. o Three hundred sixty-three (99.7%) of these 364 viruses were characterized as B/Brisbane/6/28-like, the recommended influenza B component for the o 21-11 Northern Hemisphere influenza vaccine. One (.3%) of these 364 viruses showed somewhat reduced titers with antisera produced against B/Brisbane/6/28. Yamagata Lineage [2] Twenty (5.2%) of the 384 viruses were identified as belonging to the B/Yamagata lineage of viruses. Antiviral Resistance: Testing of 29 influenza A (H1N1), influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir and zanamivir) is performed at CDC using a functional assay. Additional 29 influenza A (H1N1) clinical samples are tested for a single known mutation in the neuraminidase protein of the virus that confers oseltamivir resistance (H275Y). The data summarized below combine the results of both test methods and includes samples that were tested as part of routine surveillance purposes; it does not include diagnostic testing specifically done because of clinical suspicion of antiviral resistance. High levels of resistance to the adamantanes (amantadine and rimantadine) persist among 29 influenza A (H1N1) and A (H3N2) viruses (the adamantanes are not effective against influenza B viruses) circulating globally. As a result of the sustained high levels of resistance, data from adamantane resistance testing are not presented weekly in the table below. Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 21. Resistant Resistant Virus Viruses, Virus Viruses, Samples Number (%) Samples Number (%) tested (n) tested (n) Oseltamivir Zanamivir Seasonal Influenza A (.) (.) (H1N1) Influenza A (H3N2) 44 (.) 433 (.) Influenza B 339 (.) 339 (.) 29 Influenza A (H1N1) 481 1 (.2) 162 (.) To prevent the spread of antiviral resistant virus strains, CDC reminds clinicians and the public of the need to continue hand and cough hygiene measures for the duration of any symptoms of influenza, even while taking antiviral medications. Additional information on antiviral recommendations for treatment and chemoprophylaxis of influenza virus infection is available at http://www.cdc.gov/flu/antivirals/index.htm. 21-11 Influenza Season Week 9, ending March 5, 211 4

% of All Deaths Due to P&I Pneumonia and Influenza (P&I) Mortality Surveillance: During week 9, 8.5% of all deaths reported through the 122-Cities Mortality Reporting System were due to P&I. This percentage was above the epidemic threshold of 8.% for week 9 and is the sixth consecutive week in which P&I has been at or above the epidemic threshold. 12 Pneumonia and Influenza Mortality for 122 U.S. Cities Week ending 3/5/211 1 Epidemic Threshold 8 6 Seasonal Baseline 26 27 28 29 21 211 4 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 Weeks 21-11 Influenza Season Week 9, ending March 5, 211 5

27-4 27-46 27-52 28-6 28-12 28-18 28-24 28-3 28-36 28-42 28-48 29-1 29-7 29-13 29-19 29-25 29-31 29-37 29-43 29-49 21-3 21-9 21-15 21-21 21-27 21-33 21-39 21-45 21-51 211-5 Number of deaths Influenza-Associated Pediatric Mortality: Five influenza-associated pediatric deaths were reported to CDC during week 9. Three of these deaths were associated with an influenza B virus and two were associated with an influenza A virus for which the subtype was not determined. Sixty deaths from 25 states (Arizona, Colorado, Florida, Georgia, Hawaii, Illinois, Indiana, Kentucky, Louisiana, Michigan, Minnesota, Nevada, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Pennsylvania, Texas, Utah, Virginia, West Virginia, and Wisconsin) and New York City have been reported during this influenza season. Twenty-three of the 6 deaths reported were associated with influenza B viruses, 12 deaths reported were associated with influenza A (H3) viruses, 13 were associated with 29 influenza A (H1N1) viruses, and 12 were associated with an influenza A virus for which the subtype was not determined. Number of Influenza-Associated Pediatric Deaths by Week of Death: 27-8 season to present 4 35 29-1 Number of Deaths Reported = 282 3 25 2 27-8 28-9 21-11 15 Number of Deaths Reported = 88 Number of Deaths Reported = 133 Number of Deaths Reported = 6 1 5 Week of Death Deaths Reported Previous Week Deaths Reported Current Week Influenza-Associated Hospitalizations: FluSurv-NET conducts population-based surveillance for laboratory-confirmed influenza-associated hospitalizations in children (persons younger than 18 years) and adults. The current network covers over 8 counties in the 1 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and six additional states (ID, MI, OH, OK, RI, and UT). The current season s rates include cases from October 1, 21 to March 5, 211. 21-11 Influenza Season Week 9, ending March 5, 211 6

Cumulative Rate per 1, Cumulative Rate per 1, Cumulative Rate per 1, Cumulative Rate per 1, Cumulative Rate per 1, Cumulative Rate per 1, FluSurv-NET* Laboratory-Confirmed Cumulative Hospitalization Rates (per 1,), 21-11 Season EIP* Laboratory-Confirmed Cumulative Hospitalization Rates (per 1,), 21-11 Season 8 8 7 6 5 Age Group -4-4 yr 5-17 yr 18-49 yr 5-64 yr 65+ 65+ yr Total All Ages Case Counts Rates (per 1,) 667 32.6 31 6.1 169 7.9 782 14.8 1275 38.9 494 14.1 7 6 5 Age Group -4-4 yr 5-17 yr 18-49 yr 5-64 yr 65+ 65+ yr Total All Ages Case Counts Rates (per 1,) 424 26. 26 5.2 798 7.3 577 13.3 97 36.4 2975 12.6 4 4 3 3 2 2 1 1 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 September October November December January February March April MMWR Week *FluSurv-NET results include surveillance at EIP sites and at sites in six additional states (ID, MI, OH, OK, RI, UT) September October November December January February March April MMWR Week *EIP results represent surveillance in the 1 EIP states (CA, CO, CT, GA, MD, MN, NM, NY, OR, TN) FluSurv-NET* Laboratory-Confirmed Cumulative Hospitalization Rates (per 1,), 29-1 Season EIP* Laboratory-Confirmed Cumulative Hospitalization Rates (per 1,), 29-1 Season 8 8 7 7 6 6 5 4 3 Age Group -4 5-17 18-49 5-64 65+ Total 5 4 3 Age Group -4 5-17 18-49 5-64 65+ Total 2 2 1 1 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 September October November December January February March April MMWR Week *FluSurv-NET results include surveillance at EIP sites and at sites in six additional states (IA, ID, MI, ND, OK, SD) September October November December January February March April MMWR Week *EIP results represent surveillance in the 1 EIP states (CA, CO, CT, GA, MD, MN, NM, NY, OR, TN) 8 EIP* Laboratory-Confirmed Cumulative Hospitalization Rates (per 1,), 27-8 Season 8 EIP* Laboratory-Confirmed Cumulative Hospitalization Rates (per 1,), 28-9 Season 7 7 6 6 5 4 3 2 Age Groups -4 5-17 18-49 5-64 65+ Total 5 4 3 2 Age Groups -4 5-17 18-49 5-64 65+ Total 1 1 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 September October November December January February March April MMWR Week *EIP results represent surveillance in the 1 EIP states (CA, CO, CT, GA, MD, MN, NM, NY, OR, TN) 35 36 37 38 39 4 41 42 43 44 45 46 47 48 49 5 51 52 1 2 3 4 5 6 7 8 9 1 11 12 13 14 15 16 17 18 September October November December January February March April MMWR Week *EIP results represent surveillance in the 1 EIP states (CA, CO, CT, GA, MD, MN, NM, NY, OR, TN) Please note the following: (i) The scale of the vertical axis on the Cumulative Hospitalization Rate figures will be adjusted during the season to make the graphs easier to read; (ii) FluSurv-NET was created during the 29-21 season when surveillance in six states was added to ongoing surveillance for influenza-associated hospitalizations in1 EIP states. During the 29-21 season, FluSurv-NET included sites in the 1 EIP sites and sites in IA, ID, MI, ND, OK, and SD; (iii) the 28-29 EIP season ended April 14, 29, due to the onset of the 29 H1N1 pandemic. 21-11 Influenza Season Week 9, ending March 5, 211 7

Medical Condition Selected underlying medical conditions 1 in patients hospitalized with influenza, FluSurv-NET 21-211 2 Asthma 18.8% 21.% Cardiovascular disease 5.% 34.% Chronic lung disease 5.% 2.6% Immune suppression 4.1% 12.% Metabolic disorder Neurologic disease 3.4% 4.6% 6.4% 33.6% Obesity.9% 12.6% Pregnancy Renal disease.9% 1.4% 5.9% 14.3% Pediatric Patients (n=436) Adult Patients (n=1312) No known condition 15.9% 49.1% % 1% 2% 3% 4% 5% 6% Percentage 1 Asthma may include a diagnosis of asthma and reactive airway disease; Cardiovascular diseases may include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, pulmonary hypertension, and aortic stenosis; Chronic lung diseases may include conditions such as bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression may include conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications; Metabolic disorders may include conditions such as diabetes mellitus, thyroid dysfunction, adrenal insufficiency, and liver disease; Neurologic diseases may include conditions such as seizure disorders, neuromuscular disorders, and cognitive dysfunction; Obesity was defined as a body mass index (BMI) greater than 3 kg/m 2 in patients 2 years of age or older, or equal to or greater than the 95 th percentile of a patient s age and sex category in patients under 2 years of age; Renal diseases may include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance. 2 Data as of March 8, 211. Includes 1,748 (of a total 4,19 reported) cases for which data collection has been completed through the medical chart review stage. 21-11 Influenza Season Week 9, ending March 5, 211 8

Demographic and clinical characteristics of laboratory-confirmed, influenzaassociated hospitalizations identified in EIP 1 and FluSurv-NET 2 sites, 26-211 21-211 FluSurv-NET 3 N (%) 29-21 FluSurv-NET N (%) 28-29 EIP N (%) 27-28 EIP N (%) 26-27 EIP N (%) Total Cases 4,19 7,517 1,698 3,93 1,279 Age in Years -4 67 (16.3) 1,326 (17.6) 549 (32.3) 639 (16.3) 393 (3.7) 5-17 31 (7.3) 1,24 (16.) 244 (14.4) 221 (5.6) 13 (1.2) 18-49 1,72 (26.1) 2,779 (37.) 374 (22.) 736 (18.7) 246 (19.2) 5-64 784 (19.1) 1,458 (19.4) 21 (11.8) 585 (14.9) 155 (12.1) 65+ 1,279 (31.1) 75 (1.) 33 (19.4) 1,749 (44.5) 355 (27.8) Sex Male 1,93 (46.3) 3,517 (46.8) 832 (49.) 1,825 (46.4) 631 (49.3) Female 2,197 (53.5) 4, (53.2) 866 (51.) 2,14 (53.5) 648 (5.7) Flu Type and Subtype Influenza A 3,369 (82.) 7,355 (97.8) 1,236 (72.8) 2,562 (65.2) 1,82 (84.6) Specimens subtyped 4 722 5,325 -- -- -- A (H1) (.) (.) -- -- -- A (H3) 52 (69.5) 3 (.1) -- -- -- A (29 H1N1) 22 (3.5) 5,322 (99.9) -- -- -- Influenza B 61 (14.8) 52 (.7) 382 (22.5) 1,199 (3.5) 149 (11.6) Intensive Care Unit 291 (16.6) 1,56 (2.8) 298 (17.6) 495 (12.6) 198 (15.5) Mechanical Ventilation 125 (7.2) 758 (1.1) 157 (9.2) 252 (6.4) 111 (8.7) Diagnosis of Pneumonia 453 (25.9) 2,84 (37.3) 47 (24.) 1,22 (31.) 44 (31.6) Died 34 (1.9) 222 (3.) 49 (2.9) 14 (2.6) 24 (1.9) Columns may not sum to 1% due to missing or unknown values. 1 Surveillance in EIP states (CA, CO, CT, GA, MD, MN, NM, NY, OR, TN) was conducted from 26-211. 2 FluSurv-Net includes surveillance at EIP sites and at sites in additional states (IA, ID, MI, ND, OK, SD in 29-21; ID, MI, OH, OK, RI, UT in 21-211). 3 Data as of March 8, 211. Results describing influenza A subtype, intensive care unit admission, mechanical ventilation, diagnosis of pneumonia, and death are from 1,748 (of a total 4,19 reported) cases for which data collection has been completed through the medical chart review stage. 4 Influenza A subtype results are available beginning with the 27-28 season. Percentages for influenza A subtypes are calculated using the number of influenza A specimens that were subtyped as a denominator. 21-11 Influenza Season Week 9, ending March 5, 211 9

% of Visits for ILI Outpatient Illness Surveillance: Nationwide during week 9, 3.1% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.5%. Percentage of Visits for Influenza-like Illness (ILI) Reported by the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet), Weekly National Summary, September 3, 27 March 5, 211 9 8 7 6 5 4 3 2 1 Week % ILI National Baseline On a regional level, the percentage of outpatient visits for ILI ranged from 1.8% to 4.8% during week 9. Eight of the 1 regions (Regions 1, 2, 3, 4, 5, 7, 8 and 1) reported ILI at or above regionspecific baseline levels. 21-11 Influenza Season Week 9, ending March 5, 211 1

% of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI % of Visits for ILI Region 1 - CT, ME, MA, NH, RI, VT Region 6 - AR, LA, NM, OK, TX 1 14 8 12 1 6 8 4 6 2 4 2 284 285 291 292 293 294 295 Week 211 212 213 214 215 284 285 291 292 293 294 295 Week 211 212 213 214 215 Region 2 - NJ, NY, USVI Region 7 - IA, KS, MO, NE 1 12 8 1 6 8 6 4 4 2 2 284 285 291 292 293 294 295 Week 211 212 213 214 215 284 285 291 292 293 294 295 Week 211 212 213 214 215 Region 3 - DE, DC, MD, PA, VA, WV Region 8 - CO, MT, ND, SD, UT, WY 12 12 1 1 8 8 6 6 4 4 2 2 284 285 291 292 293 294 295 Week 211 212 213 214 215 284 285 291 292 293 294 295 Week 211 212 213 214 215 Region 4 - AL, FL, GA, KY, MS, NC, SC, TN Region 9 - AZ, CA, HI, NV 8 8 6 6 4 4 2 2 284 285 291 292 293 294 295 211 212 Week Region 5 - IL, IN, MI, MN, OH, WI 213 214 215 284 285 291 292 293 294 295 Week 211 212 213 Region 1 - AK, ID, OR, WA 214 215 1 1 8 8 6 6 4 4 2 2 284 285 291 292 293 294 295 Week 211 212 213 214 215 284 285 291 292 293 294 295 Week 211 212 213 214 215 NOTE: Scales differ between regions % ILI *Use of the regional baselines for state data is not appropriate. Baseline* 21-11 Influenza Season Week 9, ending March 5, 211 11

ILINet State Activity Indicator Map: Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during spring and fall weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than the average. Because the clinical definition of ILI is very general, not all ILI is caused by influenza; however, when combined with laboratory data, the information on ILI activity provides a clear picture of influenza activity in the United States. During week 9, the following ILI activity levels were experienced: Ten states (Alabama, Alaska, Arkansas, Idaho, Indiana, Nevada, New Mexico, Texas, Virginia, and West Virginia) experienced high ILI activity. Twelve states (California, Colorado, Hawaii, Louisiana, Missouri, Nebraska, North Dakota, Oklahoma, South Carolina, South Dakota, Tennessee, and Wisconsin) experienced moderate ILI activity. Nine states (Georgia, Illinois, Kansas, Kentucky, Massachusetts, New Jersey, North Carolina, Rhode Island, and Wyoming) experienced low ILI activity. Minimal ILI activity was experienced by New York City and 19 states (Arizona, Connecticut, Delaware, Florida, Iowa, Maine, Maryland, Michigan, Minnesota, Mississippi, Montana, New Hampshire, New York, Ohio, Oregon, Pennsylvania, Utah, Vermont, and Washington). The District of Columbia had insufficient data to calculate an activity level. Interactive web tool available at: http://gis.cdc.gov/grasp/fluview/main.html *This map uses the proportion of outpatient visits to health care providers for influenza-like illness to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels. Data collected in ILINet may disproportionately represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state. Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map are based on reports from state and territorial epidemiologists. The data presented in this map is preliminary and may change as more data is received. Differences in the data presented by CDC and state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete. 21-11 Influenza Season Week 9, ending March 5, 211 12

Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists: The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity. During week 9, the following influenza activity was reported: Widespread influenza activity was reported by 39 states (Alaska, Arizona, California, Colorado, Connecticut, Delaware, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Mexico, New York, North Dakota, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, South Dakota, Texas, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming). Regional influenza activity was reported by nine states (Alabama, Arkansas, Florida, Hawaii, Kentucky, Mississippi, New Jersey, North Carolina, and Tennessee). Local influenza activity was reported by the District of Columbia and two states (Oregon and Utah). Sporadic influenza activity was reported by Guam and the U.S. Virgin Islands. Puerto Rico did not report. 21-11 Influenza Season Week 9, ending March 5, 211 13

Additional National and International Influenza Surveillance Information Distribute Project: Additional information on the Distribute syndromic surveillance project, developed and piloted by the International Society for Disease Surveillance (ISDS) now working in collaboration with CDC, to enhance and support Emergency Department (ED) surveillance, is available at http://isdsdistribute.org/. Google Flu Trends: Google Flu Trends uses aggregated Google search data in a model created in collaboration with CDC to estimate influenza activity in the U.S. For more information and activity estimates from the U.S. and worldwide, see http://www.google.org/flutrends/. Europe: for the most recent influenza surveillance information from Europe, please see WHO/Europe at http://www.euroflu.org/index.php and visit the European Centre for Disease Prevention and Control at http://ecdc.europa.eu/en/activities/surveillance/eisn/pages/home.aspx. Public Health Agency of Canada: The most up to date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/. World Health Organization FluNet: Additional influenza surveillance information from participating WHO member nations is available at http://gamapserver.who.int/globalatlas/home.asp. A description of surveillance methods is available at: http://www.cdc.gov/flu/weekly/overview.htm Report prepared: March 11, 211. 21-11 Influenza Season Week 9, ending March 5, 211 14

WHO Collaborating Laboratory Reports 21-11 Influenza Season Update: Friday, March 11, 211 Summary for All Regions No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type/Subtype Week Laboratories Tested for Influenza A(H1) A(H3) AH1SWINE AUNSUB A-Unk B 214 128 3682 82 ( 2.23 ) 21 9 29 23 2141 128 457 123 ( 3.3 ) 35 14 43 31 2142 127 4171 135 ( 3.24 ) 33 7 53 42 2143 124 4214 163 ( 3.87 ) 53 14 47 49 2144 127 4652 242 ( 5.2 ) 64 11 68 99 2145 127 546 336 ( 6.22 ) 66 14 94 162 2146 126 5655 477 ( 8.44 ) 115 23 19 23 2147 125 5495 563 ( 1.25 ) 136 12 156 259 2148 126 5777 586 ( 1.14 ) 171 32 13 253 2149 123 5677 761 ( 13.4 ) 297 43 125 296 215 123 6984 1354 ( 19.39 ) 52 83 271 498 2151 124 7326 1848 ( 25.23 ) 696 93 425 634 2152 123 831 2156 ( 25.94 ) 861 185 498 612 2111 125 9535 2428 ( 25.46 ) 145 39 533 541 2112 123 953 2812 ( 29.59 ) 199 527 628 558 2113 125 1232 3441 ( 33.63 ) 1267 797 699 678 2114 122 11614 497 ( 35.28 ) 1367 992 854 884 2115 119 12346 4497 ( 36.42 ) 1338 1113 122 124 2116 116 13164 4673 ( 35.5 ) 1333 125 172 163 2117 115 14336 4993 ( 34.83 ) 1286 1196 137 124 2118 17 11571 3592 ( 31.4 ) 923 81 884 975 2119 85 7556 1869 ( 24.74 ) 497 396 51 466 Totals 2668 171263 41228 ( 24.7 ) 1325 7885 9557 1581 21-11 Influenza Season Week 9, ending March 5, 211 15

WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 1 (CT, ME, MA, NH, RI, VT) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 1 11 1 (.99 ) 1 2141 1 97 1 ( 1.3 ) 1 2142 1 125 1 (.8 ) 1 2143 1 133 4 ( 3.1 ) 3 1 2144 1 125 2 ( 1.6 ) 2 2145 1 13 1 (.97 ) 1 2146 1 128 5 ( 3.91 ) 5 2147 1 127 4 ( 3.15 ) 4 2148 1 164 5 ( 3.5 ) 3 2 2149 1 174 26 ( 14.94 ) 26 215 1 183 28 ( 15.3 ) 26 1 1 2151 1 22 51 ( 25.25 ) 45 2 4 2152 1 263 117 ( 44.49 ) 14 1 3 2111 1 367 153 ( 41.69 ) 129 15 1 8 2112 1 374 141 ( 37.7 ) 11 25 6 2113 9 44 22 ( 5. ) 137 45 2 18 2114 9 49 171 ( 41.81 ) 14 46 1 2 2115 9 486 229 ( 47.12 ) 146 62 3 18 2116 8 517 255 ( 49.32 ) 123 12 5 25 2117 8 694 345 ( 49.71 ) 149 136 1 5 2118 8 641 324 ( 5.55 ) 152 118 2 34 2119 6 476 196 ( 41.18 ) 83 71 9 33 Totals 27 6293 2262 ( 35.94 ) 1353 637 51 221 HHS Region 2 (NJ, NY) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 11 322 4 ( 1.24 ) 1 3 2141 1 281 2 (.71 ) 1 1 2142 11 339 2 (.59 ) 2 2143 1 293 4 ( 1.37 ) 2 2 2144 12 385 1 ( 2.6 ) 8 1 1 2145 11 441 14 ( 3.17 ) 9 5 2146 12 465 27 ( 5.81 ) 15 12 2147 12 572 31 ( 5.42 ) 12 18 1 2148 12 473 21 ( 4.44 ) 6 14 1 2149 11 325 26 ( 8. ) 11 3 11 1 215 11 433 43 ( 9.93 ) 2 4 17 2 2151 11 426 69 ( 16.2 ) 33 1 28 7 21-11 Influenza Season Week 9, ending March 5, 211 16

HHS Region 2 (NJ, NY) WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 2152 11 537 115 ( 21.42 ) 59 1 52 3 2111 11 621 131 ( 21.1 ) 59 11 55 6 2112 1 561 128 ( 22.82 ) 57 16 46 9 2113 1 562 122 ( 21.71 ) 43 24 47 8 2114 11 628 174 ( 27.71 ) 39 34 8 21 2115 11 686 216 ( 31.49 ) 53 37 9 36 2116 1 721 219 ( 3.37 ) 52 39 93 35 2117 11 758 225 ( 29.68 ) 39 34 114 38 2118 1 685 199 ( 29.5 ) 19 31 114 35 2119 1 544 14 ( 25.74 ) 1 16 91 23 Totals 239 1158 1922 ( 17.38 ) 549 251 894 228 HHS Region 3 (DE, DC, MD, PA, VA, WV) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 11 465 6 ( 1.29 ) 3 1 2 2141 11 419 1 (.24 ) 1 2142 11 478 4 (.84 ) 2 2 2143 11 49 3 (.61 ) 3 2144 1 48 8 ( 1.67 ) 4 2 2 2145 11 546 1 ( 1.83 ) 3 7 2146 11 58 25 ( 4.31 ) 12 8 5 2147 11 4 13 ( 3.25 ) 8 2 2 1 2148 12 57 28 ( 5.52 ) 18 4 1 5 2149 12 54 41 ( 8.13 ) 28 5 4 4 215 12 582 79 ( 13.57 ) 47 19 6 7 2151 12 614 117 ( 19.6 ) 75 19 9 14 2152 12 8 22 ( 25.25 ) 115 48 21 18 2111 12 959 245 ( 25.55 ) 126 68 3 21 2112 12 176 365 ( 33.92 ) 171 13 36 28 2113 12 127 534 ( 42.5 ) 235 24 51 44 2114 13 1529 731 ( 47.81 ) 285 33 77 39 2115 12 168 796 ( 47.38 ) 265 379 94 58 2116 11 1718 836 ( 48.66 ) 31 351 98 77 2117 11 1847 84 ( 45.48 ) 267 333 142 98 2118 1 1226 68 ( 49.59 ) 22 236 59 111 2119 1 192 261 ( 23.9 ) 85 68 73 35 Totals 25 19262 5753 ( 29.87 ) 2265 2214 78 566 21-11 Influenza Season Week 9, ending March 5, 211 17

WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 4 (AL, FL, GA, KY, MS, NC, SC, TN) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 24 768 39 ( 5.8 ) 3 2 16 18 2141 24 98 62 ( 6.83 ) 4 4 33 21 2142 23 916 85 ( 9.28 ) 12 44 29 2143 24 997 88 ( 8.83 ) 18 2 31 37 2144 24 1155 151 ( 13.7 ) 21 2 48 8 2145 24 1412 241 ( 17.7 ) 19 3 71 148 2146 24 1692 299 ( 17.67 ) 31 7 61 2 2147 23 1818 368 ( 2.24 ) 29 7 14 228 2148 23 1637 315 ( 19.24 ) 35 11 72 197 2149 22 1615 34 ( 18.82 ) 3 16 47 211 215 22 2197 543 ( 24.72 ) 62 21 111 349 2151 22 226 64 ( 28.32 ) 68 18 155 399 2152 22 2295 563 ( 24.53 ) 71 46 13 316 2111 23 2315 53 ( 22.89 ) 92 73 152 213 2112 23 1949 485 ( 24.88 ) 67 96 171 151 2113 25 1899 489 ( 25.75 ) 9 13 146 123 2114 2 261 574 ( 27.85 ) 89 123 25 157 2115 2 2541 715 ( 28.14 ) 96 155 28 184 2116 2 2639 723 ( 27.4 ) 13 138 316 166 2117 2 2857 689 ( 24.12 ) 77 19 356 147 2118 2 2254 455 ( 2.19 ) 47 61 239 18 2119 12 794 142 ( 17.88 ) 21 27 5 44 Totals 484 38979 85 ( 21.81 ) 185 151 2838 3526 HHS Region 5 (IL, IN, MI, MN, OH, WI) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 13 317 4 ( 1.26 ) 4 2141 13 327 1 ( 3.6 ) 8 2 2142 13 37 2 (.65 ) 1 1 2143 12 353 5 ( 1.42 ) 5 2144 14 359 6 ( 1.67 ) 5 1 2145 14 361 11 ( 3.5 ) 9 1 1 2146 13 34 14 ( 4.12 ) 1 4 2147 13 326 2 ( 6.13 ) 17 1 2 2148 12 367 32 ( 8.72 ) 26 1 5 2149 12 41 42 ( 1.24 ) 33 3 1 5 215 12 394 56 ( 14.21 ) 36 11 3 6 2151 13 45 114 ( 25.33 ) 7 21 9 14 21-11 Influenza Season Week 9, ending March 5, 211 18

WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 5 (IL, IN, MI, MN, OH, WI) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 2152 13 568 198 ( 34.86 ) 15 43 1 4 2111 14 77 24 ( 33.95 ) 19 7 9 52 2112 14 823 314 ( 38.15 ) 122 15 3 57 2113 14 947 47 ( 42.98 ) 14 137 58 72 2114 14 959 428 ( 44.63 ) 114 165 44 15 2115 13 923 412 ( 44.64 ) 125 131 47 19 2116 12 939 47 ( 43.34 ) 116 139 42 11 2117 12 961 386 ( 4.17 ) 125 133 25 13 2118 9 683 317 ( 46.41 ) 115 98 7 97 2119 1 643 261 ( 4.59 ) 9 61 44 66 Totals 279 12464 3686 ( 29.57 ) 1385 1126 332 843 HHS Region 6 (AR, LA, NM, OK, TX) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 17 586 4 (.68 ) 4 2141 17 699 12 ( 1.72 ) 8 2 2 2142 18 68 13 ( 1.91 ) 4 1 3 5 2143 18 653 18 ( 2.76 ) 4 1 8 5 2144 17 694 15 ( 2.16 ) 2 8 5 2145 18 916 17 ( 1.86 ) 5 7 5 2146 18 9 31 ( 3.44 ) 4 16 11 2147 18 767 34 ( 4.43 ) 6 1 18 9 2148 18 953 46 ( 4.83 ) 11 3 24 8 2149 16 686 63 ( 9.18 ) 18 1 18 26 215 17 1 22 ( 2.2 ) 64 2 66 7 2151 17 11 274 ( 24.91 ) 78 2 85 19 2152 17 147 334 ( 22.72 ) 83 3 122 126 2111 17 1798 467 ( 25.97 ) 171 9 153 134 2112 16 1747 536 ( 3.68 ) 175 2 186 155 2113 17 213 69 ( 32.81 ) 219 43 212 216 2114 16 2254 837 ( 37.13 ) 299 37 26 295 2115 16 223 899 ( 4.31 ) 265 78 254 32 2116 16 2224 81 ( 36.42 ) 218 78 231 283 2117 16 239 925 ( 38.7 ) 248 9 277 31 2118 15 1659 473 ( 28.51 ) 11 42 151 179 2119 1 917 182 ( 19.85 ) 38 28 41 75 Totals 365 28426 6882 ( 24.21 ) 221 439 292 233 21-11 Influenza Season Week 9, ending March 5, 211 19

WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 7 (IA, KS, MO, NE) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 8 229 (. ) 2141 7 245 (. ) 2142 7 241 2 (.83 ) 2 2143 7 272 1 (.37 ) 1 2144 6 26 3 ( 1.15 ) 1 1 1 2145 6 285 (. ) 2146 5 273 2 (.73 ) 2 2147 5 242 2 (.83 ) 1 1 2148 6 277 8 ( 2.89 ) 1 3 2 2 2149 7 324 14 ( 4.32 ) 2 1 9 2 215 6 325 43 ( 13.23 ) 15 6 15 7 2151 6 336 54 ( 16.7 ) 24 5 19 6 2152 6 394 69 ( 17.51 ) 23 6 33 7 2111 6 43 89 ( 22.8 ) 43 13 16 17 2112 6 53 164 ( 32.6 ) 51 45 37 31 2113 6 495 174 ( 35.15 ) 5 46 27 51 2114 6 674 253 ( 37.54 ) 68 9 24 71 2115 6 571 237 ( 41.51 ) 59 84 24 7 2116 7 65 26 ( 34.5 ) 68 59 17 62 2117 7 579 225 ( 38.86 ) 74 55 15 81 2118 7 567 18 ( 31.75 ) 64 36 15 65 2119 6 45 12 ( 22.67 ) 28 26 1 38 Totals 139 855 1828 ( 21.38 ) 572 476 266 514 HHS Region 8 (CO, MT, ND, SD, UT, WY) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 15 395 6 ( 1.52 ) 2 3 1 2141 16 445 13 ( 2.92 ) 7 3 3 2142 15 444 3 (.68 ) 3 2143 14 476 13 ( 2.73 ) 4 5 3 1 2144 15 523 27 ( 5.16 ) 15 2 8 2 2145 15 625 27 ( 4.32 ) 16 2 8 1 2146 14 524 43 ( 8.21 ) 27 3 13 2147 14 62 53 ( 8.55 ) 4 1 8 4 2148 16 646 68 ( 1.53 ) 47 4 12 5 2149 15 771 135 ( 17.51 ) 9 13 3 2 215 15 866 28 ( 24.2 ) 148 8 49 3 2151 15 92 325 ( 35.33 ) 191 11 11 13 21-11 Influenza Season Week 9, ending March 5, 211 2

WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 8 (CO, MT, ND, SD, UT, WY) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 2152 15 113 32 ( 31.59 ) 177 1 114 19 2111 15 1147 274 ( 23.89 ) 138 17 93 26 2112 15 1118 266 ( 23.79 ) 19 28 97 32 2113 15 1253 369 ( 29.45 ) 126 59 12 64 2114 16 1437 46 ( 28.25 ) 117 48 164 77 2115 15 1631 462 ( 28.33 ) 12 59 154 147 2116 15 183 534 ( 29.62 ) 89 69 173 23 2117 13 2172 636 ( 29.28 ) 65 64 236 271 2118 13 2173 567 ( 26.9 ) 46 71 175 275 2119 11 1135 274 ( 24.14 ) 3 22 11 121 Totals 322 22137 529 ( 22.72 ) 1586 499 1677 1267 HHS Region 9 (AZ, CA, HI, NV) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 13 311 16 ( 5.14 ) 8 5 2 1 2141 14 429 22 ( 5.13 ) 6 5 4 7 2142 13 445 23 ( 5.17 ) 9 5 3 6 2143 13 343 21 ( 6.12 ) 9 6 2 4 2144 13 48 17 ( 3.54 ) 5 4 1 7 2145 12 482 13 ( 2.7 ) 4 2 7 2146 13 555 25 ( 4.5 ) 6 1 1 17 2147 13 459 28 ( 6.1 ) 13 2 13 2148 12 511 53 ( 1.37 ) 15 4 4 3 2149 12 62 18 ( 17.42 ) 58 1 4 45 215 12 755 144 ( 19.7 ) 78 11 3 52 2151 12 778 185 ( 23.78 ) 11 13 9 62 2152 11 71 224 ( 31.95 ) 115 15 16 78 2111 11 918 244 ( 26.58 ) 135 26 24 59 2112 11 956 331 ( 34.62 ) 191 37 21 82 2113 11 89 354 ( 39.78 ) 167 82 32 73 2114 11 165 382 ( 35.87 ) 164 79 48 91 2115 11 1133 41 ( 36.19 ) 154 91 69 96 2116 11 132 481 ( 36.44 ) 164 143 83 91 2117 11 1354 512 ( 37.81 ) 136 16 118 98 2118 1 145 281 ( 26.89 ) 84 55 82 6 2119 7 889 195 ( 21.93 ) 56 35 79 25 Totals 257 16439 469 ( 24.75 ) 1678 778 69 14 21-11 Influenza Season Week 9, ending March 5, 211 21

WHO Collaborating Laboratory Reports 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 1 (AK, ID, OR, WA) No. of No. of No. (%) of Positive specimens by CDC Reporting Specimens Specimens Positive Type / Subtype Week Laboratories Tested for Influenza A(H1) AH3 AH1SWINE AUNSUB AUNK B 214 6 188 2 ( 1.6 ) 1 1 2141 6 27 (. ) 2142 6 196 (. ) 2143 5 24 6 ( 2.94 ) 5 1 2144 6 191 3 ( 1.57 ) 2 1 2145 6 235 2 (.85 ) 1 1 2146 6 198 6 ( 3.3 ) 5 1 2147 6 164 1 ( 6.1 ) 7 1 2 2148 5 242 1 ( 4.13 ) 9 1 2149 6 248 2 (.81 ) 1 1 215 6 249 8 ( 3.21 ) 6 1 1 2151 6 24 19 ( 7.92 ) 11 1 1 6 2152 6 269 14 ( 5.2 ) 9 3 2 2111 6 3 55 ( 18.33 ) 43 7 5 2112 6 396 82 ( 2.71 ) 46 25 4 7 2113 6 49 1 ( 24.45 ) 6 27 4 9 2114 6 598 141 ( 23.58 ) 88 4 5 8 2115 6 465 121 ( 26.2 ) 73 37 7 4 2116 6 678 22 ( 29.79 ) 9 87 14 11 2117 6 724 21 ( 29.1 ) 16 82 14 8 2118 5 638 188 ( 29.47 ) 93 62 22 11 2119 3 616 116 ( 18.83 ) 56 42 12 6 Totals 126 7655 1297 ( 16.94 ) 711 414 9 82 21-11 Influenza Season Week 9, ending March 5, 211 22

PNEUMONIA AND INFLUENZA MORTALITY (Reported from 122 U.S. Cities) For the Week Ending March 5, 211 (Week 9) YEAR WEEK % OF DEATHS EXPECTED THRESH. TOTAL DEATHS PNEUMONIA DEATHS INFLUENZA DEATHS 21 4 6.47 6.19 6.6 195 78 1 21 41 6.42 6.26 6.67 1366 665 21 42 6.44 6.33 6.75 11269 725 1 21 43 6.43 6.41 6.83 1123 717 3 21 44 6.65 6.5 6.91 11115 739 21 45 7.1 6.59 7.1 1321 723 1 21 46 6.43 6.69 7.1 1156 74 21 47 6.4 6.79 7.2 8543 516 21 48 6.47 6.88 7.3 12299 796 21 49 6.86 6.98 7.39 12578 86 3 21 5 6.78 7.7 7.49 1229 813 3 21 51 7.38 7.16 7.58 9655 712 1 21 52 7.19 7.25 7.66 963 687 3 211 1 7.68 7.33 7.74 13341 119 6 211 2 7.43 7.4 7.81 12385 913 7 211 3 7.5 7.46 7.87 12153 94 7 211 4 8.43 7.51 7.93 1222 17 7 211 5 8.1 7.56 7.97 11817 933 14 211 6 8.89 7.59 8. 12147 148 32 211 7 8.23 7.61 8.2 12466 16 2 211 8 7.95 7.62 8.3 12444 957 32 211 9 8.52 7.61 8.3 12137 1 34 21-11 Influenza Season Week 9, ending March 5, 211 23

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary for All Regions National Baseline: 2.5% CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 1811 742448 8422 1.134 1.111 2141 1855 745544 932 1.25 1.242 2142 1883 774864 9678 1.249 1.261 2143 196 78547 9917 1.263 1.258 2144 1925 765527 115 1.443 1.441 2145 1915 767542 1183 1.538 1.526 2146 1898 78399 13332 1.72 1.626 2147 1911 6331 1253 1.999 1.846 2148 194 768282 13912 1.811 1.724 2149 195 736531 14872 2.19 1.884 215 1884 71947 1852 2.572 2.364 2151 187 585869 249 3.422 3.123 2152 1853 589835 2176 3.421 3.136 2111 1882 74146 19892 2.684 2.534 2112 1878 7526 2597 2.92 2.919 2113 196 73787 2575 3.49 3.449 2114 1885 784614 31474 4.11 4.179 2115 189 752964 33688 4.474 4.66 2116 1852 779397 33465 4.294 4.553 2117 176 783622 34773 4.437 4.594 2118 1653 73793 28937 3.921 4.2 2119 1284 62934 18365 3.46 3.113 Totals 4483 15975626 419577 2.626 2.598 21-11 Influenza Season Week 9, ending March 5, 211 24

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 1 (CT, ME, MA, NH, RI, VT) (Baseline: 1.4 %) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 15 5877 252.495.415 2141 151 47313 37.649.584 2142 16 54188 338.624.587 2143 165 5656 345.615.572 2144 163 52485 338.644.63 2145 165 5532 32.598.556 2146 164 549 395.719.75 2147 16 37415 321.858.82 2148 167 5469 412.753.688 2149 162 5322 423.795.759 215 169 52867 44.832.81 2151 164 38377 45 1.55 1.14 2152 166 32838 411 1.252 1.149 2111 164 51257 53.981.923 2112 168 4655 554 1.23 1.183 2113 169 46349 568 1.225 1.217 2114 158 51579 78 1.512 1.428 2115 167 47546 924 1.943 1.889 2116 16 55848 1169 2.93 2.4 2117 152 51881 1227 2.365 2.3 2118 149 46666 118 2.529 2.347 2119 126 41174 81 1.967 1.815 Totals 3519 174113 1244 1.155 1.14 HHS Region 2 (NJ, NY) (Baseline: 2.4%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 153 11686 1259 1.137 1.168 2141 153 1148 1494 1.358 1.326 2142 161 11413 1419 1.243 1.219 2143 161 115176 1476 1.282 1.389 2144 17 1882 1517 1.394 1.217 2145 171 11263 183 1.61 1.393 2146 173 116955 255 1.757 1.446 2147 169 1854 2169 2.151 1.644 2148 169 115386 2799 2.426 2.199 2149 167 113395 31 2.654 2.497 215 166 114627 368 3.21 3.39 21-11 Influenza Season Week 9, ending March 5, 211 25

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 2 (NJ, NY) (Baseline: 2.4%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 2151 167 15229 4471 4.249 4.25 2152 163 94664 4173 4.48 4.529 2111 162 11775 3866 3.32 3.367 2112 159 15781 3494 3.33 3.893 2113 161 16972 3245 3.34 3.684 2114 164 14567 354 2.921 3.966 2115 157 19744 333 2.764 3.854 2116 147 112562 3134 2.784 4.11 2117 135 112141 3195 2.849 4.81 2118 115 1665 312 2.992 4.61 2119 58 91377 1891 2.69 2.465 Totals 341 2393466 59249 2.475 2.668 HHS Region 3 (DE, DC, MD, PA, VA, WV) (Baseline: 2.6%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 214 99483 1119 1.125 1.2 2141 217 1637 1277 1.269 1.293 2142 22 1824 1314 1.216 1.139 2143 219 17 1335 1.248 1.82 2144 223 13851 1357 1.37 1.224 2145 223 15532 1495 1.417 1.293 2146 215 14539 1511 1.445 1.269 2147 222 928 1464 1.59 1.485 2148 229 17394 1659 1.545 1.475 2149 214 9971 165 1.61 1.453 215 29 92557 1574 1.71 1.621 2151 28 86173 1858 2.156 2.178 2152 27 89255 2131 2.388 2.614 2111 216 14954 2383 2.271 2.196 2112 224 14826 2747 2.621 2.52 2113 223 17994 384 3.556 3.267 2114 219 11269 4751 4.39 4.71 2115 227 116143 5583 4.87 4.439 2116 218 1181 54 4.576 4.18 2117 214 115144 547 4.696 3.932 2118 27 111617 4714 4.223 3.668 2119 184 13763 3465 3.339 2.81 Totals 4752 2288946 57989 2.533 2.28 21-11 Influenza Season Week 9, ending March 5, 211 26

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 4 (AL, FL, GA, KY, MS, NC, SC, TN) (Baseline: 2.3%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 41 157897 185 1.143.937 2141 414 15778 21 1.274 1.48 2142 45 16134 261 1.277 1.53 2143 417 159125 2231 1.42 1.18 2144 411 15535 2573 1.66 1.43 2145 413 153858 348 1.981 1.6 2146 412 16332 3846 2.355 1.855 2147 42 119111 3572 2.999 2.217 2148 419 155659 359 2.254 1.953 2149 415 14248 3988 2.8 2.266 215 412 135431 5995 4.427 3.37 2151 381 19277 66 6.4 4.416 2152 45 11992 649 5.45 3.955 2111 42 14121 549 3.86 3.25 2112 413 127489 4931 3.868 3.625 2113 425 147251 6537 4.439 4.224 2114 426 16155 845 5.23 5.39 2115 42 158362 8979 5.67 5.587 2116 415 15758 876 5.543 5.347 2117 388 156729 7895 5.37 4.89 2118 373 152412 635 4.166 4.17 2119 37 128869 3884 3.14 2.896 Totals 8921 3219966 18383 3.366 3.3 HHS Region 5 (IL, IN, MI, MN, OH, WI) (Baseline: 1.8%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 249 88287 737.835.68 2141 271 9599 869.914.756 2142 265 95458 966 1.12.872 2143 275 9918 983.992.871 2144 274 97639 194 1.12 1.32 2145 27 97473 146 1.73.95 2146 27 9729 149 1.81.955 2147 271 69796 862 1.235 1.33 2148 276 9475 965 1.18.93 2149 272 9189 169 1.163.978 215 276 85245 199 1.289 1.67 2151 264 68453 1319 1.927 1.48 2152 259 66938 1559 2.329 1.74 2111 261 85289 1638 1.921 1.541 2112 263 86952 1875 2.156 1.75 2113 26 86813 2485 2.862 2.433 2114 258 94842 3618 3.815 3.377 2115 258 81344 3452 4.244 3.867 2116 259 94814 3352 3.535 3.323 2117 239 924 3123 3.461 3.298 2118 225 8258 2577 3.211 3.28 2119 188 69514 1872 2.693 2.612 Totals 573 1917231 3769 1.962 1.729 21-11 Influenza Season Week 9, ending March 5, 211 27

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 6 (AR, LA, NM, OK, TX) (Baseline: 4.9%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 193 864 1636 2.3 1.855 2141 19 79668 1578 1.981 1.861 2142 2 82642 175 2.63 1.992 2143 192 82458 1693 2.53 1.983 2144 193 83945 227 2.415 2.29 2145 198 89847 293 2.33 2.363 2146 189 84648 265 2.44 2.47 2147 188 63432 178 2.693 2.619 2148 192 8177 276 2.541 2.467 2149 189 898 1952 2.41 2.338 215 181 76293 2221 2.911 2.93 2151 159 62896 24 3.816 3.851 2152 182 7314 361 4.192 3.783 2111 184 83575 294 3.518 3.345 2112 179 835 3532 4.396 4.426 2113 192 9131 5127 5.688 5.765 2114 186 88762 5561 6.265 6.86 2115 197 82756 6338 7.659 7.631 2116 184 76199 5787 7.595 8.3 2117 182 9613 7482 7.783 7.896 2118 175 91328 5596 6.127 6.313 2119 131 61872 2881 4.656 4.748 Totals 456 1773237 71459 4.3 4.2 HHS Region 7 (IA, KS, MO, NE) (Baseline: 2.3%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 92 22989 216.94.99 2141 91 22966 227.988 1.8 2142 95 23755 241 1.15 1.61 2143 98 2716 213.784.845 2144 98 26682 178.667.741 2145 1 27431 35 1.112 1.166 2146 1 2681 27 1.7 1.79 2147 96 1635 162.994 1.4 2148 98 24641 328 1.331 1.386 2149 1 25257 318 1.259 1.31 215 98 24839 362 1.457 1.557 2151 1 19229 335 1.742 1.981 2152 94 16832 375 2.228 2.287 2111 99 23628 39 1.651 1.672 2112 98 2316 38 1.641 1.744 2113 98 25218 484 1.919 1.957 2114 97 278 869 3.218 3.283 2115 93 2695 835 4.35 4.347 2116 91 25483 85 3.336 3.513 2117 9 26428 1119 4.234 4.527 2118 88 26488 189 4.111 4.59 2119 74 2369 821 3.466 3.738 Totals 288 526694 1367 1.968 2.32 21-11 Influenza Season Week 9, ending March 5, 211 28

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 8 (CO, MT, ND, SD, UT, WY) (Baseline: 1.7%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 89 45752 315.688.659 2141 94 44774 257.574.535 2142 96 4646 291.632.621 2143 91 43355 36.76.727 2144 99 45862 354.772.754 2145 87 43551 289.664.653 2146 85 43479 316.727.719 2147 97 3322 233.72.714 2148 94 45783 343.749.749 2149 93 44228 338.764.83 215 89 485 326.798.821 2151 84 29883 32 1.11.895 2152 79 2952 33 1.118.984 2111 77 42696 356.834.725 2112 71 35922 48 1.136 1.355 2113 82 4595 618 1.522 1.446 2114 77 42197 775 1.837 1.539 2115 77 39771 946 2.379 2.228 2116 81 44213 129 2.734 2.578 2117 77 42432 1226 2.889 2.696 2118 74 39826 1136 2.852 2.586 2119 64 39498 126 2.598 2.32 Totals 1857 93435 117 1.295 1.237 HHS Region 9 (AZ, CA, HI, NV) (Baseline: 4.1%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 25 69732 996 1.428 1.742 2141 22 71553 1142 1.596 1.929 2142 229 72338 124 1.664 1.997 2143 231 79583 1177 1.479 1.77 2144 236 745 143 1.932 2.287 2145 229 6983 1247 1.786 2.355 2146 235 74571 1621 2.174 2.54 2147 237 6266 147 2.247 2.843 2148 239 74528 1667 2.237 2.448 2149 237 72295 216 2.789 2.934 215 229 68711 2235 3.253 3.582 2151 224 57833 2195 3.795 4.679 2152 243 5851 194 3.254 4.183 2111 249 79828 2228 2.791 3.256 2112 249 81288 2453 3.18 3.469 2113 245 74626 2575 3.451 3.817 2114 246 9193 3334 3.697 4.342 2115 245 8443 3223 3.817 4.285 2116 247 83125 3461 4.164 4.797 2117 237 8479 3551 4.412 5.61 2118 27 79133 2884 3.644 3.968 2119 123 35178 1326 3.769 3.433 Totals 542 1594375 45276 2.84 3.243 21-11 Influenza Season Week 9, ending March 5, 211 29

US Outpatient Influenza-like Illness Surveillance Network (ILINet) 21-211 Influenza Season Update: Friday, March 11, 211 Summary by Region HHS Region 1 (AK, ID, OR, WA) (Baseline:2.7%) CDC Week Number Reporting Patient Visits Total ILI % Unweighted ILI % Weighted ILI 214 56 16141 87.539.531 2141 54 1576 159 1.12.97 2142 52 16943 139.82.821 2143 57 16449 158.961.934 2144 58 17221 182 1.57.91 2145 59 16858 175 1.38 1.25 2146 55 16866 24 1.21 1.184 2147 51 823 155 1.883 1.77 2148 57 13744 154 1.12.957 2149 56 13148 153 1.164.941 215 55 1527 12 1.14.897 2151 56 8519 164 1.925 1.198 2152 55 8362 183 2.188 2.353 2111 5 12623 179 1.418 1.36 2112 54 13437 223 1.66 1.164 2113 51 11921 271 2.273 1.431 2114 54 13647 327 2.396 2.29 2115 49 12173 375 3.81 2.666 2116 5 1294 397 3.283 2.549 2117 46 1218 548 4.56 3.962 2118 4 9537 399 4.184 3.631 2119 29 7999 389 4.863 3.89 Totals 1144 284163 5141 1.89 1.524 21-11 Influenza Season Week 9, ending March 5, 211 3