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DMBS SMBS SYMPOSIUM ORGANISERS Society of Medical Biochemists of Serbia European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Center of Medical Biochemistry, Clinical Center of Serbia Pharmaceutical Faculty, Belgrade University AUSPICES 10 th EFLM Symposium for Balkan Region is organized under the Auspices of the International Federation of Clinical Chemistry (IFCC) Balkan Clinical Laboratory Federation (BCLF) Ministry of Education, Science and Technological Development of Serbia Ministry of Health of Serbia SYMPOSIUM SECRETARIAT CENTER OF MEDICAL BIOCHEMISTRY CLINICAL CENTER OF SERBIA Višegradska 26 11000 Belgrade, Serbia Phone/Fax: + 381 11 361 56 31 e-mail: dmbjªeunet.rs Website: www.dmbj.org.rs

DMBS SMBS ORGANISING AND SCIENTIFIC COMMITTEE SCIENTIFIC COMMITTEE Nada Majki}-Singh (Serbia) Edgard Delvin (Canada) Elizabeta Topi} (Croatia) Grazyna Sypnievska (Poland) Svetlana Ignjatovi} (Serbia) ORGANIZING COMMITTEE Nada Majki}-Singh Zorica Šumarac Svetlana Ignjatovi} Snežana Jovi~i} Tatjana Vodnik Jelena Ošap Velibor Cani} Jadranka Mitrovi} An elo Beleti} Ljubica Zatezalo 3

Dear colleagues and friends, The Society of Medical Biochemists of Serbia has the pleasure to welcome you to the 10 th EFLM Symposium for Balkan Region being held under the title»paediatric Laboratory Medicine: Some Aspects of Obesity, Metabolic Syndrome, Neonatal Screening, Reference Intervals and Critical Values«. The 10 th EFLM Symposium for Balkan Region is organized under the auspices of the International Federation of Clinical Chemistry (IFCC). The Society as a member of the IFCC and EFLM greatly appreciates the role it has in the continuing development of our discipline according to the IFCC mission and the Strategic Plan. EFLM appointed Belgrade (Serbia) and the Society of Medical Biochemists of Serbia as the organizer of educational symposia for clinical chemists in the Balkan region and as a result of this decision nine symposia have been organized thus far very successfully. Special thanks go to Professor Edgard Delvin, who helped to design the program of this symposium by suggesting topics and lecturers and who enabled the laboratory professionals in the Balkan region and our country to learn about this very important area of laboratory medicine. On behalf of the Society of Medical Biochemists of Serbia and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM), we would like to welcome all our distinguished lecturers and thank them for their participation in the 10 th EFLM Symposium for Balkan Region. Their presence gives very high recognition and prestige to this Meeting, which will influence the development of clinical chemistry and laboratory medicine in the Balkan region. Special thanks are addressed to the participants, whose presence is the main stimulus and only reward for those of us who have worked hard in organizing this meeting. We would like to thank all the industrial companies and local representatives participating in the exhibitions and sponsoring the organization of the Symposium. We hope that the EFLM Symposium in Belgrade will continue its successful progress like in previous years, striving to focus on the new data in the field of laboratory medicine. To all of you, we wish that you may enjoy these days of science, friendship and hospitality. We hope you will have a happy and pleasant stay in Belgrade. Symposium President Prof. Dr Nada Majkić-Singh 4

THURSDAY, SEPTEMBER 11, 2014 9:00 11:00 Introduction EFLM Symposium for Balkan Region Nada Majki}-Singh, Elizabeta Topi}, Zorica Šumarac Society of Medical Biochemists of Serbia and European Federation of Clinical Chemistry and Laboratory Medicine Section 1 Pediatric Obesity Insulin resistance Non-alcoholic Fatty Liver Disease (NAFLD) Chairs: E. Delvin (Canada) N. Majki}-Singh (Serbia) 9:00 9:30 Pediatric obesity and its associated co-morbidities Edgard Delvin (Montreal, Canada) 9:30 10:00 Epidemiology and natural history of NAFLD Valerio Nobili (Rome, Italy) 10:00 10:30 Metabolic setup and risks in obese children Mirjana Kocova (Skopje, Macedonia) Discussion 11:00 11:30 Coffee break 5

11:30 11:50 Insulinemia in obese children Dragan Katani} (Novi Sad, Serbia) 11:50 12:10 The diagnosis of prediabetes in adolescents Vera Zdravkovi} (Belgrade, Serbia) 12:10 12:30 Discussion 13:00 14:30 Lunch Section 2 first part Neonatal Screening for Metabolic Disorders Chairs: I. Balogh (Hungary) Z. Šumarac (Serbia) 15:00 15:30 Different Viewpoints: International Perspectives on Newborn Screening Rodney Pollitt (Scheffield, UK) 15:30 16:00 Standardization in Neonatal Screening Programmes Alberto Burlina (Padua, Italy) 16:00 16:30 CFTR molecular testing of two patient cohorts in Hungary: relevance to newborn screening Gergely Ivády, Katalin Koczok, István Balogh (Debrecen, Hungary) 16:30 16:50 Importance of screening in the prevention of Thalassemia syndromes Milica ^vorkov-draži} (Belgrade, Serbia) 16:50 17:10 Discussion 6

FRIDAY, SEPTEMBER 12, 2014 9:00 11:00 Section 2 second part Neonatal Screening for Metabolic Disorders Chairs: T. Milenkovi} (Serbia) V. Anastasovska (Macedonia) 9:00 9:20 Direct molecular diagnosis of CYP21A2 point mutations in Macedonian and Serbian patients with 21-hydroxylase deficiency Violeta Anastasovska, Tatjana Milenkovi}, Mirjana Kocova (Skopje, Macedonia) 9:20 9:40 Selective screening for metabolic disorders in a Slovenian pediatric population Barbka Repi~ Lampret, Simona Murko, Mojca @erjav Tanj{ek, Andra` [mon, Tadej Battelino (Ljubljana, Slovenia) 9:40 10:00 30 years of experience with the screening program for congenital hypothyroidism in Central Serbia (1983 2014) Tatjana Milenkovi}, Milo{ Bani~evi}, Ljubica Zatezalo, Zagorka Suboti}, Branka Opan~ina, Katarina Mitrovi}, Sla ana Todorovi} (Belgrade, Serbia) 10:00 10:10 Discussion Coffee break 7

Section 3 Paediatric Reference Intervals and Critical Values Chairs: K. Adeli (Canada) S. Ignjatovi} (Serbia) 10:30 11:00 Concepts in establishing reference values in pediatrics Joseph Henny (Villejuif, France) 11:00 11:30 Closing the Gap in Pediatric Reference Intervals: The CALIPER Initiative Khosrow Adeli (Toronto, Canada) 11:30 12:00 Population-based pediatric reference intervals in general clinical chemistry: A Swedish survey Peter Ridefelt (Uppsala, Sweden) 12:00 12:15 Discussion 13:30 15:00 Lunch 8

GENERAL INFORMATION Date and Venue The Scientific programme and exhibition of the 10 th EFLM Symposium for Balkan Region in Belgrade will be held in Best Western Hotel»M«, Bulevar oslobođenja 56, Belgrade, from 11 12 September, 2014. Registration desk The registration desk located at the Hotel»M«, Belgrade will be open for the duration of the Symposium from Wednesday, September 10, 2014 at 9:00 a.m. to Friday, September 12, 2014 at 6:00 p.m. Full registration fee 150.00 Euro Registration fees may be paid in Euros or dinars, by bank transfers or in cash at site (see Registration Form). The registration fee includes: Admission to all scientific session Symposium material (programme, JMB, congress bag, badge, etc.) Coffee breaks Two lunch Certificate of attendance Badges Badges will be distributed at the registration desk upon arri - val. Please attach your badges for admission to all scientific and social activities. Certificate of participation The certificate of participation will be issued to those who are properly registered. The certificate of participation will be available at the registration desk and must be picked up just before departure. 9

Congress language The official language of the congress will be English. Visual Equipment The Meeting hall will be equipped with data video projectors for the speakers needs. Internet The Organizer kindly invites you to visit the Meeting Web pages at www.dmbj.org.rs Weather In September Belgrade enjoys a mild climate. The average daily temperature is about 23 C. 10