A PATIENT S GUIDE TO PLASMA EXCHANGE

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Some drugs may be affected by plasma exchage; ask your doctor about ay impact to drugs you are takig. It is importat to drik water ad cosume foods high i calcium, such as cheese or milk. This ca help your procedure go smoothly. A typical plasma exchage takes 1 to hours, so visit the restroom beforehad. Pla how you will pass the time. May patiets ejoy watchig a video o a tablet or listeig to music or a audiobook. You may be allowed to have compay durig a plasma exchage procedure. Check with your healthcare provider o the policy. Plasma exchage requires drawig your blood usig a device. Qualified persoel will assess your veis before your procedure to help determie the best way to draw your blood. Drawig your blood ca usually be achieved with a eedle i oe or both arms. Depedig o the legth of treatmet, more permaet optios may be used. Plasma exchage is kow to be safe ad welltolerated, with the majority of reactios beig mild. durig your procedure: Pai at the eedle site Feelig tired or cold Dizziess Lightheadedess Nausea or vomitig Tiglig i the figers ad/or aroud the mouth Talk to your doctor about how to take care of the veis i your arms used for this procedure, such as avoidig blood draws i advace of These do ot occur i every patiet. Tell your healthcare provider immediately if you experiece ay of these symptoms. To make you more comfortable, the urse may give you calcium tablets or may slow dow or temporarily stop the procedure for a short time. You may also be give a blaket to keep your body warm ad comfortable. Before receivig treatmet, talk with your doctor to uderstad your treatmet optios ad ay Iformatio provided by Terumo BCT, maufacturer As a global leader i blood compoet, therapeutic apheresis ad cellular techologies, we believe i the potetial of blood to do eve more for patiets tha it does today. This belief ispires our iovatio ad stregthes our collaboratio with customers. Plasma exchage is performed all over the world ad is recommeded by may professioal medical orgaizatios. 2017 Terumo BCT, Ic. / PN 06610077D 06610077D-PRINT.idd 1-4

WHAT IS PLASMA? WHY DO YOU NEED? YOUR PROCEDURE: WHAT TO EXPECT Some medical coditios ca cause your body to create harmful atibodies or excess proteis. These substaces circulate throughout the body i the plasma ad may harm healthy cells or tissues. A qualified medical professioal is resposible for operatig Spectra Optia ad moitorig you throughout the procedure. WHAT IS? Recommeded Fluid Plasma is the liquid part of blood that carries red blood cells ad white blood cells through the body. Whe plasma is separated from the other parts of the blood, it is yellow i color. Plasma exchage is a commo treatmet that is kow to be safe ad well-tolerated. It is used to remove a patiet s plasma whe it cotais potetially harmful substaces. Your treatmet will be performed o a medical device, such as the Spectra Optia Apheresis System. Durig the procedure, the device takes a small amout of your blood ad separates your plasma from the other parts of your blood. While your plasma is beig removed, the device will replace it with a fluid recommeded by your doctor. Simply put, the old plasma is removed ad replaced with the ew fluid. CONNECT A sigle-use sterile tubig set is coected to oe or both of your arms with a eedle. Depedig o the legth of treatmet, more permaet optios may be used. PROCEDURE A small portio of your blood is removed ad mixed with a fluid that prevets the blood from clottig. Very little blood, less tha a cup, is i the tubig set at ay poit durig the procedure. The majority of your plasma is separated ad removed from the other parts of your blood. 1 2 T he remaiig parts of your blood are mixed with the ew fluid ad the retured to you. FINISH The tubig set ad the removed plasma are properly throw away. 06610077D-PRINT.idd 5-8

WHAT IS PLASMA? WHY DO YOU NEED? YOUR PROCEDURE: WHAT TO EXPECT Some medical coditios ca cause your body to create harmful atibodies or excess proteis. These substaces circulate throughout the body i the plasma ad may harm healthy cells or tissues. A qualified medical professioal is resposible for operatig Spectra Optia ad moitorig you throughout the procedure. WHAT IS? Recommeded Fluid Plasma is the liquid part of blood that carries red blood cells ad white blood cells through the body. Whe plasma is separated from the other parts of the blood, it is yellow i color. Plasma exchage is a commo treatmet that is kow to be safe ad well-tolerated. It is used to remove a patiet s plasma whe it cotais potetially harmful substaces. Your treatmet will be performed o a medical device, such as the Spectra Optia Apheresis System. Durig the procedure, the device takes a small amout of your blood ad separates your plasma from the other parts of your blood. While your plasma is beig removed, the device will replace it with a fluid recommeded by your doctor. Simply put, the old plasma is removed ad replaced with the ew fluid. CONNECT A sigle-use sterile tubig set is coected to oe or both of your arms with a eedle. Depedig o the legth of treatmet, more permaet optios may be used. PROCEDURE A small portio of your blood is removed ad mixed with a fluid that prevets the blood from clottig. Very little blood, less tha a cup, is i the tubig set at ay poit durig the procedure. The majority of your plasma is separated ad removed from the other parts of your blood. 1 2 T he remaiig parts of your blood are mixed with the ew fluid ad the retured to you. FINISH The tubig set ad the removed plasma are properly throw away. 06610077D-PRINT.idd 5-8

Some drugs may be affected by plasma exchage; ask your doctor about ay impact to drugs you are takig. It is importat to drik water ad cosume foods high i calcium, such as cheese or milk. This ca help your procedure go smoothly. A typical plasma exchage takes 1 to hours, so visit the restroom beforehad. Pla how you will pass the time. May patiets ejoy watchig a video o a tablet or listeig to music or a audiobook. You may be allowed to have compay durig a plasma exchage procedure. Check with your healthcare provider o the policy. Plasma exchage requires drawig your blood usig a device. Qualified persoel will assess your veis before your procedure to help determie the best way to draw your blood. Drawig your blood ca usually be achieved with a eedle i oe or both arms. Depedig o the legth of treatmet, more permaet optios may be used. Plasma exchage is kow to be safe ad welltolerated, with the majority of reactios beig mild. durig your procedure: Pai at the eedle site Feelig tired or cold Dizziess Lightheadedess Nausea or vomitig Tiglig i the figers ad/or aroud the mouth Talk to your doctor about how to take care of the veis i your arms used for this procedure, such as avoidig blood draws i advace of These do ot occur i every patiet. Tell your healthcare provider immediately if you experiece ay of these symptoms. To make you more comfortable, the urse may give you calcium tablets or may slow dow or temporarily stop the procedure for a short time. You may also be give a blaket to keep your body warm ad comfortable. Before receivig treatmet, talk with your doctor to uderstad your treatmet optios ad ay Iformatio provided by Terumo BCT, maufacturer As a global leader i blood compoet, therapeutic apheresis ad cellular techologies, we believe i the potetial of blood to do eve more for patiets tha it does today. This belief ispires our iovatio ad stregthes our collaboratio with customers. Plasma exchage is performed all over the world ad is recommeded by may professioal medical orgaizatios. 2017 Terumo BCT, Ic. / PN 06610077D 06610077D-PRINT.idd 1-4

Some drugs may be affected by plasma exchage; ask your doctor about ay impact to drugs you are takig. It is importat to drik water ad cosume foods high i calcium, such as cheese or milk. This ca help your procedure go smoothly. A typical plasma exchage takes 1 to hours, so visit the restroom beforehad. Pla how you will pass the time. May patiets ejoy watchig a video o a tablet or listeig to music or a audiobook. You may be allowed to have compay durig a plasma exchage procedure. Check with your healthcare provider o the policy. Plasma exchage requires drawig your blood usig a device. Qualified persoel will assess your veis before your procedure to help determie the best way to draw your blood. Drawig your blood ca usually be achieved with a eedle i oe or both arms. Depedig o the legth of treatmet, more permaet optios may be used. Plasma exchage is kow to be safe ad welltolerated, with the majority of reactios beig mild. durig your procedure: Pai at the eedle site Feelig tired or cold Dizziess Lightheadedess Nausea or vomitig Tiglig i the figers ad/or aroud the mouth Talk to your doctor about how to take care of the veis i your arms used for this procedure, such as avoidig blood draws i advace of These do ot occur i every patiet. Tell your healthcare provider immediately if you experiece ay of these symptoms. To make you more comfortable, the urse may give you calcium tablets or may slow dow or temporarily stop the procedure for a short time. You may also be give a blaket to keep your body warm ad comfortable. Before receivig treatmet, talk with your doctor to uderstad your treatmet optios ad ay Iformatio provided by Terumo BCT, maufacturer As a global leader i blood compoet, therapeutic apheresis ad cellular techologies, we believe i the potetial of blood to do eve more for patiets tha it does today. This belief ispires our iovatio ad stregthes our collaboratio with customers. Plasma exchage is performed all over the world ad is recommeded by may professioal medical orgaizatios. 2017 Terumo BCT, Ic. / PN 06610077D 06610077D-PRINT.idd 1-4