THURSDAY 26 TH APRIL 2018 SCHEDULE PAGE 1 15 TH ANNUAL CRITICAL CARE SYMPOSIUM KING S HOUSE CONFERENCE CENTRE, MANCHESTER

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THURSDAY 26 TH APRIL 2018 SCHEDULE PAGE 1 08.00 08.45 Registration 08.45 09.00 Introduction KEYNOTE ADDRESS 09.00 09.30 Non-antibiotic solutions for pan-resistant microbial pathogens Prof Steven Opal SEPSIS 1 FLUIDS Prof Paul Dark & Prof Fang Gao Smith & Prof Michel Slama 09.35 09.50 New sepsis guidelines, facts and controversies 09.50 10.05 Practical implication on a national scale Dr Ron Daniels 10.05 10.20 Host pathogen interactions 10.20 10.35 Sepsis biomarkers - where do we stand? 10.35 10.50 Questions 09.35 09.50 What is the ideal fluid in Critical Care? 09.50 10.05 Fluid resuscitation - when to stop fluid administration Prof Jan De Waele 10.05 10.20 Albumin in sepsis Prof Yasser Sakr 10.20 10.35 Questions 10.35 11.00 Coffee Break 10.50 11.10 Coffee Break TOPICS 1 SEPSIS - MANIFESTATIONS, DIAGNOSIS & MONITORING & & Dr Ron Daniels 11.10 11.25 Lessons learnt from emergency healthcare responses to the Manchester Arena bombing Prof Paul Dark 11.25 11.40 Risk stratification and management of the high risk surgical patient 11.40 11.55 The carmal total artificial heart: where are we up to? Prof Bernard Cholley 11.55 12.10 Hospital readmissions in ICU survivors Dr Nazir Lone 12.10 12.30 Questions 11.00 11.15 Fever - friend or foe? Prof Steven Opal 11.15 11.30 Maternal sepsis Prof Fang Gao Smith 11.30 11.45 Septic shock and ARDS 11.45 12.15 Holistic Critical Care ultrasound - can rapidly document a source of sepsis Prof Daniel Lichtenstein 11.10 12.30 Acid-base - Stewart s approach How not to run an incident investigation in your unit

THURSDAY 26 TH APRIL 2018 SCHEDULE PAGE 2 PRO-CON DEBATE Chairperson: Dr Andrew Bentley An ICU follow-up clinic is too late for survivors 12.30 12.45 PRO Prof Tim Walsh 12.45 13.00 CON Dr Peter Spronk 13.00 13.10 Questions 13.10 14.00 Lunch SEPSIS - MANIFESTATIONS, DIAGNOSIS & MONITORING (continued) & Dr Ron Daniels 12.15 12.30 How should you choose haemodynamic monitoring in septic shock patients? Prof Jean-Louis Teboul 12.30 12.50 Questions 12.50 13.50 Lunch ARDS SEPSIS - MANAGEMENT 1 Prof Tim Walsh & & 14.00 14.15 Fluid management in ARDS Prof Jean-Louis Teboul 14.15 14.30 Human models to define new treatments for ARDS 14.30 14.45 Use of stem cells in ARDS Prof Geoff Bellingan 14.45 15.00 Future therapies in ARDS 15.00 15.20 Questions 15.20 15.50 Coffee Break 13.50 14.05 Source control in septic shock Prof Jan De Waele 14.05 14.20 Septic shock: is the endotoxin removal an option? Prof Massimo Antonelli 14.20 14.35 Volume optimisation in sepsis: understanding the evidence Prof Yasser Sakr 14.35 14.50 Practical use of vasopressors in septic shock Prof Jean-Louis Teboul 14.50 15.05 Questions 15.05 15.30 Coffee Break 14.00 15.00 Safety in ICU Tricks in ICU REHABILITATION See next page SEPSIS - MANAGEMENT 2 See next page

THURSDAY 26 TH APRIL 2018 SCHEDULE PAGE 3 REHABILITATION SEPSIS - MANAGEMENT 2 Dr Nazir Lone & Dr Deepak Govil Prof Steven Opal & Dr Miguel Tavares 15.50 16.05 What quality indicators should we use for ICU rehabilitation? Prof Tim Walsh 16.05 16.20 Engaging the patient in rehabilitation - interactive gaming is the future Dr Peter Spronk 16.20 16.35 Animal assisted activity in ICU 16.35 16.50 Evidence for physical rehabilitation across the recovery continuum and the evidence reality gap Dr Bronwen Connolly 16.50 17.05 Rehabilitation post-icu - the REVIVE trial 17.05 17.30 Questions 15.30 15.45 Alkaline phosphatase for sepsis induced AKI 15.45 16.00 EGDT in sepsis for 2018 16.00 16.15 Sepsis bundles in a resource limited country 16.15 16.30 Questions EDUCATION Associate Prof Aarti Sarwal & 16.30 16.45 POCUS in Intensive Care Dr Jonathan Wilkinson 16.45 17.00 Stimulation for education in ICU: new scopes and scenarios Associate Prof Aarti Sarwal 17.00 17.15 Social media - from tweets to bedside 17.15 17.30 Questions 16.00 17.00 Anaemia and blood transfusion issues - update Prof Tim Walsh Prof Yasser Sakr Practice of the RRT in ICU - the questions you are reluctant to ask 19.00 for 19.30 SYMPOSIUM DINNER Admission by pre-booked ticket only SYMPOSIUM DINNER Venue: Directors Suite The Principal Manchester Oxford Street Manchester M60 7HA AFTER DINNER SPEECH Have we got sepsis wrong?

FRIDAY 27 TH APRIL 2018 SCHEDULE PAGE 1 08.15 09.00 Registration KEYNOTE ADDRESS Chairperson: 09.00 09.30 50 years of ARDS: what has been changed? Prof Massimo Antonelli NUTRITION Dr Bronwen Connolly & Dr Ravi Kumar 09.35 09.50 What, when and how? 09.50 10.05 A standard bag of TPN vs custom made ones - what is the point? 10.05 10.20 Future direction of nutritional research Dr Zudin Puthucheary 10.20 10.35 Questions 10.35 11.00 Coffee Break PRO-CON DEBATE Chairperson: Can expenses in ICU be brought under control? ECMO, blood purification, stem cell and LVADs etc. for ALL 11.00 11.15 PRO 11.15 11.30 CON 11.30 11.45 Questions ARDS 2 Prof Xavier Monnet & Prof Geoff Bellingan 09.35 09.50 First line intervention in hypoxemic patients: HFOT or NV Prof Massimo Antonelli 09.50 10.05 Ultrasound to assess the diaphragmatic function in ventilated and critically ill patients Prof Bernard Cholley 10.05 10.20 ECCO2R in acute respiratory failure 10.20 10.35 Latest update on interferon in ARDS Prof Geoff Bellingan 10.35 10.50 Questions 10.50 11.20 Coffee Break WEANING Prof Xavier Monnet & Dr Andrew Bentley 11.20 11.35 NAVA - when, how and to whom? Dr Deepak Govil 11.35 11.50 Weaning failure due to cardiac origin Prof Xavier Monnet 09.35 10.45 Telemedicine Ultrasound of diaphragm during mechanical ventilation Associate Prof Aarti Sarwal & 11.00 12.00 Haemodynamic monitoring Prof Bernard Cholley & Antibiotics - all you need to know in Intensive Care Prof Paul Dark & Prof Jan De Waele

FRIDAY 27 TH APRIL 2018 SCHEDULE PAGE 2 NEURO CRITICAL CARE WEANING (continued) Prof Yasser Sakr & Dr Ashley Miller Prof Xavier Monnet & Dr Andrew Bentley 11.45 12.00 Peri-operative management of patients with acute ischemic stroke 12.00 12.15 Early mobilisation in neuro critical care Associate Prof Aarti Sarwal 12.15 12.30 Prevention of delirium in ICU patients 12.30 12.45 Questions 12.45 13.45 Lunch MANAGEMENT Dr Andrew Bentley & 13.45 14.00 NOAC reversal: a dream come true 14.00 14.15 Peri-operative management of patients with pulmonary hypertension 14.15 14.30 Levosimendan in severe heart failure Dr Christian Sitzwhol 14.30 14.45 Management of the obese in Critical Care Dr Andrew Bentley 14.45 15.00 Questions 15.00 15.20 Coffee Break 11.50 12.05 Avoiding failed extubation 12.05 12.20 Weaning from prolonged ventilation Dr Andrew Bentley 12.20 12.40 Questions 12.40 13.40 Lunch RENAL Prof Michel Slama & Prof Daniel Lichtenstein 13.40 13.55 Fluid challenges for oliguria - useful or a knee-jerk reaction 13.55 14.10 Biomarkers for acute kidney injury 14.10 14.25 Early vs late initiation of CRRT 14.25 14.40 The dark side of CRRT 14.40 15.00 Questions 15.00 15.20 Coffee Break 12.15 13.15 Cardiovascular physiology relevant to Intensive Care Prof Xavier Monnet Prof Bernard Cholley Dr Miguel Tavares Ultrasound in Acute Care - all you are afraid to ask Moderator: Dr Jonathan Wilkinson Dr Deepak Govil 14.00 15.00 Simulation in ICU Associate Prof Aarti Sarwal Dr Zudin Puthucheary ROUND TABLE: Quality, safety, burnout and research in ICU - ask the experts Chairperson: Prof Fang Gao Smith Dr Nazir Lone Dr Ravi Kumar Dr Bronwen Connolly

FRIDAY 27 TH APRIL 2018 SCHEDULE PAGE 3 TOPICS 2 & Prof Paul Dark 15.20 15.35 How to recognise failing right ventricle Prof Michel Slama 15.35 15.50 When to stop antibiotics in sepsis Prof Paul Dark 15.50 16.15 Mechanisms of spread of antibiotic resistance genes; are we in a losing struggle? Prof Steven Opal 16.15 16.30 Questions CLOSING LECTURE & Prof Paul Dark 16.30 16.50 Future of Intensive Care - the challenges 16.50 17.00 Closing remarks ENDORSED BY