M Magdy EL-Sheikh FRCOG London, FRCS Glasgow Director ART unit Dr Soliman Fakeeh hospital Jeddah Saudi Arabia
The versatile nature reproduction Reproduction as a sign of life Reproduction as a sign of good health Reproduction as an evidence on the ability to give Reproduction and economy
Reproductive medicine is everybody s business You Me Doctor Media Educated Non educated Government Farmer Religion.etc
Fertility and cultural richness The pregnant from Katal Huyuk ca 7000 BC The pregnant from Malta 4000 BC
Facts of our Life Amun////Anubis
Reproduction central role
Motherhood and the ability to give Rome museum
Development of fertility therapy over the years Tradition and science Amulets Spirits Magic X Rays
Female Reproductive System oviduct ovary uterus cervix vagina Video of fertilization
Sexual Reproduction in Human testis sperms meiosis fertilization meiosis ovary eggs (ova) zygote embryo fetus baby
The aim of ART unit DSFH Education of patients Acquiring up to date technology Supply of technology to patients at a suitable cost Innovation in the field
Male Factors Female Factors Both Coital Unexplained
How fertile? The monthly possibility of pregnancy in normal fertile couples is 20% Zeinaman et al Estimates of human fertility and pregnancy loss fertil Steril 1996, 65: 503
Factors affecting fertility
Natural fertility and age III
The relationship between advanced maternal age and aneuploidy for chromosomes X, Y, 13, 15,16,18, 21,22 III From Munne et al
obesity
Smoking III
When things go wrong. (Infertility) Infertility is defined as failure to achieve pregnancy after one year period of normal marital relationship
Proper investigations Suitable and needed investigations Most up to date equipments and expertise Very active laboratories and fast feedback Quality control
Development of fertility investigations Comprehensive Female tests Male tests Couple tests
Ia
The introduction of ultrasonography
Tubal patency
Iatrogenic tubal disease
III
Earlier Attempts at in vitro fertilization
IN Vitro Fertilization IVF era
Steptoe and Edwards hard work
The success of IVF
The difficult birth of modern ART
The birth of the first IVF {test tube} baby in the middle east 1987 The pregnancy was achieved at DR Soliman Fakeeh hospital and followed by many others
The introduction of transvaginal Ultrasonography to the middle east By the team of DSFH 1987
Intra cytoplasmic sperm injection ICSI era Pregestational diagnosis PGD era
ICSI and PGD
The Birth of the first ICSI baby in the middle east 1994 By DSFH team
ICSI and sever male factor infertility ICSI and testicular tissue ICSI and frozen testicular tissues
In Vitro fertilization for the fertile couple Genetic disorders Cancer Stem cells
Reproductive medicine and fetal abnormalities Chromosomal disorders Gender selection Genetic disorders
Statistics Cancer One in every 600-700 members of our race could be a victim of one type of cancer. One in every 900 individuals between the ages of 15-45 years have survived cancer (2007) One in every 250 have survived cancer by 2010
Statistics Breast cancer in females life time risk is 11%, (RCOG Guide line 12) 178 480 new cases in 2007 in USA Leukaemia and Lymphomas in children rate of 1 in 650 13 400 new cases in 2007 in USA (Wallace review 2005)
Reproductive medicine and preservation of fertility in cancer patients Storage of human gametes Storage of ovarian tissues Storage of human embryos Reimplantation technology In vitro maturation of gametes Stem cells usage in cancer patients
The introduction of new freezing methods to the middle east Vitrification techniques The birth of the first baby from vitrification in the middle east 2006 DSFH team
Laboratory Techniques Sperms Oocytes Follicles Fertilized oocytes Divided embryos Ovarian tissues Whole ovaries Testicular tissues Blastocysts
Leukaemia party
Future is being written
Thank you