University Clinical Center Banja Luka, Breast Center - Banja Luka, Bosnia and Herzegovina

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- Banja Luka, Bosnia and Herzegovina General Information New breast cancer cases treated per year 245 Breast multidisciplinarity team members 23 Radiologists, surgeons, pathologists, medical oncologists, radiotherapists and nurses The Breast Unit was established on 1st February 2009 with the main purpose and reason to improve the results related to diagnosis and treatment of breast cancer, as well as to apply modern principles of oncoplastic surgery during treatment of breast cancer. Oncoplastic surgery implies conservative breast surgery with determination of sentinel lymphatic nodule, wire guided localization mark of breast non-palpable lesion, as well as primary and secondary reconstruction of breast after mastectomy. In the Breast Unit a multi-disciplinary approach is performed, which means that all patients' cases are discussed collectively by radiologists, pathologists, oncologists, and surgeons in multi disciplinary meeting every Friday at 12 a.m. Appointments can be scheduled at the local telephone number +38051/342 242. The specialized infirmary is open from 7.00 a.m. until 3.00 p.m. Breast Unit can always provide patients with three hospital rooms with three beds each. University Clinical Center Banja Luka, Breast Center 12 beba No. 1 78.000 Banja Luka, Phone: +38751342200 Fax: +38751310530 E-mail: breast.center@kc-bl.com Web-site: www.kc-bl.com 1/6

Available services Reconstructive/Plastic Surgery Nuclear Medicine Rehabilitation Genetic Counselling Data Management Psycho-oncology Breast Nurses Social Workers Nutritional Counselling Survivorship Groups Sexual Health Counselling Supportive and Palliative Care Integrative Medicine Dedicated Radiologists 5 Mammograms per year 5000 Breast radiographers Screening program Verification for non-palpable breast lesions on specimen Axillary US/US-guided FNAB Available imaging equipment Mammography Ultrasound Magnetic Resonance Imaging (MRI) Available work-up imaging equipment Computer Tomography Ultrasound Magnetic Resonance Imaging (MRI) PET/CT scan Primary technique for localizing non-palpable lesions Hook-wire (or needle localization) Charcoal marking/tattooing ROLL: radio-guided occult lesion localization Available breast tissue sampling equipment Stereotactic Biopsy (Mammography guided) Core Biopsy (Tru-cut) Vacuum assisted biopsy Ultrasound-guided biopsy Fine-needle aspiration biopsy (FNAB, cytology) Core Biopsy Vacuum assisted biopsy MRI-guided biopsy Core Biopsy Vacuum assisted biopsy New operated cases per year (benign and malignant) 489 Dedicated Breast Surgeons 3 Surgeons with more than 50 surgeries per year 2 beds 9 Breast Nurse specialists 7 Outpatient surgery Intra-operative evaluation of sentinel node Reconstruction performed by Breast Surgeons Primary technique for staging the axilla Axillary lymph node dissection Sentinel lymph node biopsy: Blue dye technique Radio-tracer technique Blue dye + Radio-tracer Axillary sampling 2/6

Reconstructive/Plastic Surgery Reconstructive/Plastic surgeons 3 Immediate Reconstruction available Type of breast reconstructive surgery available Remodelling after breast-conserving surgery Reconstruction after mastectomy: Two-stage reconstruction (tissue expander followed by implant) One-stage reconstruction Autogenous tissue flap Latissimus dorsi flap Transverse rectus abdominis (TRAM) Free-flaps (free TRAM, DIEP, SIEA, gluteal, etc.) Surgery on the contralateral breast for symmetry Nipple Reconstruction Dedicated Breast Pathologists 2 Available studies Cytology Haematoxylin & eosin section (H&E) Surgical specimen Sentinel node Core biopsy Frozen section (FS) Surgical specimen Sentinel node Immunohistochemistry stain (IHC) Estrogen receptors Progesterone receptors HER-2 Ki-67 Other special studies available Fluorescence in-situ Hybridization for HER-2 gene (FISH) Oncotype Dx (21-gene assay) MammaPrint (70-gene microarray) Prediction Analysis of Microarray 50-gene set (PAM 50) CISH, SISH Parameters included in the final pathology report stage (pt and pn) Tumour size (invasive component in mm) Histologic type Tumor grade ER/PR receptor status HER-2/neu receptor status Peritumoural/Lymphovascular invasion Margin status Microcalcifications Dedicated Breast Medical Oncologists 5 Outpatient systemic therapy 3/6

Dedicated Radiation Oncologists Available techniques after breast-conserving surgery (including experimental) Whole-Breast RT (WBRT) Partial breast irradiation (PBI): External beam PBI Interstitial brachytherapy Targeted brachytherapy (MammoSite, SAVI applicator, other devices) Intra-operative RT (IORT) Multidisciplinary Meeting (MDM) / Tumour Board (TB) Regular MDM/TB for case management discussion Twice a week Weekly Every two weeks Other Schedule Cases discussed at MDM/TB Preoperative cases Postoperative cases Specialties/services participating in MDM/TB Reconstructive/Plastic Surgery Genetic Counselling Breast Nurse Service Psycho-oncology Further Services and Facilities Nuclear Medicine Lymphoscintigraphy Bone scan Positron Emission Tomography (PET) PET/CT scan Rehabilitation Prosthesis service Physiotherapy Lymph-oedema treatment Genetic Counselling Specialist Providing Genetic Counselling/Risk assessment service: Dedicated Clinical Geneticist Medical Oncologist Breast Surgeon General Surgeon Gynaecologist Genetic Testing available Surveillance program for high-risk women Data Management Database used for clinical information Data manager available 4/6

Contact details Violeta Popovic, MD Breast Radiologist vpvp@blic.net +38765649079 Aleksandar Guzijan, MD, MSc Head of Breast Center aleksandar.guzijan@kc-bl.com +38751342435 Reconstructive Surgery Nikola Baroš, MD Head Of Clinic For Plastic And Reconstructive Surgery nikola.baros@kc-bl.com +38751342100 Radoslav Gajanin, PhD Breast Pathologist radoslav.gajanin@kc-bl.com +38765657787 Bozana Babic, MSc Breast Pathologist bozana.babic@kc-bl.com +38751342334 Zdenka Gojkovic, MD, PhD Head of Oncology Clinic zdenka.gojkovic@hotmail.com +38751342676 Dušan Mileusnic, MD, PhD Head of Center for +38751342100 5/6

How to reach us University Clinical Center Banja Luka, Breast Center 12 beba No. 1 78.000 Banja Luka, Phone: +38751342200 Fax: +38751310530 E-mail: breast.center@kc-bl.com Web-site: www.kc-bl.com From airport: The distance between the International Airport Banja Luka from Banja Luka downtown is 23 km. By train: From Railway station Banja Luka to Hospital: 3km. By bus or sub-way/underground: From Bus station Banja Luka to Hospital: 3km. Last modified: 13 February 2018 6/6