UNIVERSITY OF MINNESOTA

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Twin Cities Campus Department of Obstetrics, Gynecology and Women s Health Medical School Mayo Mail Code 395 420 Delaware Street SE Minneapolis, MN 55455 Office: 612-626-3111 Fax: 612-626-0665 Quarterly Grant Activities and for the Department of Obstetrics, Gynecology and Women s Health Greetings: Below please find the quarterly grant activities and publication report summary for the Department of Obstetrics, Gynecology and Women s Health for third quarter of FY18 (January -March 2018). Please find Supporting documents attached for your independent review. OBGYN FY2018 JUL AUG SEP OCT NOV DEC JAN FEB MAR APR MAY JUN YTD Grant Submissions: Gynecologic Oncology 2 1 5 13 3 1 2 2 5 34 Maternal-Fetal Medicine 2 0 1 0 0 0 0 0 1 4 Women's Health 0 0 0 0 0 0 0 1 0 1 Urogynecology - - - 0 0 0 1 0 0 1 Grant Awards: Gynecologic Oncology 2 2 0 1 0 0 3 1 1 10 Maternal-Fetal Medicine 0 0 0 0 1 0 0 0 0 1 Women's Health 0 0 0 0 0 0 0 0 0 0 Urogynecology - - - 0 0 0 0 0 0 - Publications*: Gynecologic Oncology 3 0 1 2 2 1 5 2 4 20 Maternal-Fetal Medicine 3 0 2 1 1 1 0 0 0 8 Women's Health 1 1 0 0 0 0 0 0 0 2 Urogynecology - - - 0 0 0 0 0 0 - *Epubs are not included in the numbers above, rather credit is given in the actual published month Should you have questions or concerns regarding the data above or individual reports, please let me know. Regards, Linda Carson, MD, FACOG Department Head Obstetrics, Gynecology and Women s Health p.p. Kit Brown

Grant Activies Report January 2018 Grant Submissions: Faculty Name(s) Division Role Sponsor Submitted Start Date Amt Requested Title Teoh, Deanna MD GynOnc PI Masonic Cancer Center - Driven 2 1/9/2018 7/1/2018 $ 7,500 D2D Survey of Parent/Guardian and Adolescent Roles in HPV Vaccination Decision Discover Fischer, John MD UroGyn PI Masonic Cancer Center - Driven 2 Discover 01/16/2018 07/01/2018 $ 7,500 Please don't make me cough, laugh or sneeze! What is the Prevalence of Female Pelvic Floor Disorders in Minnesota? Teoh, Deanna MD GynOnc co-i AHC Global Health Seed Grant 1/26/2018 3/1/2018 $ 25,000 A Comprehensive Survey to Identify Barriers to and Facillators of Cervical Cancer Screening in HIV Positive Women in Guangxi, China Gyn Onc 2 MFM 0 ObGyn 0 UroGyn 1 Total $ 40,000 Grant Awards: Faculty Name(s) Division Role Sponsor Funding Period Award Amount Title Geller, Melissa MD GynOnc PI Randy Shaver 01/01/2018 12/31/2018 $ 50,000 Maximizing Natural Killer Cell Immunotherapy in Ovarian Cancer Community Fund Bazzaro, Martina PhD GynOnc PI Randy Shaver Community Fund 01/01/2018 12/31/2018 $ 30,000 Testing and gene expression profiling to detect chemoresistant endometrial cancer Starr, Tim PhD GynOnc PI Randy Shaver Community Fund 01/01/2018 12/31/2018 $ 50,000 Improving natural killer cells for treating patients with ovarian cancer $ 130,000 Gyn Onc 3 MFM 0 ObGyn 0 UroGyn -

January 2018 Publications: Faculty Name(s) Division Author Journal Status Pub Date Title Geller, Melissa MD GynOnc American Journal of Obstetrics and Gynecology Published Jan-18 Surgical outcomes among elderly women with endometrial cancer treated by laparoscopic hysterectomy: A NRG/Gynecologic Oncology Group Study Geller, Melissa MD GynOnc Gynecologic Oncology Published Jan-18 An NRG Oncology/GOG Study of molecular classification for risk prediction in endometrioid endometrial cancer Geller, Melissa MD Uppendahl, Locke (fellow) Dahl, C (med student) Teoh, Deanna MD Carson, Linda MD GynOnc Last First Frontiers in Immunology GynOnc First Journal of Lower Genital Tract Diseases Published Jan-18 Natural kill cell-based immunotherapy in gynecologic malignancy. A review Published Jan-18 A Cross-Sectional Review of Cervical Cancer Awareness Month Argenta, Peter MD GynOnc Gynecologic Oncology Published Jan-18 Predictive modeling for determination of microscopic residual disease at primary cytoreduction: An NRG Oncology/Gynecologic Oncology Group 182 study. Geller, Melissa MD Teoh, Deanna MD GynOnc Last Laboratory Medicine Epub ahead Contag, Stephen MD MFM Journal of Maternal Fetal Neonatal Medicine Epub ahead Jan-18 Jan-18 Assessment of Circulating Tumor Cells as a Predictive Biomarker of Histology in Women with Suspected Ovarian Cancer The impact of maternal body mass index on external cephalic version success Published Epub* Gyn Onc 5 1 MFM 0 1 ObGyn 0 0 UroGyn 0 0 *Epubs are not included on the Medical School Calculation

Grant Activies Report February 2018 Grant Submissions: Faculty Name(s) Division Role Sponsor Submitted Start Date Amt Requested Title Bazzaro, Martina PhD GynOnc PI National Institute of Health - R01 2/5/2018 9/1/2018 $ 2,225,961 Investigation of the role of UNC-45A in Paclitaxel-mediated microtubule stability Winterhoff, Boris MD GynOnc PI National Institute of Health - R01 2/5/2018 09/01/2018 $ 3,684,483 Molecular stratification for bevacizumab and platinum based chemotherapy response in ovarian cancer Boraas, Christy MD GynOnc co-i National Institute of 2/5/2018 9/1/2018 $ 3,627,948 Bupropion for the Prevention of a Postpartum Smoking Relapse Health - R01 $ 9,538,392 Gyn Onc 2 MFM 0 ObGyn 1 UroGyn 0 Grant Awards: Faculty Name(s) Division Role Sponsor Funding Period Award Amount Title Teoh, Deanna MD GynOnc PI Masonic Cancer Center - Driven to 04/01/2018 12/31/2018 $ 7,500 D2D Survey of Parent/Guardian and Adolescent Roles in HPV Vaccination Decision Discover $ 7,500 Gyn Onc 1 MFM 0 ObGyn 0 UroGyn 0

February 2018 Publications: Faculty Name(s) Division Author Journal Status Pub Date Title GynOnc Surgical Innovations Published Negative Pressure Wound Therapy in Obese Patients Following Looby (Resident) First Cesarean Delivery Geller, Melissa MD GynOnc Gynecologic Oncology Published Clinicopathologic characteristics associated with long term survival in advanced epithelial ovarian cancer: an NRG Oncology/Gynecologic Oncology Group ancillary data study Geller, Melissa MD GynOnc JCI Insight Epub ahead Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. Erickson, Britt MD GynOnc Cancer Medicine Epub ahead Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinoma Erickson, Britt MD GynOnc Journal of Lower Genital Tract Diseases Epub ahead Vogel, Rachel RhD GynOnc Support Care Cancer Epub ahead GynOnc Laboratory Medicine Epub ahead Contag, Stephen MD MFM Journal of Perinatology Epub ahead High Rates of High-Grade Cervical Dysplasia in High-Risk Young Women with Low-Grade Cervical Cytology A pilot investigation on impact of participation in a long-term follow-up clinic (LFTU) on breast cancer and cardiovascular screening among women who received chest radiation for Hodgkin Lymphoma A pilot study evaluating chemotherapy tolerability for breast cancer patients who have received prior treatment and chest radiation for Hodgkin Lymphoma. Utility of prenatal Doppler ultrasound to predict neonatal impaired cerebral autoregulation.

February 2018 Published Epub* Gyn Onc 2 5 MFM 0 1 ObGyn 0 0 UroGyn 0 0 *Epubs are not included on the Medical School Calculation

Grant Activies Report March 2018 Grant Submissions: Faculty Name(s) Division Role Sponsor Submitted Start Date Amt Requested Title Geller, Melissa MD GynOnc Co-I MOCA 03/01/2018 5/1/2018 $ 299,648 Use of SEER-Medicare Data and Micro-Simulation Modeling to Personalize Surveillance for Ovarian Cancer Recurrence Geller, Melissa MD GynOnc Co-I MOCA 03/01/2018 05/01/2018 $ 100,000 Engineered natural killer cells expressing chimerix CD64 as a cancer immunotherapy Starr, Tim PhD GynOnc Co-I MOCA 03/01/2018 5/1/2018 $ 200,000 Genetically Engineered Natural Killer Cells for Ovarian Cancer Immunotherapy Starr, Tim PhD GynOnc PI MOCA 03/01/2018 07/01/2018 $ 178,324 Identifying platinum resistance one cell at a time Bazzaro, Martina PhD GynOnc PI MOCA 03/01/2018 7/1/2018 $ 151,878 Targeting of mitochondrial activity to prevent and treat recurrent ovarian cancer Nyholm, Jessica MD MFM Co-I National Institute of Health - R01 03/05/2018 09/01/2018 $ 3,795,159 RESUBMISSION: Progesterone and Exercise for the Prevention of Postpartum Relapse Gyn Onc 5 MFM 1 ObGyn 0 UroGyn 0 Grant Awards: Faculty Name(s) Division Role Sponsor Funding Period Award Amount Title Teoh, Deanna MD GynOnc Co-I University of Minnesota - AHC 03/01/2018 02/28/2019 $ 25,000 A Comprehensive Survevy to Identify Barriers to and Facillators of Cervical Cancer Screening in HIV Positive Women in Guangxi, China Global Health Seed $ 25,000 Gyn Onc 1 MFM 0 ObGyn 0 UroGyn -

March 2018 Publications: Faculty Name(s) Division Author Journal Status Pub Date Title Teoh, Deanna GynOnc First Journal of Women's Epub ahead Mar-18 Is the Electronic Health Record the Answer to Improving Patient Health Complaince with Recommended Health Interventions? Erickson, Britt MD GynOnc Cancer Medicine Published Mar-18 Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma Erickson, Britt MD GynOnc Current Obstetrics Gynecology Report Published Mar-18 The Current Landscape of PARP Inhibitors in Ovarian Cancer Downs, Levi Jr MD GynOnc International Journal of Cancer Published Mar-18 Endometrial carcinoma recurrence according to race and ethnicity: An NRG Oncology/Gynecologic Oncology Group Scrafford, J (resident) Rivard, Colleen MD Geller, Melissa MD Teoh, Deanna MD Kim, T (resident) GynOnc First Last Archives of Gynecologic Oncology Epub ahead Mar-18 Effect of intra-operative glove changing during cesarean section on post-operative complications: a randomized controlled trial GynOnc Lab Medicine Published Mar-18 Assessment of Circulating Tumor Cell as a Predictive Biomarker of Histology in Women with Suspected Ovarian Cancer GynOnc First BMJ Journal Epub ahead Mar-18 Simulation shoulder dystocia: does it change outcomes? Jones, Cresta MD MFM Last Obstet Gyn Clin N Am Epub ahead Mar-18 Opioid Use Disorders and Pregnancy Published Epub* Gyn Onc 4 3 MFM 0 1 ObGyn 0 0 UroGyn 0 0 *Epubs are not included on the Medical School Calculation

March 2018