Course: Biology Out of Balance Module 1: Pathophysiology of the Liver and Detoxification 1.5 CEU-NCCAOM Instructor: Debi Rene Weiss, LAc., RN
Debi Weiss, R.N., Lic. Ac., Director of Transition to Health, Minneapolis, MN Originator of the Ideal Weight Program Weissacupuncture@gmail.com dstarwynn@edastwestmed.com
Liver Physiology Liver-Gut Axis: Biotransformation Liver-Gut Axis: Immunological Response Toxicity Sources Symptomology Liver Pathophysiology Phase I & II pathways Detoxification Protocols Nutritional Herbal/neutraceuticals Clay Rebounding Acupuncture Microcurrent/Color
Simple Questions, ch. 8: The Liver is like an army s general from whom the strategy is derived. Directs Qi Stores Blood Controls Sinews Manifests in the nails Opens into the eyes Houses Ethereal Soul
Hepar- or hepat: Greek meaning root 500 functions major role in metabolism Hepatocytes: (Gut-Liver Axis) Detoxification Protein synthesis Produces biochemicals for digestion Kupffer Cells: (Gut-Immune Axis) Immunologic response Produces bile: stored in Gall Bladder Filters 2 quarts of blood per minute
75% of blood received into the liver is venous delivered via the portal vein directly from GI system Filtration of toxins is absolutely critical, as the blood from the intestines contains high levels of toxic substances. Hepatocytes transform gut-derived compounds into safe by-products then directs them to the Bile for excretion or into arterial blood circulation
Kupffer cells: phagocytes (think Pac Man) Clear portal system of circulating debris Limit entry of bacterial toxins and endotoxins into systemic circulation Always in a state of low-grade alert Exaggerated Immune Response Leaky Gut Impaired hepatic clearance
Toxin: substance that precipitates an immune reaction Ingestion Inhaled Topical Immune system tolerance: Views toxin as not self therefore dangerous Directly damage structure & function of cells Strains liver detoxification system
Heavy metals: mercury, lead, arsenic Chemicals: PCB s, dioxins Pesticides Plastics: BPA Drinking water: toxic run-off, prescriptions Non-organic animal consumption GMO s Xenobiotics Endotoxins: gut bacteria, yeast, parasites
212 chemicals typically found Widespread exposure: industrial chemicals Updated September 2013 91 chemicals not previously reported 201 tables updated 49 chemicals added currently 250 chemicals listed 770 pages www.cdc.gov/exposurereport
Body Burden: The Pollution in Newborns 2005 report on 10 newborn s cord blood Tested for industrial chemicals Found 287 total, 200 average/baby 47 common consumer product chemicals 212 banned or severely restricted chem. 28 waste byproducts 180/287 carcinogens (human or animal) 217/287 toxic to brain & nervous system 208/287 cause birth defects or abnormal development (animal tests)
PHASE 1 CYTOCROME P450 Modification: fat soluable toxins drugs steroid hormones Require: oxygen vit. B, C, E glutathione antioxidants I N T E R M E D I A R Y M E T A B O L I T E S Free Radicals Antioxidants PHASE 2 CONJUGATION Conjugation: I.M. transformed water soluable excrete via stool/urine Require: amino acids *glutamine phytochemicals
Brain fog poor focus/concentration Fatigue exhaustion Body aches - headaches Sensitivity to odors Digestive issues: bloating, nausea Tingling of extremities Weight gain - difficulty losing weight Feeling heavy, puffy, swollen Depression, irritability, apathy
Liver Qi Stagnation Liver Blood Stasis Liver-Fire Liver-Wind Damp-Heat in Liver-Gall Bladder Deficiency of Liver-Blood Liver Yang Rising Liver Invading Spleen Liver Invading Stomach
Qi Stagnation-distention, n/v, belching, gas, appetite changes, diarrhea, constipation, cramps, bitter taste, melancholy, irritability, impatience, PMS, irregular periods, pain Liver Blood-vomiting Blood, clots, headaches, floaters, menstrual >/<, muscle weakness Liver Wind/Fire-dizziness, tics, tremors, numbness, tinnitus, red eyes, high temp Damp-discharges, itching, dark urine,
Detoxification Questionnaire Part 1: Medical Symptom Questionnaire (MSQ) measures minimal/moderate/elevated toxic load Part 2: Xenobiotic Tolerability Test (XTT) A chemical compound (as a drug, pesticide, or carcinogen) that is foreign to a living organism
Nutritional Herbal/neutraceutical Clay Rebounding Acupuncture Microcurrent Color
Functional Medicine resources: Drs. Susan Blum, Mark Hyman, Diana Schwarzbein Complete Detox Elimination Diet 10-21 days Gluten, dairy, soy, corn, peanuts, oranges Processed foods-sugar, trans-fats Alcohol, caffeine, coffee, chocolate Incorporate Healing Foods Support Phase I & II: Vit. A, B s, C, phytonutrients Reduce Inflammation: Omega 3 s Heal Gut: Vit. A, zinc, antioxidants, fermented Blood Sugar: all of the above
Support Phase 1-2 Detox Pathways Advaclear: Metagenics Liver Formulas Healthy Liver Formula: herbal tincture (HerbPharm) Cell Food: 8 drops/8 oz. H2O/3 X day Generates bio-available O2 Reduces free radicals Eliminaid: stellar bowel formula
Glutathione, alpha lipoic acid Zinc Green algae Soluble fiber PGX: Natural Factors (pgx.com) Clay baths/foot soaks, internal ingestion magneticclay.com Practitioner supervised chelation
Needak rebounders Improves digestion Improves elimination of cellular waste Accelerates metabolism Increases O2 uptake Increases cellular respiration Promotes detox via lungs, skin, lymph Does not stress joints 2 minutes of rebounding flushes lymphatics
Microcurrent Pads: Ch.A: Liv-13 Ch.B: CV 12-6 Intensity ~ 50-100uA Ch.A: 50, 40, 284, 57, 49 / Ch.B: 35 (13, 38) 5-7 minutes per frequency Acupuncture: Bilateral: ST-25,36, Sp-15, K-14, SJ-5, GB-41 Auricular: Shen men, Point zero, Liver Yin tang
Cell Food Lumina Health 1-800-749-9196 luminahealth.com Rebounders Needak 1-800-232-5762 needak-rebounders.com Clay L L Magnetic Clay 925-968-1571 magneticclay.com Energique (Eliminaid) 1-800-869-8078 Emerson Ecologics 1-800-654-4432 emersonecologics.com