Desmopressin Monoacetate apollo +919146950950 Desmopressin Monoacetate apollo +919146950950 Desmopressin Monoacetate CAS Number : 62288-83-9 Protein binding : 50% Molecular Weight : 1069.22 g/mol Molecular Formula : C12H24N2O4 Systematic (IUPAC) : 2-methyl-2-({[(propan-2- yl)carbamoyl]oxy}methyl)pentyl carbamate DRUG DESCRIPTION
Desmopressin is a synthetic replacement for antidiuretic hormone, the hormone that reduces urine production during sleep. It may be taken nasally, intravenously, or as a pill. Doctors prescribe Desmopressin most frequently for treatment of diabetes insipidus or bedwetting. In December 2007, US drug regulators banned using desmopressin nasal sprays for treating bedwetting, but said that desmopressin pills are still a safe bedwetting treatment for otherwise healthy patients. The regulators reviewed the drug after two patients using desmopressin nasal sprays died from hyponatremia, an imbalance of sodium levels in the body. This medication is used to treat diabetes insipidus, for surgical procedures, head injury or other conditions requiring fluid control. DOSAGE Take this by mouth as directed. Your dose and the frequency with which you take this will be based on your condition and response. Do not increase the dose, take this more often or stop taking this medication without first consulting your doctor. Limit drinking of water or other fluids while using this medication. Adults and Children: It is recommended that patients be started on doses of 0.05 mg (1/2 of the 0.1 mg tablet) two times a day and individually adjusted to their optimum therapeutic dose. Most patients in clinical trials found that the optimal dosage range is 0.1 mg to 0.8 mg daily, administered in divided doses. Each dose should be separately adjusted for an adequate diurnal rhythm of water turnover. Total daily dosage should be increased or decreased in the range of 0.1 mg to 1.2 mg
divided into two or three daily doses as needed to obtain adequate antidiuresis. See Pediatric Use subsection for special considerations when administering desmopressin acetate to pediatric diabetes insipidus patients. SIDE EFFECTS headaches facial flushing nausea hyponatremia Headache, nausea, mild stomach cramps and flushing may occur. If any of these effects persist or worsen, inform your doctor. Notify your doctor if you experience: headache, sudden weight gain, seizures. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. PRECAUTIONS Intranasal formulationsat high doses and Injection have infrequently produced a slight elevation of blood pressure which disappears with a reduction of dosage. Although this effect has not been observed when single oral doses up to 0.6 mg have been administered, the drug should be used with caution in patients with coronary artery insufficiency and/or hypertensive cardiovascular disease, because of a possible rise in blood pressure.should be used with caution in patients with conditions associated with fluid and electrolyte imbalance, such as cystic fibrosis, heart failure and renal
disorders because these patients are prone to hyponatremia.rare severe allergic reactions have been reported Nursing Mothers: There have been no controlled studies in nursing mothers. A single study in postpartum women demonstrated a marked change in plasma, but little if any change in assayablein breast milk following an intranasal dose of 0.01 mg.it is not known whether the drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when DDAVP is administered to nursing mothers.pediatric Use: Central Diabetes Insipidus:have been used safely in pediatric patients, age 4 years and older, with diabetes insipidus for periods up to 44 months. In younger pediatric patients the dose must be individually adjusted in order to prevent an excessive decrease in plasma osmolality leading to hyponatremia and possible convulsions; dosing should start at 0.05 mg (1/2 of the 0.1 mg tablet). Use of in pediatric patients requires careful fluid intake restrictions to prevent possible hyponatremia and water intoxication. Fluid restriction should be discussed with the patient and/or guardian INTERACTION Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially
of: chlorpromazine, chlorpropamide, clofibrate, demeclocycline, drugs that increase blood pressure (e.g., dopamine, epinephrine, ephedrine, norepinephrine), fludrocortisone, heparin, lithium, narcotic pain relievers (e.g., codeine), nonsteroidal anti-inflammatory drugs (e.g., celecoxib, ibuprofen, naproxen), oxybutynin, antiseizure drugs (e.g., carbamazepine, lamotrigine), SSRI antidepressants (e.g., fluoxetine, sertraline), tricyclic antidepressants (e.g., amitriptyline, imipramine), urea, "water pills" (diuretics such as furosemide, hydrochlorothiazide), alcohol use. Ask your doctor how much alcohol you may drink, if any. Alcohol interferes with desmopressin by increasing urination. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. INTERACTION Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: chlorpromazine, chlorpropamide, clofibrate, demeclocycline, drugs that increase blood pressure (e.g., dopamine, epinephrine, ephedrine, norepinephrine), fludrocortisone, heparin, lithium, narcotic pain relievers
(e.g., codeine), nonsteroidal anti-inflammatory drugs (e.g., celecoxib, ibuprofen, naproxen), oxybutynin, antiseizure drugs (e.g., carbamazepine, lamotrigine), SSRI antidepressants (e.g., fluoxetine, sertraline), tricyclic antidepressants (e.g., amitriptyline, imipramine), urea, "water pills" (diuretics such as furosemide, hydrochlorothiazide), alcohol use. Ask your doctor how much alcohol you may drink, if any. Alcohol interferes with desmopressin by increasing urination. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. CONSUMER INFORMATION This medication is used to reduce urination in certain cases (e.g., diabetes insipidus, surgery). It is also used to control bed-wetting. It is a man-made form of a certain natural hormone made by the body (vasopressin). It works by making your kidneys concentrate your urine, so you produce less of it. Take this medication by mouth with or without food, usually 1 to 3 times daily or as directed by your doctor. Do not use it more frequently than prescribed without your doctor's approval. Limit drinking of water or other fluids from 1 hour before to 8 hours after taking this medication. Consult your doctor for details. Dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day. MISSED DOSE: If you miss a dose and use 1 dose daily, use it as soon as you remember, unless you do not remember until the next day. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. If you use more than 1 dose daily, use it as soon as you remember, unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.storage: Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. apollo asia Division apollo Pharmaceuticals INDIA [P] Ltd asia Division Mr.Vipin Saxena CEO DIRECT:+912265785588 Wireline Purchase HELPDESK: +91-22-65050001 +91-22-65650001 Wireline Sales HELPDESK: +91-22-65500009 +91-22-65050009 Wireless 24x7 HELPDESK: +9191-46-951951 +9191-46-950950
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