Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis

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Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis Srikanth Divi, MD Cody Lee, BS Douglas Dirschl, MD Kelly Hynes, MD Department of Orthopaedic Surgery and Rehabilitation

Disclosure NO CONFLICTS TO DISCLOSE Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis Srikanth Divi, MD Cody Lee, BS Douglas Dirschl, MD Kelly Hynes, MD Our disclosures are in the Final AOFAS Mobile App. We have no potential conflicts with this presentation. Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 2

Introduction Osteomyelitis (OM) of the foot and ankle is a common condition with a high economic burden, especially in the context of diabetes mellitus Timely and accurate diagnosis of OM is important for treatment initiation and for the reduction of healthcare costs MRI is considered the most sensitive imaging modality for OM of the foot and ankle, but is associated with significant cost and variable treatment impact when compared to plain radiographs Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 3

Objectives The purpose of this study is to determine: 1) the proportion of patients with a diagnosis of osteomyelitis that underwent an MRI 2) the rate of operative procedures in the MRI cohort and non-mri (NMRI) cohort 3) the proportion of MRIs that changed clinical treatment leading to an operative procedure (impact study) 4) the effective cost of MRI for osteomyelitis of the foot and ankle Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 4

Materials and Methods Patients were retrospectively identified at a single tertiary care, academic medical center and included if: treated between January 2009 and September 2015 diagnosed with OM using ICD-9 codes 730.07, 730.17, 730.27 (acute, chronic, and unspecified osteomyelitis of the foot and ankle) Demographic data, patient comorbidities, use of imaging, and any operative procedures were identified Impact MRI was defined as MRI that led to an operative procedure within the same admission encounter Cost of impact MRI was estimated using the following equation: Cost ( $ ) = average MRI cost $ " total MRIs % ( ) $ ' # impact MRIs & Student s t-test and Chi-squared test were used to statistically compare the MRI and NMRI cohorts Exclusion criteria: 1) patients <18 years old; 2) patients with <2 weeks of follow-up Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 5

Results Patient flowchart 543 pts + MRIs (144 pts) 220 MRIs 83 impact MRIs 137 non-impact MRIs - MRIs (399 pts) + procedures (102 pts) - procedures (42 pts) + procedures (281 pts) - procedures (118 pts) Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 6

Results No statistically significant differences between the two cohorts with regards to age, sex, race or ethnicity No significant difference in operative rates between the two cohorts (MRI=70.8% vs. NMRI=70.4%, p=0.93) MRI cohort had greater mean Charlson Comorbidity Index value (MRI=3.4±2.2 vs. NMRI=2.7±2.1, p<0.05) and longer mean follow-up time (MRI=98.7±82.1 vs. NMRI=74.9±68.8, p<0.05) Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 7

Results Types of procedures performed between groups were different (Chi-squared, p<0.05) NMRI group had slightly higher amputation rates (amputation through foot, ankle disarticulation, BKA, and AKA) Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 8

Results 83 of 220 (37.7%) MRIs were impactful Significant increasing trend identified for total MRIs ordered over time (p=0.012), as well as for impact MRIs (p=0.020) The proportion of impact MRIs to total MRIs remained similar year-to-year (p=0.43) MRIs over 1me 70 # MRIs performed 60 50 40 30 Impact MRIs 20 Non- impact MRIs 10 0 2009 2010 2011 2012 2013 2014 2015 Year Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 9

Results Average MRI cost increased significantly (p=0.037) No significant trend found for effective MRI cost (p=0.950) Effec1ve Cost of MRI over Time 20000 18000 16000 Cost of MRI ($) 14000 12000 10000 Avg MRI Cost 8000 EffecAve Cost MRI 6000 4000 2000 0 2009 2010 2011 2012 2013 2014 2015 Year Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 10

Conclusions 144 out of 543 patients diagnosed with osteomyelitis of the foot and ankle underwent MRI No significant difference found in operative rate between MRI and non-mri cohorts 83 out of 220 performed MRIs were impactful Effective cost of impact MRI ranged from $8,568.00 to $18,853.30, roughly 2 to 5 times the average MRI cost This study suggests that the use of MRI adds cost while not necessarily changing treatment in patients diagnosed with foot and ankle osteomyelitis Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 11

References 1. Nelson EA, O'Meara S, Craig D, Iglesias C, Golder S, Dalton J, et al. A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers. Health Technology Assessment. 2006;10(12). 2. Markanday A. Diagnosing Diabetic Foot Osteomyelitis: Narrative Review and a Suggested 2-Step Score-Based Diagnostic Pathway for Clinicians. Open Forum Infectious Diseases. 2014;1(2). 3. Dinh MT, Abad CL, Safdar N. Diagnostic Accuracy of the Physical Examination and Imaging Tests for Osteomyelitis Underlying Diabetic Foot Ulcers: Meta Analysis. Clinical Infectious Diseases. 2008;47(4):519 27. 4. Lipsky BA, Berendt AR, Cornia PB, Pile JC, Peters EJG, Armstrong DG, et al. Executive Summary: 2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infections. Clinical Infectious Diseases. 2012;54(12):1679 84. 5. Eckman MH, Greenfield S, Mackey WC, Wong JB, Kaplan S, Sullivan L, et al. Foot infections in diabetic patients: decision and cost-effectiveness analyses. JAMA. 1995;273(9):712 20. 6. Larson DL, Gilstrap J, Simonelic K, Carrera GF. Is There a Simple, Definitive, and Cost-Effective Way to Diagnose Osteomyelitis in the Pressure Ulcer Patient? Plastic and Reconstructive Surgery. 2011;127(2):670 6. 7. Keeney JA, Nunley RM, Adelani M, Mall N. Magnetic Resonance Imaging of the Hip: Poor Cost Utility for Treatment of Adult Patients With Hip Pain. Clinical Orthopaedics and Related Research. 2014;472(3):787 92. 8. Chow I, Lemos EV, Einarson TR. Management and Prevention of Diabetic Foot Ulcers and Infections. Pharmacoeconomics. 2008;26(12):1019 35. 9. Morrison WB, Schweitzer ME, Wapner KL, Hecht PJ, Gannon FH, Behm WR. Osteomyelitis in feet of diabetics: clinical accuracy, surgical utility, and costeffectiveness of MR imaging. Radiology. 1995;196(2):557 64. 10. Game FL. Osteomyelitis in the Diabetic Foot. Medical Clinics of North America. 2013;97(5):947 56. 11. Dinh T, Snyder G, Veves A. Review Papers: Current Techniques to Detect Foot Infection in the Diabetic Patient. The International Journal of Lower Extremity Wounds. 2010;9(1):24 30. 12. Donovan A, Schweitzer ME. Use of MR Imaging in Diagnosing Diabetes-related Pedal Osteomyelitis. RadioGraphics. 2010;30(3):723 36. 13. Morales Lozano R, Gonzalez Fernandez ML, Martinez Hernandez D, Beneit Montesinos JV, Guisado Jimenez S, Gonzalez Jurado MA. Validating the Probeto-Bone Test and Other Tests for Diagnosing Chronic Osteomyelitis in the Diabetic Foot. Diabetes Care. 2010;33(10):2140 5. Financial Impact of MRI in the Treatment of Foot and Ankle Osteomyelitis 12