WHAT IS IT? The Nuclear Stress exam is a diagnostic nuclear medicine exam used to determine if the heart muscle is getting the blood supply it needs.

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WHAT IS IT? The heart receives life-giving blood from vessels called coronary arteries. If these arteries become partially blocked or narrowed by the accumulation of fatty materials, the heart may not receive the blood it needs to function properly. This narrowing of coronary arteries is called coronary atherosclerosis or, more commonly, coronary artery disease (CAD). Due to recent changes in federal regulations and state radiation requirements, only patients will be allowed in the camera room and stress labs. The Nuclear Stress exam is a diagnostic nuclear medicine exam used to determine if the heart muscle is getting the blood supply it needs. As CAD progresses, the heart muscle may not receive enough blood when under stress (for example, when exercising). This often results in chest pain called angina pectoris. On the other hand, there may be no outward physical signs of the disease. If CAD is limiting blood flow to a part of your heart, the nuclear stress exam may be useful in detecting the presence and significance of CAD.

There are two types of procedures that can be used for this test. Your Cardiologist has requested the one marked below. PRECAUTIONARY INFORMATION 0 CARDIOLITE TREADMILL TEST The CARDIOLITE administered during this stress exam contains a small amount of radioactivity. The amount of radiation you will be exposed to is comparable to that from an x-ray CAT (CT) scan. Adverse patient reaction to CARDIOLITE is rare. You may briefly notice a metallic taste a few seconds after injection has occurred. Other side effects have rarely occurred. D IV. LEXISCAN I.V. Lexiscan is used for asthma patients. Side effects which may occur include chest pain, shortness of breath, headache, changes in heart rate and blood pressure, nausea and flushing. If you are pregnant, suspect you may be, or are a nursing mother, discuss this with your doctor before undergoing any of the above procedures. 2

WHATSHOULDIDOBEFORE THE TEST? You will be asked not to eat or drink 4 to 6 hours prior to the test. This will minimize the possibility of nausea, which may accompany vigorous exercise after eating. In addition, the pictures of your heart are more clear when the stomach is not full. Your cardiologist may decide to temporarily discontinue certain heart medications prior to the stress exam. These are discontinued because some heart medications may interfere with the accuracy and effectiveness of the exam. The following are a list of medications that should not be taken the evening prior or morning of your stress test. These include: Betapace!Sotolol Atenoloi/Tenorm in Propranolol/lnderal Metoproloi/Lopressor/Toprol XUBetaloc Coreg/Carvedilol Zebeta Bisoprolol/Ziac Labetalolffrandate Cardizem/Tiazal If you have asthma and use inhalers, use normally and bring them with you to the office. A hospital gown may be provided on the day of the test. Slacks or shorts are preferred for the exercise portion of the exam. You should wear comfortable footwear appropriate for brisk exercise on a treadmill (a moving belt you walk on). You will work hard during the test and comfortable clothing will make it easier for you. 3

Do not eat or drink the items below 12 hours prior to test! Commonly Used Beverages and Foods Containing Caffeine Soft Drinks Coffee brewed drip coffee instant coffee decaffeinated brewed coffee decaffeinated instant coffee Tea brewed commercial tea brewed imported tea instant tea iced tea Food cocoa chocolate milk milk chocolate dark semisweet chocolate Baker's chocolate chocolate symp chocolate cake candy, chocolate candy, chocolate covered chocolate ice cream chocolate pudding, instant nut fudge brownie Coca-Cola Cola, -decaffeinated Dr Pepper Dr Pepper, Sugar-Free Jolt Cola Mellow Yellow Mountain Dew Mr.Pibb Pepsi Cola Pepsi, Diet Tab Energy Drinks Over-the-Counter Drugs Anacin* Excedrin* NoDoz* Commonly Prescribed Drugs Containing Caffeine Cafergot* (all forms) Darvon* Compound FiorinaJ Synalgos*-DC Wigraine~ (all furms) Some of the medicines containing theophylline that should be avoided 12-24 hours before your test. Prescription Medications Containing Theophylline* Theo -24~ Theovent<~> Long-Acting Slo-bidT" Gyrocaps<~> Theospan~ SR Theobid.., Jr. Duracap <~> Theophylline S.R. Slo-Phyllin Gyrocap s<~> Quibron<~>-T/SR TheolairT" S R Theo-Dur* Theoclear L.A. Bronkodyl Su s taire<~> Uniphyl<~> Theo-Dur* Sprinkle Elixophyllin <~> SR Constant-Ttl> Theochron Theobid(D Duracap<~> Aero late Respbid Trental *See PDR for more complete list. 4

CARDIOLITE TREADMILL PROCEDURE What will happen to me? Prior to the stress exam, you will be asked to sign a consent form. Please read the form carefully. If you have any questions about the procedure, do not hesitate to ask the person supervising the test. He or she can explain the entire procedure before it begins. An intravenous line (LV.) will be placed into your arm. This line will be used to inject CARDIOLJTE into your bloodstream for the first part of your test. This line will also be used throughout the test and will be removed as soon as the procedure is completed. The technologist will begin taking pictures after your injection. This is called imaging. For this portion of the exam, you will be asked to lie flat on an imaging table. Imaging begins with the camera positioned close to your chest. 5

Single Photon Emission Computed Tomography (SPECT). During aspect procedure, the camera moves slowly around your chest in an arc-like fashion. Each image takes approximately 20 to 30 seconds. The entire SPECT procedure typically lasts 12-15 minutes. It is important to stay as still as possible while the images are being taken. After the first set of images is completed you will be moved to the exercise room. We use this room to prepare you for either the treadmill or the adenosine procedure. Several small pads called electrodes will be pl aced on your chest. The pads will be connected to an EKG monitor so the cardiologist can monitor your heart rhythm closely during this portion of the test. Several electrodes will be placed on your chest, and an IV will be placed in your arm. 6

You will exercise by walking on a moving belt, called a treadmill, or you will be given a drug called Lexiscan (including patients with asthma or severe lung disease) to stress your heart. Please follow the instructions for the test checked on the front of this pamphlet. If you walk on the treadmill, it will move very slowly at first, then increase in speed. As you exercise longer and harder, your heart rate and blood pressure will rise. This is normal and they will be monitored along wi th your EKG. 7

You will be encouraged to continually exercise throughout the stress exam. If you experience any unusual symptoms at any time, such as light headedness, immediately tell the individual monitoring the test. Adjustments will be made to the exercise test, depending on your symptoms, blood pressure, EKG, or degree of fatigue. To increase the effectiveness of the test, it is important to exercise as long as you are able. CARDIOLITE* will be injected into the IV line approximately one minute before the end of exercise. The isotope will be carried to the heart via the bloodstream. The technologist will begin taking images 15 to 45 mjnutes following your exercise. These wih be taken the same way as images taken earlier. 8

I.V. LEXISCAN STRESS TEST PROCEDURE Lexiscan will dilate the coronary arteries, similar to what would happen during vigorous exercise. The infusion will last about a minute. You may feel the sensations described on page 2. They will last for a few minutes. At the end of the infusion, Cardiolite will be injected to capture the coronary arteries delivering as much blood as possible to the heart muscle and to determine if those arteries have narrowed. Cardiolite contains a very small amount of radioactivity that can be detected by a special camera used to take images of your heart. By studying the image, the doctor will be able to see which areas of the heart may not be receiving a sufficient blood and oxygen supply. Please remember to follow the instructions mentioned earlier in this brochure to prepare for your test. Be sure to tell the doctor or technologist administering the test: a) If you have any allergy to theophylline or dipyridamole, or b) If you have asthma, chronic lung disease or any heart conditions, or c) If you have consumed any of the beverages or foods listed on page 4 within 12 hours before your test, or d) If you have taken any of the medicines listed 2 days before your test. 9

What Happens After My Treadmill or Lexiscan Stress Test? Following completion of the exam, the doctor will discuss the results of the test with your own physician and submit a written report. Your physician will explain the test results and their implications to you at the time of your followup. If follow-up testing is needed, this office will arrange all necessary appointments for you. If you have any further questions please feel free to contact us. This pamphlet is not a substitute for an informed discussion between you and your physician. Consult your physician if you want more information on the procedures and medication described in this pamphlet. 10

YOUR STRESS EXAM WILL TAKE PLACE ON... Date: Time:--------------------------- Location: 1901 Port Lane Physician: Phone: 806-358-4596 Other notes/instructions: Test will take 2-2 1/2 hours Nothing to eat or drink except water 6 hours prior to test. No caffeine 12 hours prior to testing. Wear comfortable clothing. You may have a light breakfast if you have an afternoon appointment. If you are diabetic, please take your medication/insulin and eat a light meal. Amarill9 Heart Group 190 I Port Lane Amarillo, TX 79106 (806) 358-4596 Fax: (806) 358-6726 website: www.amarilloheartgroup.com