NORTHWEST AIDS EDUCATION AND TRAINING CENTER HIV Prevention in Clinical Care Settings Jeanne Marrazzo, MD, MPH Professor, Division of Allergy and Infectious Diseases University of Washington
HIV Prevention in Clinical Care Settings: 2014 Recommendations of the International IAS-USA-Society Panel Jeanne M. Marrazzo, MD, MPH; Carlos del Rio, MD; David R. Holtgrave, PhD; Myron S. Cohen, MD; Seth C. Kalichman, PhD; Kenneth H. Mayer, MD; Julio S. G. Montaner, MD; Darrell P. Wheeler, PhD, MPH; Robert M. Grant, MD, MPH; Beatriz Grinsztejn, MD, PhD; N. Kumarasamy, MD, PhD; Steven Shoptaw, PhD; Rochelle P. Walensky, MD, MPH; François Dabis, MD, PhD; Jeremy Sugarman, MD, MPH; Constance A. Benson, MD Marrazzo et al, JAMA, 2014.
HIV Prevention in Clinical Care Settings: 2014 Recommendations of the International Antiviral Society-USA Panel Free web access to the paper at jama.com Slide 3 of 34
IAS-USA HIV Prevention Recommendations: Goal Worldwide, ~2.3 million new HIV infections in 2012 In US, ~50,000 new HIV infections each year largely unchanged since the 1990s Integrated biomedical and behavioral HIV prevention tools and ART for treatment offer chance to curb the HIV epidemic Clinicians play a crucial role in implementing combination HIV prevention interventions These recommendations seek to consolidate best practices for clinicians across a range of HIV prevention issues Marrazzo et al, JAMA, 2014.
HIV Continuum of Care General General population: population: 9.2% 9.2% engaging engaging risk in risk behaviors behaviors! HIV-positive: HIV-positive: 1,144,500! Diagnosed Diagnosed with with HIV: HIV: 963,600 963,600! Diagnosed Diagnosed with with HIV HIV in in 2011: 2011:! 79.8% 79.8% linked linked to to care! care Diagnosed with HIV as as of of 2010: 2010: 50.9%! retained in care 50.9% retained in care! Diagnosed with HIV as of of 2010: 2010: 327,485 327,485 with viral load with! <200 viral copies/ml load <200! copies/ml! ~50K new infections per year 28.6% virologically suppressed Source: CDC, 2013 and Holtgrave et al, 2012
IAS-USA HIV Prevention Recommendations: Sections HIV Testing and Knowledge of Serostatus Prevention Measures for HIV-Infected Individuals Prevention Measures for HIV-Uninfected Individuals Prevention Issues Relevant to All Persons With or At Risk for HIV Infection Marrazzo et al, JAMA, 2014
Summary After 30 years there is potential for an AIDS-free generation Clinicians are instrumental in achieving this and can Offer all adults and adolescents HIV testing Regularly assess substance use and sexual risk practices in HIV-infected patients and those at risk for infection Offer ART and adherence support at diagnosis of HIV infection and PrEP and adherence support to patients at high risk for HIV infection Be alert to the nonspecific presentation of acute HIV infection Emphasize and support linkage to care Provide or refer for individualized risk-reduction counseling for HIV-infected patients and those at risk for infection Conduct regular STI screening HIV-infected patients and those at risk of infection Marrazzo et al, JAMA, 2014
Marrazzo et al, JAMA, 2014. HIV Testing and Knowledge of Serostatus
HIV Testing and Knowledge of Serostatus (cont d) Marrazzo et al, JAMA, 2014.
HIV Testing and Knowledge of Serostatus (cont d) Marrazzo et al, JAMA, 2014.
Marrazzo et al, JAMA, 2014. Antiretroviral Therapy
Counseling on Risk Reduction, Disclosure of HIV Serostatus, and Partner Notification Marrazzo et al, JAMA, 2014.
Needle Exchange and Other Harm Reduction Interventions Marrazzo et al, JAMA, 2014.
Risk Assessment and Risk Reduction for HIV Infection Marrazzo et al, JAMA, 2014.
Efficacy of Biomedical Interventions to Prevent HIV Acquisition: Summary of the Evidence from Randomized Clinical Trials Modified from Ambitious Treatment Targets: Writing the Final Chapter of the AIDS Epidemic, UNAIDS, 2014.
Marrazzo et al, JAMA, 2014. Preexposure Prophylaxis (PrEP)
Marrazzo et al, JAMA, 2014. Preexposure Prophylaxis (cont d)
Marrazzo et al, JAMA, 2014. Preexposure Prophylaxis (cont d)
Marrazzo et al, JAMA, 2014. Postexposure Prophylaxis (PEP)
Marrazzo et al, JAMA, 2014. Screening and Treatment for STIs
Marrazzo et al, JAMA, 2014. Screening and Treatment for STIs (cont d)
Thanks!
IAS-USA HIV Prevention Recommendations: Rating System
Strategies for Promoting Movement Through the Continuum of HIV Care Marrazzo et al, JAMA, 2014.
Marrazzo et al, JAMA, 2014. Reproductive Health Care/ Hormonal Contraception
Marrazzo et al, JAMA, 2014. Voluntary Medical Male Circumcision