MSD Animal Health THERE S ONLY ONE THING THAT DRIVES US Updated Brand Video The Science of Healthier Animals TM
MSD Animal Health Breeding Herd and Progeny Vaccination Now and the Future APV Conference 10 th 12 th September 2017 Chris Brennan Technical Advisor - Swine
Purpose of Vaccination Prevent or minimise disease in the animal vaccinated Individual effect whereby antigens create immune response leading to production of memory T & B cells, and plasma cells Prevent animals from spreading disease Herd immunity increases Outbreaks less often and less severe 3
The AusVac Lab 1987 4
Bendigo Site Now 5
Swine Vaccine Range 6
Breeding Herd Vaccines ECOvac Polyvalent, killed whole cell vaccine containing E.coli serotypes including fimbrial antigens, K88, K99 and 987P involved in neonatal scours. 2 ml dose ECOvacLE Inactivated, adjuvanted vaccine comprised of E.coli, Erysipelothrix rhusiopathiae and Leptospira interrogans serovar pomona 4 ml dose PLEvac Inactivated, adjuvanted vaccine comprised of Porcine parvovirus, Erysipelothrix rhusiopathiae and Leptospira interrogans serovar pomona 4 ml dose 7
Vaccination Strategies TIMING VACCINE SELECTION 4 WEEKS AFTER SELECTION 7 WEEKS BEFORE FARROWING 3 WEEKS BEFORE FARROWING WEANING SOWS AND GILTS GILTS GILTS GILTS SOWS AND GILTS SOWS AND GILTS PLEvac ECOvac OUTDOOR SOWS AND GILTS PLEvac ALTERNATE PROGRAM ECOvacLE The use pattern in the above table is as per the registered label Product labels should always be consulted for full details for vaccine dosage and administration, prior to administration of any vaccine 8
M + PAC 9
M + PAC M + PAC Mycoplasma hyopneumoniae Inactivated Vaccine for Pigs Indication For the vaccination of healthy pigs as an aid in the prevention of pneumonia caused by Mycoplasma hyopneumoniae infection Vaccination Schedule 1 dose regime - 2 ml IM from 21 days of age 2 dose regime - 1 ml SC or IM from 7 days of age, repeated after 14 days Administration Injected intramuscularly, straight from the fridge Vaccine Storage Store between 2 C and 8 C (Refrigerate. Do not Freeze.) Protect from light. 10
Porcilis APPvac 11
Porcilis APPvac 12
Porcilis APPvac Whole cell Actinobacillus pleuropneumoniae vaccine containing: whole cells of APP serovars 1, 7 and 15 immune stimulating levels of Apx toxoids I, II and III outer membrane proteins double adjuvant system to increase immune stimulation Vaccinate pigs with 2 ml Porcilis APPvac around 8 weeks of age and again 2-3 weeks later 13
Porcilis PCV 14
Porcilis PCV For active immunisation of pigs to reduce the virus load in blood and lymphoid tissues and to reduce mortality and weight loss associated with Porcine Circovirus type 2 related infection (PCVD) occurring during the fattening period. Onset of immunity: 2 weeks Duration of immunity: 22 weeks In the case of low to medium levels of maternally derived antibodies against PCV-2 a single vaccination (2 ml) to pigs from 3 weeks of age. 15
Impact of Porcilis PCV on Viremia qpcr is: Predictive of clinical outcome Associated with lesions Indicates disease severity PCV2 DNA copies RESULT <10 6 POSITIVE SUBCLINICAL PCVD (?) >10 6 POSITIVE PCVD SUSPECT qpcr detects accurate amounts of viral genetic material in target tissues Martelli et al. Vet Microbiol 2011 10 7 POSITIVE PCVD 10 7 PCV2 genomic copies/ml of serum correlates with severe PCVD, lesions and poor prognosis 16
Impact of Porcilis PCV on Viremia cont. Paolo Martelli, Luca Ferrari, Marina Morganti, Elena De Angelis, Paolo Bonilauri, Stefano Guazzetti, Antonio Caleffi and Paolo Borghetti. One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions. Veterinary Microbiology 149 (2011) 339-351. 17
Effects of Viremia Long duration of viremia = higher PCV2 load Has negative impact on growing pigs Viremia redirects energy and feed to the immune system and maintenance Pigs eat more and gain less Increases cost of production Viremia control with Porcilis PCV helps prevent PCVAD development 18
Vaccination Technique 1. Before using the vaccine, allow it to reach room temperature (15-25 degrees C) 2. Proper needle size 3. Proper needle management 4. Proper gun management 5. Proper injection placement 6. Proper pig handling 19
Vaccination Technique 7. Proper attention post vaccination 8. Pigs undergoing the stress of vaccination need more air to breathe and to keep cool 9. Proper management of swellings 10.Due to the level of immune response, a transient rise in body temperature may occur for up to 2 days post vaccination 11.Minimise other interventions at time of vaccination e.g. tattooing, tagging 12. Ideally vaccinate 2-3 days before weaning 20
Porcilis PCV Do your clients sell at heavy market weights? Is circovirus impacting on growth in the finisher phase? Do your clients have sporadic disease outbreaks in the finisher phase which are unexpected/unexplained? 21
The Future of Vaccines Combination Vaccines Intradermal Vaccination 22
Porcilis PCV M Hyo* Ready-to-Use protection against PCV and Mycoplasma hyopneumoniae 23
Porcilis PCV M Hyo Antigens: Adjuvant: Schedule: M. hyopneumoniae: strain J PCV2: ORF 2 antigen Emunade 1 dose (2 ml) from 3 weeks of age Onset of Immunity: PCV2: 2 wks M. hyopneumoniae: 4 wks Duration of Immunity: PCV2: 22 wks M. hyopneumoniae: 21 wks 24
Porcilis PCV M Hyo Claims: Reduction of M. hyopneumoniae lesions Reduction of PCV2 viremia/shedding/virus load in lungs and lymphoid tissue Reduction of loss of daily weight gain during the finishing period in face of M. hyopneumoniae and/or PCV infections 25
IDAL Device - needle free intradermal delivery of vaccines IDAL device is currently being assessed by APVMA 26
What does needle free mean for the pig? Without needle Less stress & pain Vaccination abscess following intramuscular injection Improved welfare No tissue damage Reduced transmission of diseases 27
28 University of Veterinary Medicine Gießen, Germany in Cooperation with MSD Animal Health, Germany
QUESTIONS? AU/OSW/0917/0006 29