Dr. Vincent Wong Kam Wai Position: Associate Professor Deputy Supervisor, Center for Omics Technology and Innovative Drug Research, State Key Laboratory of Quality Research in Chinese Medicine Faculty: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health Email Address: kawwong@must.edu.mo Telephone: (853) 8897-2408 Fax No.: (853) 2882-2799 Office: H701a Mailing Address: Room 701a, Block H, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau Dr. Vincent Kam Wai Wong received both his B.S. degree (1999) and MPhil degree (2002) from Hong Kong University of Science and Technology. In 2006, he received his Ph.D. Degree from the University of Hong Kong and then worked as post-doctoral research fellow at School of Chinese Medicine in Hong Kong Baptist University for three years. In 2009, he was promoted to research assistant professor (RAP) in the same department and started his own research area. In 2011, he started to be an assistant professor in State Key Laboratory of Macau University of Science and Technology engaging in the research field of anti-inflammation and anti-cancer. In 2015, he achieved the special promotion standard to associate professor.
Dr. Vincent Wong is experienced in cancer molecular biology, chemical biology and structural activity relationship, and IKK- NF- B signaling. His recent research focus on relationship between autophagy and multidrug-resistant, apoptosis-resistant antitumor effect via SERCA inhibition and AMPK activation. Dr. Wong also focus on the anti-cancer effect of novel ginsenoside and its derivatives, discovery and characterization of novel drug targeting sites on IKK-. He has published over 45 peerreviewed SCI journals including Science, Autophagy, Oncotarget, Scientific Reports, Clinical Cancer Research, Organic Letters, Journal of Cellular Biochemistry, ChemMedChem, Cell Death and Disease, Cancer Letters, Frontier in Pharmacology. Dr. Wong obtained more than 20 US and Australia patents with the works related to the discovery of novel IKK-beta inhibitor, novel autophagy enhancer for treatment of MDR cancer and neurodegenerative diseases. Since 2013, Dr. Wong achieved the Bank of China Excellent Research Award, First-class High Institute Natural Science Award in China, and Second and First-class Natural Science Award in Macao. Teaching and Research Areas: Teaching subjects: Biochemistry, Modern Biotechnology Course, Methodology in pharmacology of Chinese medicines, Molecular and Biochemistry Research Areas: Inflammation and Cancer, Molecular Biology, Chemical Biology, Autophagy, Multidrug-resistant Cancer Academic Qualifications 2006. 9 Ph.D., The University of Hong Kong, Hong Kong
2002. 8 M.Phil., Hong Kong University of Science and Technology, Hong Kong 1999. 6 B.Sc., Hong Kong University of Science and Technology, Hong Kong Professional Chronology 2015.7- Present Associate Professor, Macau University of Science and Technology Deputy Supervisor, Center for Omics Technology and Innovative Drug Research, State Key Laboratory of Quality Research in Chinese Medicine 2011.9 Present Assistant Professor, Macau University of Science and Technology Deputy Supervisor, Center for Omics Technology and Innovative Drug Research, State Key Laboratory of Quality Research in Chinese Medicine 2009.10 2011.8 Research Assistant Professor, Hong Kong Baptist University 2006.12 2009.10 Post-doctoral-fellow, Hong Kong Baptist University 2006.7 2006.11 Research Assistant, Hong Kong Baptist University Representative Publications 1. Betty Yuen Kwan Law#, Simon Wing Fai Mok#, Juan Chen, Francesco Michelangeli, Zhi-Hong Jiang, Yu Han, Yuan Qing Qu, Alena Cong Ling Qiu, Su- Wei Xu, Wei-Wei Xue, Xiao-Jun Yao, Jia Ying Gao, Masood-ul-Hassan Javed, Paolo Coghi, Liang Liu* and Vincent Kam Wai Wong*. N-desmethyldauricine induces autophagic cell death in apoptosis-defective cells via Ca 2+ mobilization. Frontiers in Pharmacology (doi.org/10.3389/fphar.2017.00388). 2. Vincent Kam Wai Wong, Wu Zeng, Juan Chen, Xiao-Jun Yao, Elaine Lai-Han Leung, Qian Qian Wang, Pauline Chiu*, Ben C.B. Ko*, Betty Yuen-Kwan Law*. Tetrandrine, an activator of autophagy, induces autophagic cell death via PKC-α inhibition and mtor-dependent mechanisms. Frontiers in Pharmacology (08 June 2017 https://doi.org/10.3389/fphar.2017.00351). 3. Onat Kadioglu, Betty Yuen Kwan Law, Simon Wing Fai Mok, Su-Wei Xu, Thomas Efferth*, Vincent Kam Wai Wong*. Mode of action analyses of neferine, a
bisbenzylisoquinoline alkaloid of Lotus (Nelumbo nucifera) against multidrugresistant tumor cells. Frontiers in Pharmacology 2017 May 5;8:238. 4. Tian-Shu Kang, Wanhe Wang, Hai-Jing Zhong, Zhen-Zhen Dong, Qi Huang, Simon Wing Fai Mok, Chung-Hang Leung*, Vincent Kam Wai Wong*, Dik- Lung Ma. An anti-prostate cancer benzofuran-conjugated iridium(iii) complex as a dual inhibitor of STAT3 and NF- B. Cancer Letters. 2017 Jun 28;396:76-84. 5. Vincent Kam-Wai Wong, Wu Zeng and Betty Yuen Kwan Law*. Perspective: Role of Autophagy in Neuroprotective Properties of Traditional Chinese Medicines. Journal of Neuroinfectious Diseases. 8: 239. doi:10.4172/2314-7326.1000239. 6. Betty Yuen Kwan Law, Flora Gordillo-Martínez, Yuan Qing Qu, Ni Zhang, Su Wei Xu, Paolo Saul Coghi, Simon Wing Fai Mok, Jianru Guo, Wei Zhang, Elaine Lai Han Leung, Xing Xing Fan, An Guo Wu, Wai Kit Chan, Xiao Jun Yao, Jing Rong Wang, Liang Liu* and Vincent Kam Wai Wong*. Thalidezine, A Novel AMPK Activator, Eliminates Apoptosis-resistant Cancer Cells Through Energy-mediated Autophagic Cell Death. Oncotarget. DOI: 10.18632/oncotarget.15616 7. Chenfangyuan DUAN, Kam Wai WONG, Betty Yuen Kwan Law*. Analysis of the Medication Safety Knowledge among College Students in Macau. Journal of Macau University of Science and Technology Vol.10 No. 2, Dec 30, 2016. 8. An-Guo Wu*, Wu Zeng*, Vincent Kam-Wai Wong, Yi-Zhun Zhu, Amy C.Y. Lo, Liang Liu and Betty Yuen-Kwan Law. Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice. Pharmacological Research. Volume 115, January 2017, Pages 25 44. 9. Jian-Ru Guo, QianQian Chen, Christopher Wai Kei Lam, Caiyun Wang, Vincent Kam Wai Wong, Zee-Fen Chang, and Wei Zhang. Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cells. Scientific Reports 2016 Nov 15;6:37250. doi: 10.1038/srep37250 10. Li-Juan Liu, Wanhe Wang, Tianshu Kang, Jia-Xin Liang, Chenfu Liu, Daniel W. J. Kwong, Vincent Kam Wai Wong, Dik-Lung Ma, and Chung-Hang Leung. Antagonizing STAT5B dimerization with an osmium complex. Scientific Reports. 2016 Nov 17;6:36044. doi: 10.1038/srep36044. 11. Simon Wing Fai Mok, Vincent Kam Wai Wong, Betty Yuen Kwan Law. Comment: New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy: The Search of Reliable Pharmaceutical Candidates for Chronic Disorders Therapy. Journal of Neurology and Neuromedicine. (2016) 1(7): 6-9. 12. Betty Law Yuen Kwan and Vincent Wong Kam Wai* (2016). Autophagy in Multidrug-Resistant Cancers, Autophagy in Current Trends in Cellular Physiology
and Pathology, Dr. Nikolai Gorbunov (Ed.), InTech, Available from: http://www.intechopen.com/books/autophagy-in-current-trends-in-cellularphysiology-and-pathology/autophagy-in-multidrug-resistant-cancers 13. Feng gen Yan, Fen Yang, Rui Wang, Xiao Jun Yao, Li ping Bai, Xing Zeng, Jia Jun Huang, Vincent Kam Wai Wong, Christopher Wai Kei Lam, Hua Zhou, Xiaohui Su, Juan Liu, Ting Li, Liang Liu. Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase. Oncotarget. 2016 Sept 10. doi: 10.18632/oncotarget.11934. 14. Vincent Kam-Wai Wong #, Betty Yuen-Kwan Law #, Xiao-Jun Yao, Xi Chen, Su Wei Xu, Liang Liu* and Elaine Lai-Han Leung*. Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets. Pharmacological Research. 2016 Sep;111:546-555. 15. Su-Wei Xu, Betty Yuen Kwan Law, Simon Wing Fai Mok, Elaine Lai Han Leung, Xing Xing Fan, Paolo Saul Coghi, Wu Zeng, Chung-Hang Leung, Dik-Lung Ma, Liang Liu* and Vincent Kam Wai Wong*.Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol. Int J Oncol. 2016 Aug 3. doi: 10.3892/ijo.2016.3644. 16. Betty Yuen Kwan Law, Simon Wing Fai Mok, An Guo Wu, Christopher Wai Kei Lam, Margaret Sum Yee Yu, Vincent Kam Wai Wong*. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy. Molecules. 2016 Mar 17;21(3). pii: E359. doi: 10.3390/molecules21030359. 17. Klionsky DJ,,.Betty Yuen Kwan Law, Liang Liu, Vincent Kam Wai Wong, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. 18. Betty Yuen Kwan Law, Simon Wing Fai Mok, Wai Kit Chan, Su Wei Xu, An Guo Wu, Xiao Jun Yao, Jing Rong Wang, Liang Liu* and Vincent Kam Wai Wong* Hernandezine, a Novel AMPK Activator Induces Autophagic Cell Death in Drugresistant Cancers. Oncotarget. 2016 Jan 22. doi: 10.18632/oncotarget.6980. 19. Vincent Kam Wai Wong#, Hang Dong#, Xu Liang#, Li Ping Bai, Zhi-Hong Jiang, Yue Guo, Tony A.-N Kong, Rui Wang, Richard Kin Ting Kam, Betty Yuen Kwan Law, Wendy Wen Luen Hsiao, Ka Man Chan, Jingrong Wang, Rick Wai Kit Chan, Jianru Guo, Wei Zhang, Feng Gen Yen, Hua Zhou, Elaine, Lai Han Leung, Zhiling Yu, Liang Liu*. Rh2E2, a Novel Metabolic Modulator, Specifically Suppresses Tumor Cell Growth by Inhibiting Energy-based Metabolism. Oncotarget. 2016 Jan 18. doi: 10.18632/oncotarget.6934. (# Authors with equal contribution) 20. An Guo Wu, Vincent Kam Wai Wong, Wu Zeng, Liang Liu* and Betty Yuen Kwan Law* Identification of novel autophagic Radix Polygalae fraction by cell
membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins. Scientific Reports. 2015 Nov 24;5:17199. doi: 10.1038/srep17199. 21. Jianru Guo, QianQian Chen, Christopher Wai Kei Lam, Caiyun Wang, Vincent Kam-Wai Wong, Fengguo Xu, Zhi-Hong Jiang, and Wei Zhang*. Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells. Scientific Reports. 2015 Nov 18; 5:16861. 22. Xing-Xing Fan, Xiao-Jun Yao, So-Wei Xu, Vincent Kam-Wai Wong, Jian-Xing He, Jian Ding, Min Huang, Jun Huang, Da-Kai Xiao, Ze-Bo Jiang, Yan-Ling Zhou, Richard Kin-Ting Kam, Liang Liu* and Elaine Lai-Han Leung*. (Z)3,4,5,4'-transtetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant nonsmall cell lung cancer via selectively elevating intracellular calcium level. Scientific Reports. 2015 Nov 6;5:16348. doi: 10.1038/srep16348. 23. Ting Li#, Vincent Kam Wai Wong#, Zhi Hong Jiang, Shui Ping Jiang, Yan Liu, Ting Yu Wang, Xiao Jun Yao, Xiao Hui Su, Feng Gen Yan, Juan Liu, Elaine Lai- Han Leung, Xiao Qin Yi, Yuen Fan Wong, Hua Zhou*and Liang Liu*. Mutation of Cysteine 46 in IKK-beta Increases Inflammatory Responses. Oncotarget 2015 Oct 13;6(31):31805-19. (# Authors with equal contribution) 24. Wong VK, Wu AG, Wang JR, Liu L*, Law BYK*. Neferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells via induction of autophagy. Molecules. 2015, 20, 3496-3514 25. Leung ELH, Wong VK, Jiang ZH, Li T, Liu L. Integrated network-based medicine: The role of traditional Chinese medicine in developing a new generation of medicine. Science. 2014 Dec 19; Vol. 346 no. 6216 p. 1569; S16 26. Law BYK, Mo KF, Wong VK*. Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum scorzoneraefolium WILD). Chinese Medicines. 2014 Sep 11;9:21. doi: 10.1186/1749-8546-9-21. 27. Law BYK, Chan WK, Xu SW, Wang JR, Bai LP, Liu L* & Wong VK*. Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosisdefective cells. Scientific Reports. 2014, 4, 5510; DOI:10.1038 / srep05510. 28. Wu AG, Wong VK, Xu SW, Chan WK, Ng CI, Liu L* and Law BYK*. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant -synuclein and huntingtin in PC-12 cells. Int. J. Mol. Sci. 2013, 14, 22618-22641. 29. Kam KT, Liang X, Wang JR, Wong VK, Hsiao WL, Zhou H, Jiang ZH, Liu L. Evaluation on the effect of different In-gel peptide IEF parameters in global
proteomic profiling. Anal Biochem. 2013 Dec 1;443(1):27-33. doi: 10.1016/j.ab.2013.07.047. Epub 2013 Aug 11. 30. Liang X, Wang J-R, WongVK, Hsiao WL, Zhou H, Jiang ZH, Kam KTR and Liu L. Optimization of 2-dimensional gel electrophoresis for proteomic studies of solid tumor tissue samples. Molecular Medicine Reports. 2014 Feb;9(2):626-32. doi: 10.3892/mmr.2013.1815. Epub 2013 Nov 20. 31. Wong VK*, Li T, Law BYK, Ma EDL, Nga CY, Francesco M, Law CKM, Zhang M, Lam YC, Chan PL and Liu L. Saikosaponin-d, a novel SERCA inhibitor induces autophagic cell death in apoptosis-defective cells. Cell Death & Diseases, 2013 Jul 11;4:e720. doi: 10.1038/cddis.2013.217.