Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK

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2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Biochemistry Department University Hospital of North Durham Durham County Durham DH1 5TW Contact: Dr Tim Lang Tel: +44 (0) 191 333 2694 Fax: +44 (0) 191 333 2115 E-Mail: tim.lang@nhs.net Website: www.cddft.nhs.uk Laboratory locations: below s covered by the organisation and their relevant activities details Activity Locatio n code Address Biochemistry Department University hospital of North Durham North Road Durham County Durham DH1 5TW Local contact Dr Tim Lang Clinical Biochemistry UHND Address Biochemistry Department Darlington Memorial Hospital Hollyhurst Road Darlington DL3 6HX Local contact Mrs Hazel Borthwick Clinical Biochemistry Assessment Manager: GS 1 of 6

DETAIL OF ACCREDITATION Siemens Advia 2400 XPT Using supplier methods unless otherwise stated Serum Albumin LP/PA/CB/CBAU205 ALP LP/PA/CB/CBAU203 ALT LP/PA/CB/CBAU207 Ammonia LP/PA/CB/CBAU217 Amylase LP/PA/CB/CBAU213 AST LP/PA/CB/CBAU206 Bile Acids Randox kit LP/PA/CB/CBAU243 Calcium LP/PA/CB/CBAU209 Carbamazepine LP/PA/CB/CBAU235 Cholesterol LP/PA/CB/CBAU212 CK LP/PA/CB/CBAU211 Conjugated Bilirubin LP/PA/CB/CBAU227 Creatinine LP/PA/CB/CBAU221 CRP LP/PA/CB/CBAU226 Enzymatic creatinine LP/PA/CB/CBAU242 GGT LP/PA/CB/CBAU208 HDL-cholesterol LP/PA/CB/CBAU238 Iron LP/PA/CB/CBAU229 LDH LP/PA/CB/CBAU231 Lithium Thermo Infinity Kit LP/PA/CB/CBAU215 Magnesium LP/PA/CB/CBAU232 Paracetamol LP/PA/CB/CBAU219 Phenytoin LP/PA/CB/CBAU236 Phosphate LP/PA/CB/CBAU210 Salicylate Stanbio kit LP/PA/CB/CBAU218 TCO2 LP/PA/CB/CBAU222 Theophylline LP/PA/CB/CBAU237 Total Bilirubin LP/PA/CB/CBAU202 Assessment Manager: GS Page 2 of 6

Siemens Advia 2400 XPT Using supplier methods unless otherwise stated Total protein LP/PA/CB/CBAU204 Transferrin LP/PA/CB/CBAU233 Triglyceride LP/PA/CB/CBAU216 Urate LP/PA/CB/CBAU214 Urea LP/PA/CB/CBAU220 Plasma (Fluoride Glucose LP/PA/CB/CBAU239 Oxalate) Lactate LP/PA/CB/CBAU230 Urine Calcium LP/PA/CB/CBAU209 Creatinine LP/PA/CB/CBAU221 Magnesium LP/PA/CB/CBAU232 Microalbumin LP/PA/CB/CBAU241 Phosphate LP/PA/CB/CBAU210 Protein LP/PA/CB/CBAU34 Urea LP/PA/CB/CBAU220 Uric Acid LP/PA/CB/CBAU214 CSF Glucose LP/PA/CB/CBAU239 Lactate LP/PA/CB/CBAU230 Protein LP/PA/CB/CBAU234 Serum Chloride LP/PA/CB/CBAU225 Potassium LP/PA/CB/CBAU224 Sodium LP/PA/CB/CBAU223 Urine Chloride LP/PA/CB/CBAU225 Potassium LP/PA/CB/CBAU224 Sodium LP/PA/CB/CBAU223 Assessment Manager: GS Page 3 of 6

Immunoassay examination Siemens Advia Centaur XPT Serum AFP LP/PA/CB/CBIA016 C125 LP/PA/CB/CBIA018 C153 LP/ND/CB/CBIA022 UHND C199 LP/PA/CB/CBIA023 CEA LP/PA/CB/CBIA017 Cortisol LP/PA/CB/CBIA012 Digoxin LP/PA/CB/CBIA013 Ferritin LP/PA/CB/CBIA025 Folate LP/PA/CB/CBIA026 FSH LP/PA/CB/CBIA006 FT3 LP/PA/CB/CBIA004 FT4 LP/PA/CB/CBIA003 Gentamicin LP/PA/CB/CBIA032 hcg (Total) LP/PA/CB/CBIA015 LH LP/PA/CB/CBIA007 Macroprolactin Screen Inc Polyethylene glycol pretreatment LP/PA/CB/CBIA020 Oestradiol LP/PA/CB/CBIA014 Progesterone LP/PA/CB/CBIA008 Prolactin LP/PA/CB/CBIA005 PSA LP/PA/CB/CBIA009 Sodium Valproate LP/DM/CB/CBIA035 SHBG LP/ND/CB/CBIA038 UHND Testosterone LP/PA/CB/CBIA011 TnI ultra LP/PA/CB/CBIA028 TSH LP/PA/CB/CBIA002 Vitamin B12 LP/PA/CB/CBIA027 Anti-thyroid peroxidase antibody (a-tpo) LP/PA/CB/CBIA021 Plasma (EDTA) BNP LP/DM/CB/CBIA037 PTH LP/ND/CB/CBIA024 UHND Assessment Manager: GS Page 4 of 6

Siemens Advia Centaur XPT Serum/plasma/urine Anion Gap By calculation Serum/Plasma Globulin By calculation Serum Adjusted Calcium By calculation Urine egfr By calculation Serum Cholesterol:HDL ratio By calculation Serum LDL Cholesterol By calculation Serum/plasma Protein:Creatinine ratio By calculation Serum/Plasma Creatinine Clearance By calculation Serum/plasma Microalbumin:Creatinine ratio By calculation Serum Free androgen index By calculation Serum Transferrin Saturation By calculation Urine Urine urate:creatinine ratio By calculation Serum/plasma Acute Kidney Injury, derived from creatinine By calculation Whole blood Blood gases po2 pco2 ph, Na +, and K + O2 saturation Base Excess Gem 4000 analyser using ion selective electrode and co-oximetry LP/PA/POCT042 Methaemoglobin Carboxyhaemoglobin Gem 4000 analyser using spectrophotometry LP/PA/POCT042 Assessment Manager: GS Page 5 of 6

instructions for analysis Faeces Faecal Calprotectin Extraction using ThermoScientific EliA Stool Extraction Kit 2 Faecal Calprotectin Testing using ELiA method on Phadia 250 analyser LP/PA/CB/IA001 UHND Whole blood HbA1c Menarini HA9210 HPLC with specific reference to LP/PA/CB/CBSP006 Sweat Sweat Chloride Iontophoresis for sample collection Sherwood Chloride meter-titration LP/PA/CBOP208 CSF Xanthochromia Uvikon spectrophotometry with reference to LP/PA/CB/CBSP028 Urine Pregnancy test Alere-lateral flow sandwich Elisa with specific reference to LP/PA/CB/CBSP029, UHND END Assessment Manager: GS Page 6 of 6