Workshop and Final Coordination Meeting on Nuclear Medicine Techniques in Neurological Diseases II (ICNMP-PA)

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International Atomic Energy Agency Department of Technical Cooperation And Nuclear Medicine and Diagnostic Imaging Section Division of Human Health RAS6074 Improving Quality of Life of Cancer Patients through Streamlined and Emerging Therapeutic Nuclear Medicine Techniques Workshop and Final Coordination Meeting on Nuclear Medicine Techniques in Neurological Diseases II (ICNMP-PA) June 26-30, 2017 Multimedia Hall, the Center of Medical Innovation and Translational Research building 1F, Osaka University Graduate School of Medicine, Local Course Director HATAZAWA, Jun Osaka University Graduate School of Medicine Department of Nuclear Medicine and Tracer Kinetics 565-0871 Osaka Tel: 81668793461 Fax: 81668793469 E-mail: hatazawa@tracer.med.osaka-u.ac.jp

IAEA TECHNICAL OFFICER Mr. PASCUAL Thomas NB Section of Nuclear Medicine and Diagnostic Imaging Division of Human Health International Atomic Energy Agency, Vienna International Centre, PO Box 100, 1400 Vienna, Australia IAEA PROJECT MANAGEMENT OFFICER: Mr SHAKHASHIRO, Abdulghani Asia and the Pacific Section 1 Division for Asia and the Pacific Department of Technical Cooperation A.Shakhashiro@iaea.org

PROGRAM Monday 26 June 2017 09:00-09:30 Opening remarks Pre-Course Evaluation Chair SESSION 1 Pascual, Thomas (Technical Officer, IAEA) Shakhashiro, Abdulghani (IAEA Programme Management Officer) Prof. Jun Hatazawa Course Director GIESEL, Frederik University Hospital Heidelberg Department of Nuclear Medicine Clinic of Radiology 69120 Heidelberg Germany Pascual, Thomas (Technical Officer, IAEA) 09:30-10:30 Instrumentation of SPECT/CT, PET/CT, and PET/MR Review and discuss the importance of Instrumentations used in SPECT and PET combined with CT or MR for Neurological Imaging using Nuclear Medicine techniques 10:30-11:30 Handling computer software, modeling, and image analysis Review and discuss the importance of handling computer software, modeling, and image analysis for Neurological Imaging using Nuclear Medicine techniques 11:30:12:30 Brain anatomy and molecular imaging 1.Discuss the role of Brain Anatomy and Molecular Imaging in relation to practice of nuclear medicine 2. Integrate the concepts discussed in relation to best practices of brain imaging using nuclear techniques. Dr. Seiichi Yamamoto Nagoya University, Nagoya, Dr. Masanori Ichise National Institute of Radiological Sciences, Chiba, Dr. GIESEL, Frederik University Hospital Heidelberg Department of Nuclear Medicine Clinic of Radiology 69120 Heidelberg Germany

12:30-13:30 Lunch Break 13:30-14:00 Public special lecture: Introduction of Quantum Scalpel Project and future perspectives (tentative). 14:00-14:45 Radiopharmaceuticals in brain imaging: SPECT and SPECT/CT. Dr. Toshio Hirano President, Quantum and Radiological Science and Technology, Chiba, Dr. Hiroshi Toyama Fujita Health University, Nagoya, 1. Recognize the significance of radiopharmaceuticals used in SPECT/CT brain imaging. 2. Integrate the concepts of radiopharmaceuticals in brain imaging within the context of best practices of the nuclear technology on the brain imaging 14:45-15:30 Radiopharmaceuticals in brain imaging: PET/CT and PET/MR Dr. Tadashi Watabe, 1. Summarize the Radiopharmaceuticals used in PET/CT or PET/MR brain imaging 2. List examples of diseases that can be diagnosed by FDG-PET scans. 3. Discuss principal differences between FDG and non- FDG agents in brain imaging. 16:00-16:30 SPECT and PET in stroke: Theory and case presentation Dr. Eku Shimosegawa 1. Discuss the utilization of SPECT and PET imaging modalities in the evaluation of ischemic stroke 2. Determine the limitations SPECT and PET imaging technique in stroke in relation to CT and MR

16:30-17:00 Boron Neutron Capture Therapy and Nuclear Medicine understand the principle of boron neutron capture therapy and importance of nuclear medicine imaging in cancer patients. Dr. Koji Ono Kyoto University End of session 1 17:30- Welcome Reception (Venue: Minerva, Second floor of Ginkgo Kaikan) Hosted by Osaka University and IAEA

Tuesday, 27 June 2017 SESSION 2 Chair: GIESEL, Frederik University Hospital Heidelberg Department of Nuclear Medicine Clinic of Radiology 69120 Heidelberg Germany Shakhashiro, Abdulghani (IAEA Programme Management Officer) 09:00-10:00 Alzheimer s Disease 1. Understand the pathophysiology of Alzheimer s disease. Dr. Hiroshi Matsuda National Center of Neurology and Psychiatry, Tokyo, 2. Discuss the risk factors of Alzheimer s disease. 3. Discuss the role of nuclear medicine imaging in Alzheimer s dieases 10:00-11:00 Movement Disorder 1. Understand the pathophysiology of Movement disorders. Dr. Etsuko Imabayashi National Center of Neurology and Psychiatry, Tokyo, 2. Discuss the utilization of nuclear medicine imaging modalities in the evaluation of movement disorders 11:00:12:00 Brain tumor Dr. Frederik Giesel IAEA Experts 1. Understand the pathophysiology of Movement

disorders. 12:00-14:00 Lunch Break 2. Discuss the utilization of nuclear medicine imaging modalities in the evaluation of movement disorders 14:00-14:30 Seizures 1. Understand the pathophysiology of seizures Dr. Daichi Sone National Center of Neurology and Psychiatry, Tokyo, 2. Discuss the risk factors 3. Discuss the role of nuclear medicine imaging in seizures 14:30-15:00 Pediatric Nuclear Medicine Dr. Mayuki Uchiyama The Jikei Medical University 1. Understand the pathophysiology/ classification of different paediatric brain tumours and neurological disorders 2. Discuss the role of nuclear medicine imaging in paediatric brain imaging 15:00-15:30 Brain Death 16:00-16:30 Brain Trauma Discuss the role of nuclear medicine imaging techniques in brain death imaging Dr. Toshimitsu Momose International University of Health and Welfare, Chiba, Dr. Toru Shiga Hokkaido University, Sapporo, Discuss the role of nuclear medicine imaging in brain trauma

16:30-17:00 SPECT and PET in Psychiatry 1. Understand the pathophysiology/ classification of different psychiatric cases in relation to brain imaging Dr. Tetsuya Suhara National Institute of Radiological Sciences, Chiba, 2. Discuss the role of nuclear medicine imaging in psychiatry End of session 2

Wednesday, 28 June 2017 Chair: SESSION 3 GIESEL, Frederik University Hospital Heidelberg Department of Nuclear Medicine Clinic of Radiology 69120 Heidelberg Germany 9:00-10:00 Statistical Parametric Analysis in Nuclear Medicine Review and understand basic concept of statistical parametric analysis used in SPECT and PET combined with CT or MR for Neurological Imaging using Nuclear Medicine techniques Dr. Hiroki Kato Osaka University 10:00-10:30 Normal data base for statistical parametric analysis Dr. Hiroki Kato Osaka University understand the importance of normal data base for statistical parametric 11:00-12:00 Handling software and data analysis Dr. Hiroki Kato Osaka University 12:00-13:00 Lunch Break Lunch buffet hosted by Osaka University (Venue: Resting area in front of Multimedia Hall) 13:00-15:30 Review Meeting for Counterparts Presentation of country reports (5minutes each) Collection of country reports Summarization of report IAEA, Participant One Participant from each country will need to present the project achievements, lessons learned and way forward and prepare the meeting

final report for RAS6074. 16:00-17:30 Technical visit: Tenma-Tenjin PET center Please coordinate who will present from your country End of session 3

Thursday 29 June 2017 SESSION 4: Chair: 09:00-12:00 Case presentation (including report writing and group discussion): 1. Describe appropriate ways of report writing in neurological cases with CT and/or MR interpretation 2. Discuss the role of Brain Imaging using actual cases for image interpretation and its relevance in clinical practice Dr. Jun Hatazawa Dr. Tadashi Watabe 12:00-14:00 Lunch Break 14:00-17:00 Parametric image analysis of brain images (including software practice): 1. Enumerate and discuss the different Parametric image analysis used in brain imaging Dr. Hiroki Kato Dr. Tadashi Watabe END OF SESSION 4

Friday 30 June 2017 CHAIR: SESSION 5 GIESEL, Frederik University Hospital Heidelberg Department of Nuclear Medicine Clinic of Radiology 69120 Heidelberg Germany 9:00-10:00 Nuclear Medicine Theranostics (1) Understand the concept of nuclear medicine theranostics, production of radionuclides, and application 10:00-11:00 Nuclear Medicine Theranostics (2) Understand alpha-emitting radionuclide based therapy of brain tumors and prostate cancer Dr. Mitsuaki Tatsumi Dr. Jun Hatazawa, Dr. Frederik Giesel IAEA Expert 11:00-11:30 Future application of Brain Nuclear Medicine 1.Describe and explain future application of brain imaging using nuclear medicine techniques 2.Explore possibilities on how these newer technologies will have a positive impact on nuclear medicine practice 11:30-12:00 Closing Remarks Post course evaluation Dr. HATAZAWA, Jun Osaka University Graduate School of Medicine Department of Nuclear Medicine and Tracer Kinetics Osaka Pascual, Thomas (Technical Officer, IAEA) Shakhashiro,

Abdulghani (IAEA Programme Management Officer) Prof. Jun Hatazawa Course Director