SINGAPORE. 12 th PVRI Annual World Congress. on Pulmonary Vascular Disease WELCOME TO. Date // January 2018

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Date // 21-25 January 2018 12 th PVRI Annual World Congress on Disease Hotel // Mandarin Orchard Hotel. Singapore WELCOME TO SINGAPORE

Pre-Congress MEETINGS Sunday 21 January 2018 PVRI Board of Directors Meeting 10:00-17:00 Chair: PVRI President Paul Corris PVRI Pre-Clinical & Molecular Science 09:00-17:00 Chairs: Sebastien Bonnet, Duncan Stewart & Soni Pullamsetti Methodological rigour in pre-clinical pulmonary studies PVRI Imaging 10:00-13:00 Chairs: Andrew Peacock & David Kiely PVRI Paediatric Task Force Meeting 14:00-17:00 Chairs: Ian Adatia & Maria Jesus del Cerro PVRI Board of Directors Dinner 19:00-22:00

Scientific Programme // Singapore 2018 12 th PVRI Annual World Congress on Disease Monday 22 January 2018 Breakfast 07:00-08:00 Welcome 08:00-08:10 Plenary 1 Chair: Nick Morrell PROFESSOR SHEILA GLENNIS HAWORTH LECTURE: 08:00-10:00 Genes and Pulmonary Hypertension // Nick Morrell Followed by a series of talks on the genetics of pulmonary hypertension BREAK 10:00-10:30 Plenary 2 Chairs: Stuart Cook & Paul Yu PROFESSOR STUART RICH LECTURE: 10:30-12:30 Genotype-phenotype studies in the heart // Stuart Cook The Myocardium Followed by a series of talks on the myocardium of pulmonary hypertension LUNCH 12:30-13:30

Pulmonary Circulation Editorial Meeting 12:30-13:30 Plenary 3 Chair: Brad Maron The American Heart Association Partnership with PVRI 13:30-15:30 A series of talks that will address progress towards a molecular classification of pulmonary hypertension BREAK 15:30-16:00 PVRI Annual General Meeting 16:00-17:00 Poster Session CLINICAL and BASIC 17:30-20:00 Attendees mingle with posters over drinks and snacks END OF DAY ONE SCIENTIFIC SESSIONS 20:00-21:00 PVRI Pharma Task Force Meeting 15:30-17:00 PVRI Annual General Meeting for all participants & guests 17:30-20:00 Networking Cocktail Reception for all participants & guests including Poster Sessions CLINICAL & BASIC

Tuesday 23 January 2018 Plenary 4 Chairs: Kurt Stenmark & Edda Spiekerkoetter What s Hot BASIC 08:00-10:00 A series of presentations on emerging science in pulmonary vascular disease BREAK 10:00-10:30 Plenary 5 Panel: Comprises all discussants from case presentations Clinical Case Round Table 10:30-12:30 Presenters: Presenters are expected to identify an anonymised case which can be presented based on up to 3 slides. The case should clearly highlight a challenging diagnostic or management issue. (25 minutes per case) LUNCH 12:30-13:30 Asia-Pacific Meeting open to all delegates 13:30-17:30 A joint session with the Asia Pacific Cardiovascular Society END OF DAY TWO SCIENTIFIC SESSIONS 19:00-21:00 PVRI Committee for Young Clinicians & Scientists Social Evening 14:00 onwards Singapore Sightseeing Tours

Wednesday 24 January 2018 Plenary 6 Chairs: Nick Kim & Ardi Ghofrani Chronic Thromboembolic Pulmonary Hypertension (CTEPH) 08:00-10:00 Talks addressing modern day management of CTEPH BREAK 10:00-10:30 Plenary 7 Chair: Stuart Rich Precision Medicine 1 10:30-11:30 A panel discssion with the audience on the acceptability and practicality of a Master Clinical Trials Protocol for clinical studies in pulmonary hypertension Lunchtime Posters Session 11:45-13:45 LUNCH 12:45-14:00 Plenary 8 Chairs: Martin Willkins & Anna Hemnes Precision Medicine 2: Biomarkers and Clinical Trial Endpoints 14:00-15:30 Talks from industry and academia BREAK 15:30-16:00 Plenary 9 Chairs: TBC Talks from 1 Slide 16:00-17:00 Speakers present a new concept or address a big idea from 1 slide presentation (5 minutes) followed by a 10 minute discussion. END OF DAY THREE SCIENTIFIC SESSIONS PVRI GALA DINNER (all welcome, including partners & guests) Buy your ticket at the reception desk 19:00 onwards

Thursday 25 January 2018 Plenary 10 Chairs: TBC Asia-Pacific Issues 08:00-09:30 PROFESSOR GHAZWAN BUTROUS PLENARY LECTURE: Asia-Pacific Issues Talks on management of orphan diseases in the Asia-Pacific region BREAK 09:30-10:00 Plenary 11 Chair: Paul Hassoun Immunity and Inflammation 10:00-12:00 Talks on the latest science (basic and applied) investigating inflammation in pulmonary hypertension END OF MEETING Afternoon Travel WE LOOK FORWARD TO SEEING YOU IN SINGAPORE