How to Perform Hybrid Myocardial Revascularisation: Interventional Perspective Gerhard Schuler Herzzentrum Leipzig Nothing to disclose
Hybrid An animal or a plant resulting from a cross between genetically unlike individuals, usually sterile To combine useful aspects of different methods
Hybrid Plants
Hybrid Power Plant
Hybrid Procedures Combination of interventional and surgical techniques in order to reduce invasiveness, improve safety and long term results.
Sequential Procedures Time Interval PCI CABG Time Interval PCI TAVI Patient comfort Expenses Efficiency Time in hospital
Hybrid Procedures PCI + CABG PCI + TAVI Patient comfort Expenses Efficiency Time in hospital
Hybrid Procedures Personnel Infrastructure: Hybrid OR Combinations of Procedures Case Presentations
Heart Team Suitability of pt Selection of Appropriate Approach Sequence of procedures Assessment of Risks Definition of Bail Out Strategies
Type of Procedure Determined by Referring Physician Referrals A Referrals B Referrals C
Type of Procedure Determined by Heart Team Referrals A Referrals B Referrals C Heart Team
Hybrid OR
Hybrid OR: Hemodynamic recording system
Hybrid OR 'Safety Line'
DYNA CT
DYNA CT
Indications for Hybrid Procedure
Indications for Hybrid Procedure Primary PCI for posterior or inferior STEMI and severe CAD in non culprit vessels better suited for CABG. Emergent PCI prior to surgery in pts with combined valvular and coronary disease, if the pt cannot be transferred to for surgery, or in the presence of acute ischemia. Patients who had previous CABG and now require valve surgery Combination of revascularization with non-sternotomy valve intervention (e.g. PCI and minimally invasive mitral valve repair, or PCI and transapical aortic valve implantation. In pts with conditions likely to prevent healing after sternotomy, surgery can be restricted to the LAD territory using minimally invasive direct coronary bypass (MIDCAB) or left ITA grafting. Remaining lesions in other vessels are treated by PCI.
Suitable Combinations LIMA + PCI Multimorbid high risk pts COPD Pts with malignancies History of sternal wound infections Previous sternotomy TAVI + PCI Valve-in-Valve (TAVI) + PCI Minimal invasive mitral valve repair + PCI Mitraclip + PCI
Which Procedures Have Been Performed? CABG (MIC) + PCI C 13 /26 Simultaneous "hybrid" percutaneous coronary intervention and minimally invasive surgical bypass grafting: feasibility, safety, and clinical outcomes.am Heart J 2008 Apr;155(4):661-7 (ISSN: 1097-6744)Reicher B; Poston RS; Mehra MR; Joshi A; Odonkor P; Kon Z; Reyes PA; Zimrin DA = S 15 /30 Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass.j Thorac Cardiovasc Surg 2008 Feb;135(2):367-75 (ISSN: 1097-685X)Kon ZN; Brown EN; Tran R; Joshi A; Reicher B; Grant MC; Kallam S; Burris N; Connerney I; Zimrin D; Poston RS + S 11 Hybrid revascularization feasibility in minimally invasive direct coronary artery bypass grafting combined with percutaneous transluminal coronary angioplasty in patients with acute coronary syndrome and multivessel disease.jpn J Thorac Cardiovasc Surg 2001 Dec;49(12):700-5 (ISSN: 1344-4964)Matsumoto Y; Endo M; Kasashima F; Abe Y; Kosugi I; Hirano Y; Sasaki H; Ueyama T C 20 /20 Combination of minimally invasive coronary bypass and percutaneous transluminal coronary angioplasty in the treatment of double-vessel coronary disease: Two-year follow-up of a new hybrid procedure compared with "on-pump" double bypass grafting.am Heart J 2001 Oct;142(4):563-70 (ISSN: 1097-6744)de Canniere D; Jansens JL; Goldschmidt-Clermont P; Barvais L; Decroly P; Stoupel E +
RCA 99%
RCA post PCI
Angio LAD 100%
Pat. S.G. MIDCAB
Angio LIMA zur LAD
Which Procedures Have Been Performed? Valve repair/deployment + PCI PCI + MKR MIC 1 Hybrid percutaneous coronary intervention and minimally invasive reoperative mitral valve surgery [In Process Citation] J Card Surg 2009 Mar-Apr;24(2):191-3 Masroor S; Berkowitz R; Nejad K; Alexander JC PCI + AKE MIC 18 Effectiveness of same day percutaneous coronary intervention followed by minimally invasive aortic valve replacement for aortic stenosis and moderate coronary disease ("hybrid approach").am J Cardiol 2006 Dec 1;98(11):1501-3 Brinster DR; Byrne M; Rogers CD; Baim DS; Simon DI; Couper GS; Cohn LH PCI + open valve 26 Staged initial percutaneous coronary intervention followed by valve surgery ("hybrid approach") for patients with complex coronary and valve disease.j Am Coll Cardiol 2005 Jan 4;45(1):14-8 Byrne JG; Leacche M; Unic D; Rawn JD; Simon DI; Rogers CD; Cohn LH
Mitral Valve Prolaps
Minimal Invasive Mitral Valve Repair + PCI
Minimal Invasive Mitral Valve Repair + PCI
Minimal Invasive Mitral Valve Repair + PCI
TAVI + PCI in Severe Aortic Stenosis
Survival after TAVI (TF+TA) Impact of CAD Dewey TM et al. Ann Thorac Surg 2010
Leipzig Experience CAD Prevalence 400 consecutive CoreValve patients CAD Grade No CAD 87 21.8% Sclerosis 104 26.0% Relevant Stenoses >50% 209 52.2% VD (209) 1 92 44.0% 2 14 6.8% 3 103 49.2% Woitek F, Linke A, Schuler GC in prep
Leipzig Experience CAD Management Need for Re- Vascularization Staged PCI Concomitant PCI N=39 (9.8%) 33 (8.3%) 6 (1.5%) Days prior to TAVI 8.5±7.8 0 Success 33 (100%) 6 (100%) Renal Failure Stage 3 (VARC) 3 (10%) 1 (16.7%) Procedural MI (VARC) 2 (6.1%) 1 (16.7%) Woitek F, Linke A, Schuler GC
Case Presentation 77 year old male patient NSTEMI 3 vessel disease + LMCA Aortic stenosis III
Pat. S.G. : High grade distal left main
Pat. S.G. : Stenting of Left Main
Pat. S.G. Result after Stenting
Pat. S.G. Valvuloplasty
Pat. S.G. Edwards Sapien Valve transapical
Pat. S.G. Edwards Sapien Valve transapical
Pat. S.G. Edwards Sapien Valve transapical
Case Presentation 83 year old male patient 4/2003 resection of an LA tumor & mitral valve replacement (Mosaic 29 mm) 2-vessel disease Admitted with severe CHF and significant mitral stenosis
Pat. H. W. Positioning of Edwards Sapien Valve in Mitral Anulus (transapical Valve-in- Valve)
Pat. H. W. Deployment of Edwards Sapien Valve in Mitral Anulus (transapical Valve-in- Valve)
Pat. H. W. RCA, Dissection and Subtotal Occlusion
Pat. H. W. RCA, Recanalization
Pat. H. W. RCA, Positioning of Balloon 1,5mm
Pat. H. W. RCA, Balloon Dilatation 2.5 mm
Pat. H. W. RCA, Stent Implantation 3.0 mm
Pat. H. W. Final Result
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with conventional off-pump coronary artery bypass. Kon Z et al; J Thorac Cardiovasc Surg 2008;135:367-375 Costs
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with conventional off-pump coronary artery bypass. Kon Z et al; J Thorac Cardiovasc Surg 2008;135:367-375 Satisfaction
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with conventional off-pump coronary artery bypass. Kon Z et al; J Thorac Cardiovasc Surg 2008;135:367-375 Vessel Patency
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with conventional off-pump coronary artery bypass. Kon Z et al; J Thorac Cardiovasc Surg 2008;135:367-375 Ischemia, Inflammation, Coagulation
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with conventional off-pump coronary artery bypass. Kon Z et al; J Thorac Cardiovasc Surg 2008;135:367-375 Time to return to work
Downside of Hybrid Procedures Imaging system in hybrid OR usually not dedicated to coronary interventions.
Summary Presently few hybrid procedures are performed, studies are small, and no conclusive results have been published. No guideline recommendations have been defined. In the interest of pt comfort, efficiency, and infrastructure hybrid procedures should be performed simultaneously during the same session by a dedicated interdisciplinary team. A truely hybrid environment requires careful planning and synchronization of procedures. A hybrid operating room equipped with a full size x-ray imaging system, cardiopulmonary bypass, and TEE offers optimal conditions.