Management of Burns under Prolonged Field Care

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This Role 1, prolonged field care (PFC) guideline is intended to be used after TCCC Guidelines when evacuation to higher level of care is not immediately possible. A provider of PFC must first and foremost be an expert in TCCC. This Clinical Practice Guideline (CPG) is meant to provide medical professionals who encounter burns in austere environments with evidence- based guidance. Recommendations follow a minimum, better, best format that provides alternate or improvised methods when optimal hospital options are unavailable. Burns > 20% of the total body surface area (TBSA), or those with smoke inhalation injury (and airway or breathing problems), are potentially life threatening. Also, burns that affect vision, decrease hand function, or cause severe pain can take the warfighter out of action. Telemedicine: Management of burns is complex. Also, burns are highly visual and a lot can be communicated via pictures or video. Establish telemedicine consult as soon as possible. v Airway management: Goal: Avoid airway obstruction due to inhalation injury or burn- induced swelling. Patients with smoke inhalation injury may present with a range of symptoms in terms of severity. Patients with severely symptomatic smoke inhalation injury (e.g. respiratory distress, stridor) require immediate definitive airway (cuffed tube in trachea) as they are at risk of immediate airway loss. Oxygenate and ventilate. Best: Rapid sequence intubation by skilled provider, followed by continuous sedation and airway maintenance, supplemental oxygen, portable ventilator. Better: Cricothyroidotomy followed by continuous sedation and airway maintenance, supplemental oxygen via an oxygen concentrator, portable ventilator. Minimum: Cricothyroidotomy, ketamine, bag- valve mask with PEEP valve. Notes: Patients with mild symptoms of smoke inhalation injury (e.g. some cough, no respiratory distress) can be observed. Burns or explosions in a closed space are at higher risk of inhalation injury compared with explosions in open areas. All patients with burn size > 40% should be intubated as total- body swelling will tend to obstruct the airway. Some patients with facial burns may require intubation based on exam. Supraglottic airway (laryngeal mask airway [LMA], King LT, or Combitube) is not appropriate. Endotracheal tube must be secured circumferentially around the neck using cotton ties or similar. Tape does not stick to the face well enough in burn patients. Place nasogastric (or orogastric) tube to decompress stomach in intubated patients. 1

Do frequent endotracheal suction of intubated patients to ensure tube patency and remove mucus/debris. Monitoring end- tidal CO 2 is an important capability for all intubated patients. A rising end- tidal CO 2 could indicate clogging of endotracheal tube, or poor ventilation from another cause (bronchospasm; tight eschar across chest). Use positive end- expiratory pressure (PEEP) on all intubated patients. Do a surgical escharotomy of the chest for tight, circumferential, full thickness burns which impair breathing. Incision goes through the full thickness of the burn and into the fat. Expect some pain and bleeding. See Figure. Use bronchodilators (e.g., albuterol inhaler) for intubated patients with inhalation injury. Ventilator management of burn patient can be complicated and evolve as pulmonary conditions change due to volume overload/edema and ARDS. Telemedicine consultation with skilled providers is recommended. v Fluid Resuscitation: The principles of hypotensive resuscitation according to TCCC DO NOT apply in the setting of burns (without severe bleeding). HOWEVER In the unusual setting of burns associated with non- compressible (thoracic, abdominal, pelvic) hemorrhage, aggressive fluid resuscitation may result in increased hemorrhage. Balancing the risk of uncontrolled hemorrhage against the risk of worsening burn shock from under- resuscitation should be guided by expert medical advice (in- person or telemedicine). Goal: Over the first 24 to 48 hours postburn, plasma is lost into the burned and unburned tissues, causing hypovolemic shock (when burn size > 20%). The goal of burn- shock resuscitation is to replace these ongoing losses while avoiding over- resuscitation. Best: Isotonic crystalloids (e.g. lactated Ringer s, Plasmalyte); hourly urine Start IV or intra- osseous (IO) administration IMMEDIATELY IV/IO can be placed through burned skin if necessary. NO bolus (unless hypotensive- - in which case, bolus only till palpable pulses restored) Initial IV rate 500 ml/hour Measure burn size (TBSA), and multiply by 10. This is your starting IV fluid rate. Ex: burn size is 30%, 30x10=300. Starting rate is 300 ml/hr. For patients with weight > 80 kg, add an extra 100 ml/hr for each 10 kg. Ex: for a 100 kg patient with 30% burns, starting rate is 300 ml/hr + 200 ml/hr = 500 ml/hr. There is no need to catch up if resuscitation is delayed. Better: enteral (oral or gastric) intake of electrolyte solution 2

Sufficient volume replacement will require coached drinking on a schedule. Oral resuscitation of patients with burns up to about 30% TBSA should be possible (see box). If nasogastric tube (NGT) available, can also resuscitate with slow infusion of electrolyte solution via NGT, e.g. 300-500 ml/hr. But: watch for nausea/vomiting. Minimum: rectal infusion of electrolyte solution Rectal infusion of up to 500 ml/hr can be supplemented with oral hydration (see box) Plain water is ineffective for shock resuscitation and can cause hyponatremia. If using oral or rectal fluids, they must be in the form of a pre- mixed or improvised electrolyte solution to reduce this risk. Examples of mixed or improvised electrolyte solutions include: World Health Organization (WHO) Oral Rehydration Solution Mix 1 liter of D5W with 2 liters of Plasmalyte Per 1 L water: add 8 tsp sugar, 0.5 tsp salt, 0.5 tsp baking soda Per quart of Gatorade: add 0.25 tsp salt, 0.25 tsp baking soda (If no baking soda: double the amount of salt in the recipe.) v Monitoring- Vital signs Best: Portable monitor providing continuous vital- sign display; capnography if intubated; document vital sign trends frequently. Better: Capnometry in addition to minimum requirements (if intubated). Minimum: blood pressure cuff, stethoscope, pulse oximetry, document vital sign trends frequently. Document blood pressure (BP), heart rate (HR), urine output (UO), mental status, pain, pulse oximetry, temperature and input on a flowsheet (see Appendix B). Urine Output is the main indicator of resuscitation adequacy in burn shock Goal: adjust IV (or oral/rectal intake) rate to urine output (UO) goal of 30-50 ml/hr. Best: place Foley catheter If UO too low, increase IV rate by 25% every hour or two. (Ex: if UO = 20 ml/hr and IV rate = 300 ml/hr, increase IV rate by 0.25x300 = 75 ml/hr. New rate is 375 ml/hr.) If UO too high, IV rate by 25%. Document vitals, UO, mental status, pain and input on a flow sheet (Appendix B). Better: capture urine in pre- made or improvised graduated cylinder Collect all spontaneously voided urine hourly and carefully measure; > 700 ml/day (3/4 of a liter water bottle) is adequate. A Nalgene bottle is an example of an improvised graduated cylinder. 3

Minimum: use other measures If unable to measure urine output, adjust IV rate to maintain heart rate (HR) < 140, palpable peripheral pulses, good capillary refill, intact mental status. Measure the blood pressure and consider treating hypotension, but remember: blood pressure does not decrease until relatively late in burn shock due to catecholamine release. On the other hand, blood pressure may be inaccurate (artificially low) in burned extremities. Note: electric injury Patients with high- voltage electric injury causing muscle damage and gross pigment in the urine (and similar patients, such as rhabdomyolysis or crush) have a higher target urine output of 70-100 ml/hr in adults. See PFC Crush CPG. If this does not cause gradual clearing of the pigment (urine turns lighter on 3 or 4 hourly checks), the patient likely needs urgent surgery for decompression/debridement. v Extremity Burns- burned extremities are vulnerable to injury from postburn swelling. Goal: Prevent and manage swelling (edema) of burned extremities, to prevent long- term damage. Best: Elevate burned extremities above heart level. Encourage patient to exercise burned extremities to decrease edema. Monitor peripheral pulses on all burned extremities hourly, using a Doppler flowmeter if available. Do escharotomies of burned skin to restore blood flow. (Figure) Obtain teleconsultation. Better: Consider doing escharotomies for circumferential full thickness burns of an extremity if extremity is edematous, you are unable to palpate distal pulses, and evacuation will be delayed. Obtain teleconsultation. Minimum: Triage patient to more rapid evacuation if extremity is edematous and you are unable to palpate distal pulses. Elevate burned extremities above heart level and have patient exercise or provide passive range of motion (PROM) to burned extremities to mobilize edema. Provide pain control to enable PROM. v Pain Management refer to Analgesia and Sedation CPG. Burns can be painful, but can cause hypovolemia. Thus, frequent smaller doses of an IV opioid or ketamine are preferred. In hypovolemic burn patients, ketamine can be used for severe pain or for painful procedures, but less than the full anesthetic dose is safer; ex. 0.1-0.2 mg/kg IV push and assess response/re- dose ketamine as needed every 5-10 minutes. For prolonged care of burn patient, a ketamine infusion (detailed in Analgesia, Sedation CPG) may provide more consistent analgesia and help conserve supplies of analgesic medications. Consider administering an oral or IV benzodiazepine for anxiety (common with repeated painful wound care). v Infection- Burn wounds are easily infected. 4

Recommendation- Goal: Prevent burn- wound infection through wound care. Note. If evacuation to higher level of care is anticipated within 24 hours, cover burns with clean gauze. Leave intact blisters in place. Avoid wet dressings due to risk of hypothermia. If not: Best: Clean and debride wounds by scrubbing with chlorhexidine gluconate solution (ex. Hibiclens) in water; apply topical antimicrobial cream (silver sulfadiazine [Silvadene] or mafenide acetate [Sulfamylon]), followed by gauze dressing. Repeat daily. Alternative: instead of cream, use silver nylon dressing (Silverlon), followed by gauze dressing. Change Silverlon every 3 days. Better: Ensure wounds are cleaned and dressed; optimize wound and patient hygiene to the extent possible given environment. Minimum: Cover with clean sheet or dry gauze. Leave blisters in place. Avoid wet dressings. IV or oral antibiotics are not normally used for prophylaxis in burn patients. After several days, if patient develops cellulitis (spreading erythema around edges of burn), treat for gram- positive organisms. If patient develops invasive burn- wound infection (sepsis/septic shock, changes in color of wound, possible foul smell of wound) consider broad- spectrum antibiotics to include gram- negative coverage. 5

Appendix A - - Fluid and equipment planning considerations Assumptions: one patient with a 50% TBSA burn, weighing 80 kg, and requiring 500 ml/hr for resuscitation the first day (12 L), half that the 2 nd day (6 L), and half that the 3 rd day (3 L). Best: Fluids: IV fluid (lactated Ringer s solution or Plasmalyte) to provide resuscitation for 72 hours (21 L) Equipment: Portable monitor with capnography, lab capability for serum electrolytes, arterial blood gases, lactate, Foley catheter with graduated collection system, portable ventilator, portable suction, electrocautery or scapel, oxygen or oxygen concentrator, airway management kit to include endotracheal suction catheter Medications: pain medications (refer to Analgesia, Sedation CPG) Burn- specific dressings: Silver sulfadiazene and/or mafenide acetate cream (two 400 g jars per patient per day, or Silverlon dressings, Hibiclens to clean wounds. Non- specific dressings: roller gauze; torso dressings; tape or stapler Hypothermia prevention: Sleeping Bag/HPMK Monitoring: Portable monitor providing continuous vital sign display; capnography if intubated; document vital sign trends, intake and output, GCS, and pain level on a regular basisk, burn resuscitation flow sheet Communications: real- time video telemedicine consultation Push- pack capability: prepackaged additional 24- hour supplies of fluids, dressings for scenarios > 24 hours. Better: Fluids: IV fluid (lactated Ringer s solution or Plasmalyte) to provide 500 ml/hr for 24 hours (12 L); oral electrolyte replacement Equipment: Blood pressure cuff, stethoscope, pulse oximeter, capnometer, portable ventilator, oxygen or oxygen concentrator, airway management kit Graduated container to monitor urine output Pain medications Non- specific dressings: roller gauze; torso dressings; tape or stapler Hypothermia prevention: Sleeping Bag/HPMK/Blizzard Blanket Monitoring: Frequent vital signs, exam, fluid input, urine output, pain level, documented on flowsheet Communications: telephone; email digital photos Minimum: Fluids: Resuscitation with commercial or improvised electrolyte solution (oral, enteral, rectal) Equipment: Blood pressure cuff, stethoscope, pulse oximeter, bag- valve mask with PEEP valve, airway management kit Graduated or improvised graduated container to monitor urine output Pain medications Clean sheet, any available trauma dressings Hypothermia prevention: Sleeping Bag/Emergency Blanket/Blankets Monitoring: Frequent vital signs, exam, fluid input, urine output documented on pre- printed or improvised flowsheet. Communications: telephone 6

Appendix B - - JTS Burn Resuscitation Flow Sheet Date Initial Treatment Facility Name SSN Pre-burn est. wt (kg) %TBSA (Do not include superficial 1 st degree burn) Calculate Rule of Tens (if >40<80kg, %TBSA x 10 = starting rate for LR Calculate max 24hr volume (250ml x kg) Avoid overresuscitation, use adjuncts if necessary Date &Time of Injury BAMC/ISR Burn Team DSN 312-429-2876: Yes No Tx Site/ Team HR from burn Local Time Crystalloid* (LR) Colloid Total UOP (Target 30-50ml/hr) Base Deficit/ Lactate Heart Rate MAP (>55) / CVP (6-8 mmhg) Pressors (Vasopressin 0.04 u/min) Bladder Pressure (Q4) 1 st 2 nd 3 rd 4 th 5 th 6 th 7 th 8 th 9 th 10 th 11 th 12 th 13 th 14 th 15 th 16 th 17 th 18 th 19 th 20 th 21 st 22 nd 23 rd 24 th Total Fluids: (Use adjuncts if >24hr max) *Titrate LR hourly to maintain adequate UOP (30-50ml/hr) and tissue perfusion 7

Figure - - Escharotomy incisions Figure: Location of escharotomy incisions. The incisions on the extremities are placed along the mid- medial and/or mid- lateral joint lines. The bold lines indicate the importance of always carrying the incisions across any involved joints. The incisions on the chest are intended to free up a mobile plate of tissue, and thus to restore adequate chest movement with breathing. Source: Figure 26.1, p. 379, Chapter 26 (Burns). In: Anonymous, Emergency War Surgery, 4 th United States Revision. Fort Sam Houston, TX: Office of the Surgeon General, Borden Institute, 2013. 8