diaphyseal femur; allograft-fibula

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54 yo 1st referral: Feb 6th, 2013 HPI: - Pain in left thigh for 1 year. Initially very low, on charge. - no night pain, no increased sweating. - no analgesics PMH: - Arterial hypertension

54 yo 1st referral: Feb 6th, 2013 clinical findings: - normal gait - exam of hip and knee normal - neurovascular exam normal

CT left thigh: Jan 14th, 2013 Cor + contrast

Chest-CT: Jan 14th, 2013 No pulmonary nodules

MRI: Jan 16th, 2013 STIR T1

MRI: Jan 16th, 2013 T1 T1+Gado

PET: Jan 25th, 2013

PET: Jan 25th, 2013 no other lesions

Biopsy: Feb 6th, 2013

Result Biopsy: Feb 6th, 2013 Kappa/lambda Proliferationsfraktion (mib1)

Sarcoma- Board: February 14, 2013 Therapeutic decisions: The board has agreed to recommend, because of the diagnosis, a bone marrow biopsy. If there is just one lesion to see in PET- CT, the resection of the lesion would be initiated and then start with the chemotherapy.

Result Biopsy: Feb 6th, 2013

Follow-up PET-CT: Mar 28, 2013 No other lesions

Neoadj RT: Apr 4 May 17 2013 Neoadjuvant RT: 50.4Gy From April 4 to May 17 2013

MR thigh left: Jan Jun 2013 Jan 16, 2013 Jun 13, 2013 lat ap lat ap SPAIR STIR T1 fs T1 TIRM

Rx thigh left: Jun 13, 2013

Surgery: Jun 18, 2013 Jun 13, 2013 Jan 16, 2013

Surgery: Jun 18, 2013 1) Vastus lateralis 2) Vastus intermedius 3) Vastus medialis 4) Rectus femoris 5) Biceps femoris - a) Caput longum - b) Caput brevis 6) Sartorius 7) Gracilis 8) Semitendinosus 9) Semimenbranosus 10) Adductor longus/ magnus 7 6 8 3 9 10 4 5a 5b a) Septum interm. Femoris med b) Septum interm. Femoris lat a 2 b 1

Surgery: Jun 18, 2013 hip knee lateral

Surgery: Jun 18, 2013 Vastus lateralis knee hip Septum intermusculare femoris lateralis Femur

Surgery: Jun 18, 2013 NCB-locking plate knee hip

Surgery: Jun 18, 2013 Drill wholes proximal and distal to determinate lenght and rotation knee hip

Surgery: Jun 18, 2013 Remove the plate knee hip

Surgery: Jun 18, 2013 Remove the tumor Tumor

Surgery: Jun 18, 2013 Tumor Allograft with cement Allograft cement

Surgery: Jun 18, 2013 Allograft with cement Allograft cement

Surgery: Jun 18, 2013 Fixation the NCB-locking plate

Surgery: Jun 18, 2013 Fixation the NCB-locking plate

Surgery: Jun 18, 2013 Fixation the NCB-locking plate

Surgery: Jun 18, 2013 Compression bone-allograft with two small plates compression compression

Surgery: Jun 18, 2013 Compression bone-allograft with two small plates compression compression

Surgery: Jun 18, 2013 Compression bone-allograft with two small plates compression compression

Surgery: Jun 18, 2013 Definitive fixation NCB-locking plate

Surgery: Jun 18, 2013 Definitive fixation NCB-locking plate

Surgery: Jun 18, 2013

x-ray left femur, June 18, 2013

Histopathology, June 18, 2013

Histopathology, June 18, 2013

Histopathology, June 18, 2013

Sarcoma- Board: July 11, 2013 Therapeutic decisions: Radiotherapy: No Chemotherapy: Yes, the tumor is considered as a systemic disease, therefore, adjuvant chemotherapy is Recommended Surgery: tumor resection was held at the Balgrist at 18:06:13.

Follow up X-Ray: October, 23th, 2013

Follow up MRI thigh: October, 23th, 2013 No local recurrence T1_tirm T1_tse_KM

Clinical findings: November, 5th, 2013 HPI: Suddenly pain in the left thigh after change from sitting to up right position. clinical findings: Dolent distal third of the left thigh. Normal sensibility and motoric control.

X-Ray: November, 6th, 2013

Re-Surgery: November, 7th, 2013 proximal Femur with allograft distal medial Anastomosis A. femoralis V. femoralis Fibula

intra-op X-Ray: November, 7th, 2013

clinical pic: November 13, 2013