TUBERCULOSIS CONTACT INVESTIGATION

Similar documents
TUBERCULOSIS CONTACT INVESTIGATION

Contact Investigation

TB Contact Investigation

Investigation of Contacts of Persons with Infectious Tuberculosis, 2005

TB is Global. Latent TB Infection (LTBI) Sharing the Care: Working Together. September 24, 2014

INDEX CASE INFORMATION

TB Contact Investigation Basics

Diagnosis and Medical Management of Latent TB Infection

TB in Corrections Phoenix, Arizona

What s New in TB Infection Control?

Fundamentals of Tuberculosis (TB)

TB Clinical Guidelines: Revision Highlights March 2014

Contact Investigation San Antonio, Texas January 14-15, 2013

Contact Investigation and Prevention in the USA

At the end of this session, participants will be able to:

TB In Detroit 2011* Early TB: Smudge Sign. Who is at risk for exposure to or infection with TB? Who is at risk for TB after exposure or infection?

Tuberculosis Tools: A Clinical Update

Latent Tuberculosis Infection Reporting Instructions for Civil Surgeons Using CalREDIE Provider Portal

Diagnosis and Treatment of Tuberculosis, 2011

Utilizing All the Tools in the TB Toolbox

2017/2018 Annual Volunteer Tuberculosis Notice

Chapter 5 Treatment for Latent Tuberculosis Infection

2016 Annual Tuberculosis Report For Fresno County

Contact Investigation Overview

TB: Management in an era of multiple drug resistance. Bob Belknap M.D. Denver Public Health November 2012

Contact Investigation Overview

Haley Blake Sage Nagai, MPH. Disease Investigation and Intervention Specialists Tuberculosis Treatment and Control Clinic

MEMORANDUM. Re: Guidance for follow-up of newly-arrived individual with Class B1 Tuberculosis Pulmonary Tuberculosis, no treatment

PREVENTION OF TUBERCULOSIS. Dr Amitesh Aggarwal

TB Skin Test Practicum Houston, Texas Region 6/5 South September 23, 2014

TUBERCULOSIS. Presented By: Public Health Madison & Dane County

Intensified TB case finding among PLHIV and vulnerable population Identifying contacts Gunta Kirvelaite

Pediatric Tuberculosis Lisa Y. Armitige, MD, PhD September 14, 2017

Contact Investigation San Antonio, Texas January 14-15, 2013

Management of Pediatric Tuberculosis in New Jersey

Essential Mycobacteriology Laboratory Services in the Era of MDR- and XDR-TB: A TB Controller s Perspective

Overview of Contact Investigation Guidelines

Clinical Practice Guideline

Pediatric TB Lisa Armitige, MD, PhD September 28, 2011

Latent Tuberculosis Best Practices

TB Program Management San Antonio, Texas November 5-7, 2008

Chapter 7 Tuberculosis (TB)

Tuberculosis What you need to know. James Zoretic M.D., M.P.H. Regions 2 and 3 Director

Treatment of Tuberculosis, 2017

Tuberculosis and Diabetes Mellitus. Lana Kay Tyer, RN MSN WA State Department of Health TB Nurse Consultant

Latent Tuberculosis Infection (LTBI) Questions and Answers for Health Care Providers

Please distribute a copy of this information to each provider in your organization.

Tuberculosis Populations at Risk

Treatment of TB Infection Lisa Y. Armitige, MD, PhD April 7, 2015

TUBERCULOSIS. Pathogenesis and Transmission

11/3/2009 SECOND EDITION Madhukar Pai McGill University. ISTC Training Modules Introduction

Tuberculosis (TB) Fundamentals for School Nurses

Diagnosis & Medical Case Management of TB Disease. Lisa Armitige, MD, PhD October 22, 2015

MODULE SIX. Global TB Institutions and Policy Framework. Treatment Action Group TB/HIV Advocacy Toolkit

Northwestern Polytechnic University

Etiological Agent: Pulmonary Tuberculosis. Debra Mercer BSN, RN, RRT. Definition

Preventing Tuberculosis (TB) Transmission in Ambulatory Surgery Centers. Heidi Behm, RN, MPH TB Controller HIV/STD/TB Program

HEALTH SERVICES POLICY & PROCEDURE MANUAL

Tuberculosis 6/7/2018. Objectives. What is Tuberculosis?

Latent TB, TB and the Role of the Health Department

Tuberculosis Procedure ICPr016. Table of Contents

TB Intensive Houston, Texas. Childhood Tuberculosis Kim Connelly Smith. November 12, 2009

HEALTH SERVICES POLICY & PROCEDURE MANUAL

Mycobacterial Infections: What the Primary Provider Should Know about Tuberculosis

MEMORANDUM. Re: Guidance for follow-up of newly-arrived Individual with a Class B1 Tuberculosis Extrapulmonary Tuberculosis

FLORIDA DEPARTMENT OF JUVENILE JUSTICE DETENTION SERVICES FACILITY MEDICAL POLICIES

TUBERCULOSIS IN HEALTHCARE SETTINGS Diana M. Nilsen, MD, FCCP Director of Medical Affairs, Bureau of Tuberculosis Control New York City Department of

Why need to havetb Clearance. To Control and Prevent Tuberculosis

10/3/2017. Updates in Tuberculosis. Global Tuberculosis, WHO 2015 report. Objectives. Disclosures. I have nothing to disclose

Appendix B. Recommendations for Counting Reported Tuberculosis Cases (Revised July 1997)

has the following disclosures to make:

Communicable Disease Control Manual Chapter 4: Tuberculosis. Assessment and Follow-Up of TB Contacts

What you need to know about diagnosing and treating TB: a preventable, fatal disease. Bob Belknap M.D. Denver Public Health November 2014

Pre-Treatment Evaluation. Treatment of Latent TB Infection (LTBI) Initiating Treatment: Patient Education. Before initiating treatment for LTBI:

Targeted Testing and the Diagnosis of. Latent Tuberculosis. Infection and Tuberculosis Disease

Understanding and Managing Latent TB Infection Arnold, Missouri October 5, 2010

The diagnosis of active TB

TB the basics. (Dr) Margaret (DHA) and John (INZ)

Rebecca O. Sanchez, BSN., RN., MPH. has the following disclosures to make:

TB Classification (ATS/CDC)

Diagnosis and Medical Management of TB Infection Lisa Y. Armitige, MD, PhD September 12, TB Nurse Case Management September 12 14, 2017

Tuberculosis Reporting, Waco-McLennan County Public Health District TB Control WMCPHD (254)

Treatment of Tuberculosis

The Epidemiology of Tuberculosis in Minnesota,

Guidelines for Source Case Investigation (SCI) for Latent Tuberculosis (TB) Infection

CHAPTER 3: DEFINITION OF TERMS

Recognizing MDR-TB in Children. Ma. Cecilia G. Ama, MD 23 rd PIDSP Annual Convention February 2016

DIAGNOSIS AND MEDICAL MANAGEMENT OF TB DISEASE

The Public Health Impact of TB in the Correctional System. Sarah Bur, RN, MPH Federal Bureau of Prisons Infection Prevention and Control Officer

Managing Complex TB Cases Diana M. Nilsen, MD, RN

Tuberculosis Facts. TB is not spread by: Sharing food and drink Shaking someone s hand Touching bed lines or toilet seats

Disclosures. Updates in TB for the PCP: Opportunities for Prevention. Objectives PART 1: WHY TEST? 4/14/2016. None

Latent tuberculosis infection

TB BASICS: PRIORITIES AND CLASSIFICATIONS

TB Nurse Case Management San Antonio, Texas July 18 20, 2012

TB-Free California: How close are we? How can we get closer?

Tuberculosis: A Provider s Guide to

Tuberculosis (TB) and Infection Control PICNET Conference April 12, 2013

결핵노출접촉자감염관리 서울아산병원감염내과 김성한

Transcription:

TB CASE MANAGEMENT AND CONTACT INVESTIGATION INTENSIVE May 8-11, 2018 TUBERCULOSIS CONTACT INVESTIGATION LEARNING OBJECTIVES Upon completion of this session, participants will be able to: 1. Describe the criteria used and method for determining an infectious period (IP) for TB 2. Describe the characteristics of the TB patient, contact, and exposure that should be assessed in order to prioritize contacts 3. Name and apply the essential steps and timelines in a contact investigation (CI) 4. List three criteria used to determine when to expand the scope of a CI INDEX OF MATERIALS 1. Tuberculosis Contact Investigation slide outline Presented by: Renee Lucas McNally, MSN, RN, PHN PAGES 1-42 SUPPLEMENTAL MATERIAL 1. California Department of Public Health, Tuberculosis Control Branch. Patient Locating Service Fact Sheet., UCSF 300 Frank H. Ogawa Plaza, Suite 520 Oakland, CA; Office (510) 238-5100

TB CASE MANAGEMENT AND CONTACT INVESTIGATION INTENSIVE May 8-11, 2018 REFERENCES California Department of Public Health, California Tuberculosis Controllers Association. Joint Addenda to the Guidelines for the investigation of contacts of persons with infectious tuberculosis. 2011;1-118. Available online at: http://ctca.org/filelibrary/ctcaciguidelines117_.pdf Centers for Disease Control and Prevention. Guidelines for the investigation of contacts of persons with infectious tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC. 2005; 54(No. RR-15):1-56. Available online at: http://www.cdc.gov/tb/publications/guidelines/contactinvestigations.htm ADDITIONAL RESOURCES Rutgers Global Tuberculosis Institute. Tuberculosis education and the congregate setting contact investigation: A resource for the public health worker. 2009:1-15. Available online at: http://globaltb.njms.rutgers.edu/educationalmaterials/productfolder/congregatesetting.html Rutgers Global Tuberculosis Institute. TB interviewing for contact investigation: A practical resource for the healthcare worker. 2008:1-17. Available online at: http://globaltb.njms.rutgers.edu/educationalmaterials/productfolder/tbinterviewing.html Southeastern National Tuberculosis Center. Corrections Toolkit. Available at: http://sntc.medicine.ufl.edu/correctionstoolkit.aspx#.wa JC0rLIU. Homeless and TB Toolkit. Available at: http://www.currytbcenter.ucsf.edu/sites/default/files/product_tools/homelessnessandtbtoolkit/, UCSF 300 Frank H. Ogawa Plaza, Suite 520 Oakland, CA; Office (510) 238-5100

Tuberculosis Contact Investigation Renee Lucas McNally, RN, MSN, PHN Case Management and Contact Investigation Intensive May 8-11, 2018 Learning Objectives Upon completion of this session, participants will be able to: Describe the criteria used and method for determining the infectious period (IP) for TB Describe the characteristics of the TB patient, contact, and exposure that should be assessed in order to prioritize contacts Name and apply the essential steps and timelines in a contact investigation (CI) List 3 criteria used to determine when to expand the scope of a CI May 8-11, 2018 1

Background CDC National Guidelines for the Investigation of Contacts of Persons with Infectious TB (2005) Provide a standard framework for assembling information related to exposure to TB Describe how to use findings to: Assess for evidence of transmission Inform decisions on whether to expand the investigation CDPH/CTCA Joint Addenda (2011) Why do we do TB contact investigations? May 8-11, 2018 2

TB Control Priority Strategies 1. Prompt detection, reporting and treatment of persons with active TB 2. Identification and evaluation of contacts of persons with contagious TB 3. Targeted testing and treatment of persons with latent TB infection 4. Strengthening infection control measures in settings at high risk for TB transmission Why TB Contact Investigation? Find active TB cases: treat and prevent ongoing transmission Find persons with TB infection: treat and prevent future cases May 8-11, 2018 3

Contact Investigation (CI) Performance Targets and Average 5-Year Outcomes United States and California, 2009-2013 National Performance Targets for 2020 Performance Outcomes (range 2009-2013) United States California Contacts are identified for 100% of sputum AFB smear-positive TB patients 93% of contacts are evaluated 91% of contacts to sputum AFB smear(+) patients with newly diagnosed LTBI will start treatment 81% of contacts who start LTBI treatment will complete treatment 94% (94-95%) 81% (78-83%) 70% (68-72%) 71% (66-71%) 94% (93-95%) 85% (80-88%) 61% (55-65%) 62% (58-63%) Data provided by the California TB Control Branch Trends in CI Performance Outcomes California, 2010-2014 CA Performance Targets for 2019 Contacts are identified for 98% of sputum AFB smearpositive TB patients CA Performance Outcomes 5- Year 2010 2011 2012 2013 2014 Trend 94% 93% 95% 95% 93% 96% of contacts are evaluated 80% 81% 88% 87% 82% 94% of contacts to sputum AFB smear(+) patients with newly diagnosed LTBI will start treatment 88% of contacts who start treatment will complete treatment 59% 65% 55% 65% 55% 62% 63% 62% 62% 67% Data provided by the California TB Control Branch May 8-11, 2018 4

Definitions Case a particular instance of disease (e.g., TB). A case is detected, documented, and reported Index case the first case or patient that comes to attention as an indicator of a potential public health problem Source case the case or person who was the original source of infection for secondary cases or contacts Infectious refers either to TB disease of the lung or throat which has the potential to cause transmission to other persons, OR to the patient who has TB disease Definitions (2) Contact someone who has been exposed to M. tuberculosis infection by sharing air space with a person with infectious TB Converter a change in the result of a test for M. tuberculosis infection that is interpreted to indicate a change from uninfected to infected May 8-11, 2018 5

Definitions (3) Infectious period the time during which a person with TB disease might have transmitted M. tb organisms to others Exposure period the coincident period when a contact shared the same air space as a person with TB during the infectious period Window period the interval between infection and detectable reactivity to the tuberculin skin test (TST) TB Contact Investigation Steps 1) Collect and Evaluate Index Case Information: Decide Whether to Initiate a CI 2) Interview the Index Case 3) Determine the Infectious Period 4) Examine Sites of Transmission 5) Prioritize Contacts 6) Locate and Evaluate Contacts 7) Treat and Follow up Contacts 8) Evaluate Contact Investigation Activities May 8-11, 2018 6

Step 1 Collect and Evaluate Index Case Information: Decide Whether to Initiate a CI What information is collected? Background information regarding the patient and circumstances of the illness Demographics, identifiers, locating information Site of disease, TB regimen, and start date(s) History of previous TB exposure History of previous TB disease and treatment TB symptoms and the onset date(s) Results of diagnostic tests Concurrent medical conditions, diagnoses, or important social factors May 8-11, 2018 7

Assessing Transmission Risk TB CASE FACTORS Site of TB Disease LIKELIHOOD OF DISEASE TRANSMISSION MORE LIKELY Laryngeal / pulmonary or pleural LOWER LIKELIHOOD Extra-pulmonary alone Smear status Positive Negative Chest X-ray Cavitation Non-cavitary Symptoms/ behaviors Coughing, singing, sneezing, sociability Not coughing, singing, sneezing Age Adult or adolescent Child <10 years of age Anti-TB drugs No or ineffective Rx Yes (2 weeks or more) Decision to Initiate a TB Contact Investigation *Acid-fast bacilli Nucleic acid assay Approved indication for NAA Chest radiograph Handout 1.1a May 8-11, 2018 8

Decision to Initiate a Contact Investigation (2) Index Case TB Classification TB 3: Culture + Pulmonary, laryngeal or pleural TB TB 5: High Pulmonary, laryngeal or pleural TB and TB treatment initiated TB 5: Low Pulmonary, laryngeal or pleural TB and TB treatment not initiated TB 3 or 5: EPTB No pulmonary laryngeal or pleural involvement Always Always C+ C- Not indicated Always Not indicated TB3= Active TB case; TB5= Suspect case Handout 1.1b Exercise #1: Deciding Whether to Initiate a CI May 8-11, 2018 9

Contact Investigation Case Scenario October 4, 2015: Analyn, a 24-year-old woman from the Philippines, presented to the county hospital outpatient department Symptoms: fatigue, productive cough, weight loss, and fever Chest x-ray: right upper lobe fibronodular densities and a left upper lobe infiltrate Sputum: AFB smear positive; cultures are pending Plan: admit to hospital and isolate; tuberculin skin test (TST) placed October 5, 2015: lab reports +AFB smear; Health Department notified October 6, 2015: started on isoniazid, rifampin, ethambutol and pyrazinamide; TST = 16mm Q2. What criteria did you use in making your decision to initiate a CI? Sputum AFB smear-positive TB symptoms (persistent cough, fever, weight loss) Abnormal CXR consistent with active tuberculosis Other risk factors from the Philippines, a country where TB is prevalent May 8-11, 2018 10

Step 2 Interview the Index Case Index Case TB Interview Goals Patient understands transmission and treatment of TB Problems/concerns identified and addressed Infectious period (IP) determined Areas of transmission identified Contacts identified, prioritized, and locating information obtained Contact investigation priorities established May 8-11, 2018 11

Interview Timeframes Conduct a minimum of 2 interviews 1st interview 1 business day of reporting for infectious patients 3 business days for others 2nd interview 1 2 weeks later May need additional interviews Use a trained interpreter when indicated Step 3 Determine the Infectious Period May 8-11, 2018 12

What is the Infectious Period? Time during which a TB case is likely to transmit M. tuberculosis Importance of Estimating the Infectious Period Focuses the investigation on contacts most likely to be at risk of infection Sets the timeframe for testing contacts (e.g., when repeat TST or IGRA is due) NOTE: current methods only estimate the IP. Certain circumstances might warrant extending the onset or end of the IP beyond the recommended guidelines May 8-11, 2018 13

Estimating Onset of Infectious Period Characteristic TB symptoms AFB sputum smear positive Cavitary chest radiograph Recommended minimum beginning of likely period of infectiousness Yes No No 3 months before symptom onset or 1 st positive findings consistent with TB disease, whichever is longer Yes Yes Yes 3 months before symptom onset or 1 st positive findings consistent with TB disease, whichever is longer No Yes Yes 3 months before 1 st positive finding consistent with TB disease No No No 4 weeks before date of suspected diagnosis Handout 1.2 TABLE 2. Guidelines for estimating the beginning of the period of infectiousness of persons with tuberculosis (TB), by index case characteristic. Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis. Recommendations from the National Tuberculosis Controllers Association and CDC. 2005. Closing the Infectious Period The infectious period (IP) is closed when further transmission of tuberculosis is unlikely General criteria for closing IP include: Effective treatment for 2 weeks Diminished symptoms Mycobacteriologic response May 8-11, 2018 14

Who is considered a contact? Must have shared same airspace as the index case during the infectious period Important to determine for each contact (or group of contacts): When did exposure occur (in relation to index case diagnosis)? How frequent and what duration was the exposure? What was the date of last exposure? Exercise #2: Determining the Infectious Period May 8-11, 2018 15

CI Case Scenario (continued) You arrange to interview Analyn at the hospital the following day but were unable to secure an interpreter to accompany you. During the initial interview, Analyn verifies that she had been having symptoms consistent with TB for about a month prior to her admission to the hospital. She has stayed in three different houses in the area with various relatives since she arrived from the Philippines in August 2014. She had trouble finding work initially due to her limited English skills, so she has been helping out with childcare for the young children in two of these households, as well as for another neighbor. CI Case Scenario (continued) In addition, the week prior to her diagnosis, Analyn had just started a job-training program to learn cosmetology. Analyn is very emotional during the interview to elicit contacts. She is shocked that she has TB and expresses feelings of guilt and shame. She is afraid that once her relatives learn about her TB situation they will disown her and ask her to leave. She is worried she will have no place to live and that she will die soon. Analyn is also very worried about her financial situation. The interview is cut short with the arrival of Analyn s physician. May 8-11, 2018 16

Determining Analyn s Infectious Period Q3: What information in this case scenario can you use to help you estimate the onset of Analyn s infectious period? Q4: Using the table in handout 1.2, calculate the onset date of Analyn s infectious period. Determining Onset of Analyn s Infectious Period Characteristic TB symptoms AFB sputum smear positive Cavitary chest radiograph Recommended minimum beginning of likely period of infectiousness Yes No No 3 months before symptom onset or 1 st positive findings consistent with TB disease, whichever is longer Yes Yes Yes 3 months before symptom onset or 1 st positive findings consistent with TB disease, whichever is longer Infectious period start = June 4, 2015. Admitted to hospital October 4 Symptoms began 1 month prior September 4 Infectious Period began = June 4 (3 months prior to symptom onset) May 8-11, 2018 17

Determining End of Analyn s Infectious Period Q5: What information will you use to help you determine the end of Analyn s infectious period? Determining End of Analyn s Infectious Period (2) Consider: TB treatment start date - at least 14 daily doses of effective treatment Bacteriology results smear conversion Evidence of clinical improvement diminished symptoms (e.g., decreased frequency of cough, resolution of fever, etc.) May 8-11, 2018 18

Step 4 Examine Sites of Transmission (Field Investigation) Examine Sites of Transmission (Field Investigation) Visit the sites where the patient spent time during infectious period Components include: Assess physical conditions of the setting Interview, arrange for evaluation and provide TB information to contacts Identify additional contacts May 8-11, 2018 19

Assessing the Environment ENVIRONMENTAL LIKELIHOOD OF DISEASE TRANSMISSION FACTOR HIGH LOW Volume of shared air space Adequacy of ventilation Low (small) Poor High (large) Good Re-circularized air Yes No Upper room ultraviolet light Not present Present Step 5 Prioritize Contacts May 8-11, 2018 20

Assign Priority Level to each Contact Contact Roster High Priority 3-5 business days (from listing to initial encounter) Medium Priority 14 business days Low Priority Non-contact How to Prioritize Contacts Consider both: Factors associated with transmission Factors associated with increased risk for progression to TB disease (vulnerability) May 8-11, 2018 21

High Priority Contacts High Priority Contacts are: 1. Most likely to be infected (exposure) 2. Most likely to progress to disease if infected 3. Most likely to suffer increased morbidity or mortality from TB disease When assigning priority, consider: Infectiousness of the TB case Circumstances of the exposure Environment where transmission likely occurred Frequency & duration of exposure Infectiousness Exposure intensity Susceptibility/vulnerability Susceptibility factors of the contact Age, immune suppressed, other medical risk factors Any contact with TB symptoms = High priority May 8-11, 2018 22

Assessing Exposure Circumstances Determine when exposure occurred in relation to TB case s infectious period including date of last contact (contact break date) Close to date of diagnosis? Toward beginning of infectious period? Evaluate how often (frequency) the TB case and contact shared air space and how long (duration) each exposure lasted (e.g., number of hours) Susceptibility/Vulnerability Factors Contact Risk Assessment Is the contact at high risk for rapid progression to active TB? Under five years of age? HIV infected? Other immune suppressed? May 8-11, 2018 23

Susceptibility/Vulnerability Factors Contact Risk Assessment (2) Children TB disease is more likely to occur once infected Incubation or latency period is briefer If <5 years of age, assign high priority Susceptibility/Vulnerability Factors Contact Risk Assessment (3) Immune Status - HIV Infection results in the progression of M. tuberculosis infection to TB disease more frequently and more rapidly than any other known factor CDC 2005 May 8-11, 2018 24

Susceptibility/Vulnerability Factors Contact Risk Assessment (4) Immune Status Other Immunosuppressive treatment that increases the likelihood of progression to TB disease after infection: Corticosteroids - >15 mg daily for >4 weeks Multiple cancer chemotherapy agents Anti-rejection drugs for organ transplants Tumor necrosis factor alpha antagonists Susceptibility/Vulnerability Factors Contact Risk Assessment (5) Medical conditions that increase the likelihood of progression to TB disease after infection: Silicosis Diabetes mellitus Status post gastrectomy or jejunoileal bypass surgery May 8-11, 2018 25

Prioritizing Contacts - Guidelines CDC CI guidelines propose various algorithms to guide the priority classification process (handout 1.3a) CDPH/CTCA revised CI guidelines include additional detail and criteria, particularly for classifying high and medium priority (handout 1.3b) Exercise #3: Examine Site(s) of Transmission and Prioritize Contacts May 8-11, 2018 26

Contact Investigation Case Scenario (continued) On follow-up interview with the interpreter, Analyn clarifies that she has been living with her 42 y/o Aunt Riza, her husband, and their 3 children (son age 16, and two daughters ages 9 and 6) since the end of June, 2015. Prior to Aunt Riza s, she stayed with her cousin Areva. Areva has a daughter that just turned 2 and Analyn babysits for Areva as needed. When Analyn first came to the US, she lived at another aunt and uncle s home in the neighboring health jurisdiction until March, 2015 when she moved to the city to help her cousin when Areva returned to work. Contact Investigation Case Scenario (continued) Analyn also babysat for her Aunt Riza s neighbor who has two children (daughter age 4 and a 3-year-old son), but the last time she babysat was over a month ago. Analyn was hoping to become a certified beautician and began classes at the Cosmetology College one week before she was hospitalized. She attended classes M, W, and F from 3:00 4:30pm. She states she has not yet gotten to know her classmates and did not socialize with them. Analyn named 4 friends that she hangs out with some evenings and weekends but states she has not been out with them for several weeks now. May 8-11, 2018 27

Identifying Potential Sites of Transmission and Prioritizing Contacts Q6: List the sites of possible transmission. Q7: Designate a priority level (high, medium, low, or no contact) for each individual or group listed. Prioritizing Analyn s Contacts Q7: How would you prioritize Analyn s contacts at this stage? By households By age By medical risk factor HIV status Tumor necrosis factor antagonists Other immunocompromising conditions or treatments By environment of exposure (high-risk setting) By intensity of exposure (duration, location, etc.) May 8-11, 2018 28

Who are the high-priority contacts? Contacts in Aunt Riza s and Areva s households Contacts, especially < 5 y.o., in the 4th house where she cared for children Any contact with TB symptoms Any contact that is known to be HIV positive, on tumor necrosis factor antagonists, or with other immunocompromising conditions or treatments Who are the medium and/or low-priority contacts? Those in the 4 th house that are aged 5 years or greater (assuming they are without symptoms) Analyn s 4 other named contacts (friends) Classmates and instructor from the job training class (assuming they are without symptoms and without medical risk factors) May 8-11, 2018 29

Step 6 Locate and Evaluate Contacts Locating Contacts Consider: Social networks Re-interviews Jails, shelters DMV; Postal service CDPH Patient Locating Service May 8-11, 2018 30

Evaluation of Contacts 1. Medical and TB history 2. TB symptom evaluation 3. TST or IGRA; if initial test is negative, then repeat 8-10 weeks post contact If symptomatic or positive TB test: Obtain chest X-ray and medical evaluation Consider sputum for AFB smear and culture if indicated Important information for Evaluating the TB Contact Prior TB test history: Employment or immigration health record Primary care provider medical record School / immunization health record Cure-TB, TBNet, other program record (e.g., foster care) Country of birth, year of arrival in US, and travel history Other medical conditions May 8-11, 2018 31

Timeframes: Initial Contact Evaluation Case TB Classification TB3 or TB5 High pulmonary, laryngeal or pleural TB with: AFB S+ respiratory spec., OR Cavitary CXR, OR TB symptoms TB3 or TB5 High pulmonary, laryngeal or pleural TB with: Negative AFB smears, AND CXR abnormal, not cavitary AND No TB symptoms Business days from listing as a contact to initial encounter High priority contact 3-5 Medium priority contact 14 High priority contact 7 Medium priority contact 14 Business days from initial encounter to completion of medical evaluation High priority contact 5 Medium priority contact 10 High priority contact 10 Medium priority contact 10 Source: Adapted from Addendum 6; 2011 CDPH/CTCA Joint Addenda to the 2005 CDC TB CI guidelines Evaluation: Special Contact Groups Child < 5 y/o or immunocompromised: Medical history Physical exam Chest X-ray (PA & lateral views) Tuberculin skin test Documented prior positive TST or IGRA: Obtain medical and exposure history Obtain prior treatment history If treatment for LTBI is indicated, obtain CXR prior to treatment initiation May 8-11, 2018 32

Step 7 Treat and Follow Up Contacts Treatment and Follow-up Prioritize efforts with contacts who are most in need of treatment Monitor throughout treatment (monthly face-toface) Window-period prophylaxis TST-negative high-risk contacts during the period following last contact until the follow-up TST (8-10 weeks after last contact) MDR-TB exposure seek expert consultation; follow-up 2 years post exposure May 8-11, 2018 33

Exercise #4: Locate, Evaluate, Treat, and Follow Up Contacts Case Scenario Update Analyn s culture is reported positive for M. tuberculosis complex on October 29 th. The first round of skin testing among high- and medium-priority contacts is completed three weeks after Analyn s initial interview A few additional contacts were identified through the field investigation and initial testing process. It was difficult to locate a few of the Cosmetology College contacts. Initial contact evaluation results are as follows: Refer to CI Worksheet May 8-11, 2018 34

Evaluation and Treatment of Analyn s Contacts Q8: What further evaluation is required for contacts in House #1? Q9: Which contacts are your priorities for treating and why? Q8: House #1 Contact Evaluation Contacts: evaluation completed Aunt Riza: Prior + TST; asymptomatic Husband: Prior + TST; asymptomatic Additional evaluation required Assess for history of prior LTBI treatment Assess for history of prior LTBI treatment 16 y/o son: TST +; asymptomatic Physical exam and chest X-ray (CXR) 9 y/o daughter: TB5, symptom +, abnormal CXR 6 y/o daughter: TST -, asymptomatic Aunt s brother: TST +, asymptomatic Physical exam, sputum AFB smear and culture, weight Repeat TST 8-10 weeks Physical exam and chest X-ray May 8-11, 2018 35

Evaluation and Treatment of Analyn s Contacts (2) Analyn s susceptibility results are now back, and the report shows the isolate to be sensitive to all first-line anti-tb drugs Evaluation and Treatment of Analyn s Contacts (3) Q10: What treatment regimen would be recommended for contacts in House #4? May 8-11, 2018 36

House #4 s Treatment Regimen for the Contacts Neighbor No treatment Husband 4 year old daughter INH x 9 months INH+rifapentine x 12 weeks RIF x 4 months INH window prophylaxis 3 year old son INH x 9 mo OR RIFx 4mo Step 8 Evaluate Contact Investigation Activities May 8-11, 2018 37

When to Evaluate? When should you evaluate the contact investigation? Answer: The evaluation should begin when the CI is initiated and continue throughout until the investigation is closed Why Evaluate? Will help in the management, care, and follow-up of the TB case and contacts Analysis of the investigation in progress will allow prioritization of program activities and resources Will allow you to report on how well your objectives are being met for program monitoring and planning Will help you determine whether or not the investigation should be expanded May 8-11, 2018 38

Deciding Whether to Expand Testing Evidence of Recent Transmission: High infection rate in high-priority contacts Infection in a child (< 5 y/o) TST converters Secondary case TB disease in any contact assigned a low priority Exercise #5: Decide Whether to Expand the Contact Investigation May 8-11, 2018 39

Summary of Initial Test Results 37 high-, medium-, and low-risk contacts: 7 did not have TSTs placed/read: One 9 y/o TB suspect with symptoms and abnormal CXR 1 boyfriend of Named Friend #3 3 classmates from Cosmetology College 2 with prior positive TST (House #1) 30 of 35 who required TST had TSTs placed and read: 12 TST+, all had normal CXRs 18 TST- (one 2 y/o with abnormal CXR is TB suspect; all other high-risk contacts had normal CXRs) Q11: Would you expand the contact investigation at this point? (2) If yes, explain which group/setting you will include in the investigation or what additional steps you would take to inform you on whom to test If not, explain what your rationale is for not expanding the testing at this point and what information would lead you to reconsider your decision May 8-11, 2018 40

When to Call It Quits Before closing a contact to follow-up: Try different methods of contacting Visit or call at different times of the day Explore obstacles, offer incentives/enablers Consult your supervisor and other health team members When to Call It Quits (2) Inform the contact of the risks of not completing their evaluation or treatment Document your efforts and strategies used and the contact s response to each For certain high-risk contacts, more effort may be required May 8-11, 2018 41

Special Settings TB contact investigation steps also apply to CIs in special settings (schools, correctional facilities, healthcare facilities, etc.) School CI toolkit Corrections toolkit http://sntc.medicine.ufl.edu/correctionstoolkit.aspx#.wa JC0rLIU Homeless and TB toolkit - http://www.currytbcenter.ucsf.edu/sites/default/files/product_tools/homeless nessandtbtoolkit/ Identify stakeholders early and keep them informed Be prepared for possible media attention Summary Contact investigations are an essential component to TB control and prevention Determining the infectious period helps to maintain focus on those most likely to have been infected Evaluating CI activities in real time will help maintain a focus on priorities Seek consultation for special situations (drug resistance, outbreak, large CI, etc.) May 8-11, 2018 42

California Department of Public Health (CDPH) Tuberculosis Control Branch (TBCB) Patient Locating Service Purpose: To return TB patients to care by providing local health departments prompt technical and/or direct assistance with locating strategies and tools Background TB patients with risk factors for poor adherence are more likely to have delays in diagnosis, treatment interruptions, serious medical consequences and default. If a TB patient cannot be located or becomes lost, he/she may also pose a public health risk and continue to transmit TB to others if infectious. TB Patient Locating Service Team Members of the team include experienced and motivated specialists in communicable disease investigation. All members have extensive training and experience in the areas of cultural diversity, field investigation, patient interviews and social networking. When to Request Our Services As soon as the TB case manager has determined that a TB patient cannot be located, give us a call. The Project Coordinator will review the information thoroughly and make recommendations to assist with locating the TB patient. Please don t wait! Call or email: Carol Greene, Coordinator Phone: (510) 620-3033 Email: carol.greene@cdph.ca.gov FAX: (510) 620-3031 Services Provided The team s first priority is to assist local TB programs in locating lost patients with active or suspected TB. As resources permit, the team can also assist with locating high priority contacts or high priority B notification patients. The TB Patient Locating Service is available to assist in the following ways: Prompt telephone consultation to evaluate the available patient information and likelihood of finding the patient Offer recommendations based on common investigative strategies in locating individuals Using available tools and investigative methods, perform people searches, interviews and field investigations Provide strategies and methods to prevent patients from becoming lost Locating patients who have become lost when moving between jurisdiction Individual and group training in how to conduct patient interviews, social networking strategies and field investigations August 2011