Institut za zaštitu zdravlja Srbije Dr Milan Jovanovi ć - Batut Institute of Public Health of Serbia Dr Milan Jovanovi ć - Batut Centar za prevenciju i kontrolu nezaraznih oboljenja Center for prevention and control of noncommunicable diseases INCIDENCIJA I MORTALITET OD RAKA U CENTRALNOJ SRBIJI CANCER INCIDENCE AND MORTALITY IN CENTRAL SERBIA 1999 REGISTAR ZA RAK U CENTRALNOJ SRBIJI CANCER REGISTRY OF CENTRAL SERBIA ISBN 86-7358-030-7 IZVEŠTAJ BR.1 REPORT No.1 Beograd, 2002.
Institut za javno zdravlje Srbije Dr Milan Jovanović - Batut Institute of Public Health of Serbia Dr Milan Jovanović - Batut Odeljenje za prevenciju i kontrolu nezaraznih bolesti Department for Prevention and Control of Noncommunicable Diseases INCIDENCIJA I MORTALITET OD RAKA U CENTRALNOJ SRBIJI CANCER INCIDENCE AND MORTALITY IN CENTRAL SERBIA 1999 REGISTAR ZA RAK U CENTRALNOJ SRBIJI CANCER REGISTRY OF CENTRAL SERBIA ISBN 86-7358-030-7 IZVEŠTAJ BR. 1 REPORT No. 1 Beograd, 2002.
Izdavač Institut za zaštitu zdravlja Srbije Dr Milan Jovanović - Batut Published by Institute of Public Health of Serbia Dr Milan Jovanović - Batut Direktor Prof. dr Ivanka Gajić Director Ivanka Gajić MD,PhD Centar za prevenciju i kontrolu nezaraznih oboljenja Center for prevention and control of noncommunicable diseases Mr sc. dr Anđelka Vukičević- načelnik / Head Mr sc. dr Dragan Miljuš Dr Snežana Živković Mr sc. dr Nataša Mickovski - Katalina Uređivački odbor Editorial Board Mr sc. dr Anđelka Vukičević Mr sc. dr Dragan Miljuš Dr Snežana Živković Dizajn i priprema za štampu Design and typesetting Mr sc. dr Dragan Miljuš Dr Snežana Živković Lektor Proofrided Mr Tamara Gruden Korespondencija Correspondence to Mr sc. dr Anđelka Vukičević Institut za zaštitu zdravlja Srbije Dr Subotića 5, 11 000 Beograd, Srbija, Jugoslavija Tel: +381 (011) 2684 566/160 Fax: +381 (011) 2684 140 E-mail: nezaraznibatut@yahoo.com Web site://www. batut.org.yu Štampa Printed by HARFA,Beograd,
SADRŽAJ / CONTENTS Uvod i objašnjenja Introduction and Comments Tabele i slike / Tables and Figures 1. Broj stanovnika prema uzrastu i polu, centralna Srbija, 1999. godina Population of Central Serbia by age and sex, 1999 2. Broj stanovnika prema okruzima i polu, centralna Srbiji, 1999. godina Population of Central Serbia by administrative regions by sex, 1999 3. Stanovništvo prema uzrastu i polu, centralna Srbija, popis 2002. i 1999. godine Population of Central Serbia by age sex, census 2002 and estimate 1999 4. Broj novoobolelih osoba od raka prema polu, centralna Srbija, 1990-1999. Number of new cancer cases by sex, Central Serbia, 1990-1999 5. Broj umrlih osoba od raka prema polu, centralna Srbija, 1990-1999. Number of death cancer cases by sex, Central Serbia, 1990-1999 6. Incidencija i mortalitet od raka na 100 000 stanovnika, centralna Srbija, 1990-1999. godina Cancer incidence and mortality rates per 100 000 population, Central Serbia, 1990-1999 7. Standardizovane stope mortaliteta od vodećih lokalizacija raka na 100.000 stanovnika,muškarci, centralna Srbija,1990-1999god. Standardized cancer mortality rates per 100.000 population, males, Central Serbia, 1990-1999 8. Standardizovane stope mortaliteta od vodećih lokalizacija raka na 100.000 stanovnika, žene, centralna Srbija,1990-1999god. Standardized cancer mortality rates per 100.000 population, females, Central Serbia, 1990-1999 9. Vodeće lokalizacije u obolevanju od raka prema polu, centralna Srbija, 1999 godina The leading cancer sites by sex, Central Serbia, 1999 10. Vodeće lokalizacije u umiranju od raka prema polu, centralna Srbija, 1999 godina Deaths for leading cancer sites by sex, Central Serbia, 1999
11. Broj novoobolelih slučajeva od raka prema vodećim lokalizacijama, okruzima i polu, centralna Srbija, 1999 godina Number of new cancer cases by sex and leading primary sites, Central Serbia, 1999 12. Sirove stope incidencije od raka prema vodećim lokalizacijama, okruzima i polu, centralna Srbija, 1999 godina Crude cancer incidence rates by sex and leading primary sites, Central Serbia, 1999 13. Standardizovane stope incidencije od raka prema vodećim lokalizacijama okruzima i polu, centralna Srbija, 1999 godina Standardized cancer incidence rates by sex and leading primary sites, Central Serbia, 1999 14. Broj umrlih slučajeva od raka prema prema vodećim lokalizacijama, okruzima i polu, centralna Srbija, 1999 godina Number of death cancer cases by sex and leading primary sites, Central Serbia, 1999 15. Sirove stope mortaliteta od raka prema vodećim lokalizacijama, okruzima i polu, centralna Srbija, 1999 godina Crude cancer mortality rates by sex and leading primary sites, Central Serbia, 1999 16. Standardizovane stope mortaliteta od raka prema vodećim lokalizacijama, okruzima i polu, centralna Srbija, 1999 godina Standardized cancer mortality rates by sex and leading primary sites, Central Serbia, 1999 17. Ukupan broj novoobolelih i broj novoobolelih od raka sa procentom registrovanih samo na osnovu prijave smrti, prema primarnoj lokalizaciji i polu, centralna Srbija, 1999 godina Total number of new cancer cases and number and percentage of cases registered from death certificates only, of corpus uteri, Central Serbia, 1999 18. Broj novoobolelih slučajeva od raka, prema primarnoj lokalizaciji, uzrastu i polu, centralna Srbija, 1999 godina Number of new cancer cases by primary site, age and sex, Central Serbia, 1999 19. Sirove i standardizovane stope incidencije od raka na 100 000 stanovnika, prema primarnoj lokalizaciji, uzrastu i polu, centralna Srbija, 2007 godina Crude and standardized cancer incidence rates per 100 000 population by primary site, age and sex, Central Serbia, 1999 20. Broj umrlih slučajeva od raka, prema primarnoj lokalizaciji, uzrastu i polu, centralna Srbija, 1999 godina Number of death cancer cases by primary site, age and sex, Central Serbia, 1999
21. Sirove i standardizovane stope mortaliteta od raka na 100 000 stanovnika, prema primarnoj lokalizaciji, uzrastu i polu, centralna Srbija, 1999 godina Crude and standardized cancer mortality rates per 100 000 population by primary site, age and sex, Central Serbia, 1999 22. Ukupan broj novoobolelih, broj i procenat histološki i citološki verifikovanih slučajeva raka prema primarnoj lokalizaciji i polu, centralna Srbija, 1999 godina Total number of new cancer cases, number and percentage of histologically and cytologically confirmed cancer cases, by primary site and sex, Central Serbia, 1999 23. Broj novoobolelih i incidencija od raka prema primarnoj lokalizaciji, uzrastu i polu, centralna Srbija, 1999 godina Number of new cancer cases and cancer incidence rates by primary site, age and sex, Central Serbia, 1999 24. Broj umrlih i mortalitet od raka prema primarnoj lokalizaciji, uzrastu i polu, centralna Srbija, 1999 godina Number of death cancer cases and cancer mortality rates by primary site, age and sex, Central Serbia, 1999
UVOD Populacioni registar za rak osnovan je u Srbiji 1970. godine na osnovu Plana statističkih istraživanja od interesa za Republiku (Sl. glasnik SRS br. 32/69). U cilju primene jedinstvene metodologije u vođenju Registra u svim teritorijalnim jedinicama bivše Jugoslavije, 1986. godine doneti su Uputstvo o načinu i postupku prijavljivanja lica obolelih od malignih neoplazmi (Sl. list SFRJ, br. 3/86) i Pravilnik o obrascu Registra i načinu njegovog vođenja, obrascu prijave i postupku prijavljivanja i odjavljivanja određenih bolesti (Sl. glasnik SRS, br. 42/86). Neprecizno uputstvo, nedovoljna edukacija zdravstvenih radnika, kao i nedostatak informatičke podrške imali su za posledicu subregistraciju novootkrivenih slučajeva raka, kao i relativno loš kvalitet podataka na samoj prijavi. U periodu od 1986. do 1995. godine, broj obolelih slučajeva malignih tumora koji su prijavljeni Registru bio je približno isti ili čak i manji od broja umrlih od raka. Polazeći od zakonske obaveze i uloge Registra (pre svega, za procenu opterećenosti društva rakom, donošenje programa primarne prevencije, planiranje onkološke zdravstvene zaštite, kao i za klinička i epidemioloških istraživanja), u toku 1996. godine pristupljeno je njegovoj reorganizaciji u skladu sa preporukama Internacionalne (Interational Agency for Research on Cancer - IACR) i Evropske (European Network of Cancer Registries - ENCR) asocijacije registara za rak. Reorganizacija je obuhvatala: - decentralizaciju (registri se vode na nivou okruga, a baza podataka za centralnu Srbiju se nalazi u Institutu za javno zdravlje Srbije), - pored pasivnog i aktivni način prikupljanja podataka, - nove izvore informacija, - edukaciju zdravstvenih radnika, - informatičku podršku i - povratni sistem informacija. Zahvaljujući uspešnoj reorganizaciji, u toku 1998. godine Registar za rak u centralnoj Srbiji je primljen u Internacionalnu (IACR) i Evropsku asocijaciju registara za rak (ENCR). Posle navedenih aktivnosti i vremenskog perioda od nekoliko godina, koji je neophodan za stabilnost podataka, ostvareni su uslovi za izradu prvog izveštaja u decembru 2002. godine. U registrima koji funkcionišu više decenija, zbog mnogobrojnih izvora podataka i potrebe za njihovom proverom i analizom, uobičajeni vremenski period za prikupljanje podataka iznosi dve godine posle čega se publikuje izveštaj.
INTRODUCTION The Population Register for Cancer was formed in Serbia in 1970, originated from the Plan of Statistical Research of Interest for the Republic (Official Gazette of the Republic of Serbia No. 32/69). In 1986, aiming to apply a unified Register implementation methodology in all territorial units of Former Yugoslavia, the Guidelines On Ways And Procedures Of Reporting Persons With Malign Neoplasms (Official Gazette SFRY, No. 3/86) and the Regulation Book For The Register Form And The Method Of Updating, The Report Forms And Reporting And Cancelation Procedures For Certain Diseases (Official Gazette Gazette of the Republic of Serbia No. 42/86) were adopted. Unprecise Guidelines, insufficient education of the medical personnel, as well as the lack of informatics support resulted in the subregistration of newly found cases of cancer, as well as a relatively poor quality of data on the report forms themselves. In the period of 1986-1995, the number of cases with malignant tumors reported to the Register was approximately the same or even lower compared to the number of cases deceased from cancer. Starting from legal obligations and role of the Register, (foremost for the evaluation of the cancer burden on society, adoption of primary prevention programs, planning oncology health care, as well as clinical and epidemiological research), the reorganization of the Register began in 1996, in accordance with the recommendations of the Interational Agency for Research on Cancer - IACR, and European Network of Cancer Registries - ENCR. The reorganization encompassed: - Decentralization (registers are formed on the level of regions, while the main database for Central Serbia is located in the Institute of Public Health of Serbia), - Apart from passive, active data collection, - New sources of information, - Education of medical personnel, - Informatics support and - Feedback system of information. During 1998, due to a successful reorganization, the Cancer Register in Central Serbia was admitted into the Interational Agency for Research on Cancer (IACR) and European Network of Cancer Registries (ENCR). Following the afore-mentioned activities and several years period necessary for achieving stability of the data, conditions were created for issuing the first Report in December 2002. In Registers functioning over a period of several decades, due to numerous data sources and the need to check and analyze them, the usual time span for data collection is two years, after which the Report is published.
METOD Registar za rak u centralnoj Srbiji obuhvata podatke o: ličnim karakteristikama obolelih/umrlih, mogućoj pojavi multiplog primarnog tumora, datumu utvrđivanja sadašnjeg oboljenja, načinu dijagnostike, karakteristikama tumora (primarna i sekundarna anatomska lokalizacija, histološki tip, stadijum), ishodu bolesti, kao i podatke o zdravstvenoj ustanovi koja je prijavila maligni tumor. Izvori informacija o obolelim/umrlim od raka su podaci iz instituta za onkologiju, onkoloških dispanzera, onkoloških klinika, bolničkih i vanbolničkih zdravstvenih ustanova, patohistoloških/citoloških, hematoloških i drugih laboratorija, prijava smrti, fondova zdravstvenog osiguranja i ciljanih istraživanja. Informatičku podršku Registru pružio je programski paket CanReg4 (Department of Descriptive Epidemiology, IARC, Lyon, France, 2002). U cilju obezbeđenja kvalitetnog prikupljanja, unosa, čuvanja, obrade i analize podataka u Registru, primenjena je metodologija međunarodnih asocijacija (IARC i ENCR) registara za rak. Za analizu umiranja od malignih tumora u centralnoj Srbiji u 1999 godini, korišćeni su nepublikovani podaci Republičkog zavoda za statistiku. Izvor podataka o populaciji bila je procena stanovništva za 1999 godinu Republičkog zavoda za statistiku. Maligni tumori su šifrirani prema Međunarodnoj klasifikaciji bolesti - deseta revizija, knjiga 1- (šifre C00-C96) i prema Međunarodnoj klasifikaciji onkoloških bolesti - drugo izdanje (šifre 8000/3-9941/3) - International Classification of Diseases for Oncology - Third Edition, World Health Organization, 2000, Geneva. Registrom nisu obuhvaćeni tumori in situ (šifre D00-D09). U izveštaju pored nestandardizovanih, prikazane su i standardizovane stope incidencije (tabele 37-55) i mortaliteta (tabele 75-96). Navedene stope standardizovane su metodom direktne standardizacije, a kao standardna populacija korišćena je populacija sveta (ASR-W), Evrope (ASR-E) i trankova (ASR-TRUNC). Učešće prijavljenih slučajeva malignih tumora koji su registrovani samo na osnovu prijave smrti (tabela 17), kao i učešće histološki i citološki verifikovanih malignih tumora (tabela 94) u ukupnom broju prijavljenih malignih tumora, bili su osnov za procenu kvaliteta podataka Registra.
METHOD The Central Serbia Cancer Register includes the following data: personal characteristics of new cases/deceased, possible appearance of multiple primary tumors, date of determination of current illness, diagnostic methods, tumor characteristics (primary and secondary anatomy localization, histology type, stage), outcome of the disease, as well as data on the health institution reporting the malign tumor. Information sources concerning new cancer cases/deceased cases are data from the oncology institutes, oncology dispensaries, oncology clinics, hospitals and out-patients health institutions, pahtohistology/cytology, hematology and other laboratories, death reports, health insurance funds and targeted research. The Register is informatically supported by the CanReg4 progame package (Department of Descriptive Epidemiology, IARC, Lyon, France, 2002). With the aim of providing quality in collection, entry, keeping, processing and analysis of data in the Register, the methodology of international associations was applied (IARC I ENCR) for cancer registers. Unpublished data of the Republic Statistics Institute were used for the analysis of death due to malign tumors in Central Serbia in 1999 The source of data concerning the population was the 1999 estimate of the Republic Statistics Institute. Malign tumors are coded according to the International Classification of Diseases - Tenth Revision, Volume 1(codes C00-C96) and according to the International Classification of Diseases for Oncology - Third Edition (codes 8000/3-9941/3), World Health Organization, 2000, Geneva. The Register does not include tumors in situ (codes D00-D09). Apart from crude rates, the Report includes standardized incidence rates (tables 37-55) and mortality rates (tables 75-96). These rates were standardized by the method of direct standardization, with the World (ASR-W), European (ASR-E) or truncated (ASR-TRUNC) population as the standard population. The percentage of new malign tumor cases registered only on the basis of death reports (table 17), as well as the percentage of histologically and cytologically verified malign tumors (table 94) out of the total number of reported cancer cases, were the foundation for the evaluation of Register data quality.
DEFINICIJE Incidencija je broj novodijagnostikovanih slučajeva raka u definisanoj populaciji, prijavljenih registru u datoj kalendarskoj godini. Uzrasno specifična stopa incidencije je broj novoobolelih od raka u definisanoj uzrasnoj grupi (najčešće petogodišnji interval) na 100.000 stanovnika te uzrasne grupe. Mortalitet je broj slučajeva umrlih od raka koji se javljaju u definisanoj populaciji tokom određenog vremenskog perioda. Uzrasno specifična stopa mortaliteta je broj umrlih od raka u definisanoj uzrasnoj grupi (najčešće petogodišnji interval) na 100.000 stanovnika te uzrasne grupe. Standardizovane stope incidencije i mortaliteta predstavljaju fiktivne vrednosti koje se dobijaju određenim tehničkim postupkom, uvođenjem standardne populacije, obično je to: populacija sveta (ASR-W), Evrope (ASR-E) ili tranka (ASR-TRUNC). Njima se prevazilaze razlike (najčešće po polu i uzrastu) koje postoje u različitim populacijama, tako da su pogodne za poređenja. DEFINITIONS Incidence is the number of newly diagnosed cancer cases in a defined population, reported to the Register in the given calendar year. The age-specific incidence rate is the number of new cancer cases in a defined age-group (usually five-year interval) per 100 000 population of that age group. Mortality is the number of cases deceased from cancer appearing in a defined population during a determined period of time. The age-specific mortality rate is the number of deceased from cancer in a defined age-group (usually five-year interval) per 100 000 population of that age group. Standardized incidence and mortality rates represent fictive values reached by a certain technique, introducing standard population: usually World (ASR-W), European (ASR-E) or truncated population (ASR-TRUNC). They are used to eliminate differences (mostly gender and age) existing in different populations and are, therefore, convenient for comparison.
U realizaciji ovog izveštaja učestvovali su zdravstveni radnici i saradnici: - Instituta za javno zdravlje u Nišu i Kragujevcu; - Zavoda za javno zdravlje na teritoriji centralne Srbije; - Hospitalnog Registra za rak Instituta za onkologiju i radiologiju Srbije; - Instituta kliničkog centra Srbije i kliničkog centra u Nišu; - Kliničko bolničkih centara u Beogradu i Kragujevcu; - Instituta za zdravstvenu zaštitu majke i deteta ''Dr Vukan Čupić''; - Univerzitetske dečije klinike u Beogradu; - Ginekološko akušerske klinike ''Narodni front''; - Zdravstvenih centara; - Specijalnih / opštih bolnica, i - Domova zdravlja na teritoriji centralne Srbije. Health experts and administrative staff from the following institutions participated in the realization of this Report: - Institutes of Public Health of Nis and Kragujevac; - Institutes of Public Health on the territory of Central Serbia; - Hospital Cancer Register of the Oncology and Radiology Institute of Serbia; - Institutes of the Clinical Centre of Serbia and the Clinical Centre of Nis; - Clinical-Hospital Centres in Belgrade and Kragujevac; - Institute for Health Care of Mother and Child ''Dr Vukan Čupić''; - University Childrens' Clinic in Belgrade; - Gyneacology and Obstretics Clinic ''Narodni front''; - Health Centres; - Special / General Hospitals and - Primary Health Centres on the territory of Central Serbia.
Koordinatori okružnih Registara za rak / Coordinators of Cancer Registries: Zavod za javno zdravlje Šabac / Institute of Public Health Sabac Dr Olivera Stojanović, specijalista socijalne medicine / Olivera Stojanovic, MD, specialist specialist in social medicine Vesna Maksimović, viši sanitarni tehničar / Vesna Maksimovic, senior sanitary technician Zavod za javno zdravlje Valjevo / Institute of Public Health Valjevo Marija Jovanović, medicinska sestra / Marija Jovanovic, nurse Zavod za javno zdravlje Požarevac / Institute of Public Health Pozarevac Dr Goran Nikolić, specijalista epidemiologije / Goran Nikolic, MD, specialist in epidemiology Srđan Klimek, viši sanitarni tehničar / Srdjan Klimek, senior sanitary technician Nataša Peurača, dipl. biolog / Natasa Peuraca, graduate biologist Institut za javno zdravlje Kragujevac / Institute of Public Health Kragujevac Prof. dr Vesna Pantović, specijalista epidemiologije / Prof. Vesna Pantovic, MD, PhD, specialist in epidemiology Ass. dr Gordana Đorđević, specijalista epidemiologije / Ass. Prof. Gordana Djordjevic, MD, PhD, specialist in epidemiology Jelena Hadžić - Radisavljević, viši sanitarni tehničar / Jelena Hadžic - Radisavljevic, senior sanitary technician Zavod za javno zdravlje Ćuprija / Institute of Public Health Cuprija Dr Vesna Stefanović, specijalista epidemiolog / Vesna Stefanovic, MD, specialist in epidemiology Sonja Anđelković, viši sanitarni tehničar / Sonja Anđelkovic, senior sanitary technician Zavod za javno zdravlje Zaječar / Institute of Public Health Zajecar Dr Svetlana Živković, specijalista epidemiolog / Svetlana Zivkovic, MD, specialist in epidemiology Nena Đorđević, operater / Nena Đorđevic, IT technician Zavod za javno zdravlje Užice / Institute of Public Health Uzice Dr sc med Biljana Mijović / Biljana Mijović MD, PhD, specialist in epidemiology Dr Aleksandra Andrić, specijalista epidemiolog / Aleksandra Andric, MD, specialist in epidemiology Marija Dulović, sanitarni tehničar / Marija Dulovic, sanitary technician Zavod za javno zdravlje Čačak / Institute of Public Health Cacak Dr Aksentije Tošić, specijalista epidemiolog / Aksentije Tosic, MD, specialist in epidemiology Radoica Gojgić, dipl. inženjer metalurgije / Radoica Gojgic, dipl. engineer of metallurgy Zavod za javno zdravlje Kraljevo / Institute of Public Health Kraljevo Dr Vladan Šaponjić, specijalista epidemiolog / Vladan Saponjic, MD, specialist in epidemiology Dr Verica Đukić, specijalista epidemiolog / Verica Djukic, MD, specialist in epidemiology Zvonko Marinković, viši sanitarni tehničar / Zvonko Marinkovic, senior sanitary technician Zavod za javno zdravlje Kruševac / Institute of Public Health Krusevac Dr Mirjana Avramović, specijalista epidemiolog / Mirjana Avramovic, MD, specialist in epidemiology Verica Mijailović, viši sanitarni tehničar / Verica Mijailovic, senior sanitary technician
Insitut za javno zdravlje Niš / Institute of Public Health Nis Dr Mirko Ilić, specijalista epidemiolog / Mirko Ilic, MD, specialist in epidemiology Aleksandar Stojanović,viši sanitarni tehničar / Aleksandar Stojanovic, senior sanitary technician Zavod za javno zdravlje Pirot / Institute of Public Health Pirot Dr Radmila Zec, specijalista epidemiolog / Radmila Zec, MD, specialist in epidemiology Sonja Petrov, viši sanitarni tehničar / Sonja Petrov, senior sanitary technician Zavod za javno zdravlje Leskovac / Institute of Public Health Leskovac Prim. dr sc. med. Miroslava Dimitrijević, specijalista socijalne medicine / Prim. Miroslava Dimitrijevic, MD, PhD, specialist in social medicine Rosica Pejčić, viši sanitarni tehničar / Rosica Pejcic, senior sanitary technician Zavod za javno zdravlje Vranje / Institute of Public Health Vranje Dr Svetlana Stojanović, specijalista socijalne medicine / Svetlana Stojadinovic, MD, specialist in social medicine Petar Veličković, zdravstveni statističar / Petar Velickovic, health statistician Gradski zavod za javno zdravlje Beograd / Institute of Public Health Beograd Mr sc. med. Ljubinka Marčetić, specijalista socijalne medicine / Ljubinka Marcetic, MD, M. Sc. specialist in social medicine Dr Svetlana Trtica, specijalista socijalne medicine / Svetlana Trtica, MD, specialist in social medicine Aleksandra Čukić, zdravstveni statističar / Aleksandra Cukic, health statistician
Tabela 1. Broj stanovnika prema uzrastu i polu, centralna Srbija, 1999*. godina Table 1. Population of Central Serbia by age and sex, 1999* Uzrast Muškarci Žene Ukupno Age Males Females Total 0-4 141995 134753 276748 5-9 156034 149074 305108 10-14 174569 166589 341158 15-19 188776 180948 369724 20-24 190633 185664 376297 25-29 177773 177759 355532 30-34 170739 174454 345193 35-39 182365 187262 369627 40-44 205520 208398 413918 45-49 228088 230022 458110 50-54 168858 175704 344562 55-59 150036 161295 311331 60-64 168643 187444 356087 65-69 164672 193589 358261 70-74 117084 156775 273859 75+ 98563 152858 251421 Ukupno (Total) 2684348 2822588 5506936 Tabela 2. Broj stanovnika prema okruzima i polu, centralna Srbija, 1999*. godina Table 2. Population of Central Serbia by administrative districts by sex, 1999* Teritorija Muškarci Žene Ukupno District Males Females Total Grad Beograd 746855 821899 1568754 Kolubarski 96318 98692 195010 Mačvanski 165742 169211 334953 Raški 142551 146958 289509 Moravički 111547 115370 226917 Zlatiborski 156870 160931 317801 Rasinski 128714 134589 263303 Šumadijski 148026 154439 302465 Pomoravski 111743 118787 230530 Braničevski 97798 104946 202744 Podunavski 104555 108037 212592 Zaječarski 68797 73356 142153 Borski 73491 76604 150095 Nišavski 190187 195736 385923 Pčinjski 112436 113508 225944 Jablanički 122034 122902 244936 Toplički 52105 52528 104633 Pirotski 54579 54095 108674 Centralna Srbija (Central Serbia) 2684348 2822588 5506936 Slika 1. Stanovništvo prema uzrastu i polu, centralna Srbija, 2002 i 1999*. godina Figure 1. Population of Central Serbia by age and sex, 2002 and 1999* 2002 u z r a s t ( a g e s ) 75 + 70 do 74 65 do 69 60 do 64 55 do 59 50 do 54 45 do 49 40 do 44 35 do 39 30 do 34 25 do 29 20 do 24 15 do 19 10 do 14 5 do 9 0 do 4 1999 300 200 100 0 100 200 300 300 200 100 0 100 200 300 u h I lj a d a m a ( t h o u s a n d s ) Muškarci (males) Žene (females) - Popis,2002 - Republički zavod statistiku,beograd,2004 - Census,2002 - Republic statistical office,belgrade,2004 * - Procena,1999 - Republički zavod za statistiku,beograd 2002 * - Estimate,1999 -Republic statistical office,belgrade,2002
Tabela 3. Broj novoobolelih osoba od raka prema polu, centralna Srbija, 1990-1999. godina Table 3. Number of new cancer cases by sex, Central Serbia, 1990-1999 G o d i n e (Y e a r s ) P o l (Sex ) 1990* 1991* 1992* 1993* 1994* 1995* 1996* 1997* 1998* 1999 Muškarci (Males ) 4879 4479 4417 2900 2639 3101 8987 9412 9788 9964 Žene (Females ) 5019 4696 4174 3354 3250 3955 8236 8562 9053 9661 Ukupno (Total ) 9898 9175 8591 6254 5889 7056 17223 17974 18841 19625 * subregistracija (subregistration) Tabela 4. Broj umrlih osoba od raka prema polu, centralna Srbija, 1990-1999. godina Table 4. Number of death cancer cases by sex, Central Serbia, 1990-1999 G o d i n e (Y e a r s ) P o l (Sex ) 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 Muškarci (Males ) 5612 5658 6083 6093 6146 6287 6488 6736 6874 6962 Žene (Females ) 4202 4303 4544 4581 4569 4907 4919 5052 5288 5350 Ukupno (Total ) 9814 9961 10627 10674 10715 11194 11407 11788 12162 12312 Slika 1. Incidencija i mortalitet od raka na 100 000 stanovnika, centralna Srbija, 1990-1999. godina Figure 1. Cancer incidence and mortality rates per 100 000 population, Central Serbia, 1990-1999. 400 350 Sirova stopa na 100 000 Crude rate per 100 000 300 250 200 150 100 Incidencija (Incidence) Mortalitet (Mortality) 50 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 G o d i n e (Y e a r s) Slika 3. Standardizovane stope mortaliteta od vodećih lokalizacija raka na 100.000 stanovnika,muškarci, centralna Srbija,1990-1999.god. Figure 3. Standardized cancer mortality rates per 100.000 population, males, Central Serbia, 1990-1999 Standardizovane stope raka na 100.000 Standardized cancer rate per 100.000 50 45 40 35 30 25 20 15 10 5 0 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 G o d in e ( Y e a r s ) C34 - Pluća/bronh (Lung/bronchus) C18-C20 - Kolon/rektum (Colon/rectum) C16 - Želudac (Stomach) C61 - Prostata (Prostate) C25 - Pankreas (Pancreas) Slika 4. Standardizovane stope mortaliteta od vodećih lokalizacija raka na 100.000 stanovnika, žene, centralna Srbija,1990-1999.god. Figure 4. Standardized cancer mortality rates per 100.000 population, females, Central Serbia, 1990-1999 Standardizovane stope raka na 100.000 Standardized cancer rate per 100.000 25 20 15 10 5 0 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 C50 - Dojka (Breast) C34 - Pluća/bronh (Lung/bronchus) C18-C20 - Kolon/rektum (Colon/rectum) C53 - Grlić materice (Cervix uteri) C16 - Želudac (Stomach) G o d in e ( Y e a r s )
Slika 5. Vodeće lokalizacije u obolevanju od malignih tumora kod muškaraca,centralna Srbija, 1999.godina Figure 5. The leading cancer sites in males, Central Serbia, 1999 Mozak (C71) Brain 2.6% Pankreas (C25) Pancreas 2.5% Jetra (C22) Liver 2.4% Usna šuplj. /farinks (C00-C10) Mouth & pharynx 3.2% Druge lokalizacije Other sites 31.4% Larinks (C32) Larynx 4.7% Pluća / bronh (C34) Lung / bronchus 22.7% Želudac (C16) Stomach 6.0% Mokraćna bešika (C67) Bladder 5.9% Prostata (C61) Prostate 6.6% Kolon / rektum (C18-C20) Colon / rectum 12.3% Slika 6. Vodeće lokalizacije u obolevanju od malignih tumora kod žena, centralna Srbija, 1999. godina Figure 6. The leading cancer sites in females, Central Serbia, 1999 Želudac (C16) Stomach 3.0% Ovarijum (C56) Ovary 4.3% Pankreas (C25) Pancreas 2.1% Mokraćna bešika (C67) Bladder 2.0% Mozak (C71) Brain 1.9% Druge lokalizacije Other sites 30.2% Materica (C54) Corpus uteri 5.9% Pluća / bronh (C34) Lung / bronchus 6.4% Kolon i rektum (C18-C20) Colon and rectum 9.0% Grlić materice (C53) Cervix uteri 10.5% Dojka (C50) Breast 24.7%
Slika 7. Vodeće lokalizacije u umiranju od malignih tumora kod muškaraca, centralna Srbija, 1999. godina Figure 7. The leading cancer sites, deaths, males in Central Serbia, 1999 Jetra (C22) Liver 4.6% Larinks (C32) Larinx 4.5% Mokraćna bešika (C67) Bladder 3.8% Mozak (C71) Brain 3.3% Usna šuplj. /farinks (C00-C10) Mouth and phariynx 1.9% Pankreas (C25) Pancreas 4.9% Druge lokalizacije Other sites 22.8% Prostata (C61) Prostate 6.5% Želudac (C16) Stomach 7.8% Kolon / rektum (C18-C20) Colon & rectum 10.8% Pluća / bronh (C34) Lung & bronchus 29.2% Slika 8. Vodeće lokalizacije u umiranju od malignih tumora kod žena, centralna Srbija, 1999. godina Figure 8. The leading cancer sites, deaths, females in Central Serbia, 1999 Jetra (C22) Liver 4.0% Mozak (C71) Brain 3.0% Bubreg (C64) Kidney 1.7% Druge lokalizacije Other sites 30.9% Ovarijum (C56) Ovary 4.1% Pankreas (C25) Pancreas 4.6% Želudac (C16) Stomach 5.7% Dojka (C50) Breast 18.5% Grlić materice (C53) Cervix uteri 6.6% Pluća/bronh (C34) Lung & bronchus 10.3% Kolon/ rektum (C18-C20) Colon & rectum 10.5%
Tabela 5. Broj novoobolelih slučajeva od raka prema vodećim lokalizacijama i okruzima, muškarci, centralna Srbija, 1999. godina Table 5. Number of new cancer cases by leading primary sites, males, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Pluća i bronh, (C34) 2260 943 70 87 102 107 94 62 138 116 58 57 26 15 205 23 72 46 39 Lung and bronchus Kolon i rektum (C18-C20) 1225 497 39 47 60 56 50 28 75 24 35 21 41 13 123 34 39 10 33 Colon and rectum Prostata (C61) 662 344 9 29 26 20 39 14 32 6 16 13 21 6 37 10 21 9 10 Prostate Mokraćna bešika (C67) 583 230 18 29 33 24 33 18 49 13 14 18 11 2 34 19 30 4 4 Bladder Želudac (C16) 599 211 22 32 33 26 27 5 24 18 22 15 3 4 57 29 30 22 19 Stomach Larinks (C32) 464 187 16 17 18 12 27 29 16 11 20 10 17 1 37 14 15 9 8 Larynx Usna šuplj. i farinks (C00-C10) 317 107 14 13 7 16 16 12 26 3 8 13 13 1 30 10 13 7 8 Mouth and pharynx Mozak (C71) 259 132 4 10 10 9 7 2 19 8 6 5 5 5 21 3 4 6 3 Brain Pankreas (C25) 245 116 11 3 18 8 10 3 14 2 0 5 6 2 20 3 9 5 10 Pancreas Jetra (C22) 236 83 5 5 14 5 9 2 27 0 12 0 6 1 41 4 8 4 10 Liver Leukemije (C91-C95) 222 112 9 9 8 9 9 3 17 4 4 6 5 1 9 1 7 5 4 Leukaemias Bubreg (C64) 173 81 11 3 15 5 6 7 4 0 3 6 4 0 16 3 5 0 4 Kidney Druge lokalizacije 2719 958 78 140 127 122 143 91 188 55 86 63 101 25 215 132 89 70 36 Other sites Sve lokalizacije (C00-C97) 9964 4001 306 424 471 419 470 276 629 260 284 232 259 76 845 285 342 197 188 All sites Sve lokalizacije bez kože (C44) 9048 3749 279 346 417 380 415 234 591 255 243 213 211 70 794 199 314 160 185 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski Tabela 6. Broj novoobolelih slučajeva od raka prema vodećim lokalizacijama i okruzima, žene, centralna Srbija, 1999. godina Table 6. Number of new cancer cases by leading primary sites, females, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Dojka (C50) 2387 1038 69 88 99 61 100 86 162 87 59 75 58 21 192 48 64 39 41 Breast Grlić materice (C53) 1010 379 22 55 26 38 44 32 51 65 47 41 16 13 71 35 37 24 14 Cervix uteri Kolon i rektum (C18-C20) 872 364 21 30 46 39 45 12 70 25 29 13 25 4 61 22 26 20 20 Colon and rectum Pluća i bronh (C34) 621 324 16 23 22 25 21 11 45 16 11 16 4 6 42 4 20 5 10 Lung and bronchus Materica (C54) 573 208 19 16 13 22 23 26 33 11 34 18 16 4 42 30 36 12 10 Corpus uteri Ovarijum (C56) 412 173 8 17 18 15 14 18 24 14 16 3 12 6 40 6 13 5 10 Ovary Želudac (C16) 290 127 9 10 14 18 9 6 16 4 6 4 5 1 23 15 12 6 5 Stomach Pankreas (C25) 205 102 5 2 10 9 12 3 10 1 3 3 4 4 27 2 3 4 1 Pancreas Mokraćna bešika (C67) 189 71 7 13 3 6 9 7 18 2 4 9 9 5 11 10 4 0 1 Bladder Mozak (C71) 182 84 7 6 10 5 7 2 15 7 0 2 0 3 23 2 2 3 4 Brain Koža, maligni melanom (C43 ) 174 90 2 8 5 9 13 1 9 6 2 3 2 2 5 3 3 7 4 Malignant melanoma of skin Leukemije (C91-C95) 160 85 2 5 3 8 2 2 13 3 1 2 7 0 10 3 9 3 2 Leukaemias Druge lokalizacije 2586 1036 62 119 153 90 127 67 179 50 97 40 71 37 174 93 69 67 55 Other sites Sve lokalizacije (C00-C97) 9661 4081 249 392 422 345 426 273 645 291 309 229 229 106 721 273 298 195 177 All sites Sve lokalizacije bez kože (C44) 8818 3823 225 324 374 309 389 232 601 288 274 212 184 90 684 203 278 164 173 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski
Tabela 7. Stope incidencije od raka na 100.000 stanovnika prema vodećim lokalizacijama i okruzima, muškarci, centralna Srbija, 1999. godina Table 7. Cancer incidence rates per 100.000 population by leading primary sites, males, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Pluća i bronh, (C34) 84.2 126.3 72.7 52.5 71.6 95.9 59.9 48.2 93.2 103.8 59.3 54.5 37.8 20.4 107.8 20.5 59.0 88.3 71.5 Lung and bronchus Kolon i rektum (C18-C20) 45.6 66.5 40.5 28.4 42.1 50.2 31.9 21.8 50.7 21.5 35.8 20.1 59.6 17.7 64.7 30.2 32.0 19.2 60.5 Colon and rectum Prostata (C61) 24.7 46.1 9.3 17.5 18.2 17.9 24.9 10.9 21.6 5.4 16.4 12.4 30.5 8.2 19.5 8.9 17.2 17.3 18.3 Prostate Mokraćna bešika (C67) 21.7 30.8 18.7 17.5 23.1 21.5 21.0 14.0 33.1 11.6 14.3 17.2 16.0 2.7 17.9 16.9 24.6 7.7 7.3 Bladder Želudac (C16) 22.3 28.3 22.8 19.3 23.1 23.3 17.2 3.9 16.2 16.1 22.5 14.3 4.4 5.4 30.0 25.8 24.6 42.2 34.8 Stomach Larinks (C32) 17.3 25.0 16.6 10.3 12.6 10.8 17.2 22.5 10.8 9.8 20.5 9.6 24.7 1.4 19.5 12.5 12.3 17.3 14.7 Larynx Usna šuplj. i farinks (C00-C10) 8.8 11.1 5.2 3.0 9.8 4.5 5.7 1.6 18.2 0.0 12.3 0.0 8.7 1.4 21.6 3.6 6.6 7.7 18.3 Mouth and pharynx Mozak (C71) 9.6 17.7 4.2 6.0 7.0 8.1 4.5 1.6 12.8 7.2 6.1 4.8 7.3 6.8 11.0 2.7 3.3 11.5 5.5 Brain Pankreas (C25) 9.1 15.5 11.4 1.8 12.6 7.2 6.4 2.3 9.5 1.8 0.0 4.8 8.7 2.7 10.5 2.7 7.4 9.6 18.3 Pancreas Jetra (C22) 8.3 15.0 9.3 5.4 5.6 8.1 5.7 2.3 11.5 3.6 4.1 5.7 7.3 1.4 4.7 0.9 5.7 9.6 7.3 Liver Leukemije (C91-C95) 8.3 15.0 9.3 5.4 5.6 8.1 5.7 2.3 11.5 3.6 4.1 5.7 7.3 1.4 4.7 0.9 5.7 9.6 7.3 Leukaemias Bubreg (C64) 6.4 10.8 3.1 1.8 10.5 4.5 3.8 5.4 2.7 0.0 3.1 5.7 5.8 0.0 8.4 2.7 4.1 0.0 7.3 Kidney Druge lokalizacije 104.8 127.6 94.5 86.9 88.4 115.6 95.6 77.7 133.1 48.3 92.0 67.0 158.4 34.0 124.1 125.4 77.8 138.2 73.3 Other sites Sve lokalizacije (C00-C97) 371.2 535.7 317.7 255.8 330.4 375.6 299.6 214.4 424.9 232.7 290.4 221.9 376.5 103.4 444.3 253.5 280.2 378.1 344.5 All sites Sve lokalizacije bez kože (C44) 337.1 502.0 289.7 208.8 292.5 340.7 264.6 181.8 399.3 228.2 248.5 203.7 306.7 95.2 417.5 177.0 257.3 307.1 339.0 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski Tabela 8. Stope incidencije od raka na 100.000 stanovnika prema vodećim lokalizacijama i okruzima, žene, centralna Srbija, 1999. godina Table 8. Cancer incidence rates per 100.000 population by leading primary sites, females, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Dojka (C50) 84.6 126.3 69.9 52.0 67.4 52.9 62.1 63.9 104.9 73.2 56.2 69.4 79.1 27.4 98.1 42.3 52.1 74.2 75.8 Breast Grlić materice (C53) 35.8 46.1 22.3 32.5 17.7 32.9 27.3 23.8 33.0 54.7 44.8 37.9 21.8 17.0 36.3 30.8 30.1 45.7 25.9 Cervix uteri Kolon i rektum (C18-C20) 30.9 44.3 21.3 17.7 31.3 33.8 28.0 8.9 45.3 21.0 27.6 12.0 34.1 5.2 31.2 19.4 21.2 38.1 37.0 Colon and rectum Pluća i bronh (C34) 22.0 39.4 16.2 13.6 15.0 21.7 13.0 8.2 29.1 13.5 10.5 14.8 5.5 7.8 21.5 3.5 16.3 9.5 18.5 Lung and bronchus Materica (C54) 20.3 25.3 19.3 9.5 8.8 19.1 14.3 19.3 21.4 9.3 32.4 16.7 21.8 5.2 21.5 26.4 29.3 22.8 18.5 Corpus uteri Ovarijum (C56) 14.6 21.0 8.1 10.0 12.2 13.0 8.7 13.4 15.5 11.8 15.2 2.8 16.4 7.8 20.4 5.3 10.6 9.5 18.5 Ovary Želudac (C16) 10.3 15.5 9.1 5.9 9.5 15.6 5.6 4.5 10.4 3.4 5.7 3.7 6.8 1.3 11.8 13.2 9.8 11.4 9.2 Stomach Pankreas (C25) 7.3 12.4 5.1 1.2 6.8 7.8 7.5 2.2 6.5 0.8 2.9 2.8 5.5 5.2 13.8 1.8 2.4 7.6 1.8 Pancreas Mokraćna bešika (C67) 6.7 8.6 7.1 7.7 2.0 5.2 5.6 5.2 11.7 1.7 3.8 8.3 12.3 6.5 5.6 8.8 3.3 0.0 1.8 Bladder Mozak (C71) 6.4 10.2 7.1 3.5 6.8 4.3 4.3 1.5 9.7 5.9 0.0 1.9 0.0 3.9 11.8 1.8 1.6 5.7 7.4 Brain Koža, maligni melanom (C43 ) 6.2 11.0 2.0 4.7 3.4 7.8 8.1 0.7 5.8 5.1 1.9 2.8 2.7 2.6 2.6 2.6 2.4 13.3 7.4 Malignant melanoma of skin Leukemije (C91-C95) 5.7 10.3 2.0 3.0 2.0 6.9 1.2 1.5 8.4 2.5 1.0 1.9 9.5 0.0 5.1 2.6 7.3 5.7 3.7 Leukaemias Druge lokalizacije 91.6 126.0 62.8 70.3 104.1 78.0 78.9 49.8 115.9 42.1 92.4 37.0 96.8 48.3 88.9 81.9 56.1 127.6 101.7 Other sites Sve lokalizacije (C00-C97) 342.3 496.5 252.3 231.7 287.2 299.0 264.7 202.8 417.6 245.0 294.4 212.0 312.2 138.4 368.4 240.5 242.5 371.2 327.2 All sites Sve lokalizacije bez kože (C44) 312.4 465.1 228.0 191.5 254.5 267.8 241.7 172.4 389.2 242.5 261.1 196.2 250.8 117.5 349.5 178.8 226.2 312.2 319.8 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski
Tabela 9. Standardizovane stope incidencije od raka na 100.000 stanovnika prema vodećim lokalizacijama i okruzima, muškarci, centralna Srbija, 1999. godina Table 9. Standardized cancer incidence rates per 100.000 population by leading primary sites, males, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Pluća i bronh, (C34) 51.2 77.5 43.3 33.6 49.5 56.7 38.8 28.5 56.6 63.4 31.6 36.5 17.1 12.1 61.9 16.3 34.1 53.0 36.6 Lung and bronchus Kolon i rektum (C18-C20) 26.6 39.4 23.1 17.8 28.3 28.6 20.6 12.0 29.9 11.7 18.9 11.7 27.6 11.2 36.0 22.8 18.6 10.9 30.0 Colon and rectum Prostata (C61) 13.2 26.3 4.7 10.0 11.7 9.8 15.3 4.9 11.8 2.1 6.9 7.3 10.7 4.5 9.6 6.2 9.3 8.0 8.0 Prostate Mokraćna bešika (C67) 12.5 18.0 10.0 10.7 15.4 12.8 13.7 7.3 21.1 5.1 8.4 10.0 8.3 1.5 9.7 12.8 13.4 4.9 2.6 Bladder Želudac (C16) 13.2 17.1 11.9 12.1 15.7 13.4 11.5 2.8 9.9 9.9 11.8 8.8 1.5 3.4 16.1 19.0 14.6 24.1 15.6 Stomach Larinks (C32) 10.9 15.8 9.9 6.1 9.4 7.7 12.1 13.9 6.3 5.5 10.1 5.6 13.9 0.6 11.9 10.2 8.2 8.7 9.3 Larynx Usna šuplj. i farinks (C00-C10) 5.1 6.6 2.4 1.9 6.5 2.6 3.4 1.1 11.0 0.0 6.7 0.0 5.1 0.6 11.0 2.6 4.1 5.3 9.6 Mouth and pharynx Mozak (C71) 7.1 12.1 4.5 6.2 5.4 6.4 3.7 1.5 8.6 7.5 5.1 2.8 4.8 6.8 7.8 2.7 2.3 8.2 3.3 Brain Pankreas (C25) 5.3 9.3 5.9 1.2 8.4 4.1 4.1 1.3 5.4 1.3 0.0 3.0 3.8 1.9 5.9 2.0 4.2 5.2 9.5 Pancreas Jetra (C22) 6.0 10.8 10.8 4.1 3.8 5.2 4.4 1.5 8.2 4.8 1.9 4.4 4.2 0.6 3.3 0.7 3.7 8.8 4.0 Liver Leukemije (C91-C95) 6.0 10.8 10.8 4.1 3.8 5.2 4.4 1.5 8.2 4.8 1.9 4.4 4.2 0.6 3.3 0.7 3.7 8.8 4.0 Leukaemias Bubreg (C64) 4.1 6.8 6.7 1.3 7.9 2.5 2.8 3.5 1.8 0.0 1.6 4.1 3.2 0.0 5.2 2.0 3.0 0.0 3.8 Kidney Druge lokalizacije 67.2 39.9 48.6 57.3 62.0 77.9 67.0 50.1 86.7 38.6 50.3 47.7 77.4 20.9 76.1 95.8 54.4 73.5 39.9 Other sites Sve lokalizacije (C00-C97) 228.4 333.1 192.6 166.41 227.8 233.0 201.7 129.7 265.4 154.6 155.2 146.4 182.0 64.8 257.6 193.9 173.7 219.4 176.2 All sites Sve lokalizacije bez kože (C44) 208.7 313.1 177.7 137.2 203.2 211.3 179.3 112.1 250.9 151.8 133.5 134.3 152.3 59.9 242.9 137.2 160.5 181.6 173.0 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski Tabela 10. Standardizovane stope incidencije od raka na 100.000 stanovnika prema vodećim lokalizacijama i okruzima, žene centralna Srbija, 1999. godina Table 10. Standardized cancer incidence rates per 100.000 population by leading primary sites, females, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Dojka (C50) 52.7 74.5 44.5 34.5 48.9 32.6 42.8 38.8 68.4 49.9 32.8 47.8 50.3 17.4 59.2 32.8 32.3 45.2 49.0 Breast Grlić materice (C53) 24.7 30.8 16.2 22.0 12.3 21.2 20.2 16.1 22.0 38.7 29.8 27.1 16.4 11.9 25.8 25.1 22.2 32.9 17.0 Cervix uteri Kolon i rektum (C18-C20) 16.1 23.3 9.5 10.3 19.8 18.6 16.4 5.3 24.7 8.1 11.6 5.9 12.6 2.3 15.5 13.1 13.0 17.1 16.6 Colon and rectum Pluća i bronh (C34) 12.6 21.6 8.9 8.9 9.2 12.3 8.7 6.4 16.6 9.0 6.7 10.9 2.9 5.7 11.5 2.5 10.0 7.2 6.0 Lung and bronchus Materica (C54) 11.9 14.3 10.7 6.4 6.6 11.3 9.9 10.3 13.6 5.7 17.2 10.2 10.2 3.2 12.2 19.4 17.6 13.3 8.9 Corpus uteri Ovarijum (C56) 9.3 13.0 4.1 7.1 9.0 9.3 5.6 8.4 9.4 8.5 8.6 1.4 7.1 5.0 13.7 4.4 6.2 4.1 10.7 Ovary Želudac (C16) 5.3 7.8 4.5 3.1 5.7 8.3 3.5 2.7 5.5 1.4 2.9 2.3 3.6 0.4 5.7 7.8 6.2 5.3 2.9 Stomach Pankreas (C25) 3.6 6.3 2.4 0.7 4.1 3.9 4.1 1.6 3.2 0.3 2.2 1.5 1.8 2.9 6.1 1.1 1.1 3.4 1.5 Pancreas Mokraćna bešika (C67) 3.3 4.4 2.6 3.7 1.2 3.0 3.1 2.6 6.2 0.6 1.8 3.9 3.0 3.3 2.7 5.1 1.4 0.0 0.5 Bladder Mozak (C71) 4.8 7.6 8.1 3.2 5.4 2.9 2.9 1.7 5.6 5.0 0.0 1.5 0.0 2.8 7.5 2.1 1.1 4.3 7.0 Brain Koža, maligni melanom (C43 ) 3.8 6.4 1.1 3.2 2.3 5.3 4.4 0.2 3.7 3.1 0.9 2.0 1.6 2.3 1.8 2.1 2.5 10.2 3.7 Malignant melanoma of skin Leukemije (C91-C95) 4.2 8.5 1.1 2.2 1.5 3.5 1.3 1.2 6.7 3.0 0.2 1.7 6.7 0.0 2.6 2.4 4.8 2.2 1.2 Leukaemias Druge lokalizacije 52.2 49.9 33.8 40.1 67.3 48.7 55.0 29.5 66.6 31.6 47.1 22.4 37.3 27.0 46.8 54.9 32.4 62.0 49.9 Other sites Sve lokalizacije (C00-C97) 204.4 290.1 147.5 145.3 193.4 180.8 177.8 125.0 252.2 165.1 161.8 138.6 153.4 84.3 211.2 172.8 150.7 207.1 174.8 All sites Sve lokalizacije bez kože (C44) 189.2 273.3 137.2 124.1 172.0 164.6 165.3 111.1 237.6 163.6 147.1 129.9 132.1 74.1 202.9 133.4 143.2 181.7 171.1 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski
Tabela 11. Broj umrlih slučajeva od raka prema vodećim lokalizacijama i okruzima, muškarci, centralna Srbija, 1999. godina Table 11. Number of death cancer cases by leading primary sites, males, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Pluća i bronh, (C34) 2032 684 74 115 83 97 102 74 111 108 68 90 39 57 148 46 61 42 33 Lung and bronchus Kolon i rektum (C18-C20) 751 235 21 50 28 43 33 35 30 39 23 32 26 27 64 17 23 7 18 Colon and rectum Želudac (C16) 545 133 22 40 29 33 25 21 17 23 17 28 9 13 44 29 29 18 15 Stomach Prostata (C61) 451 153 16 22 10 20 27 19 21 28 15 17 15 13 26 12 13 12 12 Prostate Pankreas (C25) 338 98 14 14 10 15 22 17 24 28 9 8 5 13 20 15 9 8 9 Pancreas Jetra (C22) 319 76 16 20 10 10 16 12 17 14 12 10 9 11 39 14 23 4 6 Liver Larinks (C32) 314 90 8 19 15 10 18 16 17 25 16 19 6 9 13 13 10 4 6 Larynx Mokraćna bešika (C67) 266 83 12 16 8 10 12 19 7 12 8 9 8 3 31 7 15 2 4 Bladder Mozak (C71) 228 87 3 8 11 9 8 11 11 10 13 5 5 9 15 7 9 2 5 Brain Usna šuplj. i farinks (C00-C10) 134 47 4 4 7 7 6 7 6 7 7 5 4 3 7 3 5 3 2 Mouth and pharynx Druge lokalizacije 1584 454 70 116 84 70 70 73 88 63 62 84 49 30 140 33 54 18 26 Other sites Sve lokalizacije (C00-C97) 6962 2140 260 424 295 324 339 304 349 357 250 307 175 188 547 196 251 120 136 All sites Sve lokalizacije bez kože (C44) 6923 2132 260 421 292 321 339 301 346 354 250 302 173 187 536 195 251 119 136 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski Tabela 12. Broj umrlih slučajeva od raka prema vodećim lokalizacijama i okruzima, žene, centralna Srbija, 1999. godina Table 12. Number of death cancer cases by leading primary sites, females, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija Grad Beograd Kolubarski Mačvanski Raški Moravički Zlatiborski O k r u g (R e g i o n) Dojka (C50) 989 358 26 36 40 40 46 52 55 43 34 46 29 20 60 33 38 14 19 Breast Kolon i rektum (C18-C20) 561 197 24 34 21 23 19 29 27 28 19 20 18 15 30 18 20 8 11 Colon and rectum Pluća i bronh (C34) 550 249 17 31 15 24 12 25 27 18 24 21 11 11 31 9 10 7 8 Lung and bronchus Grlić materice (C53) 355 107 12 7 16 14 18 16 12 16 20 26 11 20 23 7 17 8 5 Cervix uteri Želudac (C16) 305 107 20 21 14 18 14 12 9 14 10 10 3 7 12 14 11 4 5 Stomach Pankreas (C25) 248 87 0 17 2 17 10 17 17 7 0 8 8 8 18 8 0 8 8 Pancreas Ovarijum (C56) 222 78 3 11 7 9 10 10 15 13 7 12 5 3 17 7 8 1 6 Ovary Jetra (C22) 215 50 11 15 10 10 8 8 19 9 11 8 4 10 16 7 7 6 6 Liver Mozak (C71) 162 55 4 8 7 0 5 8 9 5 4 4 3 5 21 2 3 3 5 Brain Bubreg (C64) 90 28 5 7 3 7 7 7 7 8 2 7 1 1 5 1 5 0 1 Kidney Druge lokalizacije 1653 515 55 95 94 74 78 71 87 70 65 70 40 36 121 54 62 34 39 Other sites Sve lokalizacije (C00-C97) 5350 1831 177 282 229 236 227 255 284 231 196 232 133 136 354 160 181 93 113 All sites Sve lokalizacije bez kože (C44) 5315 1821 176 282 226 234 225 255 282 230 194 230 133 136 352 158 180 92 113 All sites but skin (C44) Rasinski Šumadijski Pomoravski Braničevski Podunavski Zaječarski Borski Nišavski Pčinjski Jablanički Toplički Pirotski
Tabela 13. Stope mortaliteta od raka na 100.000 stanovnika prema vodećim lokalizacijama i okruzima, muškarci, centralna Srbija, 1999. godina Table 13. Cancer mortality rates per 100.000 population by leading primary sites, males, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) Pluća i bronh, (C34) 75.7 91.6 76.8 69.4 58.2 87.0 65.0 57.5 75.0 96.7 69.5 86.1 56.7 77.6 77.8 40.9 50.0 80.6 60.5 Lung and bronchus Kolon i rektum (C18-C20) 28.0 31.5 21.8 30.2 19.6 38.5 21.0 27.2 20.3 34.9 23.5 30.6 37.8 36.7 33.7 15.1 18.8 13.4 33.0 Colon and rectum Želudac (C16) 20.3 17.8 22.8 24.1 20.3 29.6 15.9 16.3 11.5 20.6 17.4 26.8 13.1 17.7 23.1 25.8 23.8 34.5 27.5 Stomach Prostata (C61) 16.8 20.5 16.6 13.3 7.0 17.9 17.2 14.8 14.2 25.1 15.3 16.3 21.8 17.7 13.7 10.7 10.7 23.0 22.0 Prostate Pankreas (C25) 12.6 13.1 14.5 8.4 7.0 13.4 14.0 13.2 16.2 25.1 9.2 7.7 7.3 17.7 10.5 13.3 7.4 15.4 16.5 Pancreas Jetra (C22) 11.9 10.2 16.6 12.1 7.0 9.0 10.2 9.3 11.5 12.5 12.3 9.6 13.1 15.0 20.5 12.5 18.8 7.7 11.0 Liver Larinks (C32) 11.7 12.1 8.3 11.5 10.5 9.0 11.5 12.4 11.5 22.4 16.4 18.2 8.7 12.2 6.8 11.6 8.2 7.7 11.0 Larynx Mokraćna bešika (C67) 9.8 11.1 12.5 9.7 5.6 9.0 7.6 14.8 4.7 10.7 8.2 8.6 11.6 4.1 16.3 6.2 12.3 3.8 7.3 Bladder Mozak (C71) 8.5 11.6 3.1 4.8 7.7 8.1 5.1 8.5 7.4 8.9 13.3 4.8 7.3 12.2 7.9 6.2 7.4 3.8 9.2 Brain Usna šuplj. i farinks (C00-C10) 5.0 6.3 4.2 2.4 4.9 6.3 3.8 5.4 4.1 6.3 7.2 4.8 5.8 4.1 3.7 2.7 4.1 5.8 3.7 Mouth and pharynx Druge lokalizacije 59.2 60.8 72.7 70.0 58.9 62.8 44.6 56.7 59.4 56.4 63.4 80.3 71.2 40.8 73.6 29.4 44.2 34.5 47.6 Other sites Sve lokalizacije (C00-C97) 259.4 286.5 269.9 255.8 206.9 290.5 216.1 236.2 235.8 319.5 255.6 293.6 254.4 255.8 287.6 174.3 205.7 230.3 249.2 All sites Sve lokalizacije bez kože (C44) 257.9 285.5 269.9 254.0 204.8 287.8 216.1 233.9 233.7 316.8 255.6 288.8 251.5 254.5 281.8 173.4 205.7 228.4 249.2 All sites but skin (C44) Tabela 14. Stope mortaliteta od raka na 100.000 stanovnika prema vodećim lokalizacijama i okruzima, žene, centralna Srbija, 1999. godina Table 14. Cancer mortality rates per 100.000 population by leading primary sites, females, regions in Central Serbia, 1999 Primarne lokalizacije (10-MKB) Primary sites (ICD-10) centralna Srbija centralna Srbija Grad Beograd Grad Beograd Kolubarski Kolubarski Mačvanski Mačvanski Raški Raški Moravički Moravički Zlatiborski Zlatiborski O k r u g (R e g i o n) O k r u g (R e g i o n) Dojka (C50) 35.0 43.6 26.3 21.3 27.2 34.7 28.6 38.6 35.6 36.2 32.4 42.6 39.5 26.1 30.7 29.1 30.9 26.7 35.1 Breast Kolon i rektum (C18-C20) 19.9 24.0 24.3 20.1 14.3 19.9 11.8 21.5 17.5 23.6 18.1 18.5 24.5 19.6 15.3 15.9 16.3 15.2 20.3 Colon and rectum Pluća i bronh (C34) 19.5 30.3 17.2 18.3 10.2 20.8 7.5 18.6 17.5 15.2 22.9 19.4 15.0 14.4 15.8 7.9 8.1 13.3 14.8 Lung and bronchus Grlić materice (C53) 12.6 13.0 12.2 4.1 10.9 12.1 11.2 11.9 7.8 13.5 19.1 24.1 15.0 26.1 11.8 6.2 13.8 15.2 9.2 Cervix uteri Želudac (C16) 10.8 13.0 20.3 12.4 9.5 15.6 8.7 8.9 5.8 11.8 9.5 9.3 4.1 9.1 6.1 12.3 9.0 7.6 9.2 Stomach Pankreas (C25) 8.8 10.6 0.0 10.0 1.4 14.7 6.2 12.6 11.0 5.9 0.0 7.4 10.9 10.4 9.2 7.0 0.0 15.2 14.8 Pancreas Ovarijum (C56) 7.9 9.5 3.0 6.5 4.8 7.8 6.2 7.4 9.7 10.9 6.7 11.1 6.8 3.9 8.7 6.2 6.5 1.9 11.1 Ovary Jetra (C22) 7.6 6.1 11.1 8.9 6.8 8.7 5.0 5.9 12.3 7.6 10.5 7.4 5.5 13.1 8.2 6.2 5.7 11.4 11.1 Liver Mozak (C71) 5.7 6.7 4.1 4.7 4.8 0.0 3.1 5.9 5.8 4.2 3.8 3.7 4.1 6.5 10.7 1.8 2.4 5.7 9.2 Brain Bubreg (C64) 3.2 3.4 5.1 4.1 2.0 6.1 4.3 5.2 4.5 6.7 1.9 6.5 1.4 1.3 2.6 0.9 4.1 0.0 1.8 Kidney Druge lokalizacije 58.6 62.7 55.7 56.1 64.0 64.1 48.5 52.8 56.3 58.9 61.9 64.8 54.5 47.0 61.8 47.6 50.4 64.7 72.1 Other sites Sve lokalizacije (C00-C97) 189.5 222.8 179.3 166.7 155.8 204.6 141.1 189.5 183.9 194.5 186.8 214.7 181.3 177.5 180.9 141.0 147.3 177.0 208.9 All sites Sve lokalizacije bez kože (C44) 188.3 221.6 178.3 166.7 153.8 202.8 139.8 189.5 182.6 193.6 184.9 212.9 181.3 177.5 179.8 139.2 146.5 175.1 208.9 All sites but skin (C44) Rasinski Rasinski Šumadijski Šumadijski Pomoravski Pomoravski Braničevski Braničevski Podunavski Podunavski Zaječarski Zaječarski Borski Borski Nišavski Nišavski Pčinjski Pčinjski Jablanički Jablanički Toplički Toplički Pirotski Pirotski